azlocillin indications/contra

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 277 37091-66-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azlocillin
  • azlocillin sodium
  • azlocillin sodium salt
A semisynthetic ampicillin-derived acylureido penicillin.
  • Molecular weight: 461.49
  • Formula: C20H23N5O6S
  • CLOGP: 1.56
  • LIPINSKI: 1
  • HAC: 11
  • HDO: 4
  • TPSA: 148.15
  • ALOGS: -3.30
  • ROTB: 5

Drug dosage:

DoseUnitRoute
12 g P

Approvals:

DateAgencyCompanyOrphan
Sept. 3, 1982 FDA BAYER PHARMACEUTICALS CORP

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01CA09 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:36047 antibacterial drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Bacterial septicemia indication 10001005
Infection of skin AND/OR subcutaneous tissue indication 19824006
Pneumonia due to Pseudomonas indication 41381004
Pneumonia due to Escherichia coli indication 51530003
Urinary tract infectious disease indication 68566005
Haemophilus influenzae pneumonia indication 70036007
Bacterial infection due to Serratia indication 71120004
Infection of bone indication 111253001
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Infectious disorder of joint indication 363162000 DOID:381
Aspiration pneumonia indication 422588002 DOID:3240
Enterobacter Pneumonia indication
Kidney disease contraindication 90708001 DOID:2527
Infectious mononucleosis contraindication 271558008 DOID:8568
Pseudomembranous enterocolitis contraindication 397683000 DOID:0060185
Cholangitis off-label use 82403002 DOID:9446
Infectious disease of abdomen off-label use 128070006
Abscess of brain off-label use 441806004
Pseudomonas Aeruginosa Meningitis off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 12.4 acidic
pKa3 12.92 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4019621 VUID
N0000147715 NUI
C0004499 UMLSCUI
D02339 KEGG_DRUG
DB01061 DRUGBANK_ID
1266 RXNORM
387308000 SNOMEDCT_US
55432002 SNOMEDCT_US
4019621 VANDF
N0000005863 NDFRT
N0000147715 NDFRT
004836 NDDF
CHEMBL1537 ChEMBL_ID
6479523 PUBCHEM_CID
CHEMBL1201041 ChEMBL_ID
DWV1EFW947 UNII
37091-65-9 SECONDARY_CAS_RN
4011 INN_ID
D001390 MESH_DESCRIPTOR_UI
CHEBI:2956 CHEBI

Pharmaceutical products:

None