All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

triamcinolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	2725	124-94-7

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: triamcinolone triamcinlon triamcinolon rodinolone

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) Molecular weight: 394.44 Formula: C21H27FO6 CLOGP: 0.71 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 115.06 ALOGS: -2.67 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
7.50	mg	O
7.50	mg	P
0.22	mg	N

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.08 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
BA (Bioavailability)	23 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Dec. 3, 1957	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	447.67	14.30	155	21087	9569	63458211
Psoriasis	409.83	14.30	291	20951	86666	63381114
Adrenal insufficiency	391.92	14.30	166	21076	17749	63450031
Body height below normal	259.39	14.30	72	21170	2111	63465669
Human antichimeric antibody positive	233.71	14.30	63	21179	1651	63466129
Polyarthritis	228.44	14.30	96	21146	10050	63457730
Joint destruction	192.10	14.30	74	21168	6178	63461602
Wheelchair user	191.34	14.30	74	21168	6245	63461535
Obesity	180.82	14.30	117	21125	29835	63437945
Drug ineffective	143.62	14.30	707	20535	1044058	62423722
Bone density decreased	134.80	14.30	75	21167	14537	63453243
Drug specific antibody	125.82	14.30	42	21200	2313	63465467
Product use in unapproved indication	124.07	14.30	218	21024	178862	63288918
Antibody test positive	108.68	14.30	39	21203	2668	63465112
Gastroenteritis viral	108.36	14.30	78	21164	23622	63444158
Therapy non-responder	104.68	14.30	128	21114	75773	63392007
Septic shock	99.48	14.30	117	21125	66512	63401268
Macular degeneration	97.45	14.30	74	21168	24302	63443478
Immunodeficiency	95.68	14.30	68	21174	20186	63447594
Ankle arthroplasty	79.92	14.30	28	21214	1785	63465995
Impaired quality of life	78.65	14.30	52	21190	13731	63454049
Skin plaque	74.80	14.30	42	21200	8278	63459502
Hypocalcaemia	72.76	14.30	70	21172	31643	63436137
Papule	71.75	14.30	36	21206	5655	63462125
Arthritis	67.44	14.30	131	21111	115790	63351990
Quality of life decreased	64.73	14.30	39	21203	8764	63459016
Skin exfoliation	63.17	14.30	75	21167	43027	63424753
Hypothalamic pituitary adrenal axis suppression	62.35	14.30	14	21228	166	63467614
Product dose omission issue	61.41	14.30	195	21047	234118	63233662
Drug ineffective for unapproved indication	59.63	14.30	65	21177	33998	63433782
Eczema	57.19	14.30	62	21180	32229	63435551
Rash	54.57	14.30	347	20895	560524	62907256
Pruritus	54.36	14.30	252	20990	361201	63106579
Red blood cell sedimentation rate abnormal	51.79	14.30	47	21195	19735	63448045
Sleep disorder	49.65	14.30	94	21148	81472	63386308
Injection site atrophy	48.89	14.30	15	21227	628	63467152
Bursitis infective	48.88	14.30	18	21224	1325	63466455
Mobility decreased	48.76	14.30	118	21124	121041	63346739
Foot operation	47.97	14.30	30	21212	7201	63460579
Nodule	47.45	14.30	46	21196	20980	63446800
Red blood cell sedimentation rate increased	46.33	14.30	65	21177	43917	63423863
Eye infection toxoplasmal	45.71	14.30	12	21230	283	63467497
Dry skin	42.89	14.30	72	21170	56815	63410965
Skin atrophy	42.03	14.30	24	21218	4882	63462898
Diarrhoea	40.80	14.30	391	20851	714975	62752805
Condition aggravated	40.36	14.30	251	20991	401966	63065814
Short stature	39.64	14.30	13	21229	677	63467103
Toxicity to various agents	37.37	14.30	18	21224	247232	63220548
Product dose omission in error	36.96	14.30	26	21216	7586	63460194
Hepatic enzyme increased	36.78	14.30	11	21231	202317	63265463
Drug tolerance	36.72	14.30	25	21217	6924	63460856
Adrenal suppression	35.92	14.30	13	21229	911	63466869
Nausea	34.87	14.30	437	20805	854034	62613746
Pleural effusion	34.55	14.30	88	21154	93122	63374658
Bone density increased	34.54	14.30	12	21230	746	63467034
Dermatitis	34.38	14.30	35	21207	16923	63450857
Loss of personal independence in daily activities	34.16	14.30	90	21152	97200	63370580
Chorioretinopathy	33.35	14.30	12	21230	827	63466953
