torsemide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diuretics, furosemide derivatives 2708 56211-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • torasemide
  • torsemide
  • toradiur
A pyridine and sulfonamide derivative that acts as a sodium-potassium chloride symporter inhibitor (loop diuretic). It is used for the treatment of EDEMA associated with CONGESTIVE HEART FAILURE; CHRONIC RENAL INSUFFICIENCY; and LIVER DISEASES. It is also used for the management of HYPERTENSION.
  • Molecular weight: 348.42
  • Formula: C16H20N4O3S
  • CLOGP: 3.21
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 100.19
  • ALOGS: -3.77
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
15 mg O
15 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.16 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.56 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 91 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.21 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.53 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 23, 1993 FDA MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1792.17 12.46 1599 68467 199803 63219153
Product prescribing error 1008.62 12.46 519 69547 25770 63393186
Product monitoring error 825.39 12.46 273 69793 4243 63414713
Haematochezia 656.26 12.46 513 69553 53031 63365925
Cardiac failure 608.80 12.46 613 69453 88529 63330427
Drug ineffective 548.71 12.46 236 69830 1044529 62374427
Renal impairment 474.63 12.46 535 69531 87820 63331136
Dyspnoea 451.15 12.46 1673 68393 659640 62759316
Oedema peripheral 434.55 12.46 762 69304 188749 63230207
Labelled drug-drug interaction medication error 430.11 12.46 235 69831 13164 63405792
Systemic infection 426.54 12.46 169 69897 4491 63414465
Acute kidney injury 421.90 12.46 910 69156 262505 63156451
Anaemia 411.09 12.46 961 69105 292469 63126487
Dehydration 296.92 12.46 616 69450 172738 63246218
Atrial fibrillation 291.99 12.46 488 69578 116148 63302808
Syncope 238.13 12.46 448 69618 116937 63302019
Fall 222.73 12.46 939 69127 391395 63027561
Joint swelling 221.48 12.46 46 70020 327620 63091336
Bradycardia 216.97 12.46 331 69735 72896 63346060
Electrolyte imbalance 215.23 12.46 178 69888 19898 63399058
Rash 214.34 12.46 183 69883 560688 62858268
Hyponatraemia 213.34 12.46 416 69650 111484 63307472
Therapeutic drug monitoring analysis not performed 212.52 12.46 73 69993 1279 63417677
Arthropathy 210.68 12.46 12 70054 234780 63184176
Drug intolerance 205.18 12.46 45 70021 308616 63110340
Drug interaction 200.83 12.46 632 69434 228499 63190457
Arrhythmia 194.49 12.46 225 69841 37915 63381041
Off label use 193.11 12.46 279 69787 674183 62744773
Treatment failure 192.39 12.46 6 70060 199037 63219919
Drug hypersensitivity 189.66 12.46 54 70012 310633 63108323
Synovitis 186.80 12.46 4 70062 186914 63232042
Systemic lupus erythematosus 186.44 12.46 11 70055 208907 63210049
Hypotension 183.87 12.46 689 69377 271915 63147041
Infusion related reaction 182.12 12.46 27 70039 245494 63173462
Haematemesis 180.11 12.46 194 69872 30218 63388738
Pulmonary arterial hypertension 170.09 12.46 164 69902 22413 63396543
Therapeutic product effect decreased 169.88 12.46 11 70055 193176 63225780
Hyperkalaemia 166.18 12.46 249 69817 53954 63365002
Alopecia 165.49 12.46 83 69983 337453 63081503
Hypersensitivity 162.50 12.46 60 70006 292625 63126331
Hypokalaemia 159.23 12.46 353 69713 103451 63315505
Orthostatic intolerance 151.43 12.46 55 70011 1142 63417814
Blood creatinine increased 149.96 12.46 312 69754 87532 63331424
Dyspnoea exertional 146.35 12.46 249 69817 60053 63358903
Discomfort 145.77 12.46 10 70056 167364 63251592
Fluid retention 140.30 12.46 243 69823 59443 63359513
Rheumatoid arthritis 137.58 12.46 54 70012 253765 63165191
Pallor 132.38 12.46 166 69900 30402 63388554
Abdominal discomfort 129.41 12.46 99 69967 320786 63098170
Lower respiratory tract infection 127.77 12.46 4 70062 132303 63286653
Renal failure 125.27 12.46 348 69718 117304 63301652
Product administration error 124.14 12.46 138 69928 22259 63396697
Swelling 118.83 12.46 79 69987 275299 63143657
Dizziness 117.56 12.46 844 69222 429081 62989875
Anuria 117.56 12.46 103 69963 12448 63406508
Pain 114.86 12.46 426 69640 740202 62678754
Maternal exposure during pregnancy 112.53 12.46 51 70015 220011 63198945
Arthralgia 112.06 12.46 294 69772 569416 62849540
Melaena 109.93 12.46 151 69915 30214 63388742
Glomerular filtration rate decreased 109.55 12.46 102 69964 13339 63405617
Angina pectoris 108.03 12.46 149 69917 29929 63389027
Musculoskeletal stiffness 107.29 12.46 35 70031 184583 63234373
Gastrointestinal haemorrhage 106.82 12.46 260 69806 80916 63338040
Cardiac failure chronic 105.68 12.46 64 70002 4354 63414602
Haematoma 105.33 12.46 159 69907 34661 63384295
Hypervolaemia 103.92 12.46 142 69924 28271 63390685
Pericarditis 103.42 12.46 12 70054 131567 63287389
Right ventricular failure 102.38 12.46 110 69956 17078 63401878
Product use issue 101.00 12.46 59 70007 220461 63198495
Lactic acidosis 99.42 12.46 163 69903 38124 63380832
Tachypnoea 98.29 12.46 108 69958 17194 63401762
Pulmonary hypertension 97.69 12.46 159 69907 36964 63381992
Electrocardiogram abnormal 95.49 12.46 80 69986 9099 63409857
Completed suicide 95.15 12.46 22 70044 145651 63273305
Tachycardia 94.36 12.46 316 69750 117840 63301116
Sinusitis 91.22 12.46 70 69996 226583 63192373
Hyperglycaemia 87.53 12.46 162 69904 41705 63377251
Hepatic enzyme increased 85.96 12.46 59 70007 202269 63216687
Pancreatic steatosis 79.74 12.46 33 70033 983 63417973
Helicobacter infection 79.44 12.46 6 70060 92779 63326177
Atrial flutter 75.51 12.46 72 69994 9700 63409256
Injection site pain 74.70 12.46 25 70041 129775 63289181
Aortic valve stenosis 74.33 12.46 46 70020 3253 63415703
Therapeutic product effect incomplete 72.12 12.46 24 70042 125032 63293924
Irritable bowel syndrome 71.50 12.46 5 70061 82407 63336549
Mitral valve incompetence 70.25 12.46 97 69969 19497 63399459
Upper gastrointestinal haemorrhage 70.12 12.46 95 69971 18757 63400199
Haemoglobin decreased 69.96 12.46 332 69734 145153 63273803
Nasopharyngitis 69.69 12.46 108 69958 254149 63164807
Exposure during pregnancy 69.25 12.46 43 70023 155504 63263452
Contraindicated product administered 68.12 12.46 84 69982 217564 63201392
Intentional product use issue 67.94 12.46 28 70038 127864 63291092
Tricuspid valve incompetence 67.47 12.46 82 69984 14539 63404417
Blood loss anaemia 67.06 12.46 65 70001 8936 63410020
Tachyarrhythmia 66.35 12.46 48 70018 4402 63414554
Disorientation 65.96 12.46 139 69927 39313 63379643
Urticaria 65.68 12.46 52 70014 165750 63253206
Pleural effusion 65.48 12.46 239 69827 92971 63325985
Chronic kidney disease 64.66 12.46 150 69916 45248 63373708
Blood urea increased 62.74 12.46 108 69958 26271 63392685
Psoriatic arthropathy 61.40 12.46 13 70053 91507 63327449
N-terminal prohormone brain natriuretic peptide increased 58.74 12.46 34 70032 2127 63416829
Femoral hernia incarcerated 58.27 12.46 25 70041 816 63418140
Peripheral circulatory failure 58.07 12.46 26 70040 942 63418014
Medication error 57.93 12.46 157 69909 52127 63366829
Polyneuropathy 56.52 12.46 75 69991 14514 63404442
Hypoglycaemia 56.47 12.46 170 69896 59895 63359061
Blood uric acid increased 56.29 12.46 47 70019 5320 63413636
Cardiac failure congestive 55.10 12.46 225 69841 92208 63326748
Diverticulum intestinal 54.81 12.46 51 70015 6662 63412294
Arterial haemorrhage 54.76 12.46 30 70036 1687 63417269
Blood cholesterol increased 54.29 12.46 18 70048 94014 63324942
Restlessness 54.23 12.46 108 69958 29345 63389611
Stomatitis 53.08 12.46 45 70021 138680 63280276
Arthritis 53.05 12.46 31 70035 115890 63303066
Cardiogenic shock 52.97 12.46 81 69985 17851 63401105
Gastroenteritis clostridial 52.53 12.46 21 70045 571 63418385
Gastrointestinal disorder 50.92 12.46 42 70024 131197 63287759
Malaise 50.39 12.46 262 69804 415692 63003264
Lymphatic fistula 50.00 12.46 22 70044 764 63418192
Cardiac failure acute 49.90 12.46 57 70009 9466 63409490
Eructation 49.04 12.46 53 70013 8280 63410676
Fibromyalgia 48.94 12.46 14 70052 80406 63338550
