triamcinolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
steroids not used as glucocorticosteroids	2725	124-94-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: triamcinolone triamcinlon triamcinolon rodinolone	A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739) Molecular weight: 394.44 Formula: C21H27FO6 CLOGP: 0.71 LIPINSKI: 0 HAC: 6 HDO: 4 TPSA: 115.06 ALOGS: -2.67 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

triamcinolone
triamcinlon
triamcinolon
rodinolone

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

Molecular weight: 394.44
Formula: C21H27FO6
CLOGP: 0.71
LIPINSKI: 0
HAC: 6
HDO: 4
TPSA: 115.06
ALOGS: -2.67
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
7.50	mg	O
7.50	mg	P
0.22	mg	N

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	23 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.08 mg/mL	Benet LZ, Broccatelli F, Oprea TI

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Approvals:

Date	Agency	Company	Orphan
Dec. 3, 1957	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	447.67	14.30	155	21087	9569	63458211
Psoriasis	409.83	14.30	291	20951	86666	63381114
Adrenal insufficiency	391.92	14.30	166	21076	17749	63450031
Body height below normal	259.39	14.30	72	21170	2111	63465669
Human antichimeric antibody positive	233.71	14.30	63	21179	1651	63466129
Polyarthritis	228.44	14.30	96	21146	10050	63457730
Joint destruction	192.10	14.30	74	21168	6178	63461602
Wheelchair user	191.34	14.30	74	21168	6245	63461535
Obesity	180.82	14.30	117	21125	29835	63437945
Drug ineffective	143.62	14.30	707	20535	1044058	62423722

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	302.60	16.61	95	9551	5252	34942033
Drug ineffective	216.17	16.61	420	9226	456331	34490954
Psoriasis	186.17	16.61	122	9524	38690	34908595
Pruritus	140.89	16.61	184	9462	141797	34805488
Rash	123.32	16.61	220	9426	222532	34724753
Skin exfoliation	97.97	16.61	72	9574	27360	34919925
Product use in unapproved indication	83.45	16.61	130	9516	117369	34829916
Product dose omission issue	83.01	16.61	131	9515	119580	34827705
Sleep disorder	80.40	16.61	68	9578	31620	34915665
Deposit eye	77.71	16.61	13	9633	31	34947254

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dermatitis atopic	480.68	13.57	161	24096	9895	79710236
Psoriasis	424.47	13.57	290	23967	89297	79630834
Adrenal insufficiency	378.37	13.57	181	24076	28306	79691825
Human antichimeric antibody positive	232.72	13.57	61	24196	1580	79718551
Body height below normal	228.38	13.57	63	24194	1990	79718141
Polyarthritis	210.44	13.57	93	24164	12109	79708022
Joint destruction	191.73	13.57	71	24186	5854	79714277
Wheelchair user	164.22	13.57	64	24193	6068	79714063
Obesity	150.41	13.57	107	24150	35018	79685113
Drug ineffective	137.45	13.57	669	23588	1080244	78639887

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A01AC01	ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Corticosteroids for local oral treatment
ATC	C05AA12	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Corticosteroids
ATC	D07AB09	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, moderately potent (group II)
ATC	D07BB03	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS Corticosteroids, moderately potent, combinations with antiseptics
ATC	D07CB01	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS Corticosteroids, moderately potent, combinations with antibiotics
ATC	D07XB02	DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, OTHER COMBINATIONS Corticosteroids, moderately potent, other combinations
ATC	H02AB08	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS CORTICOSTEROIDS FOR SYSTEMIC USE CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN Glucocorticoids
ATC	R01AD11	RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Corticosteroids
ATC	R03BA06	RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Glucocorticoids
ATC	S01BA05	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFLAMMATORY AGENTS Corticosteroids, plain

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Disorder of musculoskeletal system	indication	928000	DOID:17
Cerebral edema	indication	2032001
Lichen planus	indication	4776004	DOID:9201
Berylliosis	indication	8247009	DOID:10322
Psoriasis	indication	9014002	DOID:8893
Ankylosing spondylitis	indication	9631008	DOID:7147
Rheumatic heart disease	indication	23685000
Atopic dermatitis	indication	24079001	DOID:3310
Inflammatory bowel disease	indication	24526004	DOID:0050589
Multiple sclerosis	indication	24700007	DOID:2377

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.2	acidic
pKa2	11.84	acidic
pKa3	13.18	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	Ki	7.59	DRUG MATRIX	CHEMBL
Annexin A1	Cytosolic other	P04083	ANXA1_HUMAN				WOMBAT-PK
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN				WOMBAT-PK

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External reference:

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ID	Source
002188	NDDF
10759	RXNORM
116594009	SNOMEDCT_US
1ZK20VI6TY	UNII
2870	IUPHAR_LIGAND_ID
31307	PUBCHEM_CID
4017599	VUID
4017599	VANDF
4582	MMSL
5613	MMSL

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Naltrexone	HUMAN PRESCRIPTION DRUG LABEL	2	69364-3143	IMPLANT	6.50 mg	SUBCUTANEOUS	Unapproved drug other	25 sections
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-470	CREAM	0.25 mg	TOPICAL	ANDA	17 sections
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-471	CREAM	1 mg	TOPICAL	ANDA	17 sections
TRIAMCINOLONE ACETONIDE	Human Prescription Drug Label	1	67877-472	CREAM	5 mg	TOPICAL	ANDA	17 sections

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