azosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diuretics, furosemide derivatives	278	27589-33-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: azosemide diurapid azosemid	Molecular weight: 370.83 Formula: C12H11ClN6O2S2 CLOGP: 1.36 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 126.65 ALOGS: -3.59 ROTB: 5

Molecule

Description

Molfile Inchi Smiles

Synonyms:

azosemide
diurapid
azosemid

Molecular weight: 370.83
Formula: C12H11ClN6O2S2
CLOGP: 1.36
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 126.65
ALOGS: -3.59
ROTB: 5

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	10 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)	1.48 mL/min/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution)	0.28 L/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	251.86	26.08	125	4533	89017	63395347
Renal impairment	154.00	26.08	90	4568	88265	63396099
Cardiac failure chronic	120.00	26.08	33	4625	4385	63479979
Anaemia	83.67	26.08	105	4553	293325	63191039
Blood pressure decreased	67.79	26.08	48	4610	64974	63419390
Pulmonary arterial hypertension	67.49	26.08	33	4625	22544	63461820
Cerebral infarction	65.72	26.08	33	4625	23860	63460504
Brain natriuretic peptide increased	63.55	26.08	21	4637	5192	63479172
Cardiac failure acute	61.64	26.08	24	4634	9499	63474865
Right ventricular failure	60.15	26.08	28	4630	17160	63467204
Hepatic function abnormal	57.19	26.08	35	4623	37107	63447257
Pulmonary congestion	56.72	26.08	27	4631	17391	63466973
Concomitant disease aggravated	55.58	26.08	22	4636	9090	63475274
Pleural effusion	48.68	26.08	46	4612	93164	63391200
Pulmonary hypertension	47.20	26.08	31	4627	37092	63447272
Platelet count decreased	47.19	26.08	50	4608	116072	63368292
Fatigue	45.22	26.08	6	4652	888022	62596342
Drug ineffective	42.85	26.08	12	4646	1044753	62439611
Hyperuricaemia	40.01	26.08	15	4643	5355	63479009
Dehydration	39.93	26.08	56	4602	173298	63311066
Iron deficiency anaemia	39.11	26.08	22	4636	19947	63464417
Upper respiratory tract inflammation	38.26	26.08	12	4646	2511	63481853
Hypokalaemia	35.75	26.08	41	4617	103763	63380601
Hypernatraemia	34.95	26.08	15	4643	7594	63476770
Cardiac failure congestive	32.66	26.08	37	4621	92396	63391968
Interstitial lung disease	31.25	26.08	30	4628	61878	63422486
Atrial fibrillation	30.35	26.08	40	4618	116596	63367768
Altered state of consciousness	27.13	26.08	19	4639	25211	63459153
Embolic stroke	26.15	26.08	10	4648	3766	63480598

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	250.68	24.73	150	4202	91098	34861481
Renal impairment	151.02	24.73	111	4241	94402	34858177
Cardiac failure chronic	84.12	24.73	33	4319	7846	34944733
Hepatic function abnormal	77.22	24.73	55	4297	44308	34908271
Altered state of consciousness	66.03	24.73	39	4313	22854	34929725
Concomitant disease aggravated	61.27	24.73	24	4328	5677	34946902
Cerebral infarction	59.51	24.73	39	4313	27416	34925163
Blood pressure decreased	55.23	24.73	48	4304	51467	34901112
Pneumonia aspiration	50.98	24.73	42	4310	41861	34910718
Brain natriuretic peptide increased	47.67	24.73	20	4332	5639	34946940
Interstitial lung disease	47.35	24.73	49	4303	65233	34887346
Dehydration	44.68	24.73	67	4285	129902	34822677
Pulmonary arterial hypertension	39.36	24.73	20	4332	8719	34943860
Right ventricular failure	36.38	24.73	19	4333	8765	34943814
Low cardiac output syndrome	34.09	24.73	9	4343	599	34951980
Pleural effusion	32.30	24.73	45	4307	81501	34871078
Subdural haematoma	30.25	24.73	23	4329	20398	34932181
Cardiac failure acute	27.84	24.73	17	4335	10553	34942026
Decreased appetite	26.88	24.73	62	4290	166330	34786249
Hyperkalaemia	25.55	24.73	37	4315	69352	34883227
Drug ineffective	24.90	24.73	13	4339	456738	34495841
Pulmonary alveolar haemorrhage	24.84	24.73	14	4338	7498	34945081

