azosemide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 278 27589-33-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azosemide
  • diurapid
  • azosemid
  • Molecular weight: 370.83
  • Formula: C12H11ClN6O2S2
  • CLOGP: 1.36
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 126.65
  • ALOGS: -3.59
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 1.48 mL/min/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
Vd (Volume of distribution) 0.28 L/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 251.86 26.08 125 4533 89017 63395347
Renal impairment 154.00 26.08 90 4568 88265 63396099
Cardiac failure chronic 120.00 26.08 33 4625 4385 63479979
Anaemia 83.67 26.08 105 4553 293325 63191039
Blood pressure decreased 67.79 26.08 48 4610 64974 63419390
Pulmonary arterial hypertension 67.49 26.08 33 4625 22544 63461820
Cerebral infarction 65.72 26.08 33 4625 23860 63460504
Brain natriuretic peptide increased 63.55 26.08 21 4637 5192 63479172
Cardiac failure acute 61.64 26.08 24 4634 9499 63474865
Right ventricular failure 60.15 26.08 28 4630 17160 63467204
Hepatic function abnormal 57.19 26.08 35 4623 37107 63447257
Pulmonary congestion 56.72 26.08 27 4631 17391 63466973
Concomitant disease aggravated 55.58 26.08 22 4636 9090 63475274
Pleural effusion 48.68 26.08 46 4612 93164 63391200
Pulmonary hypertension 47.20 26.08 31 4627 37092 63447272
Platelet count decreased 47.19 26.08 50 4608 116072 63368292
Fatigue 45.22 26.08 6 4652 888022 62596342
Drug ineffective 42.85 26.08 12 4646 1044753 62439611
Hyperuricaemia 40.01 26.08 15 4643 5355 63479009
Dehydration 39.93 26.08 56 4602 173298 63311066
Iron deficiency anaemia 39.11 26.08 22 4636 19947 63464417
Upper respiratory tract inflammation 38.26 26.08 12 4646 2511 63481853
Hypokalaemia 35.75 26.08 41 4617 103763 63380601
Hypernatraemia 34.95 26.08 15 4643 7594 63476770
Cardiac failure congestive 32.66 26.08 37 4621 92396 63391968
Interstitial lung disease 31.25 26.08 30 4628 61878 63422486
Atrial fibrillation 30.35 26.08 40 4618 116596 63367768
Altered state of consciousness 27.13 26.08 19 4639 25211 63459153
Embolic stroke 26.15 26.08 10 4648 3766 63480598

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 250.68 24.73 150 4202 91098 34861481
Renal impairment 151.02 24.73 111 4241 94402 34858177
Cardiac failure chronic 84.12 24.73 33 4319 7846 34944733
Hepatic function abnormal 77.22 24.73 55 4297 44308 34908271
Altered state of consciousness 66.03 24.73 39 4313 22854 34929725
Concomitant disease aggravated 61.27 24.73 24 4328 5677 34946902
Cerebral infarction 59.51 24.73 39 4313 27416 34925163
Blood pressure decreased 55.23 24.73 48 4304 51467 34901112
Pneumonia aspiration 50.98 24.73 42 4310 41861 34910718
Brain natriuretic peptide increased 47.67 24.73 20 4332 5639 34946940
Interstitial lung disease 47.35 24.73 49 4303 65233 34887346
Dehydration 44.68 24.73 67 4285 129902 34822677
Pulmonary arterial hypertension 39.36 24.73 20 4332 8719 34943860
Right ventricular failure 36.38 24.73 19 4333 8765 34943814
Low cardiac output syndrome 34.09 24.73 9 4343 599 34951980
Pleural effusion 32.30 24.73 45 4307 81501 34871078
Subdural haematoma 30.25 24.73 23 4329 20398 34932181
Cardiac failure acute 27.84 24.73 17 4335 10553 34942026
Decreased appetite 26.88 24.73 62 4290 166330 34786249
Hyperkalaemia 25.55 24.73 37 4315 69352 34883227
Drug ineffective 24.90 24.73 13 4339 456738 34495841
Pulmonary alveolar haemorrhage 24.84 24.73 14 4338 7498 34945081