Peripheral arterial occlusive disease 48.70 12.46 39 70027 4162 63414794
Blister 48.58 12.46 43 70023 129771 63289185
Limb reduction defect 48.08 12.46 18 70048 408 63418548
Loss of personal independence in daily activities 47.46 12.46 24 70042 97266 63321690
Circulatory collapse 47.25 12.46 86 69980 21852 63397104
Ascites 46.83 12.46 124 69942 40604 63378352
Migraine 46.78 12.46 28 70038 103318 63315638
Waist circumference increased 46.51 12.46 22 70044 906 63418050
Dementia 46.08 12.46 78 69988 18716 63400240
Hypertensive crisis 45.08 12.46 69 69997 15217 63403739
Back pain 44.71 12.46 146 69920 263999 63154957
Injection site reaction 44.35 12.46 6 70060 58518 63360438
Dysuria 43.22 12.46 107 69959 33631 63385325
Hyperthyroidism 42.95 12.46 66 70000 14607 63404349
Renal function test abnormal 42.53 12.46 34 70032 3619 63415337
Fracture 42.47 12.46 77 69989 19507 63399449
Haematuria 42.24 12.46 97 69969 29060 63389896
Product use in unapproved indication 41.85 12.46 84 69982 178996 63239960
Flatulence 41.27 12.46 107 69959 34595 63384361
Abdominal pain lower 41.22 12.46 89 69977 25589 63393367
Pruritus 40.82 12.46 233 69833 361220 63057736
Gamma-glutamyltransferase increased 40.54 12.46 105 69961 33926 63385030
Therapeutic drug monitoring analysis incorrectly performed 40.53 12.46 15 70051 329 63418627
Coagulation test abnormal 40.24 12.46 19 70047 779 63418177
Hypoaesthesia 40.20 12.46 78 69988 168315 63250641
Drug abuse 39.95 12.46 15 70051 72503 63346453
Adverse drug reaction 39.89 12.46 19 70047 79695 63339261
Erysipelas 39.21 12.46 46 70020 7859 63411097
Wound infection pseudomonas 39.06 12.46 22 70044 1306 63417650
Rhonchi 38.89 12.46 28 70038 2548 63416408
Mobility decreased 38.68 12.46 46 70020 121113 63297843
Oedema 38.64 12.46 211 69855 97411 63321545
Acute respiratory failure 38.64 12.46 104 69962 34381 63384575
Blood potassium increased 38.45 12.46 71 69995 18238 63400718
Retrograde amnesia 38.43 12.46 16 70050 484 63418472
Haemarthrosis 38.05 12.46 30 70036 3131 63415825
Toxicity to various agents 37.59 12.46 143 69923 247107 63171849
Faecaloma 37.40 12.46 45 70021 7896 63411060
Respiratory failure 36.91 12.46 215 69851 101643 63317313
Vascular resistance pulmonary decreased 36.90 12.46 10 70056 74 63418882
Coronary artery disease 36.64 12.46 98 69968 32279 63386677
Accidental overdose 36.51 12.46 80 69986 23229 63395727
Left-to-right cardiac shunt 36.39 12.46 11 70055 125 63418831
Paraesthesia 36.36 12.46 74 69992 156892 63262064
Anaphylactic reaction 35.86 12.46 14 70052 66086 63352870
Stasis dermatitis 35.71 12.46 17 70049 710 63418246
Insomnia 35.70 12.46 120 69946 215132 63203824
Limb hypoplasia congenital 35.65 12.46 12 70054 197 63418759
Injection site erythema 35.63 12.46 24 70042 83150 63335806
Coronavirus test positive 35.32 12.46 17 70049 728 63418228
Prothrombin time prolonged 35.27 12.46 48 70018 9516 63409440
Psoriasis 34.76 12.46 27 70039 86930 63332026
Wound 34.49 12.46 81 69985 163182 63255774
C-reactive protein abnormal 34.29 12.46 5 70061 46091 63372865
Internal haemorrhage 34.23 12.46 35 70031 5130 63413826
Liver injury 34.21 12.46 12 70054 60508 63358448
Seroma 34.11 12.46 24 70042 2107 63416849
Glomerular filtration rate abnormal 33.40 12.46 17 70049 822 63418134
Left ventricular failure 33.17 12.46 36 70030 5651 63413305
Urosepsis 32.99 12.46 67 69999 18457 63400499
Injury 32.93 12.46 20 70046 73227 63345729
Atrioventricular block complete 32.86 12.46 43 70023 8208 63410748
Thirst 32.75 12.46 57 70009 13984 63404972
Crush syndrome 32.66 12.46 10 70056 119 63418837
Hepatic cyst 32.49 12.46 34 70032 5120 63413836
Exercise tolerance decreased 32.41 12.46 35 70031 5462 63413494
Knee arthroplasty 31.95 12.46 10 70056 54196 63364760
Congenital oral malformation 31.85 12.46 11 70055 196 63418760
Depressed level of consciousness 31.52 12.46 144 69922 61934 63357022
Headache 31.38 12.46 501 69565 632740 62786216
Congenital coronary artery malformation 31.31 12.46 10 70056 138 63418818
Concomitant disease aggravated 31.01 12.46 44 70022 9068 63409888
Product used for unknown indication 30.99 12.46 14 70052 518 63418438
Diverticulum intestinal haemorrhagic 30.76 12.46 20 70046 1541 63417415
Ill-defined disorder 30.68 12.46 27 70039 81728 63337228
Spinal pain 30.21 12.46 53 70013 13086 63405870
Joint stiffness 30.10 12.46 5 70061 41864 63377092
Febrile neutropenia 29.92 12.46 53 70013 118396 63300560
Cardiorenal syndrome 29.89 12.46 16 70050 859 63418097
Cholestatic liver injury 29.77 12.46 24 70042 2586 63416370
Bradyarrhythmia 29.69 12.46 22 70044 2093 63416863
Depression 29.62 12.46 114 69952 196378 63222578
Transfusion 29.46 12.46 57 70009 15160 63403796
Device stimulation issue 29.43 12.46 8 70058 60 63418896
Spontaneous haemorrhage 29.40 12.46 14 70052 585 63418371
Epistaxis 29.32 12.46 158 69908 72567 63346389
Tooth erosion 29.32 12.46 13 70053 460 63418496
Psychomotor retardation 28.93 12.46 28 70038 3842 63415114
Polyuria 28.70 12.46 41 70025 8501 63410455
Anxiety 28.61 12.46 133 69933 217408 63201548
Lower gastrointestinal haemorrhage 28.19 12.46 39 70027 7851 63411105
Bundle branch block right 28.04 12.46 31 70035 4967 63413989
Red blood cell sedimentation rate increased 28.00 12.46 7 70059 43975 63374981
Urinary retention 27.76 12.46 85 69981 30216 63388740
Hip arthroplasty 27.71 12.46 9 70057 47637 63371319
Neuropathy peripheral 27.69 12.46 52 70014 113615 63305341
Osteoarthritis 27.54 12.46 39 70027 95304 63323652
Hypotonia 27.50 12.46 42 70024 9243 63409713
Pregnancy 27.39 12.46 4 70062 36832 63382124
Therapeutic response decreased 27.38 12.46 17 70049 61508 63357448
Sudden cardiac death 27.25 12.46 21 70045 2119 63416837
Pericardial effusion 27.24 12.46 84 69982 29974 63388982
Constipation 27.23 12.46 373 69693 224570 63194386
Cerebral haemorrhage 27.04 12.46 85 69981 30644 63388312
Administration site discomfort 26.87 12.46 8 70058 86 63418870
N-terminal prohormone brain natriuretic peptide abnormal 26.69 12.46 7 70059 45 63418911
Ear pain 26.67 12.46 4 70062 36114 63382842
Abdominal pain 26.48 12.46 463 69603 292993 63125963
Labelled drug-drug interaction issue 26.46 12.46 16 70050 1085 63417871
Pulmonary congestion 26.40 12.46 59 70007 17359 63401597
Cardiovascular disorder 26.32 12.46 47 70019 11765 63407191
Injection site bruising 26.05 12.46 7 70059 41903 63377053
Sleep disorder 26.00 12.46 31 70035 81535 63337421
Biopsy skin abnormal 25.99 12.46 8 70058 97 63418859
Oropharyngeal pain 25.98 12.46 40 70026 94447 63324509
Orthopnoea 25.51 12.46 33 70033 6228 63412728
Pulmonary oedema 25.46 12.46 124 69942 54749 63364207
Injection site pruritus 25.41 12.46 9 70057 45107 63373849
Thrombin time prolonged 25.28 12.46 8 70058 107 63418849
Hypothermia 25.24 12.46 50 70016 13531 63405425
Parkinsonism 25.16 12.46 43 70023 10396 63408560
Hypertensive emergency 25.14 12.46 19 70047 1863 63417093
Cleft palate 25.08 12.46 15 70051 997 63417959
Escherichia infection 24.97 12.46 48 70018 12706 63406250
Skin haemorrhage 24.89 12.46 42 70024 10052 63408904
Condition aggravated 24.88 12.46 600 69466 401617 63017339
Multiple drug therapy 24.69 12.46 25 70041 3621 63415335
Cardioversion 24.48 12.46 16 70050 1244 63417712
Painful respiration 24.45 12.46 22 70044 2752 63416204
Musculoskeletal pain 24.41 12.46 180 69886 92097 63326859
Therapy non-responder 24.03 12.46 29 70037 75872 63343084
Sprue-like enteropathy 23.75 12.46 13 70053 730 63418226
Feeling abnormal 23.73 12.46 84 69982 148308 63270648
Glycosylated haemoglobin increased 23.47 12.46 46 70020 12352 63406604
Adverse event 23.37 12.46 24 70042 67535 63351421
Contusion 23.29 12.46 86 69980 149958 63268998
Femoral artery dissection 23.23 12.46 6 70060 36 63418920
Fracture blisters 23.20 12.46 7 70059 79 63418877
Infection 23.09 12.46 153 69913 229020 63189936
Haemorrhagic erosive gastritis 23.05 12.46 11 70055 462 63418494
Decreased appetite 22.97 12.46 397 69669 250655 63168301
Suicidal ideation 22.96 12.46 21 70045 62400 63356556
Neuroglycopenia 22.94 12.46 11 70055 467 63418489
Antineutrophil cytoplasmic antibody positive 22.88 12.46 12 70054 618 63418338