Seborrhoeic keratosis	33.05	14.30	16	21226	2326	63465454
Human anti-human antibody test	32.33	14.30	10	21232	430	63467350
Mycotic endophthalmitis	31.99	14.30	7	21235	73	63467707
Off label use	31.45	14.30	354	20888	674108	62793672
Ocular hypertension	30.73	14.30	12	21230	1038	63466742
Steroid withdrawal syndrome	30.23	14.30	10	21232	535	63467245
Wound	29.44	14.30	9	21233	163254	63304526
Rhegmatogenous retinal detachment	29.41	14.30	7	21235	109	63467671
Necrotising fasciitis	29.11	14.30	16	21226	3025	63464755
Foot deformity	29.09	14.30	41	21201	27812	63439968
Tractional retinal detachment	28.96	14.30	6	21236	47	63467733
Chronic sinusitis	28.79	14.30	28	21214	12815	63454965
Joint swelling	28.42	14.30	41	21201	327625	63140155
Lower respiratory tract infection	28.40	14.30	5	21237	132302	63335478
Paraesthesia oral	27.37	14.30	33	21209	19223	63448557
Necrotising scleritis	27.30	14.30	7	21235	150	63467630
Microsporidia infection	27.21	14.30	8	21234	289	63467491
Limb discomfort	27.05	14.30	41	21201	29675	63438105
Dermatitis contact	26.57	14.30	25	21217	10983	63456797
Psoriatic arthropathy	26.55	14.30	79	21163	91441	63376339
Plastic surgery	26.35	14.30	6	21236	76	63467704
Macule	26.07	14.30	13	21229	2015	63465765
Skin lesion	26.03	14.30	41	21201	30680	63437100
Skin odour abnormal	25.39	14.30	12	21230	1654	63466126
Pyloric abscess	25.24	14.30	4	21238	4	63467776
Staphylococcal infection	24.42	14.30	47	21195	41209	63426571
General physical health deterioration	24.39	14.30	19	21223	201383	63266397
Death	24.29	14.30	56	21186	374325	63093455
Confusional state	24.23	14.30	26	21216	236354	63231426
Guttate psoriasis	23.78	14.30	8	21234	451	63467329
Erythema	23.78	14.30	119	21123	175632	63292148
Perioral dermatitis	23.62	14.30	7	21235	260	63467520
Dystrophic calcification	23.43	14.30	6	21236	128	63467652
Rapidly progressive osteoarthritis	22.47	14.30	4	21238	12	63467768
Retinal artery occlusion	22.45	14.30	11	21231	1642	63466138
Synovitis	22.15	14.30	122	21120	186796	63280984
Neutropenia	21.84	14.30	16	21226	174989	63292791
Infectious crystalline keratopathy	21.79	14.30	4	21238	15	63467765
Birdshot chorioretinopathy	21.70	14.30	5	21237	67	63467713
Non-infectious endophthalmitis	21.57	14.30	6	21236	177	63467603
Hypokalaemia	20.70	14.30	79	21163	103725	63364055
Product contamination microbial	20.51	14.30	6	21236	213	63467567
Vaginal flatulence	20.19	14.30	13	21229	3280	63464500
Therapeutic product effect incomplete	20.07	14.30	89	21153	124967	63342813
Cushingoid	19.97	14.30	19	21223	8466	63459314
Skin discolouration	19.87	14.30	41	21201	37787	63429993
Rash pruritic	19.65	14.30	54	21188	59745	63408035
Joint effusion	19.14	14.30	26	21216	17034	63450746
Intraocular pressure increased	19.04	14.30	16	21226	6062	63461718
C-reactive protein increased	18.82	14.30	72	21170	94635	63373145
Maternal exposure during pregnancy	18.61	14.30	28	21214	220034	63247746
Procedural pain	18.57	14.30	29	21213	21540	63446240
Musculoskeletal stiffness	18.15	14.30	21	21221	184597	63283183
Cataract subcapsular	18.09	14.30	7	21235	591	63467189
Articular calcification	17.93	14.30	5	21237	149	63467631
Secondary adrenocortical insufficiency	17.90	14.30	9	21233	1419	63466361
Impaired healing	17.87	14.30	6	21236	102536	63365244
Keratitis fungal	17.53	14.30	5	21237	162	63467618
Pulmonary fibrosis	17.32	14.30	40	21202	39769	63428011
Exposure during pregnancy	17.20	14.30	16	21226	155531	63312249
Peripheral vascular disorder	17.10	14.30	15	21227	6020	63461760
Cross sensitivity reaction	16.99	14.30	10	21232	2152	63465628
Squamous cell carcinoma of skin	16.90	14.30	15	21227	6117	63461663
Retinal exudates	16.87	14.30	7	21235	709	63467071
Deposit eye	16.85	14.30	3	21239	9	63467771
Tendon rupture	16.69	14.30	17	21225	8222	63459558
Choroiditis	16.69	14.30	5	21237	193	63467587
Pemphigus	15.90	14.30	23	21219	183703	63284077
Arthritis fungal	15.64	14.30	3	21239	15	63467765
Dyspnoea	15.55	14.30	144	21098	661169	62806611
Eye irritation	15.49	14.30	27	21215	21944	63445836
Intentional overdose	15.48	14.30	3	21239	74149	63393631