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac failure	436.97	22.97	252	8904	154590	79580642
Renal impairment	281.03	22.97	192	8964	157591	79577641
Cardiac failure chronic	168.54	22.97	59	9097	11076	79724156
Hepatic function abnormal	129.89	22.97	89	9067	73018	79662214
Cerebral infarction	116.87	22.97	70	9086	45606	79689626
Concomitant disease aggravated	112.73	22.97	46	9110	13121	79722111
Brain natriuretic peptide increased	100.50	22.97	38	9118	8862	79726370
Blood pressure decreased	99.36	22.97	86	9070	99380	79635852
Pulmonary arterial hypertension	98.24	22.97	53	9103	28313	79706919
Right ventricular failure	87.27	22.97	46	9110	23451	79711781
Anaemia	82.62	22.97	167	8989	444848	79290384
Altered state of consciousness	81.71	22.97	55	9101	43767	79691465
Cardiac failure acute	78.76	22.97	40	9116	18889	79716343
Interstitial lung disease	77.16	22.97	79	9077	112521	79622711
Dehydration	75.76	22.97	116	9040	248071	79487161
Pneumonia aspiration	71.11	22.97	60	9096	66907	79668325
Pleural effusion	68.73	22.97	84	9072	145178	79590054
Fatigue	64.78	22.97	14	9142	929713	78805519
Drug ineffective	64.62	22.97	22	9134	1080891	78654341
Pulmonary hypertension	59.27	22.97	47	9109	48033	79687199
Hyperuricaemia	58.20	22.97	28	9128	11771	79723461
Platelet count decreased	57.97	22.97	90	9066	194574	79540658
Hypernatraemia	55.67	22.97	29	9127	14422	79720810
Pulmonary congestion	55.31	22.97	36	9120	27064	79708168
Iron deficiency anaemia	52.14	22.97	34	9122	25638	79709594
Subdural haematoma	43.69	22.97	33	9123	31401	79703831
Atrial fibrillation	43.60	22.97	80	9076	197806	79537426
Hyperkalaemia	41.39	22.97	58	9098	114340	79620892
Cardiac failure congestive	41.19	22.97	65	9091	142337	79592895
Low cardiac output syndrome	38.83	22.97	11	9145	1034	79734198
Decreased appetite	38.69	22.97	106	9050	342312	79392920
Haemorrhage subcutaneous	38.43	22.97	16	9140	4793	79730439
Upper respiratory tract inflammation	37.64	22.97	15	9141	4020	79731212
Pain	35.99	22.97	18	9138	703784	79031448
Disseminated intravascular coagulation	35.75	22.97	31	9125	35811	79699421
Pneumonia bacterial	35.38	22.97	24	9132	19307	79715925
Embolic stroke	33.90	22.97	17	9139	7809	79727423
Cardiothoracic ratio increased	33.37	22.97	6	9150	68	79735164
Pulmonary alveolar haemorrhage	33.07	22.97	19	9137	11438	79723794
Pneumonia	32.74	22.97	156	9000	660090	79075142
Oedema peripheral	32.45	22.97	82	9074	252206	79483026
Gastric cancer	29.70	22.97	17	9139	10162	79725070
Enterocolitis	28.93	22.97	19	9137	14493	79720739
Spinal compression fracture	28.55	22.97	20	9136	16938	79718294
Pemphigoid	28.00	22.97	19	9137	15296	79719936
Urine output decreased	27.46	22.97	20	9136	18002	79717230
Oedema	27.14	22.97	49	9107	119531	79615701
Transfusion	26.59	22.97	21	9135	21309	79713923
Hypokalaemia	26.51	22.97	54	9102	143986	79591246
Immobilisation syndrome	26.18	22.97	7	9149	531	79734701
Marasmus	25.85	22.97	8	9148	1020	79734212
Asthenia	24.78	22.97	14	9142	511675	79223557
Blood urea increased	24.31	22.97	29	9127	48761	79686471
Hepatic encephalopathy	24.30	22.97	21	9135	24145	79711087
Embolic cerebral infarction	24.18	22.97	8	9148	1263	79733969
Drug hypersensitivity	24.06	22.97	3	9153	298913	79436319
Physical deconditioning	23.95	22.97	9	9147	2061	79733171
Atrial tachycardia	23.77	22.97	13	9143	7120	79728112

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D004232	Diuretics
MeSH PA	D045283	Natriuretic Agents
CHEBI has role	CHEBI:77608	loop diuretics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Congestive heart failure	indication	42343007	DOID:6000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.68	acidic
pKa2	10.12	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D01323	KEGG_DRUG
18651	RXNORM
C0052820	UMLSCUI
CHEBI:31248	CHEBI
IWE	PDB_CHEM_ID
CHEMBL1097235	ChEMBL_ID
DB08961	DRUGBANK_ID
C018222	MESH_SUPPLEMENTAL_RECORD_UI
2273	PUBCHEM_CID
3954	INN_ID
MR40VT1L8Z	UNII
007033	NDDF

Pharmaceutical products:

None