Injection site swelling 22.80 12.46 12 70054 47560 63371396
Aortic arteriosclerosis 22.65 12.46 31 70035 6178 63412778
Asthma 22.61 12.46 69 69997 127492 63291464
Aplastic anaemia 22.52 12.46 39 70027 9530 63409426
Pneumothorax traumatic 22.40 12.46 8 70058 158 63418798
Abdominal distension 22.36 12.46 168 69898 86447 63332509
Cerebral ischaemia 22.18 12.46 32 70034 6696 63412260
Pelvic venous thrombosis 21.87 12.46 17 70049 1738 63417218
Type 2 diabetes mellitus 21.74 12.46 23 70043 63845 63355111
International normalised ratio increased 21.60 12.46 105 69961 46320 63372636
Catheterisation cardiac 21.54 12.46 26 70040 4577 63414379
Thirst decreased 21.53 12.46 9 70057 275 63418681
Polyserositis 21.48 12.46 10 70056 397 63418559
Pulmonary vein occlusion 21.44 12.46 7 70059 104 63418852
Gout 21.30 12.46 46 70020 13225 63405731
Generalised oedema 21.14 12.46 51 70015 15767 63403189
Pulpitis dental 21.06 12.46 13 70053 915 63418041
Coma 21.01 12.46 24 70042 64340 63354616
Helplessness 20.94 12.46 9 70057 295 63418661
Product dose omission issue 20.90 12.46 162 69904 234151 63184805
Gastritis 20.80 12.46 89 69977 37214 63381742
Pain in extremity 20.75 12.46 250 69816 331236 63087720
Multiple sclerosis relapse 20.74 12.46 14 70052 48464 63370492
Dyspnoea at rest 20.67 12.46 24 70042 4055 63414901
Chest wall haematoma 20.56 12.46 8 70058 202 63418754
Retrognathia 20.44 12.46 10 70056 444 63418512
Bicytopenia 20.39 12.46 19 70047 2486 63416470
Inflammatory marker increased 20.35 12.46 31 70035 6808 63412148
Upper respiratory tract irritation 20.24 12.46 8 70058 211 63418745
Thrombocytopenia 20.09 12.46 255 69811 150902 63268054
Antidiuretic hormone abnormality 19.96 12.46 5 70061 26 63418930
Dysmorphism 19.83 12.46 18 70048 2278 63416678
Sensorimotor disorder 19.79 12.46 10 70056 476 63418480
Inflammation 19.72 12.46 38 70028 82235 63336721
Night sweats 19.70 12.46 15 70051 48799 63370157
Haemoptysis 19.60 12.46 73 69993 28653 63390303
Serotonin syndrome 19.39 12.46 4 70062 28678 63390278
Talipes 19.37 12.46 15 70051 1525 63417431
Lethargy 19.26 12.46 20 70046 55987 63362969
Necrotising fasciitis 19.06 12.46 20 70046 3021 63415935
Sinoatrial block 19.04 12.46 12 70054 876 63418080
Brain natriuretic peptide increased 18.97 12.46 26 70040 5187 63413769
Subdural haematoma 18.94 12.46 46 70020 14282 63404674
Glomerular filtration rate increased 18.92 12.46 12 70054 886 63418070
Stress 18.88 12.46 28 70038 67139 63351817
Diastolic dysfunction 18.79 12.46 29 70037 6442 63412514
Language disorder 18.78 12.46 17 70049 2143 63416813
Upper respiratory tract infection 18.72 12.46 39 70027 82008 63336948
Procalcitonin increased 18.43 12.46 13 70053 1146 63417810
Irritability 18.41 12.46 6 70060 31688 63387268
Blood cholesterol decreased 18.37 12.46 12 70054 932 63418024
Amnesia 17.84 12.46 21 70045 55564 63363392
Throat tightness 17.83 12.46 3 70063 24884 63394072
Hyperparathyroidism secondary 17.82 12.46 14 70052 1453 63417503
Vomiting 17.82 12.46 771 69295 558846 62860110
Ventricular fibrillation 17.76 12.46 40 70026 11827 63407129
White blood cell count decreased 17.71 12.46 86 69980 139018 63279938
Post procedural haematuria 17.69 12.46 5 70061 44 63418912
Drug clearance decreased 17.68 12.46 14 70052 1470 63417486
No adverse event 17.66 12.46 12 70054 41393 63377563
Presyncope 17.64 12.46 69 69997 27716 63391240
Left ventricular dysfunction 17.49 12.46 40 70026 11948 63407008
COVID-19 17.43 12.46 65 70001 113038 63305918
Vascular graft infection 17.39 12.46 5 70061 47 63418909
Cerebral infarction 17.39 12.46 62 70004 23831 63395125
Toxoplasmosis 17.36 12.46 14 70052 1509 63417447
Drug ineffective for unapproved indication 17.22 12.46 8 70058 34055 63384901
Atrial thrombosis 17.18 12.46 15 70051 1803 63417153
Wound dehiscence 17.17 12.46 24 70042 4879 63414077
Gangrene 17.16 12.46 27 70039 6096 63412860
Dry eye 17.14 12.46 12 70054 40749 63378207
Anal haemorrhage 17 12.46 16 70050 2120 63416836
Dry gangrene 16.92 12.46 10 70056 650 63418306
Herbal interaction 16.92 12.46 6 70060 116 63418840
Bursitis 16.81 12.46 10 70056 37031 63381925
End stage renal disease 16.70 12.46 28 70038 6665 63412291
Palpitations 16.61 12.46 194 69872 112576 63306380
Cerebral artery occlusion 16.50 12.46 11 70055 884 63418072
Developmental hip dysplasia 16.47 12.46 13 70053 1359 63417597
Aggression 16.47 12.46 3 70063 23495 63395461
Influenza 16.42 12.46 63 70003 108659 63310297
Hypochromic anaemia 16.33 12.46 15 70051 1927 63417029
Low density lipoprotein abnormal 16.30 12.46 7 70059 229 63418727
Chronic respiratory failure 16.30 12.46 15 70051 1932 63417024
Blindness cortical 16.24 12.46 9 70057 518 63418438
Cyanosis 15.97 12.46 48 70018 16887 63402069
Sciatica 15.95 12.46 9 70057 34315 63384641
Drug resistance 15.92 12.46 3 70063 22930 63396026
Brain natriuretic peptide abnormal 15.85 12.46 8 70058 380 63418576
Sinus arrhythmia 15.66 12.46 13 70053 1460 63417496
HCoV-HKU1 infection 15.63 12.46 4 70062 23 63418933
Nephrolithiasis 15.59 12.46 14 70052 41970 63376986
Red cell distribution width abnormal 15.52 12.46 6 70060 149 63418807
Blood pressure fluctuation 15.41 12.46 17 70049 46300 63372656
Supraventricular extrasystoles 15.38 12.46 22 70044 4567 63414389
Ventricular assist device insertion 15.35 12.46 4 70062 25 63418931
Grip strength decreased 15.29 12.46 3 70063 22284 63396672
Hypertensive heart disease 15.14 12.46 16 70050 2436 63416520
Road traffic accident 15.12 12.46 11 70055 36621 63382335
Influenza like illness 15.04 12.46 32 70034 66792 63352164
Sinus node dysfunction 15.03 12.46 22 70044 4663 63414293
Atrioventricular block first degree 15.01 12.46 28 70038 7245 63411711
Ventricular extrasystoles 14.90 12.46 37 70029 11650 63407306
Vascular encephalopathy 14.88 12.46 8 70058 433 63418523
Blood creatine increased 14.74 12.46 24 70042 5577 63413379
Ecthyma 14.74 12.46 7 70059 291 63418665
Hepatic failure 14.73 12.46 78 69988 35578 63383378
Gastritis erosive 14.72 12.46 25 70041 6014 63412942
Leukopenia 14.69 12.46 140 69926 77150 63341806
Atrial septal defect 14.69 12.46 27 70039 6911 63412045
Accidental exposure to product 14.54 12.46 6 70060 27399 63391557
Sinus rhythm 14.54 12.46 10 70056 846 63418110
Neutrophil count decreased 14.45 12.46 25 70041 56381 63362575
Periodontitis 14.39 12.46 18 70048 3285 63415671
International normalised ratio abnormal 14.39 12.46 18 70048 3286 63415670
Septic encephalopathy 14.38 12.46 5 70061 91 63418865
Ischaemic stroke 14.29 12.46 48 70018 17909 63401047
Hyperuricaemia 14.12 12.46 23 70043 5347 63413609
Blood pressure systolic increased 14.07 12.46 19 70047 47378 63371578
Lymphadenopathy 14.07 12.46 13 70053 38445 63380511
Fungal infection 14.05 12.46 12 70054 36862 63382094
Burning sensation 14.04 12.46 24 70042 54383 63364573
Arteriosclerosis 14.04 12.46 33 70033 10033 63408923
Dyskinesia 14.02 12.46 9 70057 31993 63386963
Rash pruritic 14.00 12.46 28 70038 59771 63359185
Blood pressure decreased 14.00 12.46 121 69945 64901 63354055
Sepsis 13.93 12.46 242 69824 152881 63266075
Nausea 13.86 12.46 1108 68958 853363 62565593
Oral pain 13.85 12.46 7 70059 28387 63390569
Iron deficiency anaemia 13.84 12.46 51 70015 19918 63399038
Leukocytosis 13.79 12.46 61 70005 25874 63393082
Alanine aminotransferase decreased 13.71 12.46 9 70057 705 63418251
Cardiac murmur functional 13.69 12.46 4 70062 40 63418916
Chronic obstructive pulmonary disease 13.68 12.46 117 69949 62569 63356387
Aplasia 13.66 12.46 20 70046 4239 63414717
Rhinorrhoea 13.47 12.46 33 70033 65544 63353412
Muscle spasms 13.43 12.46 109 69957 156041 63262915
Hemiparesis 13.33 12.46 56 70010 23226 63395730
Concomitant disease progression 13.31 12.46 14 70052 2120 63416836
Product quality issue 13.27 12.46 12 70054 35853 63383103
Lip erosion 13.21 12.46 10 70056 983 63417973
Gastritis haemorrhagic 13.12 12.46 12 70054 1533 63417423
Femoral neck fracture 13.06 12.46 29 70037 8494 63410462
Hepatocellular carcinoma 12.99 12.46 14 70052 2180 63416776
Urinary tract infection 12.93 12.46 383 69683 264301 63154655
Neutropenia 12.93 12.46 127 69939 174878 63244078