Systemic lupus erythematosus	15.43	14.30	29	21213	208889	63258891
Neurodermatitis	15.41	14.30	8	21234	1348	63466432
Overdose	15.04	14.30	10	21232	115068	63352712
Glossodynia	14.89	14.30	23	21219	178853	63288927
Asthenia	14.80	14.30	72	21170	383532	63084248
Parakeratosis	14.73	14.30	5	21237	290	63467490
Shared psychotic disorder	14.66	14.30	3	21239	22	63467758
Rebound psoriasis	14.45	14.30	4	21238	116	63467664
Proctitis	14.38	14.30	13	21229	5428	63462352
Rebound effect	14.36	14.30	12	21230	4514	63463266
Skin irritation	14.34	14.30	17	21225	9724	63458056
Acute kidney injury	14.32	14.30	43	21199	263372	63204408

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	302.60	16.61	95	9551	5252	34942033
Drug ineffective	216.17	16.61	420	9226	456331	34490954
Psoriasis	186.17	16.61	122	9524	38690	34908595
Pruritus	140.89	16.61	184	9462	141797	34805488
Rash	123.32	16.61	220	9426	222532	34724753
Skin exfoliation	97.97	16.61	72	9574	27360	34919925
Product use in unapproved indication	83.45	16.61	130	9516	117369	34829916
Product dose omission issue	83.01	16.61	131	9515	119580	34827705
Sleep disorder	80.40	16.61	68	9578	31620	34915665
Deposit eye	77.71	16.61	13	9633	31	34947254
Mycotic endophthalmitis	73.11	16.61	14	9632	87	34947198
Treatment failure	71.96	16.61	76	9570	46621	34900664
Dry skin	63.16	16.61	59	9587	31228	34916057
Eczema	62.68	16.61	47	9599	18389	34928896
Product compounding quality issue	61.32	16.61	10	9636	19	34947266
Papule	53.32	16.61	25	9621	4114	34943171
Discomfort	48.75	16.61	41	9605	18897	34928388
Ocular hypertension	47.72	16.61	15	9631	829	34946456
Skin fissures	47.64	16.61	25	9621	5234	34942051
Product contamination microbial	46.98	16.61	14	9632	646	34946639
Steroid withdrawal syndrome	45.04	16.61	11	9635	235	34947050
Transmission of an infectious agent via product	42.67	16.61	10	9636	178	34947107
Mediastinal abscess	40.95	16.61	8	9638	56	34947229
Perioral dermatitis	39.60	16.61	9	9637	139	34947146
Skin plaque	39.16	16.61	21	9625	4593	34942692
Non-infectious endophthalmitis	38.91	16.61	9	9637	151	34947134
Endophthalmitis	38.55	16.61	19	9627	3489	34943796
Psoriatic arthropathy	35.52	16.61	35	9611	19763	34927522
Drug ineffective for unapproved indication	33.69	16.61	37	9609	23678	34923607
Visual acuity reduced	33.62	16.61	31	9615	16118	34931167
Necrotising scleritis	33.17	16.61	7	9639	75	34947210
Chorioretinopathy	32.29	16.61	13	9633	1480	34945805
Myoclonic epilepsy	31.85	16.61	12	9634	1145	34946140
Glaucoma	31.30	16.61	21	9625	6891	34940394
Skin haemorrhage	30.74	16.61	18	9628	4660	34942625
Eye infection toxoplasmal	30.36	16.61	8	9638	234	34947051
Off label use	29.50	16.61	207	9439	419317	34527968
Cystoid macular oedema	29.46	16.61	10	9636	705	34946580
Adrenal insufficiency	29.31	16.61	27	9619	14020	34933265
Rhegmatogenous retinal detachment	29.28	16.61	6	9640	55	34947230
Therapy non-responder	28.66	16.61	44	9602	39102	34908183
Intraocular pressure increased	28.40	16.61	18	9628	5365	34941920
Retinal scar	28.19	16.61	8	9638	310	34946975
Scleromalacia	28.14	16.61	5	9641	19	34947266
Chondritis	28.09	16.61	7	9639	163	34947122
Pneumonia lipoid	27.65	16.61	6	9640	74	34947211
Product dose omission in error	27.04	16.61	13	9633	2261	34945024
Adrenal suppression	26.46	16.61	9	9637	638	34946647
Retinal oedema	26.45	16.61	9	9637	639	34946646
Guttate psoriasis	24.88	16.61	7	9639	263	34947022
Skin weeping	24.72	16.61	8	9638	486	34946799
Toxicity to various agents	22.15	16.61	14	9632	200348	34746937
Shared psychotic disorder	21.97	16.61	4	9642	18	34947267
Injection site plaque	21.59	16.61	3	9643	0	34947285
Therapeutic product ineffective	20.91	16.61	8	9638	796	34946489
Infective scleritis	20.87	16.61	4	9642	25	34947260
Drug effect less than expected	20.77	16.61	9	9637	1232	34946053
Skin discolouration	20.56	16.61	25	9621	17820	34929465
Erythema	20.14	16.61	62	9584	88718	34858567
Application site pruritus	19.50	16.61	9	9637	1428	34945857
Rash pruritic	19.31	16.61	30	9616	26911	34920374
