treosulfan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, methanesulfonates 2718 299-75-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • treosulfan
  • threosulphan
  • treosulphan
  • tresulfan
  • trecondi
immunosuppressant; RN given refers to (S-(R*,R*))-isomer
  • Molecular weight: 278.29
  • Formula: C6H14O8S2
  • CLOGP: -2.20
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 127.20
  • ALOGS: -1.21
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 97 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.59 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.90 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.83 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 20, 2019 EMA medac Gesellschaft fur klinische Spezialpraparate mbH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Adenovirus infection 204.67 87.80 40 1552 3531 63483899
Graft versus host disease in skin 169.24 87.80 33 1559 2872 63484558
Human herpesvirus 6 infection 162.55 87.80 32 1560 2925 63484505
Acute graft versus host disease in skin 157.61 87.80 32 1560 3420 63484010
Cytomegalovirus infection reactivation 135.97 87.80 29 1563 3934 63483496
Mucosal inflammation 135.63 87.80 49 1543 46879 63440551
Cytomegalovirus infection 121.37 87.80 37 1555 20915 63466515
Acute graft versus host disease 110.73 87.80 25 1567 4403 63483027
Skin toxicity 109.17 87.80 25 1567 4689 63482741
Graft versus host disease in gastrointestinal tract 101.46 87.80 22 1570 3219 63484211
Adenovirus reactivation 101.08 87.80 14 1578 137 63487293
Varicella zoster virus infection 99.77 87.80 21 1571 2668 63484762

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 308.65 61.20 99 2142 26036 34928654
Graft versus host disease in skin 178.73 61.20 43 2198 3882 34950808
Mucosal inflammation 167.44 61.20 70 2171 38552 34916138
Cytomegalovirus infection reactivation 167.39 61.20 43 2198 5075 34949615
Adenovirus infection 161.39 61.20 42 2199 5215 34949475
Graft versus host disease in gastrointestinal tract 150.55 61.20 37 2204 3646 34951044
Acute graft versus host disease in skin 128.48 61.20 35 2206 5166 34949524
Off label use 107.43 61.20 132 2109 419392 34535298
Human herpesvirus 6 infection 90.56 61.20 22 2219 2059 34952631
Pneumatosis intestinalis 85.78 61.20 24 2217 3899 34950791
Acute graft versus host disease in intestine 84.81 61.20 22 2219 2686 34952004
Cytomegalovirus viraemia 82.65 61.20 27 2214 7403 34947287
Acute graft versus host disease 77.90 61.20 25 2216 6478 34948212
Adenovirus reactivation 75.44 61.20 13 2228 213 34954477
Product use in unapproved indication 70.57 61.20 59 2182 117440 34837250
Epstein-Barr virus infection 66.17 61.20 23 2218 7605 34947085
Posterior reversible encephalopathy syndrome 63.82 61.20 24 2217 9930 34944760

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Adenovirus infection 443.14 66.80 98 3665 8349 79732276
Cytomegalovirus infection 424.51 66.80 132 3631 42512 79698113
Graft versus host disease in skin 326.88 66.80 72 3691 6001 79734624
Cytomegalovirus infection reactivation 295.81 66.80 71 3692 8645 79731980
Acute graft versus host disease in skin 294.38 66.80 69 3694 7589 79733036
Mucosal inflammation 272.27 66.80 110 3653 75470 79665155
Human herpesvirus 6 infection 246.96 66.80 56 3707 5314 79735311
Off label use 195.70 66.80 225 3538 906990 78833635
Graft versus host disease in gastrointestinal tract 191.15 66.80 47 3716 6309 79734316
Cytomegalovirus viraemia 189.53 66.80 54 3709 12767 79727858
Adenovirus reactivation 177.36 66.80 28 3735 361 79740264
Acute graft versus host disease 155.55 66.80 44 3719 10123 79730502
Product use in unapproved indication 137.37 66.80 105 3658 250254 79490371
Acute graft versus host disease in intestine 132.26 66.80 32 3731 4009 79736616
Skin toxicity 122.74 66.80 35 3728 8279 79732346
Autoimmune haemolytic anaemia 109.12 66.80 32 3731 8348 79732277
Epstein-Barr virus infection 103.76 66.80 35 3728 14381 79726244
BK virus infection 103.22 66.80 31 3732 8773 79731852
Cytomegalovirus chorioretinitis 94.18 66.80 26 3737 5464 79735161
Epstein-Barr virus infection reactivation 72.36 66.80 17 3746 1875 79738750
Posterior reversible encephalopathy syndrome 70.14 66.80 31 3732 26250 79714375
Pneumatosis intestinalis 68.45 66.80 21 3742 6376 79734249

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AB02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Alkyl sulfonates
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allogeneic peripheral blood stem cell transplant indication 425843001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07253 KEGG_DRUG
C0076959 UMLSCUI
CHEBI:82557 CHEBI
CHEMBL455186 ChEMBL_ID
DB11678 DRUGBANK_ID
C018404 MESH_SUPPLEMENTAL_RECORD_UI
9882105 PUBCHEM_CID
8281 IUPHAR_LIGAND_ID
3103 INN_ID
CO61ER3EPI UNII
38508 RXNORM
004465 NDDF
326774002 SNOMEDCT_US
395912000 SNOMEDCT_US

Pharmaceutical products:

None