trometamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2771 77-86-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tromethamine
  • trisamin
  • trisamine
  • trisaminol
  • trometamol
An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
  • Molecular weight: 121.14
  • Formula: C4H11NO3
  • CLOGP: -0.94
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: 0.76
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 1965 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05BB03 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTIONS
Solutions affecting the electrolyte balance
ATC B05XX02 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Other i.v. solution additives
CHEBI has role CHEBI:35225 buffer compounds
MeSH PA D002021 Buffers
MeSH PA D005079 Excipients
MeSH PA D010592 Pharmaceutic Aids
MeSH PA D014677 Pharmaceutical Vehicles

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic conjunctivitis indication 473460002 DOID:11204
Post-Op Photophobia indication
Postoperative Ocular Pain indication
Post-Op Ocular Inflammation indication
Anuria contraindication 2472002 DOID:2983
Respiratory acidosis contraindication 12326000
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Disorder of cornea contraindication 15250008 DOID:10124
Acute gastric ulcer with perforation contraindication 19850005
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Hypovolemia contraindication 28560003
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Uremia contraindication 44730006 DOID:4676
Tear film insufficiency contraindication 46152009
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Corneal erosion contraindication 50792001
Duodenal ulcer disease contraindication 51868009 DOID:1724
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Rheumatoid arthritis contraindication 69896004 DOID:7148
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Corneal degeneration contraindication 111521006 DOID:1237
Perioperative care contraindication 133897009
Asthma contraindication 195967001 DOID:2841
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Anemia contraindication 271737000 DOID:2355
Cerebral hemorrhage contraindication 274100004
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Smokes tobacco daily contraindication 449868002
Salicylate Intoxication contraindication
Preoperative Pain Management contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.07 acidic
pKa2 13.54 acidic
pKa3 8.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018096 VUID
N0000146434 NUI
D00396 KEGG_DRUG
4018096 VANDF
C0041175 UMLSCUI
CHEBI:9754 CHEBI
TMN PDB_CHEM_ID
TRS PDB_CHEM_ID
CHEMBL1200391 ChEMBL_ID
DB03754 DRUGBANK_ID
7328 IUPHAR_LIGAND_ID
6503 PUBCHEM_CID
10865 RXNORM
5644 MMSL
80879 MMSL
d00472 MMSL
000751 NDDF
404882002 SNOMEDCT_US
59034000 SNOMEDCT_US
D014325 MESH_DESCRIPTOR_UI
1108 INN_ID
023C2WHX2V UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
THAM HUMAN PRESCRIPTION DRUG LABEL 1 0409-1593 INJECTION, SOLUTION 3.60 g INTRAVENOUS NDA 17 sections
SOORYEHAN HYO FERMENTED SUN BLOCK HUMAN OTC DRUG LABEL 7 53208-549 CREAM 2.63 mL TOPICAL OTC monograph not final 7 sections
AnubisMed HUMAN OTC DRUG LABEL 28 83021-551 CREAM 0.22 g TOPICAL OTC monograph final 7 sections
Anubis Barcelona Protective Line HUMAN OTC DRUG LABEL 27 83021-686 CREAM 0.22 g TOPICAL OTC monograph final 9 sections
Anubis Barcelona Protective Line HUMAN OTC DRUG LABEL 27 83021-686 CREAM 0.22 g TOPICAL OTC monograph final 9 sections