alimemazine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
2749 84-96-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alimemazine
  • alimemazine tartrate
  • temaril
  • trimeprazine tartrate
  • trimeprazine
  • teralene
  • alimezine
  • methylpromazine
A phenothiazine derivative that is used as an antipruritic.
  • Molecular weight: 298.45
  • Formula: C18H22N2S
  • CLOGP: 5
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -4.55
  • ROTB: 4

Drug dosage:

DoseUnitRoute
30 mg O
30 mg P

Approvals:

DateAgencyCompanyOrphan
None FDA ALLERGAN HERBERT

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 286.84 79.60 63 303 21703 4616923
Intentional self-injury 269.06 79.60 50 316 7333 4631293
Toxicity to various agents 216.41 79.60 64 302 71976 4566650
Drug abuse 96.54 79.60 28 338 27919 4610707
Tachycardia 80.62 79.60 25 341 31120 4607506

Pharmacologic Action:

SourceCodeDescription
ATC R06AD01 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Phenothiazine derivatives
MeSH PA D000982 Antipruritics
MeSH PA D003879 Dermatologic Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Angioedema indication 41291007 DOID:1558
General anesthesia indication 50697003
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Urticaria indication 126485001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Alcoholism contraindication 7200002
Organophosphate poisoning contraindication 8260003
Weight gain finding contraindication 8943002
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Chronic disease of respiratory system contraindication 17097001
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Orthostatic hypotension contraindication 28651003
Torsades de pointes contraindication 31722008
Parkinsonism contraindication 32798002
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Extrapyramidal disease contraindication 76349003
Hyperglycemia contraindication 80394007 DOID:4195
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Stupor contraindication 89458003
Tardive dyskinesia contraindication 102449007
Prolonged QT interval contraindication 111975006
Acute disease of cardiovascular system contraindication 128487001
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Visual impairment contraindication 397540003
Breastfeeding (mother) contraindication 413712001
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Congenital long QT syndrome contraindication 442917000
Carcinoma of female breast contraindication 447782002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.92 Basic
pKa2 3.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST CHEMBL CHEMBL
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 5.90 CHEMBL

External reference:

IDSource
4019960 VUID
N0000148045 NUI
C0041031 UMLSCUI
D02245 KEGG_DRUG
362NW1LD6Z UNII
4330-99-8 SECONDARY_CAS_RN
706 INN_ID
387471006 SNOMEDCT_US
8109005 SNOMEDCT_US
4019960 VANDF
10825 RXNORM
d00788 MMSL
001535 NDDF
CHEBI:9725 CHEBI
CHEMBL829 ChEMBL_ID
DB01246 DRUGBANK_ID
7237 IUPHAR_LIGAND_ID
5574 PUBCHEM_CID
D014291 MESH_DESCRIPTOR_UI
CHEMBL1713082 ChEMBL_ID
CHEMBL3989885 ChEMBL_ID
C031242 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None