trimethobenzamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2754 138-56-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tigan
  • trimethobenzamide hydrochloride
  • emedur
  • trimethobenzamide
  • trimethobenzamide HCl
major descriptor (64-84); on-line search BENZAMIDES (64-84); Index Medicus search TRIMETHOBENZAMIDE (64-84); RN given refers to parent cpd
  • Molecular weight: 388.46
  • Formula: C21H28N2O5
  • CLOGP: 2.69
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 69.26
  • ALOGS: -3.99
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
July 12, 1974 FDA PAR STERILE PRODUCTS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 58.51 30.08 40 743 310647 63177592

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nausea 34.32 25.91 49 908 957147 78786284
Drug hypersensitivity 33.44 25.91 28 929 298888 79444543

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AA10 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Aminoalkyl ethers
FDA PE N0000009034 Emesis Suppression
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018373 Peripheral Nervous System Agents
FDA EPC N0000178372 Antiemetic
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nausea and vomiting indication 16932000
Vomiting indication 422400008
Nausea indication 422587007
Dehydration contraindication 34095006
Encephalitis contraindication 45170000 DOID:9588
Bleeding hemorrhoids contraindication 51551000
Kidney disease contraindication 90708001 DOID:557
Disorder of mucous membrane contraindication 95351003
Disorder of electrolytes contraindication 237840007
Fever greater than 100.4 Fahrenheit contraindication 426000000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02733 KEGG_DRUG
554-92-7 SECONDARY_CAS_RN
4018405 VANDF
4019961 VANDF
CHEBI:27796 CHEBI
CHEMBL1201256 ChEMBL_ID
CHEMBL1200887 ChEMBL_ID
C100146 MESH_SUPPLEMENTAL_RECORD_UI
7614 IUPHAR_LIGAND_ID
DB00662 DRUGBANK_ID
W2X096QY97 UNII
227528 RXNORM
2183 MMSL
3031 MMSL
5632 MMSL
d00862 MMSL
001679 NDDF
001680 NDDF
14814001 SNOMEDCT_US
24261009 SNOMEDCT_US
372657005 SNOMEDCT_US
C0077163 UMLSCUI
957 INN_ID
5577 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 0404-9964 INJECTION 100 mg INTRAMUSCULAR NDA 11 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 0404-9964 INJECTION 100 mg INTRAMUSCULAR NDA 11 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-448 CAPSULE 300 mg ORAL ANDA 16 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 21695-853 INJECTION 100 mg INTRAMUSCULAR NDA 17 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 42023-118 INJECTION 100 mg INTRAMUSCULAR NDA 17 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 42023-119 INJECTION 100 mg INTRAMUSCULAR NDA 17 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 42023-119 INJECTION 100 mg INTRAMUSCULAR NDA 17 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43386-660 CAPSULE 300 mg ORAL ANDA 18 sections
TIGAN(R) (TRIMETHOBENZAMIDE HYDROCHLORIDE) HUMAN PRESCRIPTION DRUG LABEL 1 51662-1430 INJECTION 100 mg INTRAMUSCULAR NDA 12 sections
TIGAN(R) (TRIMETHOBENZAMIDE HYDROCHLORIDE) HUMAN PRESCRIPTION DRUG LABEL 1 51662-1430 INJECTION 100 mg INTRAMUSCULAR NDA 12 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 52584-119 INJECTION 100 mg INTRAMUSCULAR NDA 11 sections
Tigan HUMAN PRESCRIPTION DRUG LABEL 1 52584-119 INJECTION 100 mg INTRAMUSCULAR NDA 11 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 53489-376 CAPSULE 300 mg ORAL ANDA 20 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 54868-5741 CAPSULE 300 mg ORAL ANDA 10 sections
Trimethobenzamide HUMAN PRESCRIPTION DRUG LABEL 1 61919-884 CAPSULE 300 mg ORAL ANDA 9 sections
Trimethobenzamide HUMAN PRESCRIPTION DRUG LABEL 1 61919-884 CAPSULE 300 mg ORAL ANDA 9 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 63629-3685 CAPSULE 300 mg ORAL ANDA 20 sections
TIGAN HUMAN PRESCRIPTION DRUG LABEL 1 70518-1225 CAPSULE 300 mg ORAL NDA 20 sections
Trimethobenzamide Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 71335-0800 CAPSULE 300 mg ORAL ANDA 18 sections