tropicamide indications/contra

Stem definitionDrug idCAS RN
atropine derivatives 2774 1508-75-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tropicamide
  • bistropamide
  • epitromina
  • mydriacyl
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
  • Molecular weight: 284.36
  • Formula: C17H20N2O2
  • CLOGP: 1.18
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 53.43
  • ALOGS: -2.88
  • ROTB: 6

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 23, 1960 FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 114.82 80.13 16 184 517 3385142
Angle closure glaucoma 91.51 80.13 14 186 866 3384793

Pharmacologic Action:

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SourceCodeDescription
ATC S01FA06 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
ATC S01FA56 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Anticholinergics
FDA EPC N0000175574 Anticholinergic
MeSH PA D001337 Autonomic Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D009184 Mydriatics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Dilated pupil indication 37125009
Cycloplegia indication 68158006 DOID:10033
Perioperative Mydriasis indication
Ocular hypertension contraindication 4210003 DOID:9282
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus contraindication 73211009 DOID:9351
Open-angle glaucoma contraindication 84494001 DOID:1067
Shallow anterior chamber of eye contraindication 246986004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Primary Closed Angle Glaucoma contraindication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 7.52 DRUG MATRIX CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.17 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 7.43 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 8.46 PDSP
Muscarinic acetylcholine receptor M5 GPCR Ki 7.19 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 6 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 6 DRUG MATRIX

External reference:

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IDSource
4018592 VUID
N0000146908 NUI
C0041190 UMLSCUI
7319 IUPHAR_LIGAND_ID
D00397 KEGG_DRUG
DB00809 DRUGBANK_ID
5593 PUBCHEM_CID
3084 MMSL
10869 RXNORM
387526001 SNOMEDCT_US
9190005 SNOMEDCT_US
5645 MMSL
4018592 VANDF
N0000006959 NDFRT
N0000146908 NDFRT
001726 NDDF
CHEBI:9757 CHEBI
CHEMBL1200604 ChEMBL_ID
N0A3Z5XTC6 UNII
1059 INN_ID
D014331 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Mydriacyl HUMAN PRESCRIPTION DRUG LABEL 1 0065-0355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 0404-7192 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Mydriacyl HUMAN PRESCRIPTION DRUG LABEL 1 0998-0355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-101 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 11 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 17478-102 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Paremyd HUMAN PRESCRIPTION DRUG LABEL 2 17478-704 SOLUTION 2.50 mg OPHTHALMIC NDA 12 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 24208-585 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 10 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 24208-590 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 10 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 61314-355 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 68071-4004 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 10 sections
Tropicamide HUMAN PRESCRIPTION DRUG LABEL 1 70518-0744 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 11 sections