Hypothalamic pituitary adrenal axis suppression	19.11	16.61	5	9641	142	34947143
Cytomegalovirus chorioretinitis	18.93	16.61	12	9634	3577	34943708
Eye pruritus	18.82	16.61	16	9630	7473	34939812
Polypoidal choroidal vasculopathy	18.39	16.61	5	9641	165	34947120
Surgery	18.24	16.61	21	9625	14136	34933149
Eye infection syphilitic	17.98	16.61	3	9643	7	34947278
Choroidal detachment	17.77	16.61	6	9640	416	34946869
Meningitis aseptic	17.56	16.61	11	9635	3213	34944072
Retinal artery occlusion	17.18	16.61	9	9637	1876	34945409
Intracranial hypotension	16.61	16.61	5	9641	239	34947046

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	480.68	13.57	161	24096	9895	79710236
Psoriasis	424.47	13.57	290	23967	89297	79630834
Adrenal insufficiency	378.37	13.57	181	24076	28306	79691825
Human antichimeric antibody positive	232.72	13.57	61	24196	1580	79718551
Body height below normal	228.38	13.57	63	24194	1990	79718141
Polyarthritis	210.44	13.57	93	24164	12109	79708022
Joint destruction	191.73	13.57	71	24186	5854	79714277
Wheelchair user	164.22	13.57	64	24193	6068	79714063
Obesity	150.41	13.57	107	24150	35018	79685113
Drug ineffective	137.45	13.57	669	23588	1080244	78639887
Therapy non-responder	129.73	13.57	150	24107	92155	79627976
Drug specific antibody	125.22	13.57	42	24215	2586	79717545
Bone density decreased	124.98	13.57	67	24190	13280	79706851
Gastroenteritis viral	118.84	13.57	81	24176	24750	79695381
Immunodeficiency	101.78	13.57	70	24187	21698	79698433
Mycotic endophthalmitis	101.59	13.57	21	24236	181	79719950
Product dose omission issue	100.38	13.57	228	24029	247309	79472822
Deposit eye	92.98	13.57	16	24241	42	79720089
Product use in unapproved indication	85.74	13.57	216	24041	250143	79469988
Drug ineffective for unapproved indication	83.51	13.57	90	24167	51148	79668983
Ankle arthroplasty	83.21	13.57	27	24230	1498	79718633
Antibody test positive	81.39	13.57	31	24226	2761	79717370
Off label use	78.46	13.57	507	23750	906708	78813423
Eczema	77.85	13.57	78	24179	40740	79679391
Eye infection toxoplasmal	71.02	13.57	19	24238	533	79719598
Steroid withdrawal syndrome	70.49	13.57	20	24237	701	79719430
Hypothalamic pituitary adrenal axis suppression	70.10	13.57	17	24240	318	79719813
Adrenal suppression	69.20	13.57	23	24234	1376	79718755
Product compounding quality issue	68.81	13.57	12	24245	35	79720096
Ocular hypertension	67.33	13.57	23	24234	1497	79718634
Product contamination microbial	65.12	13.57	20	24237	926	79719205
Impaired quality of life	64.28	13.57	45	24212	14341	79705790
Rash	63.87	13.57	345	23912	578013	79142118
Perioral dermatitis	62.92	13.57	16	24241	366	79719765
Chorioretinopathy	62.27	13.57	24	24233	2207	79717924
Arthritis	59.47	13.57	117	24140	114763	79605368
Necrotising scleritis	59.32	13.57	14	24243	232	79719899
Septic shock	57.54	13.57	120	24137	122681	79597450
Hypocalcaemia	55.31	13.57	72	24185	49852	79670279
Non-infectious endophthalmitis	55.19	13.57	14	24243	317	79719814
Toxicity to various agents	54.85	13.57	30	24227	421510	79298621
Sleep disorder	52.74	13.57	94	24163	85583	79634548
Injection site atrophy	51.85	13.57	14	24243	407	79719724
Transmission of an infectious agent via product	51.42	13.57	12	24245	189	79719942
Red blood cell sedimentation rate abnormal	51.31	13.57	46	24211	20917	79699214
Mobility decreased	48.83	13.57	112	24145	122063	79598068
Foot operation	48.73	13.57	27	24230	5706	79714425
Pruritus	48.01	13.57	242	24015	394406	79325725
Completed suicide	46.79	13.57	9	24248	245758	79474373
Rhegmatogenous retinal detachment	46.46	13.57	11	24246	185	79719946
Quality of life decreased	45.18	13.57	32	24225	10388	79709743
Condition aggravated	44.89	13.57	283	23974	500841	79219290
Skin exfoliation	44.05	13.57	68	24189	55032	79665099
Dry skin	43.65	13.57	76	24181	67919	79652212
Skin atrophy	43.39	13.57	25	24232	5693	79714438
Endophthalmitis	43.24	13.57	26	24231	6402	79713729
Red blood cell sedimentation rate increased	41.44	13.57	60	24197	45882	79674249
Retinal artery occlusion	40.88	13.57	20	24237	3274	79716857
Short stature	40.36	13.57	13	24244	704	79719427