Alcoholic liver disease 12.90 12.46 5 70061 125 63418831
Right aortic arch 12.89 12.46 6 70060 238 63418718
Periorbital haematoma 12.84 12.46 9 70057 785 63418171
Atrioventricular block 12.84 12.46 27 70039 7620 63411336
Inappropriate schedule of product administration 12.82 12.46 65 70001 103900 63315056
Pulse absent 12.77 12.46 22 70044 5352 63413604
Ear infection 12.74 12.46 14 70052 38199 63380757
Hyperphosphataemia 12.71 12.46 14 70052 2234 63416722
Cardiac pacemaker insertion 12.70 12.46 19 70047 4107 63414849
Acne 12.52 12.46 5 70061 23288 63395668
Ischaemic cerebral infarction 12.51 12.46 11 70055 1335 63417621

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1672.12 12.06 1636 67941 126633 34760721
Oedema peripheral 670.41 12.06 996 68581 118816 34768538
Cardiac failure 659.15 12.06 858 68719 90390 34796964
Product monitoring error 479.91 12.06 214 69363 4167 34883187
Product prescribing error 450.75 12.06 370 69207 22557 34864797
Haematochezia 428.44 12.06 495 69082 46039 34841315
Dyspnoea 423.10 12.06 1670 67907 375112 34512242
Drug ineffective 326.70 12.06 260 69317 456491 34430863
Systemic infection 321.57 12.06 172 69405 5040 34882314
Anaemia 279.24 12.06 1057 68520 232278 34655076
Cardiac failure chronic 260.60 12.06 174 69403 7705 34879649
Electrocardiogram abnormal 217.66 12.06 166 69411 9081 34878273
Electrolyte imbalance 211.47 12.06 197 69380 14215 34873139
Off label use 210.01 12.06 320 69257 419204 34468150
Atrial fibrillation 193.58 12.06 609 68968 121784 34765570
Syncope 183.95 12.06 496 69081 90955 34796399
Dizziness 182.25 12.06 888 68689 217633 34669721
Renal impairment 181.54 12.06 504 69073 94009 34793345
Toxicity to various agents 178.51 12.06 88 69489 200274 34687080
Dyspnoea exertional 170.92 12.06 308 69269 42971 34844383
Bradycardia 158.66 12.06 416 69161 75002 34812352
Labelled drug-drug interaction medication error 152.79 12.06 168 69409 14771 34872583
N-terminal prohormone brain natriuretic peptide increased 146.45 12.06 82 69495 2633 34884721
Acute kidney injury 136.60 12.06 1055 68522 303933 34583421
Drug abuse 127.20 12.06 22 69555 99074 34788280
Glomerular filtration rate decreased 121.00 12.06 139 69438 12822 34874532
Angina pectoris 118.47 12.06 219 69358 31144 34856210
Haematoma 117.78 12.06 195 69382 25410 34861944
Inferior vena cava dilatation 112.61 12.06 46 69531 714 34886640
Dehydration 112.27 12.06 534 69043 129435 34757919
Therapeutic drug monitoring analysis not performed 111.19 12.06 42 69535 523 34886831
Ventricular arrhythmia 110.20 12.06 90 69487 5438 34881916
Neutropenia 108.03 12.06 92 69485 156686 34730668
Pallor 106.56 12.06 186 69391 25294 34862060
Dyspnoea at rest 106.46 12.06 76 69501 3752 34883602
Exercise tolerance decreased 102.30 12.06 84 69493 5114 34882240
Arrhythmia 98.27 12.06 219 69358 35589 34851765
Ventricular enlargement 97.73 12.06 40 69537 624 34886730
Completed suicide 95.35 12.06 38 69539 98130 34789224
Ejection fraction decreased 93.68 12.06 150 69427 19004 34868350
Febrile neutropenia 93.41 12.06 81 69496 136768 34750586
Melaena 92.21 12.06 212 69365 35168 34852186
Fall 91.77 12.06 704 68873 202181 34685173
Hypotension 88.25 12.06 747 68830 220902 34666452
Hyperkalaemia 88.08 12.06 321 69256 69068 34818286
Rash 85.38 12.06 199 69378 222553 34664801
Wound 84.78 12.06 125 69452 14739 34872615
Respiratory tract haemorrhage 84.24 12.06 44 69533 1226 34886128
Right ventricular failure 79.96 12.06 93 69484 8691 34878663
Condition aggravated 77.12 12.06 649 68928 191547 34695807
Hypokalaemia 77.01 12.06 273 69304 57941 34829413
Anxiety 75.22 12.06 53 69524 99375 34787979
Pulmonary hypertension 73.90 12.06 142 69435 20782 34866572
Computerised tomogram coronary artery abnormal 72.86 12.06 24 69553 193 34887161
Infusion related reaction 72.10 12.06 10 69567 53047 34834307
Malaise 70.37 12.06 167 69410 185658 34701696
Mitral valve incompetence 70.32 12.06 115 69462 14828 34872526
Fracture 69.98 12.06 77 69500 6772 34880582
Cardiac aneurysm 68.69 12.06 35 69542 925 34886429
Ventricular hypokinesia 68.46 12.06 69 69508 5483 34881871
Arthralgia 68.29 12.06 148 69429 169893 34717461
Musculoskeletal pain 67.83 12.06 177 69400 31786 34855568
Blood creatinine increased 67.75 12.06 370 69207 94606 34792748
Neuropathy peripheral 67.57 12.06 41 69536 83222 34804132
Urinary hesitation 67.46 12.06 51 69526 2751 34884603
Ventricular tachycardia 66.77 12.06 157 69420 26422 34860932
Chronic kidney disease 66.76 12.06 207 69370 41003 34846351
Weight increased 66.07 12.06 362 69215 92671 34794683
Urosepsis 63.64 12.06 101 69476 12698 34874656
Treatment failure 62.98 12.06 9 69568 46688 34840666
Tachypnoea 62.92 12.06 123 69454 18229 34869125
Pulmonary arterial hypertension 62.57 12.06 82 69495 8657 34878697
Low cardiac output syndrome 61.18 12.06 28 69549 580 34886774
Product dose omission issue 60.80 12.06 90 69487 119621 34767733
Degenerative mitral valve disease 59.27 12.06 22 69555 260 34887094
Hyperuricaemia 56.86 12.06 75 69502 7968 34879386
Aortic valve incompetence 56.25 12.06 64 69513 5840 34881514
Rales 56.20 12.06 83 69494 9800 34877554
Disease progression 56.11 12.06 80 69497 107997 34779357
Therapeutic drug monitoring analysis incorrectly performed 56.04 12.06 22 69555 306 34887048
Glomerular filtration rate abnormal 54.69 12.06 29 69548 834 34886520
Drug hypersensitivity 53.30 12.06 49 69528 80480 34806874
Febrile infection 52.69 12.06 40 69537 2171 34885183
Brain natriuretic peptide increased 51.65 12.06 60 69517 5599 34881755
Product use in unapproved indication 50.76 12.06 98 69479 117401 34769953
Waist circumference increased 50.60 12.06 28 69549 878 34886476
Rectal prolapse 50.58 12.06 23 69554 469 34886885
Hypochromic anaemia 49.67 12.06 28 69549 911 34886443
Atrial enlargement 49.54 12.06 25 69552 647 34886707
Agitation 48.35 12.06 27 69550 57372 34829982
Foetal exposure during pregnancy 47.69 12.06 9 69568 38092 34849262
Depression 47.37 12.06 75 69502 97023 34790331
Contraindicated product administered 46.64 12.06 120 69457 21361 34865993
Gamma-glutamyltransferase increased 46.57 12.06 146 69431 29085 34858269
Suicidal ideation 45.60 12.06 12 69565 40376 34846978
Dysuria 45.47 12.06 138 69439 27014 34860340
Deep vein thrombosis 45.23 12.06 38 69539 65210 34822144
Cardio-respiratory arrest 45.13 12.06 27 69550 55246 34832108
Death 44.96 12.06 542 69035 397507 34489847
Urticaria 44.89 12.06 35 69542 62342 34825012
Hepatic vein dilatation 44.76 12.06 17 69560 215 34887139
Paresis 44.43 12.06 36 69541 2150 34885204
Left ventricular failure 44.39 12.06 53 69524 5091 34882263
Diverticulum intestinal 44.22 12.06 47 69530 3974 34883380
Micturition disorder 43.55 12.06 36 69541 2212 34885142
Concomitant disease aggravated 43.17 12.06 55 69522 5646 34881708
Pleural effusion 43.10 12.06 294 69283 81252 34806102
Circulatory collapse 43.09 12.06 115 69462 20923 34866431
Nicotine dependence 42.68 12.06 22 69555 596 34886758
Left atrial enlargement 42.57 12.06 25 69552 880 34886474
Renal cyst haemorrhage 41.99 12.06 22 69555 617 34886737
Gastritis erosive 41.45 12.06 55 69522 5877 34881477
Injection site pain 41.43 12.06 13 69564 38992 34848362
Infective exacerbation of chronic obstructive airways disease 40.86 12.06 32 69545 1819 34885535
Helicobacter test positive 40.70 12.06 24 69553 851 34886503
Lower respiratory tract infection 40.62 12.06 7 69570 31630 34855724
Asthma 40.59 12.06 17 69560 42639 34844715
Osteochondrosis 40.31 12.06 26 69551 1084 34886270
Pulmonary vascular disorder 40.28 12.06 22 69555 672 34886682
Joint swelling 40.15 12.06 36 69541 59854 34827500
Renal cyst 40.13 12.06 68 69509 9025 34878329
Glycosylated haemoglobin increased 39.99 12.06 77 69500 11283 34876071
Intraductal papillary mucinous neoplasm 39.73 12.06 20 69557 515 34886839
Hypervolaemia 39.63 12.06 107 69470 19602 34867752
Aortic dilatation 39.38 12.06 28 69549 1373 34885981
Loss of personal independence in daily activities 39.13 12.06 9 69568 33170 34854184
Intentional overdose 39.07 12.06 19 69558 43655 34843699
Coronary artery stenosis 38.64 12.06 69 69508 9547 34877807
Abdominal wall haemorrhage 38.40 12.06 19 69558 471 34886883
