tretamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2739 51-18-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triethylenemelamine
  • tretamin
  • tretamine
  • triamelin
  • triaziridinyl triazine
  • triethanomelamine
  • trisaziridinyltriazine
Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.
  • Molecular weight: 204.24
  • Formula: C9H12N6
  • CLOGP: -0.27
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 47.70
  • ALOGS: -1.30
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae
CHEBI has role CHEBI:67105 insect sterilants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant tumor of ovary indication 363443007 DOID:2394
Mood swings contraindication 18963009
Ataxia contraindication 20262006
Leukopenia contraindication 84828003 DOID:615
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Bone marrow depression contraindication 307762000
Vertigo contraindication 399153001
Breastfeeding (mother) contraindication 413712001
Unconscious contraindication 418107008
Severe Bone Marrow Depression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.42 Basic
pKa2 1.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0040975 UMLSCUI
CHEBI:27919 CHEBI
CHEMBL502384 ChEMBL_ID
DB14031 DRUGBANK_ID
5799 PUBCHEM_CID
002636 NDDF
20887007 SNOMEDCT_US
D014265 MESH_DESCRIPTOR_UI
329 INN_ID
F7IY6HZG9D UNII

Pharmaceutical products:

None