Diarrhoea	39.12	13.57	424	23833	880065	78840066
Bone density increased	38.51	13.57	13	24244	816	79719315
General physical health deterioration	38.14	13.57	18	24239	275220	79444911
Intraocular pressure increased	37	13.57	27	24230	9178	79710953
Nodule	36.77	13.57	40	24217	22954	79697177
Shared psychotic disorder	36.37	13.57	7	24250	40	79720091
Nausea	35.85	13.57	446	23811	956750	78763381
Loss of personal independence in daily activities	35.55	13.57	89	24168	102491	79617640
Foot deformity	35.26	13.57	40	24217	24034	79696097
Mediastinal abscess	34.96	13.57	8	24249	115	79720016
Scleromalacia	34.55	13.57	7	24250	54	79720077
Macular degeneration	34.19	13.57	28	24229	11268	79708863
Product dose omission in error	33.95	13.57	24	24233	7764	79712367
Human anti-human antibody test	33.66	13.57	10	24247	413	79719718
Staphylococcal infection	33.38	13.57	62	24195	58233	79661898
Chronic sinusitis	30.73	13.57	28	24229	12998	79707133
Visual acuity reduced	30.32	13.57	41	24216	29428	79690703
Paraesthesia oral	29.96	13.57	34	24223	20437	79699694
Cushingoid	29.59	13.57	24	24233	9528	79710603
Drug tolerance	29.45	13.57	23	24234	8652	79711479
Retinal scar	29.26	13.57	9	24248	419	79719712
Glaucoma	29.22	13.57	33	24224	19728	79700403
Dermatitis contact	28.57	13.57	25	24232	11008	79709123
Rapidly progressive osteoarthritis	28.57	13.57	5	24252	15	79720116
Limb discomfort	28.32	13.57	42	24215	32808	79687323
Synovitis	27.92	13.57	105	24152	150629	79569502
Plastic surgery	27.62	13.57	6	24251	67	79720064
Cystoid macular oedema	27.54	13.57	13	24244	1967	79718164
Dermatitis	27.19	13.57	33	24224	21288	79698843
Pyloric abscess	25.62	13.57	4	24253	4	79720127
Cataract subcapsular	25.62	13.57	10	24247	951	79719180
Retinal oedema	25.58	13.57	10	24247	955	79719176
Pleural effusion	24.31	13.57	98	24159	145164	79574967
Vaginal flatulence	24.31	13.57	13	24244	2562	79717569
Rebound effect	24.18	13.57	19	24238	7207	79712924
Dystrophic calcification	23.77	13.57	6	24251	133	79719998
Acute kidney injury	23.68	13.57	80	24177	519324	79200807
Rash pruritic	23.62	13.57	61	24196	71568	79648563
Confusional state	23.30	13.57	38	24219	317959	79402172
Chondritis	22.75	13.57	6	24251	159	79719972
Cataract	22.68	13.57	55	24202	62065	79658066
Bursitis infective	22.67	13.57	10	24247	1294	79718837
Pneumonia lipoid	22.58	13.57	6	24251	164	79719967
Hepatic enzyme increased	22.29	13.57	14	24243	182596	79537535
Intentional overdose	22.13	13.57	3	24254	105957	79614174
Birdshot chorioretinopathy	22.11	13.57	5	24252	68	79720063
Lower respiratory tract infection	22.05	13.57	6	24251	129214	79590917
Joint effusion	21.55	13.57	27	24230	17987	79702144
Infectious crystalline keratopathy	21.40	13.57	4	24253	19	79720112
Skin fissures	21.35	13.57	23	24234	13050	79707081
Lipoatrophy	21.35	13.57	8	24249	681	79719450
Skin odour abnormal	20.75	13.57	11	24246	2130	79718001
Tractional retinal detachment	20.75	13.57	5	24252	91	79720040
Necrotising fasciitis	20.45	13.57	16	24241	6034	79714097
Psoriatic arthropathy	20.36	13.57	61	24196	77938	79642193
Bradycardia	20.14	13.57	8	24249	135549	79584582
Hypotony of eye	20.10	13.57	6	24251	252	79719879
Papule	19.61	13.57	17	24240	7390	79712741
Depressed level of consciousness	19.57	13.57	3	24254	96649	79623482
Procedural pain	19.16	13.57	29	24228	23055	79697076
Choroiditis	19.00	13.57	9	24248	1372	79718759
Cauda equina syndrome	18.87	13.57	9	24248	1394	79718737
Microsporidia infection	18.73	13.57	8	24249	958	79719173
Cardio-respiratory arrest	18.59	13.57	5	24252	108505	79611626
Retinal artery embolism	18.56	13.57	5	24252	144	79719987
Squamous cell carcinoma of skin	18.35	13.57	22	24235	14011	79706120
Thrombocytopenia	18.23	13.57	33	24224	265226	79454905
Skin discolouration	17.93	13.57	39	24218	40995	79679136
Electrocardiogram QT prolonged	17.86	13.57	3	24254	90383	79629748
Skin plaque	17.72	13.57	19	24238	10726	79709405
Infective scleritis	17.71	13.57	4	24253	54	79720077
Intentional product use issue	17.54	13.57	92	24165	152020	79568111
Tendon rupture	17.50	13.57	20	24237	12106	79708025