Normocytic anaemia 38.20 12.06 34 69543 2310 34885044
Bradyarrhythmia 38.15 12.06 33 69544 2158 34885196
Therapeutic product effect incomplete 38.12 12.06 27 69550 50514 34836840
Musculoskeletal stiffness 37.83 12.06 23 69554 46657 34840697
Hepatojugular reflux 37.53 12.06 20 69557 581 34886773
Liver palpable 37.42 12.06 16 69561 280 34887074
Skin ulcer 37.28 12.06 113 69464 22103 34865251
Acute abdomen 37.23 12.06 31 69546 1924 34885430
Lethargy 36.62 12.06 18 69559 41104 34846250
Therapeutic response decreased 36.52 12.06 7 69570 29306 34858048
Eye injury 35.92 12.06 22 69555 837 34886517
Haematuria 35.63 12.06 195 69382 49871 34837483
Fluid retention 35.45 12.06 126 69451 26761 34860593
Vena cava injury 35.29 12.06 16 69561 324 34887030
Cardiac failure acute 35.21 12.06 70 69507 10500 34876854
Product administration error 35.17 12.06 91 69486 16253 34871101
White blood cell count decreased 35.10 12.06 87 69490 95358 34791996
Hypersensitivity 34.92 12.06 42 69535 60993 34826361
SARS-CoV-2 antibody test positive 34.90 12.06 17 69560 407 34886947
Intentional product misuse 34.89 12.06 24 69553 45587 34841767
Therapeutic product effect decreased 34.45 12.06 13 69564 34730 34852624
Gastrointestinal haemorrhage 34.44 12.06 297 69280 88180 34799174
Tachyarrhythmia 34.18 12.06 39 69538 3569 34883785
Drug intolerance 34.07 12.06 41 69536 59529 34827825
Delayed graft function 33.81 12.06 31 69546 2190 34885164
Back pain 33.41 12.06 127 69450 121662 34765692
Cardiovascular insufficiency 32.65 12.06 27 69550 1660 34885694
Headache 32.41 12.06 250 69327 200385 34686969
C-reactive protein increased 32.20 12.06 201 69376 53897 34833457
Type V hyperlipidaemia 32.11 12.06 20 69557 784 34886570
Abdominal pain lower 31.66 12.06 67 69510 10504 34876850
Congestive cardiomyopathy 31.61 12.06 55 69522 7455 34879899
Nasopharyngitis 31.39 12.06 57 69520 69911 34817443
Vascular anastomotic haemorrhage 31.36 12.06 14 69563 273 34887081
Drug ineffective for unapproved indication 30.99 12.06 5 69572 23710 34863644
Haematemesis 30.84 12.06 123 69454 27588 34859766
Erysipelas 30.81 12.06 43 69534 4820 34882534
Stress 30.69 12.06 11 69566 30336 34857018
Bone marrow failure 30.62 12.06 10 69567 29243 34858111
Tricuspid valve incompetence 30.56 12.06 63 69514 9697 34877657
Jugular vein distension 30.28 12.06 18 69559 648 34886706
Hyperparathyroidism secondary 30.14 12.06 25 69552 1543 34885811
Disorientation 29.77 12.06 138 69439 33050 34854304
Cough 29.60 12.06 441 69136 149699 34737655
Platelet distribution width increased 29.41 12.06 11 69566 133 34887221
Insomnia 29.37 12.06 107 69470 103800 34783554
Orthopnoea 29.22 12.06 43 69534 5060 34882294
Abnormal behaviour 28.99 12.06 7 69570 24962 34862392
Perineal cyst 28.86 12.06 13 69564 259 34887095
Depressed level of consciousness 28.58 12.06 164 69413 42677 34844677
Intestinal haemorrhage 28.50 12.06 35 69542 3461 34883893
Intentional product use issue 28.41 12.06 47 69530 59769 34827585
Suicide attempt 28.07 12.06 22 69555 39094 34848260
Vascular compression 27.75 12.06 14 69563 362 34886992
Procalcitonin increased 27.75 12.06 25 69552 1726 34885628
Nephrolithiasis 27.43 12.06 13 69564 30320 34857034
Peripheral venous disease 27.08 12.06 30 69547 2658 34884696
Carotid arteriosclerosis 26.48 12.06 25 69552 1833 34885521
Rhinorrhoea 26.47 12.06 9 69568 25659 34861695
Periarthritis calcarea 26.33 12.06 9 69568 82 34887272
Palisaded neutrophilic granulomatous dermatitis 26.11 12.06 5 69572 0 34887354
Articular calcification 26.05 12.06 9 69568 85 34887269
Peripheral arterial occlusive disease 26.01 12.06 44 69533 5830 34881524
Red cell distribution width increased 25.98 12.06 45 69532 6078 34881276
Pulmonary congestion 25.95 12.06 73 69504 13692 34873662
Low density lipoprotein abnormal 25.64 12.06 13 69564 340 34887014
Aortic valve sclerosis 25.62 12.06 19 69558 995 34886359
Type 2 diabetes mellitus 25.46 12.06 80 69497 15952 34871402
Urinary incontinence 25.35 12.06 89 69488 18785 34868569
Sinusitis 25.30 12.06 27 69550 41375 34845979
Pruritus 25.28 12.06 172 69405 141809 34745545
Renal function test abnormal 25.08 12.06 28 69549 2502 34884852
Upper gastrointestinal haemorrhage 25.05 12.06 109 69468 25409 34861945
Hypotonia 24.95 12.06 51 69526 7802 34879552
Thirst 24.76 12.06 51 69526 7844 34879510
Atrial thrombosis 24.56 12.06 26 69551 2188 34885166
Hypertensive crisis 24.53 12.06 54 69523 8697 34878657
Migraine 24.44 12.06 3 69574 17475 34869879
Drug reaction with eosinophilia and systemic symptoms 24.42 12.06 18 69559 32994 34854360
Heat stroke 24.20 12.06 18 69559 947 34886407
Medication error 24.19 12.06 108 69469 25457 34861897
Duodenitis 23.86 12.06 38 69539 4790 34882564
Activated partial thromboplastin time prolonged 23.63 12.06 53 69524 8642 34878712
Aortic arteriosclerosis 23.62 12.06 37 69540 4599 34882755
Arteriosclerotic gangrene 23.59 12.06 8 69569 71 34887283
Intraventricular haemorrhage 23.54 12.06 32 69545 3499 34883855
Coma 23.50 12.06 34 69543 45644 34841710
Disturbance in attention 23.35 12.06 108 69469 25837 34861517
Abdominal discomfort 23.22 12.06 53 69524 59782 34827572
COVID-19 23.16 12.06 78 69499 77472 34809882
Neurotoxicity 23.08 12.06 4 69573 18006 34869348
Blood glucose abnormal 23.01 12.06 42 69535 5910 34881444
Psoriasis 22.96 12.06 26 69551 38786 34848568
Neuroleptic malignant syndrome 22.95 12.06 4 69573 17930 34869424
Osteonecrosis of jaw 22.87 12.06 4 69573 17885 34869469
Hepatitis E antibody positive 22.86 12.06 11 69566 256 34887098
Prescribed underdose 22.68 12.06 53 69524 8880 34878474
Colitis 22.64 12.06 25 69552 37725 34849629
Left ventricular hypertrophy 22.60 12.06 50 69527 8080 34879274
Immature granulocyte count increased 22.55 12.06 9 69568 131 34887223
Oedema 22.44 12.06 162 69415 45579 34841775
Acute respiratory failure 22.36 12.06 121 69456 30807 34856547
Blood loss anaemia 22.33 12.06 50 69527 8144 34879210
Atrial flutter 22.28 12.06 75 69502 15499 34871855
Blood pressure decreased 22.21 12.06 177 69400 51338 34836016
Drug withdrawal syndrome 22.18 12.06 6 69571 19828 34867526
Acute respiratory distress syndrome 22.18 12.06 12 69565 25957 34861397
Product use issue 22.17 12.06 59 69518 63157 34824197
Drug resistance 22.11 12.06 12 69565 25915 34861439
Immobile 22.02 12.06 26 69551 2468 34884886
Left ventricular enlargement 22.00 12.06 15 69562 687 34886667
Ventricular extrasystoles 21.97 12.06 63 69514 11945 34875409
Prostate cancer 21.92 12.06 28 69549 39621 34847733
Influenza like illness 21.86 12.06 14 69563 27620 34859734
Premature baby 21.84 12.06 6 69571 19627 34867727
Neutrophil count decreased 21.72 12.06 43 69534 51061 34836293
Hepatitis E virus test positive 21.68 12.06 11 69566 288 34887066
Blood pressure systolic decreased 21.65 12.06 35 69542 4468 34882886
Encephalopathy 21.62 12.06 23 69554 35296 34852058
Traumatic haemothorax 21.58 12.06 11 69566 291 34887063
Mitral valve thickening 21.52 12.06 12 69565 382 34886972
Haemothorax 21.39 12.06 32 69545 3820 34883534
Stenosis 21.34 12.06 20 69557 1453 34885901
Internal haemorrhage 21.32 12.06 37 69540 5004 34882350
Adrenal cyst 21.23 12.06 9 69568 154 34887200
Post-traumatic amnestic disorder 21.17 12.06 7 69570 57 34887297
Hyperventilation 21.00 12.06 27 69550 2797 34884557
Blood pressure increased 20.97 12.06 97 69480 88005 34799349
Mental status changes 20.95 12.06 27 69550 38056 34849298
Influenza 20.93 12.06 42 69535 49624 34837730
Pleurothotonus 20.68 12.06 18 69559 1187 34886167
Interstitial lung disease 20.65 12.06 64 69513 65218 34822136
Skin pressure mark 20.56 12.06 7 69570 63 34887291
Hallucination 20.48 12.06 45 69532 51453 34835901
Gastrointestinal adenocarcinoma 20.46 12.06 7 69570 64 34887290
Therapy non-responder 20.27 12.06 29 69548 39117 34848237
Unevaluable event 20.20 12.06 21 69556 32569 34854785
Hepatic calcification 20.14 12.06 11 69566 336 34887018
Pulmonary embolism 20.08 12.06 101 69476 89645 34797709
Bladder cancer 20.04 12.06 4 69573 16274 34871080
Psychotic disorder 19.88 12.06 12 69565 24440 34862914
Cardiovascular somatic symptom disorder 19.87 12.06 6 69571 35 34887319
