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tyramine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2784 | 51-67-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An indirect sympathomimetic that occurs naturally in cheese and other foods. Tyramine does not directly activate adrenergic receptors, but it can serve as a substrate for adrenergic uptake systems and MONOAMINE OXIDASE to prolong the actions of adrenergic transmitters. It also provokes transmitter release from adrenergic terminals and may be a neurotransmitter in some invertebrate nervous systems.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D013566 | Sympathomimetics |
| MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
| MeSH PA | D049990 | Membrane Transport Modulators |
| CHEBI has role | CHEBI:25512 | neurotransmitter |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:50514 | vasoconstrictor agent |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypercholesterolemia | indication | 13644009 | |
| Hyperlipidemia | indication | 55822004 | DOID:1168 |
| Biliary Obstruction with Pruritus | indication | ||
| Poisoning by digitalis glycoside | off-label use | 12876009 | |
| Chronic diarrhea | off-label use | 236071009 | |
| Classical phenylketonuria | contraindication | 7573000 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Hypovolemia | contraindication | 28560003 | |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Hemorrhoids | contraindication | 70153002 | DOID:9746 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Calculus in biliary tract | contraindication | 266474003 | |
| Complete Biliary Obstruction | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.46 | acidic |
| pKa2 | 9.73 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Trace amine-associated receptor 1 | GPCR | AGONIST | EC50 | 7.16 | WOMBAT-PK | SCIENTIFIC LITERATURE | |||
| Beta-secretase 1 | Enzyme | Kd | 2.70 | CHEMBL | |||||
| 5-hydroxytryptamine receptor 3A | Ion channel | EC50 | 4.59 | CHEMBL | |||||
| Trace amine-associated receptor 1 | GPCR | AGONIST | EC50 | 7.20 | IUPHAR | ||||
| TyR1 | GPCR | EC50 | 6.43 | CHEMBL | |||||
| Serotonin (5-HT) receptor | GPCR | Kd | 5.07 | CHEMBL | |||||
| Trace amine-associated receptor 1 | GPCR | AGONIST | EC50 | 7.10 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| 4021457 | VUID |
| N0000148848 | NUI |
| 4021457 | VANDF |
| C0041479 | UMLSCUI |
| CHEBI:15760 | CHEBI |
| AEF | PDB_CHEM_ID |
| CHEMBL11608 | ChEMBL_ID |
| DB08841 | DRUGBANK_ID |
| CHEMBL1255790 | ChEMBL_ID |
| D014439 | MESH_DESCRIPTOR_UI |
| 5610 | PUBCHEM_CID |
| 2150 | IUPHAR_LIGAND_ID |
| 60-19-5 | SECONDARY_CAS_RN |
| X8ZC7V0OX3 | UNII |
| 10958 | RXNORM |
| 007120 | NDDF |
| 007121 | NDDF |
| X8ZC7V0OX3 | INXIGHT DRUGS |
Pharmaceutical products:
None