Macular fibrosis	17.44	13.57	7	24250	716	79719415
Eye pruritus	17.30	13.57	26	24231	20544	79699587
Application site pruritus	17.21	13.57	12	24245	3798	79716333
Eye infection syphilitic	17.14	13.57	3	24254	9	79720122
Radiculopathy	17.07	13.57	17	24240	8807	79711324
Hypoglycaemia	16.81	13.57	5	24252	101589	79618542
Articular calcification	16.64	13.57	5	24252	215	79719916
Drug abuse	16.61	13.57	15	24242	162676	79557455
Pulmonary fibrosis	16.04	13.57	39	24218	44073	79676058
Product use issue	16.00	13.57	114	24143	209708	79510423
Extraskeletal ossification	15.71	13.57	4	24253	92	79720039
Proctitis	15.51	13.57	14	24243	6418	79713713
Lenticular opacities	15.47	13.57	6	24251	561	79719570
Skin irritation	15.32	13.57	18	24239	11222	79708909
Hypokalaemia	15.18	13.57	85	24172	143955	79576176
Cross sensitivity reaction	15.17	13.57	11	24246	3701	79716430
Coma	14.85	13.57	6	24251	100643	79619488
Secondary adrenocortical insufficiency	14.81	13.57	10	24247	3004	79717127
Choroidal detachment	14.80	13.57	6	24251	630	79719501
Keratitis fungal	14.73	13.57	5	24252	319	79719812
Renal failure	14.72	13.57	24	24233	200944	79519187
Retinal detachment	14.63	13.57	16	24241	9231	79710900
Overdose	14.45	13.57	21	24236	184185	79535946
Infusion site urticaria	14.42	13.57	7	24250	1127	79719004
Female genital tract fistula	14.40	13.57	13	24244	5962	79714169
Therapeutic product effect decreased	14.27	13.57	92	24165	163771	79556360
Hyperadrenocorticism	14.26	13.57	5	24252	352	79719779
Injection site plaque	14.19	13.57	4	24253	137	79719994
Juvenile melanoma benign	14.11	13.57	3	24254	30	79720101
Eyelid ptosis	13.93	13.57	17	24240	11027	79709104
Retinal exudates	13.85	13.57	7	24250	1228	79718903
Parakeratosis	13.78	13.57	5	24252	389	79719742
Uveitis	13.77	13.57	21	24236	16809	79703322
Hyperkalaemia	13.64	13.57	9	24248	114389	79605742
Infective tenosynovitis	13.57	13.57	5	24252	406	79719725

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A01AC01	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Corticosteroids for local oral treatment
ATC	C05AA12	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids
ATC	D07AB09	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB03	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
ATC	D07CB01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, moderately potent, combinations with antibiotics
ATC	D07XB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, moderately potent, other combinations
ATC	H02AB08	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids
ATC	R01AD11	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03BA06	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
ATC	S01BA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain
ATC	S02CA04	SENSORY ORGANS OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION Corticosteroids and antiinfectives in combination
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:50857	anti-allergic drugs
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Lichen planus	indication	4776004	DOID:9201
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377
Severe adrenal insufficiency	indication	24867002
Sarcoidosis	indication	31541009	DOID:11335
Idiopathic thrombocytopenic purpura	indication	32273002	DOID:8924
Psoriasis with arthropathy	indication	33339001
Keloid scar	indication	33659008
Crohn's disease	indication	34000006
Tendinitis	indication	34840004	DOID:971
Erythema multiforme	indication	36715001
Contact dermatitis	indication	40275004	DOID:2773
Angioedema	indication	41291007	DOID:1558
Miliary tuberculosis	indication	47604008	DOID:9861
Humoral hypercalcemia of malignancy	indication	47709007
Articular gout	indication	48440001	DOID:13189
Candidiasis of skin	indication	49883006
Seborrheic dermatitis	indication	50563003	DOID:8741
Edema of larynx	indication	51599000
Nephrotic syndrome	indication	52254009	DOID:1184
Lichen simplex chronicus	indication	53891004
Systemic lupus erythematosus	indication	55464009	DOID:9074
Necrobiosis lipoidica diabeticorum	indication	56391002
Allergic rhinitis	indication	61582004