Respiratory arrest 19.84 12.06 16 69561 28027 34859327
Blood 25-hydroxycholecalciferol decreased 19.81 12.06 10 69567 259 34887095
Blood potassium increased 19.80 12.06 75 69502 16420 34870934
Small intestinal obstruction 19.73 12.06 3 69574 14863 34872491
Fluid intake reduced 19.50 12.06 30 69547 3671 34883683
Cardiorenal syndrome 19.29 12.06 14 69563 709 34886645
Renal artery stenosis 19.02 12.06 23 69554 2238 34885116
Sedation 18.99 12.06 9 69568 20997 34866357
Renal failure 18.95 12.06 365 69212 130192 34757162
Urogenital haemorrhage 18.92 12.06 14 69563 731 34886623
Spinal osteoarthritis 18.87 12.06 45 69532 7638 34879716
Blood glucose fluctuation 18.85 12.06 31 69546 4013 34883341
Systolic dysfunction 18.75 12.06 25 69552 2683 34884671
Psoriatic arthropathy 18.66 12.06 8 69569 19790 34867564
Arthritis 18.54 12.06 21 69556 31325 34856029
Hyperglycaemia 18.32 12.06 138 69439 39342 34848012
Cardiac amyloidosis 18.15 12.06 17 69560 1234 34886120
Atrioventricular block complete 18.14 12.06 50 69527 9269 34878085
Lung diffusion test abnormal 17.92 12.06 6 69571 51 34887303
Mucosal haemorrhage 17.88 12.06 19 69558 1606 34885748
Polyuria 17.69 12.06 47 69530 8527 34878827
Left ventricular false tendon 17.62 12.06 6 69571 54 34887300
Vision blurred 17.60 12.06 41 69536 45922 34841432
Blood urea increased 17.55 12.06 112 69465 30252 34857102
Appendicitis 17.49 12.06 4 69573 14803 34872551
Genitourinary tract infection 17.47 12.06 7 69570 103 34887251
Costal cartilage fracture 17.42 12.06 9 69568 245 34887109
Suspected transmission of an infectious agent via product 17.31 12.06 14 69563 834 34886520
Diplopia 17.21 12.06 6 69571 16837 34870517
Faecaloma 17.18 12.06 35 69542 5342 34882012
Cytomegalovirus infection 17.16 12.06 16 69561 26119 34861235
Sepsis 17.14 12.06 231 69346 166330 34721024
Mean cell volume increased 17.14 12.06 26 69551 3143 34884211
Arthropathy 17.06 12.06 17 69560 26890 34860464
Hyperhidrosis 17.04 12.06 85 69492 75607 34811747
Peripheral artery stenosis 16.97 12.06 14 69563 858 34886496
Respiratory distress 16.95 12.06 28 69549 35637 34851717
Hiatus hernia 16.89 12.06 43 69534 7602 34879752
Inferior vena cava syndrome 16.89 12.06 6 69571 62 34887292
Obstructive airways disorder 16.75 12.06 5 69572 15489 34871865
Thoracic haemorrhage 16.64 12.06 8 69569 186 34887168
Intervertebral disc space narrowing 16.59 12.06 15 69562 1040 34886314
Activated partial thromboplastin time shortened 16.57 12.06 11 69566 482 34886872
Akinesia 16.43 12.06 21 69556 2163 34885191
Blood pressure systolic increased 16.35 12.06 13 69564 22939 34864415
Irritability 16.35 12.06 15 69562 24675 34862679
Overdose 16.35 12.06 110 69467 90949 34796405
No adverse event 16.32 12.06 13 69564 22914 34864440
Myelosuppression 16.31 12.06 9 69568 19256 34868098
Adenocarcinoma of appendix 16.19 12.06 7 69570 126 34887228
Rash macular 16.14 12.06 3 69574 12839 34874515
Insulin autoimmune syndrome 16.13 12.06 9 69568 287 34887067
N-terminal prohormone brain natriuretic peptide abnormal 16.07 12.06 8 69569 201 34887153
Scrotal oedema 16.06 12.06 19 69558 1807 34885547
Cold sweat 16.01 12.06 50 69527 9937 34877417
Rash pruritic 15.98 12.06 18 69559 26923 34860431
Mucosal inflammation 15.98 12.06 33 69544 38589 34848765
Paraplegia 15.91 12.06 24 69553 2887 34884467
Lower gastrointestinal haemorrhage 15.78 12.06 48 69529 9404 34877950
Anaphylactic shock 15.74 12.06 6 69571 15935 34871419
Intentional self-injury 15.72 12.06 4 69573 13767 34873587
Plasma cell myeloma 15.69 12.06 38 69539 41999 34845355
Paraesthesia 15.65 12.06 70 69507 64102 34823252
Testicular swelling 15.60 12.06 18 69559 1667 34885687
Rash erythematous 15.58 12.06 16 69561 24961 34862393
Bacteraemia 15.58 12.06 10 69567 19707 34867647
Rheumatoid arthritis 15.55 12.06 33 69544 38205 34849149
Oliguria 15.37 12.06 44 69533 8336 34879018
Congenital vas deferens absence 15.31 12.06 5 69572 39 34887315
Congenital muscle absence 15.31 12.06 5 69572 39 34887315
Non-compaction cardiomyopathy 15.31 12.06 5 69572 39 34887315
Diabetic foot 15.25 12.06 23 69554 2765 34884589
Hepatic cytolysis 15.09 12.06 5 69572 14491 34872863
Heart rate decreased 15.02 12.06 25 69552 31720 34855634
Mitral valve calcification 15.00 12.06 11 69566 566 34886788
Actinic keratosis 14.91 12.06 30 69547 4537 34882817
Inguinal hernia 14.87 12.06 41 69536 7600 34879754
Hepatic cirrhosis 14.79 12.06 71 69506 17243 34870111
Paranoia 14.78 12.06 3 69574 12065 34875289
Anaphylactic reaction 14.76 12.06 26 69551 32275 34855079
Hepatorenal syndrome 14.60 12.06 22 69555 2644 34884710
Rectal haemorrhage 14.54 12.06 37 69540 40212 34847142
Seizure 14.50 12.06 136 69441 104721 34782633
Micturition frequency decreased 14.47 12.06 9 69568 352 34887002
Stress urinary incontinence 14.41 12.06 6 69571 98 34887256
Bacterial infection 14.40 12.06 8 69569 17055 34870299
Sacroiliac joint dysfunction 14.40 12.06 5 69572 48 34887306
Adrenal adenoma 14.29 12.06 10 69567 478 34886876
Adrenomegaly 14.29 12.06 9 69568 360 34886994
Cardiac failure congestive 14.26 12.06 239 69338 83031 34804323
Pneumocystis jirovecii pneumonia 14.25 12.06 11 69566 19699 34867655
Subarachnoid haematoma 14.23 12.06 8 69569 259 34887095
Extrapyramidal disorder 14.21 12.06 4 69573 12876 34874478
Papillary renal cell carcinoma 14.20 12.06 8 69569 260 34887094
Anhidrosis 14.14 12.06 6 69571 103 34887251
Chronic coronary syndrome 14.13 12.06 7 69570 174 34887180
Pulmonary mass 14.09 12.06 4 69573 12808 34874546
Injection site erythema 14.09 12.06 7 69570 15892 34871462
Abdominal distension 14.02 12.06 178 69399 58314 34829040
Blast cells present 14.02 12.06 10 69567 493 34886861
Albumin urine present 13.96 12.06 9 69568 375 34886979
Aggression 13.94 12.06 36 69541 38928 34848426
Metamyelocyte count increased 13.92 12.06 9 69568 377 34886977
Urogenital infection bacterial 13.71 12.06 5 69572 56 34887298
Cardiac arrest 13.60 12.06 124 69453 96035 34791319
Pain 13.60 12.06 307 69270 204368 34682986
Lymphoma 13.58 12.06 4 69573 12503 34874851
Disseminated intravascular coagulation 13.58 12.06 14 69563 21802 34865552
Pollakiuria 13.57 12.06 76 69501 19598 34867756
Blood potassium abnormal 13.46 12.06 15 69562 1337 34886017
Haemoglobin decreased 13.45 12.06 325 69252 120447 34766907
Bladder tamponade 13.35 12.06 10 69567 532 34886822
Haemoptysis 13.34 12.06 117 69460 34889 34852465
Vitamin B6 deficiency 13.31 12.06 7 69570 198 34887156
Iron deficiency anaemia 13.26 12.06 48 69529 10281 34877073
Prothrombin time prolonged 13.19 12.06 45 69532 9361 34877993
Respiratory depression 13.16 12.06 8 69569 16237 34871117
Hepatosplenomegaly 13.16 12.06 27 69550 4142 34883212
Disease recurrence 13.14 12.06 14 69563 21476 34865878
Pneumonitis 13.14 12.06 30 69547 33848 34853506
Anxiety disorder 13.10 12.06 17 69560 1777 34885577
Subclavian artery occlusion 13.08 12.06 6 69571 125 34887229
Large intestine polyp 13.03 12.06 40 69537 7874 34879480
Dysdiadochokinesis 13.02 12.06 7 69570 207 34887147
Occult blood 12.99 12.06 12 69565 856 34886498
Polypectomy 12.90 12.06 10 69567 560 34886794
Multiple sclerosis relapse 12.87 12.06 5 69572 13128 34874226
Unresponsive to stimuli 12.77 12.06 22 69555 27547 34859807
Injection site reaction 12.71 12.06 5 69572 13028 34874326
Fungal infection 12.70 12.06 8 69569 15927 34871427
Oral pain 12.64 12.06 3 69574 10824 34876530
Drug interaction 12.62 12.06 560 69017 225386 34661968
Skin exfoliation 12.61 12.06 22 69555 27410 34859944
Ascites 12.59 12.06 145 69432 46426 34840928
Mouth ulceration 12.59 12.06 4 69573 11906 34875448
Benign gastrointestinal neoplasm 12.50 12.06 6 69571 139 34887215
Cachexia 12.47 12.06 37 69540 7149 34880205
Hypertrophy 12.47 12.06 9 69568 452 34886902
Gastrointestinal disorder 12.43 12.06 31 69546 33917 34853437
Complications of transplanted kidney 12.42 12.06 28 69549 4581 34882773
Gallbladder hypofunction 12.38 12.06 3 69574 6 34887348
Foot amputation 12.33 12.06 11 69566 750 34886604
Fear of falling 12.29 12.06 8 69569 339 34887015
Diabetic nephropathy 12.28 12.06 18 69559 2110 34885244
Vertigo 12.26 12.06 90 69487 25446 34861908
