triclabendazole indications/contra

Stem definitionDrug idCAS RN
anthelminthics, tiabendazole derivatives 2734 68786-66-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • triclabendazole
  • fasinex
  • Molecular weight: 359.65
  • Formula: C14H9Cl3N2OS
  • CLOGP: 6.44
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 37.91
  • ALOGS: -5.85
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1990 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC P02BX04 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTHELMINTICS
ANTITREMATODALS
Other antitrematodal agents
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.08 acidic
pKa2 3.81 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cruzipain Enzyme IC50 4.82 CHEMBL

External reference:

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IDSource
D07364 KEGG_DRUG
4784C8E03O UNII
5003 INN_ID
010991 NDDF
713429009 SNOMEDCT_US
714020008 SNOMEDCT_US
50248 PUBCHEM_CID
CHEMBL1086440 ChEMBL_ID
C039276 MESH_SUPPLEMENTAL_RECORD_UI
DB12245 DRUGBANK_ID

Pharmaceutical products:

None