Löffler's syndrome	indication	64936001	DOID:9503
Pemphigus	indication	65172003	DOID:9182
Granuloma annulare	indication	65508009	DOID:3777
Tenosynovitis	indication	67801009	DOID:970
Alopecia areata	indication	68225006	DOID:986
Rheumatoid arthritis	indication	69896004	DOID:7148
Transfusion reaction due to serum protein reaction	indication	72284000
Epicondylitis	indication	73583000	DOID:14087
Acquired thrombocytopenia	indication	74576004	DOID:11126
Sympathetic uveitis	indication	75315001	DOID:12029
Thyroiditis	indication	82119001	DOID:7166
Bursitis	indication	84017003	DOID:2965
Autoimmune disease	indication	85828009
Congenital hypoplastic anemia	indication	88854002	DOID:1339
Pruritus ani	indication	90446007
Acute lymphoid leukemia	indication	91857003	DOID:9952
Disorder of skin	indication	95320005	DOID:37
Subacute bursitis	indication	109298000
Dermatitis herpetiformis	indication	111196000	DOID:8505
Hodgkin's disease	indication	118599009
Non-Hodgkin's lymphoma	indication	118601006
Mycosis fungoides	indication	118618005
Uveitis	indication	128473001	DOID:13141
Aspiration pneumonitis	indication	155597006
Asthma	indication	195967001	DOID:2841
Discoid lupus erythematosus	indication	200938002
Plaque psoriasis	indication	200965009
Transplanted organ rejection	indication	213148006
Congenital adrenal hyperplasia	indication	237751000
Scalp psoriasis	indication	238608008
Adrenogenital disorder	indication	267395000	DOID:0050811
Pruritus of genital organs	indication	267802000
Eruption of skin	indication	271807003	DOID:0050486
Follicular non-Hodgkin's lymphoma	indication	308121000
Disorder of eye	indication	371405004	DOID:5614
Primary adrenocortical insufficiency	indication	373662000
Adrenal cortical hypofunction	indication	386584007	DOID:10493
Erythroderma	indication	399992009
Primary cutaneous T-cell lymphoma	indication	400122007
Asthma management	indication	406162001
Juvenile rheumatoid arthritis	indication	410795001
Autoimmune hemolytic anemia	indication	413603009	DOID:718
Giant cell arteritis	indication	414341000	DOID:13375
Synovitis	indication	416209007	DOID:2703
Aphthous ulcer of mouth	indication	426965005	DOID:9663
Post traumatic osteoarthritis	indication	699262001
Cystic Aponeurosis Tumor	indication
Erythroblastic Anemia	indication
Diagnostic Test for Cushing's Syndrome	indication
Chronic Non-Allergic Rhinitis	indication
Transfusion Reaction Urticaria	indication
Severe Ocular Inflammation	indication
Gingival Disorders	indication
Vitrectomy Adjunct to Enhance Visualization	indication
Allergic Rhinitis Prevention	indication
Systemic Dermatomyositis	indication
Synovitis due to Osteoarthritis	indication
Pericarditis	off-label use	3238004	DOID:1787
Chronic obstructive lung disease	off-label use	13645005	DOID:3083
West syndrome	off-label use	28055006
Vasculitis	off-label use	31996006	DOID:865
Bronchitis	off-label use	32398004	DOID:6132
Eczema	off-label use	43116000
Respiratory distress syndrome in the newborn	off-label use	46775006
Nasal polyp	off-label use	52756005
Rheumatic fever	off-label use	58718002	DOID:1586
Pseudogout	off-label use	60782007
Polymyalgia rheumatica	off-label use	65323003	DOID:853
Chronic hepatitis	off-label use	76783007	DOID:2237
Pemphigoid	off-label use	86142006
Hepatic necrosis	off-label use	87248009
Multiple myeloma	off-label use	109989006	DOID:9538
Polyarteritis nodosa	off-label use	155441006	DOID:9810
Severe chronic obstructive pulmonary disease	off-label use	313299006
Celiac disease	off-label use	396331005	DOID:10608
Carditis	off-label use	399617002
Neonatal Bronchopulmonary Dysplasia	off-label use
Hypercalcemia associated with Sarcoidosis	off-label use
Infection by Strongyloides	contraindication	1214006	DOID:10955
Mycosis	contraindication	3218000	DOID:1564
Ocular hypertension	contraindication	4210003	DOID:9282
Gastritis	contraindication	4556007	DOID:4029
Inactive tuberculosis	contraindication	11999007
Epistaxis	contraindication	12441001
Peptic ulcer	contraindication	13200003	DOID:750
Hypercholesterolemia	contraindication	13644009