Swelling of eyelid 12.24 12.06 13 69564 1098 34886256
Eosinophilia 12.08 12.06 21 69556 26201 34861153
Hyperchromic anaemia 12.08 12.06 6 69571 150 34887204

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 3457.45 11.34 3102 122828 272136 79346322
Product prescribing error 1426.62 11.34 886 125044 43927 79574531
Product monitoring error 1247.10 11.34 485 125445 8421 79610037
Cardiac failure 1114.31 11.34 1296 124634 153546 79464912
Haematochezia 1101.11 11.34 991 124939 86654 79531804
Oedema peripheral 1069.50 11.34 1629 124301 250659 79367799
Dyspnoea 848.47 11.34 3116 122814 853909 78764549
Systemic infection 727.97 11.34 340 125590 9412 79609046
Drug ineffective 723.23 11.34 407 125523 1080506 78537952
Anaemia 701.25 11.34 1903 124027 443112 79175346
Renal impairment 642.44 11.34 1001 124929 156782 79461676
Labelled drug-drug interaction medication error 525.71 11.34 398 125532 27252 79591206
Atrial fibrillation 467.07 11.34 991 124939 196895 79421563
Acute kidney injury 459.63 11.34 1826 124104 517578 79100880
Dehydration 422.90 11.34 1094 124836 247093 79371365
Electrolyte imbalance 422.89 11.34 367 125563 30514 79587944
Syncope 407.66 11.34 885 125045 178564 79439894
Off label use 380.89 11.34 528 125402 906687 78711771
Bradycardia 375.75 11.34 726 125204 134831 79483627
Cardiac failure chronic 331.04 11.34 211 125719 10924 79607534
Electrocardiogram abnormal 327.17 11.34 245 125685 16492 79601966
Therapeutic drug monitoring analysis not performed 301.64 11.34 114 125816 1822 79616636
Fall 284.55 11.34 1518 124412 486111 79132347
Rash 265.50 11.34 314 125616 578044 79040414
Dyspnoea exertional 264.33 11.34 485 125445 86588 79531870
Dizziness 264.29 11.34 1574 124356 524867 79093591
Joint swelling 262.89 11.34 66 125864 288580 79329878
Infusion related reaction 256.70 11.34 31 125899 230206 79388252
Arrhythmia 250.73 11.34 390 125540 60882 79557576
Pallor 242.66 11.34 345 125585 49717 79568741
Drug hypersensitivity 238.50 11.34 87 125843 298829 79319629
Drug intolerance 231.75 11.34 65 125865 264054 79354404
Hyperkalaemia 229.18 11.34 537 125393 113861 79504597
Completed suicide 226.08 11.34 55 125875 245712 79372746
Hypotension 224.95 11.34 1323 124607 438994 79179464
Synovitis 222.13 11.34 3 125927 150731 79467727
Arthropathy 221.08 11.34 15 125915 177096 79441362
Toxicity to various agents 214.23 11.34 210 125720 421330 79197128
Treatment failure 214.10 11.34 14 125916 170472 79447986
Hypersensitivity 204.69 11.34 79 125851 262160 79356298
Pulmonary arterial hypertension 201.11 11.34 236 125694 28130 79590328
Glomerular filtration rate decreased 200.75 11.34 212 125718 22490 79595968
Melaena 199.90 11.34 351 125579 60539 79557919
Angina pectoris 198.83 11.34 320 125610 51412 79567046
Arthralgia 195.17 11.34 380 125550 571423 79047035
Haematoma 194.00 11.34 318 125612 51877 79566581
Therapeutic product effect decreased 193.02 11.34 18 125912 163845 79454613
Hypokalaemia 183.41 11.34 572 125358 143468 79474990
N-terminal prohormone brain natriuretic peptide increased 182.17 11.34 106 125824 4649 79613809
Haematemesis 172.49 11.34 302 125628 51962 79566496
Rheumatoid arthritis 169.07 11.34 59 125871 208411 79410047
Musculoskeletal stiffness 167.22 11.34 36 125894 174972 79443486
Alopecia 165.69 11.34 79 125851 231276 79387182
Blood creatinine increased 164.60 11.34 579 125351 154478 79463980
Lower respiratory tract infection 164.05 11.34 10 125920 129210 79489248
Tachypnoea 161.34 11.34 225 125705 31838 79586620
Product administration error 161.03 11.34 224 125706 31622 79586836
Drug abuse 156.39 11.34 33 125897 162658 79455800
Right ventricular failure 155.89 11.34 189 125741 23308 79595150
Systemic lupus erythematosus 154.94 11.34 9 125921 121140 79497318
Glossodynia 144.45 11.34 4 125926 103333 79515125
Drug interaction 141.66 11.34 1130 124800 414053 79204405
Fluid retention 141.16 11.34 329 125601 69480 79548978
Nasopharyngitis 140.15 11.34 117 125813 253764 79364694
Pulmonary hypertension 139.81 11.34 263 125667 47817 79570641
Hyponatraemia 138.25 11.34 602 125328 177246 79441212
Malaise 132.84 11.34 368 125562 489501 79128957
Chronic kidney disease 131.82 11.34 310 125620 65844 79552614
Abdominal discomfort 128.27 11.34 124 125806 250603 79367855
Orthostatic intolerance 128.03 11.34 62 125868 1862 79616596
Urticaria 126.93 11.34 67 125863 185134 79433324
Sinusitis 126.41 11.34 76 125854 195425 79423033
Febrile neutropenia 124.38 11.34 109 125821 230890 79387568
Mitral valve incompetence 121.27 11.34 185 125745 28380 79590078
Hypervolaemia 121.01 11.34 231 125699 42459 79575999
Injection site pain 119.44 11.34 29 125901 129809 79488649
Gastrointestinal haemorrhage 118.60 11.34 505 125425 147214 79471244
Exercise tolerance decreased 118.52 11.34 105 125825 8966 79609492
Inferior vena cava dilatation 116.84 11.34 46 125884 825 79617633
Pain 113.06 11.34 651 125279 703151 78915307
Dyspnoea at rest 112.70 11.34 93 125837 7209 79611249
Ventricular arrhythmia 110.89 11.34 100 125830 8740 79609718
Discomfort 108.10 11.34 32 125898 125585 79492873
Fracture 106.72 11.34 151 125779 21650 79596808
Renal failure 105.63 11.34 609 125321 200359 79418099
Therapeutic product effect incomplete 105.05 11.34 46 125884 141599 79476859
Hepatic enzyme increased 103.42 11.34 82 125848 182528 79435930
Ventricular enlargement 102.92 11.34 40 125890 692 79617766
Product use issue 102.47 11.34 108 125822 209714 79408744
Disorientation 101.79 11.34 272 125658 62504 79555954
Anuria 100.86 11.34 144 125786 20819 79597639
Anxiety 96.50 11.34 152 125778 248360 79370098
Arthritis 95.73 11.34 31 125899 114849 79503609
Hyperglycaemia 95.70 11.34 286 125644 70049 79548409
Maternal exposure during pregnancy 95.62 11.34 48 125882 136490 79481968
Neutropenia 95.52 11.34 194 125736 287516 79330942
Dysuria 94.23 11.34 232 125698 50719 79567739
Condition aggravated 93.30 11.34 1204 124726 499920 79118538
Therapeutic drug monitoring analysis incorrectly performed 93.20 11.34 37 125893 679 79617779
Respiratory tract haemorrhage 92.78 11.34 49 125881 1774 79616684
Diverticulum intestinal 91.88 11.34 89 125841 8516 79609942
Swelling 91.52 11.34 125 125805 216586 79401872
Product use in unapproved indication 90.84 11.34 160 125770 250199 79368259
Pericarditis 90.70 11.34 26 125904 104210 79514248
Intentional product use issue 89.07 11.34 66 125864 152046 79466412
Pleural effusion 88.97 11.34 459 125471 144803 79473655
Circulatory collapse 87.89 11.34 188 125742 37480 79580978
Haematuria 87.20 11.34 273 125657 68563 79549895
Pruritus 86.97 11.34 325 125605 394323 79224135
Loss of personal independence in daily activities 86.69 11.34 27 125903 102553 79515905
Glomerular filtration rate abnormal 85.87 11.34 45 125885 1603 79616855
Tachycardia 85.25 11.34 526 125404 177242 79441216
Back pain 84.21 11.34 226 125704 303954 79314504
Upper gastrointestinal haemorrhage 83.61 11.34 195 125735 41185 79577273
Cardiac failure acute 82.34 11.34 124 125806 18805 79599653
Waist circumference increased 82.01 11.34 44 125886 1645 79616813
Tachyarrhythmia 81.95 11.34 76 125854 6886 79611572
Neuropathy peripheral 81.85 11.34 62 125868 141243 79477215
Blood loss anaemia 81.33 11.34 111 125819 15387 79603071
Psoriatic arthropathy 80.99 11.34 13 125917 77986 79540472
Tricuspid valve incompetence 79.94 11.34 125 125805 19587 79598871
Musculoskeletal pain 79.88 11.34 347 125583 102007 79516451
Urosepsis 79.60 11.34 147 125783 26348 79592110
Helicobacter infection 78.58 11.34 9 125921 69695 79548763
Computerised tomogram coronary artery abnormal 78.21 11.34 24 125906 194 79618264
Atrial flutter 76.63 11.34 129 125801 21496 79596962
Ventricular tachycardia 76.54 11.34 190 125740 41745 79576713
Urinary hesitation 75.78 11.34 59 125871 4207 79614251
Medication error 75.08 11.34 259 125671 68383 79550075
Gamma-glutamyltransferase increased 73.11 11.34 221 125709 54459 79563999
Asthma 72.37 11.34 64 125866 135031 79483427
Headache 71.52 11.34 674 125256 653098 78965360
Folliculitis 71.14 11.34 4 125926 55376 79563082
Ejection fraction decreased 71.01 11.34 164 125766 34413 79584045
Haemoglobin decreased 70.96 11.34 596 125334 221523 79396935
