unoprostone isopropyl 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prostaglandins	2794	120373-24-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

unoprostone isopropyl ester
isopropyl unoprostone
rescula
unoprostone isopropyl

a safe and effective ocular hypotensive drug

Molecular weight: 424.62
Formula: C25H44O5
CLOGP: 4.54
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 83.83
ALOGS: -4.80
ROTB: 17

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 3, 2000	FDA	SUCAMPO PHARMA LLC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002317	Cardiovascular Agents
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:39456	antiglaucoma agent
CHEBI has role	CHEBI:50266	Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ocular hypertension	indication	4210003	DOID:9282
Open-angle glaucoma	indication	84494001	DOID:1067

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4021244	VUID
N0000179516	NUI
D01452	KEGG_DRUG
4021244	VANDF
CHEBI:31731	CHEBI
CHEMBL1200661	ChEMBL_ID
C072630	MESH_SUPPLEMENTAL_RECORD_UI
8282	IUPHAR_LIGAND_ID
5M161S5O5P	UNII
135313	RXNORM
15695	MMSL
37952	MMSL
008857	NDDF
410844009	SNOMEDCT_US
410845005	SNOMEDCT_US
C0527038	UMLSCUI
5282175	PUBCHEM_CID
120373-36-6	SECONDARY_CAS_RN

Pharmaceutical products:

None