triclofos indications/contra

Stem definitionDrug idCAS RN
2735 306-52-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclofos
  • trichlophos
  • trichloroethyl dihydrogen phosphate
  • trichloroethyl phosphate
  • triclofos sodium
derivative 7 metabolic precursor of trichloroethanol; RN given refers to parent cpd; structure
  • Molecular weight: 229.37
  • Formula: C2H4Cl3O4P
  • CLOGP: -0.11
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 66.76
  • ALOGS: -1.47
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05CM07 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Other hypnotics and sedatives

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.37 acidic
pKa2 6.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE MODULATOR CHEMBL CHEMBL

External reference:

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IDSource
C0077073 UMLSCUI
D00388 KEGG_DRUG
5563 PUBCHEM_CID
420762008 SNOMEDCT_US
421583009 SNOMEDCT_US
38610 RXNORM
004583 NDDF
9F90KA5Q8U UNII
7246-20-0 SECONDARY_CAS_RN
CHEBI:9695 CHEBI
CHEMBL1200789 ChEMBL_ID
CHEMBL1201317 ChEMBL_ID
C004345 MESH_SUPPLEMENTAL_RECORD_UI
1518 INN_ID

Pharmaceutical products:

None