Measles	contraindication	14189004	DOID:8622
Disease caused by parasite	contraindication	17322007
Cirrhosis of liver	contraindication	19943007	DOID:5082
Arginase deficiency	contraindication	23501004	DOID:9278
Glaucoma	contraindication	23986001	DOID:1686
Acute tuberculosis	contraindication	25629007
Fungal infection of eye	contraindication	31194008
Immunosuppression	contraindication	38013005
Hypertensive disorder	contraindication	38341003	DOID:10763
Infectious disease	contraindication	40733004
Hypothyroidism	contraindication	40930008	DOID:1459
Herpes zoster keratoconjunctivitis	contraindication	42448002
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Tuberculosis of eye	contraindication	49107007
Cerebral malaria	contraindication	53622003	DOID:14069
Tuberculosis	contraindication	56717001
Congenital hyperammonemia, type I	contraindication	62522004
Osteoporosis	contraindication	64859006	DOID:11476
Psychotic disorder	contraindication	69322001
Diabetes mellitus	contraindication	73211009	DOID:9351
Hypopituitarism	contraindication	74728003	DOID:9406
Candidiasis of mouth	contraindication	79740000	DOID:14262
Perforation of nasal septum	contraindication	80142000
Hyperglycemia	contraindication	80394007	DOID:4195
Ornithine Carbamyltransferase Deficiency	contraindication	80908008	DOID:9271
Open-angle glaucoma	contraindication	84494001	DOID:1067
Bacterial infectious disease	contraindication	87628006
Muscle atrophy	contraindication	88092000	DOID:767
Herpes simplex	contraindication	88594005	DOID:8566
Operation on nose	contraindication	88733004
Bilateral cataracts	contraindication	95722004
Seizure disorder	contraindication	128613002
Disorder of muscle	contraindication	129565002	DOID:423
Ophthalmic herpes simplex	contraindication	186542001
Anastomosis of intestine	contraindication	235407009
Disease of liver	contraindication	235856003	DOID:409
Telangiectasia disorder	contraindication	247479008
Edema	contraindication	267038008
Pathological fracture	contraindication	268029009
Diverticulitis of gastrointestinal tract	contraindication	271366000
Cerebral trauma	contraindication	275382005
Oral infection	contraindication	275393007
Varicella-zoster virus infection	contraindication	309465005
Viral eye infection	contraindication	312132001
Osteopenia	contraindication	312894000
Skin irritation	contraindication	367466007
Herpes zoster keratitis	contraindication	397573005
Avascular necrosis of bone	contraindication	397758007	DOID:10159
Citrullinemia	contraindication	398680004	DOID:9273
Atrophoderma	contraindication	399979006
Traumatic rupture of tendon	contraindication	415749005
Exposure to varicella	contraindication	444453009
Arginosuccinate Lyase Deficiency	contraindication
Oropharyngeal Candidiasis	contraindication
Nasal Candidiasis	contraindication
Periodontal Infections	contraindication
Nasal Trauma	contraindication
Untreated Fungal Infection	contraindication
Nasal Septal Ulcers	contraindication
Uncontrolled Bacterial Infections	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.2	acidic
pKa2	11.84	acidic
pKa3	13.18	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	7.59		DRUG MATRIX	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN					WOMBAT-PK
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN					WOMBAT-PK

External reference:

ID	Source
4017599	VUID
N0000145980	NUI
D00385	KEGG_DRUG
4017599	VANDF
C0040864	UMLSCUI
CHEBI:9667	CHEBI
CHEMBL1451	ChEMBL_ID
D014221	MESH_DESCRIPTOR_UI
DB00620	DRUGBANK_ID
31307	PUBCHEM_CID
2870	IUPHAR_LIGAND_ID
755	INN_ID
1ZK20VI6TY	UNII
10759	RXNORM
4582	MMSL
5613	MMSL
d00620	MMSL
002188	NDDF
116594009	SNOMEDCT_US
6028009	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-470	CREAM	0.25 mg	TOPICAL	ANDA	17 sections
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-471	CREAM	1 mg	TOPICAL	ANDA	17 sections
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-472	CREAM	5 mg	TOPICAL	ANDA	17 sections
Naltrexone	HUMAN PRESCRIPTION DRUG LABEL	2	69364-3143	IMPLANT	6.50 mg	SUBCUTANEOUS	Unapproved drug other	25 sections