bacampicillin indications/contra

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 280 50972-17-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bacampicillin
  • bacampicillin hydrochloride
  • carampicillin
  • bacampicillin HCl
ester prodrug that is hydrolyzed to ampicillin after its absorption from the gastrointestinal tract; RN given refers to parent cpd; structure
  • Molecular weight: 465.52
  • Formula: C21H27N3O7S
  • CLOGP: 2.06
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 2
  • TPSA: 137.26
  • ALOGS: -3.58
  • ROTB: 10

Drug dosage:

DoseUnitRoute
1.20 g O

Approvals:

DateAgencyCompanyOrphan
Dec. 22, 1980 FDA

FDA Adverse Event Reporting System

scroll-->
MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Oesophageal ulcer 26.09 0 3 2 1234 3384620

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC J01CA06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:50266 prodrug

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Sinusitis indication 36971009
Urinary tract infectious disease indication 68566005
Haemophilus influenzae pneumonia indication 70036007
Infective otitis media indication 312218008
Pharyngitis indication 405737000 DOID:2275
Kidney disease contraindication 90708001 DOID:2527
Infectious mononucleosis contraindication 271558008 DOID:8568
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185
Cholangitis off-label use 82403002 DOID:9446

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

scroll-->
IDSource
4019623 VUID
N0000147716 NUI
C0052865 UMLSCUI
D00927 KEGG_DRUG
d00151 MMSL
18687 RXNORM
372865005 SNOMEDCT_US
82312001 SNOMEDCT_US
4019623 VANDF
N0000005940 NDFRT
N0000147716 NDFRT
004839 NDDF
8GM2J22278 UNII
3630 INN_ID
441397 PUBCHEM_CID
CHEMBL1583 ChEMBL_ID
CHEMBL1200965 ChEMBL_ID
DB01602 DRUGBANK_ID
37661-08-8 SECONDARY_CAS_RN
C011674 MESH_SUPPLEMENTAL_RECORD_UI
DB00415 DRUGBANK_ID
CHEBI:2968 CHEBI

Pharmaceutical products:

None