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure 436.97 22.97 252 8904 154590 79580642
Renal impairment 281.03 22.97 192 8964 157591 79577641
Cardiac failure chronic 168.54 22.97 59 9097 11076 79724156
Hepatic function abnormal 129.89 22.97 89 9067 73018 79662214
Cerebral infarction 116.87 22.97 70 9086 45606 79689626
Concomitant disease aggravated 112.73 22.97 46 9110 13121 79722111
Brain natriuretic peptide increased 100.50 22.97 38 9118 8862 79726370
Blood pressure decreased 99.36 22.97 86 9070 99380 79635852
Pulmonary arterial hypertension 98.24 22.97 53 9103 28313 79706919
Right ventricular failure 87.27 22.97 46 9110 23451 79711781
Anaemia 82.62 22.97 167 8989 444848 79290384
Altered state of consciousness 81.71 22.97 55 9101 43767 79691465
Cardiac failure acute 78.76 22.97 40 9116 18889 79716343
Interstitial lung disease 77.16 22.97 79 9077 112521 79622711
Dehydration 75.76 22.97 116 9040 248071 79487161
Pneumonia aspiration 71.11 22.97 60 9096 66907 79668325
Pleural effusion 68.73 22.97 84 9072 145178 79590054
Fatigue 64.78 22.97 14 9142 929713 78805519
Drug ineffective 64.62 22.97 22 9134 1080891 78654341
Pulmonary hypertension 59.27 22.97 47 9109 48033 79687199
Hyperuricaemia 58.20 22.97 28 9128 11771 79723461
Platelet count decreased 57.97 22.97 90 9066 194574 79540658
Hypernatraemia 55.67 22.97 29 9127 14422 79720810
Pulmonary congestion 55.31 22.97 36 9120 27064 79708168
Iron deficiency anaemia 52.14 22.97 34 9122 25638 79709594
Subdural haematoma 43.69 22.97 33 9123 31401 79703831
Atrial fibrillation 43.60 22.97 80 9076 197806 79537426
Hyperkalaemia 41.39 22.97 58 9098 114340 79620892
Cardiac failure congestive 41.19 22.97 65 9091 142337 79592895
Low cardiac output syndrome 38.83 22.97 11 9145 1034 79734198
Decreased appetite 38.69 22.97 106 9050 342312 79392920
Haemorrhage subcutaneous 38.43 22.97 16 9140 4793 79730439
Upper respiratory tract inflammation 37.64 22.97 15 9141 4020 79731212
Pain 35.99 22.97 18 9138 703784 79031448
Disseminated intravascular coagulation 35.75 22.97 31 9125 35811 79699421
Pneumonia bacterial 35.38 22.97 24 9132 19307 79715925
Embolic stroke 33.90 22.97 17 9139 7809 79727423
Cardiothoracic ratio increased 33.37 22.97 6 9150 68 79735164
Pulmonary alveolar haemorrhage 33.07 22.97 19 9137 11438 79723794
Pneumonia 32.74 22.97 156 9000 660090 79075142
Oedema peripheral 32.45 22.97 82 9074 252206 79483026
Gastric cancer 29.70 22.97 17 9139 10162 79725070
Enterocolitis 28.93 22.97 19 9137 14493 79720739
Spinal compression fracture 28.55 22.97 20 9136 16938 79718294
Pemphigoid 28.00 22.97 19 9137 15296 79719936
Urine output decreased 27.46 22.97 20 9136 18002 79717230
Oedema 27.14 22.97 49 9107 119531 79615701
Transfusion 26.59 22.97 21 9135 21309 79713923
Hypokalaemia 26.51 22.97 54 9102 143986 79591246
Immobilisation syndrome 26.18 22.97 7 9149 531 79734701
Marasmus 25.85 22.97 8 9148 1020 79734212
Asthenia 24.78 22.97 14 9142 511675 79223557
Blood urea increased 24.31 22.97 29 9127 48761 79686471
Hepatic encephalopathy 24.30 22.97 21 9135 24145 79711087
Embolic cerebral infarction 24.18 22.97 8 9148 1263 79733969
Drug hypersensitivity 24.06 22.97 3 9153 298913 79436319
Physical deconditioning 23.95 22.97 9 9147 2061 79733171
Atrial tachycardia 23.77 22.97 13 9143 7120 79728112

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004232 Diuretics
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:77608 loop diuretics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Congestive heart failure indication 42343007 DOID:6000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.68 acidic
pKa2 10.12 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01323 KEGG_DRUG
18651 RXNORM
C0052820 UMLSCUI
CHEBI:31248 CHEBI
IWE PDB_CHEM_ID
CHEMBL1097235 ChEMBL_ID
DB08961 DRUGBANK_ID
C018222 MESH_SUPPLEMENTAL_RECORD_UI
2273 PUBCHEM_CID
3954 INN_ID
MR40VT1L8Z UNII
007033 NDDF

Pharmaceutical products:

None