uracil mustard indications/contra

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 2795 66-75-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • uracil mustard
  • aminouracil mustard
  • chlorethaminacil
  • demethyldopan
  • desmethyldopan
  • uracil nitrogen mustard
  • uramustin
  • uramustine
Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.
  • Molecular weight: 252.10
  • Formula: C8H11Cl2N3O2
  • CLOGP: 0.60
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 61.44
  • ALOGS: -2.28
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 13, 1962 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Chronic lymphoid leukemia, disease indication 92814006 DOID:1040
Chronic myeloid leukemia indication 92818009 DOID:8552
Polycythemia vera indication 109992005 DOID:8432
Non-Hodgkin's lymphoma indication 118601006 DOID:8675

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 2.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA DNA OTHER CHEMBL CHEMBL

External reference:

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IDSource
4018098 VUID
N0000146436 NUI
C0041920 UMLSCUI
D06265 KEGG_DRUG
DB00791 DRUGBANK_ID
6194 PUBCHEM_CID
4018098 VANDF
N0000006304 NDFRT
N0000146436 NDFRT
3099 MMSL
10996 RXNORM
17243005 SNOMEDCT_US
5655 MMSL
d01340 MMSL
002634 NDDF
CHEMBL1488 ChEMBL_ID
CHEBI:9884 CHEBI
W7KQ46GJ8U UNII
1351 INN_ID
D014499 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None