azelnidipine indications/contra

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 272 123524-52-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azelnidipine
  • calblock
  • CS-905
  • Molecular weight: 582.66
  • Formula: C33H34N4O6
  • CLOGP: 6.96
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 2
  • TPSA: 137.03
  • ALOGS: -5.85
  • ROTB: 11

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.74 Basic
pKa2 1.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER DRUG LABEL KEGG DRUG

External reference:

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IDSource
D01145 KEGG_DRUG
CHEMBL1275868 ChEMBL_ID
C061679 MESH_SUPPLEMENTAL_RECORD_UI
65948 PUBCHEM_CID
PV23P19YUG UNII
7109 INN_ID
DB09230 DRUGBANK_ID
CHEBI:31247 CHEBI

Pharmaceutical products:

None