trimebutine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2748 39133-31-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimebutine maleate
  • trimebutine
  • (+/-)-Trimebutine
Proposed spasmolytic with possible local anesthetic action used in gastrointestinal disorders.
  • Molecular weight: 387.48
  • Formula: C22H29NO5
  • CLOGP: 4.36
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 57.23
  • ALOGS: -4.31
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.60 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyponatraemia 110.74 26.83 66 2735 111834 63374387
Necrosis ischaemic 105.46 26.83 20 2781 840 63485381
Pneumonia streptococcal 90.61 26.83 20 2781 1791 63484430
Beta haemolytic streptococcal infection 88.38 26.83 20 2781 2005 63484216
Coma 61.04 26.83 37 2764 64327 63421894
Colitis microscopic 58.13 26.83 20 2781 9319 63476902
Acute kidney injury 57.30 26.83 64 2737 263351 63222870
Drug reaction with eosinophilia and systemic symptoms 55.70 26.83 28 2773 33808 63452413
Interstitial lung disease 54.64 26.83 34 2767 61874 63424347
Poisoning deliberate 54.55 26.83 20 2781 11198 63475023
Fall 54.38 26.83 76 2725 392258 63093963
Septic shock 47.49 26.83 32 2769 66597 63419624
Hypokalaemia 47.19 26.83 38 2763 103766 63382455
Rash maculo-papular 39.97 26.83 22 2779 31874 63454347
Colitis 38.68 26.83 25 2776 48503 63437718
Toxic skin eruption 38.01 26.83 16 2785 12869 63473352
Cardio-respiratory arrest 36.16 26.83 26 2775 59933 63426288
Granulomatous liver disease 35.66 26.83 8 2793 770 63485451
Hypophosphataemia 33.07 26.83 14 2787 11412 63474809
Transverse sinus thrombosis 32.59 26.83 7 2794 551 63485670
Superior sagittal sinus thrombosis 30.15 26.83 7 2794 784 63485437

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Wrong patient received product 36.93 29.00 11 1876 2643 34952401
Acute kidney injury 34.57 29.00 60 1827 304928 34650116
Encephalopathy 31.39 29.00 21 1866 35298 34919746
Tumour necrosis 30.05 29.00 8 1879 1280 34953764
Mydriasis 29.52 29.00 12 1875 7225 34947819

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Necrosis ischaemic 94.77 23.89 20 4717 1070 79738581
Hyponatraemia 91.01 23.89 79 4658 177769 79561882
Beta haemolytic streptococcal infection 81.74 23.89 20 4717 2077 79737574
Acute kidney injury 78.86 23.89 123 4614 519281 79220370
Pneumonia streptococcal 76.39 23.89 20 4717 2725 79736926
Coma 75.52 23.89 56 4681 100593 79639058
Colitis microscopic 49.53 23.89 20 4717 10748 79728903
Poisoning deliberate 47.71 23.89 23 4714 18805 79720846
Drug reaction with eosinophilia and systemic symptoms 44.27 23.89 34 4703 64210 79675441
Rash maculo-papular 41.56 23.89 31 4706 56047 79683604
Toxic skin eruption 41.19 23.89 22 4715 22271 79717380
Fall 39.12 23.89 88 4649 487541 79252110
Interstitial lung disease 36.56 23.89 39 4698 112561 79627090
Encephalopathy 36.53 23.89 31 4706 67366 79672285
Septic shock 35.48 23.89 40 4697 122761 79616890
Hypomagnesaemia 34.91 23.89 26 4711 46885 79692766
Hypocalcaemia 33.47 23.89 26 4711 49898 79689753
Inappropriate antidiuretic hormone secretion 32.58 23.89 20 4717 26293 79713358
Wrong patient received product 29.89 23.89 11 4726 4607 79735044
Transverse sinus thrombosis 29.29 23.89 7 4730 658 79738993
Febrile bone marrow aplasia 27.34 23.89 14 4723 13006 79726645
Hypokalaemia 27.30 23.89 38 4699 144002 79595649
Hypophosphataemia 26.88 23.89 16 4721 19897 79719754
Cholestasis 26.27 23.89 23 4714 52086 79687565
Tumour necrosis 26.12 23.89 8 4729 1914 79737737
Superior sagittal sinus thrombosis 26.03 23.89 7 4730 1056 79738595
Miosis 24.80 23.89 14 4723 15775 79723876
Granulomatous liver disease 24.46 23.89 7 4730 1326 79738325

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AA05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, esters with tertiary amino group
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01500 KEGG_DRUG
34140-59-5 SECONDARY_CAS_RN
C0041023 UMLSCUI
CHEBI:32261 CHEBI
CHEMBL190044 ChEMBL_ID
DB09089 DRUGBANK_ID
D014287 MESH_DESCRIPTOR_UI
5573 PUBCHEM_CID
2773 INN_ID
QZ1OJ92E5R UNII
10819 RXNORM
003502 NDDF
003503 NDDF
698184001 SNOMEDCT_US
703719009 SNOMEDCT_US

Pharmaceutical products:

None