Blood urea increased 70.77 11.34 203 125727 48587 79569871
Pancreatic steatosis 70.52 11.34 35 125895 1110 79617348
Stomatitis 68.91 11.34 78 125852 146679 79471779
Ventricular hypokinesia 68.77 11.34 79 125851 9200 79609258
Depression 67.89 11.34 151 125779 216639 79401819
Irritable bowel syndrome 67.81 11.34 9 125921 62232 79556226
Exposure during pregnancy 67.21 11.34 38 125892 101094 79517364
Cardiac aneurysm 66.66 11.34 37 125893 1481 79616977
Fibromyalgia 66.18 11.34 11 125919 64329 79554129
Abdominal pain lower 65.55 11.34 151 125779 31631 79586827
Migraine 65.52 11.34 28 125902 87465 79530993
Brain natriuretic peptide increased 64.66 11.34 75 125855 8825 79609633
Bradyarrhythmia 64.39 11.34 53 125877 4093 79614365
Gastrointestinal disorder 62.96 11.34 60 125870 122145 79496313
Hyperuricaemia 62.66 11.34 85 125845 11714 79606744
Degenerative mitral valve disease 61.86 11.34 22 125908 293 79618165
Hypotonia 61.31 11.34 88 125842 12782 79605676
Cardio-respiratory arrest 61.07 11.34 49 125881 108461 79509997
Left ventricular failure 60.21 11.34 75 125855 9506 79608952
Suicidal ideation 57.85 11.34 24 125906 76316 79542142
C-reactive protein abnormal 57.77 11.34 5 125925 48362 79570096
Renal function test abnormal 57.75 11.34 54 125876 4944 79613514
Aortic valve incompetence 57.34 11.34 73 125857 9457 79609001
Acute respiratory failure 56.90 11.34 215 125715 59326 79559132
Glycosylated haemoglobin increased 56.78 11.34 106 125824 19154 79599304
Paraesthesia 56.70 11.34 121 125809 176202 79442256
Insomnia 56.53 11.34 198 125732 244972 79373486
Faecaloma 56.46 11.34 80 125850 11484 79606974
Cardiac failure congestive 55.94 11.34 401 125529 142001 79476457
Thirst 55.55 11.34 103 125827 18516 79599942
Blister 55.54 11.34 64 125866 119412 79499046
Injection site erythema 55.48 11.34 27 125903 78170 79540288
Internal haemorrhage 55.27 11.34 69 125861 8764 79609694
Lactic acidosis 55.24 11.34 239 125691 70120 79548338
Blood cholesterol increased 54.85 11.34 32 125898 83688 79534770
Lethargy 54.80 11.34 30 125900 81262 79537196
Helicobacter test positive 54.38 11.34 31 125899 1307 79617151
Product dose omission issue 54.37 11.34 204 125726 247333 79371125
Orthopnoea 54.15 11.34 73 125857 10000 79608458
Concomitant disease aggravated 54.09 11.34 84 125846 13083 79605375
Peripheral arterial occlusive disease 54.08 11.34 66 125864 8192 79610266
Dementia 54.02 11.34 120 125810 24539 79593919
Therapeutic response decreased 54.02 11.34 19 125911 66834 79551624
Arterial haemorrhage 53.43 11.34 39 125891 2522 79615936
Sleep disorder due to general medical condition, insomnia type 53.42 11.34 4 125926 43552 79574906
Hypoaesthesia 52.87 11.34 129 125801 179223 79439235
Injection site reaction 52.85 11.34 11 125919 54774 79563684
Depressed level of consciousness 52.10 11.34 295 125635 96357 79522101
Gastritis erosive 51.43 11.34 74 125856 10773 79607685
Abdominal wall haemorrhage 51.17 11.34 24 125906 670 79617788
Anaphylactic reaction 50.76 11.34 35 125895 83708 79534750
Low cardiac output syndrome 50.12 11.34 27 125903 1018 79617440
Femoral hernia incarcerated 49.68 11.34 25 125905 817 79617641
Joint stiffness 49.37 11.34 4 125926 40826 79577632
Coronary artery stenosis 49.01 11.34 78 125852 12406 79606052
Hypochromic anaemia 48.76 11.34 38 125892 2713 79615745
Stress 48.62 11.34 33 125897 79579 79538879
Psoriasis 48.51 11.34 42 125888 89545 79528913
Febrile infection 48.29 11.34 41 125889 3305 79615153
Drug ineffective for unapproved indication 47.98 11.34 11 125919 51227 79567231
Hepatic vein dilatation 47.49 11.34 17 125913 231 79618227
Polyuria 47.25 11.34 85 125845 14929 79603529
Mobility decreased 47.13 11.34 75 125855 122100 79496358
Erysipelas 47.08 11.34 71 125859 10779 79607679
Low density lipoprotein abnormal 47.08 11.34 20 125910 439 79618019
Flatulence 46.53 11.34 161 125769 42563 79575895
Coma 45.62 11.34 55 125875 100594 79517864
Blood potassium increased 45.59 11.34 125 125805 29150 79589308
Hyperparathyroidism secondary 45.54 11.34 36 125894 2624 79615834
Vena cava injury 45.15 11.34 18 125912 334 79618124
Renal cyst haemorrhage 45.15 11.34 22 125908 670 79617788
Peripheral circulatory failure 45.10 11.34 26 125904 1120 79617338
Lymphatic fistula 44.92 11.34 23 125907 780 79617678
Atrial enlargement 44.65 11.34 25 125905 1018 79617440
Pulmonary congestion 44.50 11.34 118 125812 26982 79591476
Oropharyngeal pain 44.22 11.34 65 125865 109288 79509170
Intentional product misuse 44.21 11.34 51 125879 95114 79523344
Pulmonary vascular disorder 44.20 11.34 25 125905 1038 79617420
Left atrial enlargement 43.93 11.34 26 125904 1177 79617281
Procalcitonin increased 43.73 11.34 37 125893 2969 79615489
Micturition disorder 43.64 11.34 42 125888 3986 79614472
Injury 43.60 11.34 35 125895 77461 79540997
Atrioventricular block complete 43.56 11.34 87 125843 16523 79601935
Paresis 43.49 11.34 43 125887 4218 79614240
Blood pressure systolic increased 43.32 11.34 26 125904 66960 79551498
Lower gastrointestinal haemorrhage 42.94 11.34 85 125845 16040 79602418
Aortic valve stenosis 42.52 11.34 47 125883 5247 79613211
Aortic arteriosclerosis 42.51 11.34 61 125869 8857 79609601
Hypoglycaemia 42.18 11.34 290 125640 101304 79517154
Ascites 41.63 11.34 232 125698 75330 79543128
White blood cell count decreased 41.45 11.34 155 125775 188133 79430325
Prothrombin time prolonged 41.34 11.34 86 125844 16813 79601645
Therapy non-responder 41.24 11.34 51 125879 92254 79526204
Rhinorrhoea 40.78 11.34 36 125894 76038 79542420
Hepatojugular reflux 40.48 11.34 20 125910 628 79617830
Abdominal distension 39.75 11.34 324 125606 119326 79499132
Intentional self-injury 39.69 11.34 3 125927 32416 79586042
Restlessness 39.66 11.34 162 125768 46330 79572128
Cardiorenal syndrome 39.66 11.34 27 125903 1562 79616896
Renal cyst 39.64 11.34 78 125852 14654 79603804
Atrial thrombosis 39.38 11.34 38 125892 3618 79614840
COVID-19 39.31 11.34 123 125807 157551 79460907
Injection site swelling 38.76 11.34 13 125917 47119 79571339
Blood uric acid increased 38.72 11.34 73 125857 13287 79605171
N-terminal prohormone brain natriuretic peptide abnormal 38.57 11.34 15 125915 260 79618198
Nicotine dependence 38.47 11.34 22 125908 933 79617525
Influenza 38.36 11.34 93 125837 129513 79488945
SARS-CoV-2 antibody test positive 38.09 11.34 17 125913 422 79618036
Liver palpable 37.92 11.34 16 125914 345 79618113
Infective exacerbation of chronic obstructive airways disease 37.92 11.34 33 125897 2751 79615707
Intentional overdose 37.24 11.34 69 125861 105891 79512567
Knee arthroplasty 37.22 11.34 11 125919 43237 79575221
Blood pressure increased 36.80 11.34 190 125740 211170 79407288
Intraductal papillary mucinous neoplasm 36.55 11.34 20 125910 778 79617680
Cardiogenic shock 36.51 11.34 147 125783 41767 79576691
Disturbance in attention 36.43 11.34 168 125762 50633 79567825
Hypertensive crisis 35.70 11.34 92 125838 20678 79597780
Product used for unknown indication 35.63 11.34 25 125905 1519 79616939
Polyneuropathy 35.52 11.34 101 125829 24050 79594408
Osteoarthritis 35.20 11.34 52 125878 87257 79531201
Left-to-right cardiac shunt 34.51 11.34 11 125919 102 79618356
Vascular anastomotic haemorrhage 34.48 11.34 14 125916 273 79618185
Duodenitis 34.38 11.34 52 125878 7915 79610543
Osteochondrosis 34.15 11.34 27 125903 1969 79616489
Coagulation test abnormal 33.92 11.34 23 125907 1322 79617136
Osteonecrosis of jaw 33.71 11.34 13 125917 43213 79575245
Disease progression 33.66 11.34 163 125767 184199 79434259
Intraventricular haemorrhage 33.54 11.34 40 125890 4847 79613611
Obstructive airways disorder 33.21 11.34 5 125925 31454 79587004
Multiple sclerosis relapse 33.11 11.34 16 125914 46517 79571941
Oedema 33.06 11.34 311 125619 119269 79499189
Vascular resistance pulmonary decreased 33.01 11.34 10 125920 77 79618381
Haemoptysis 32.91 11.34 175 125755 55824 79562634
Retrograde amnesia 32.90 11.34 17 125913 588 79617870
Acute abdomen 32.66 11.34 32 125898 3105 79615353
Nephrolithiasis 32.66 11.34 22 125908 53269 79565189
Injection site bruising 32.53 11.34 12 125918 40990 79577468
Injection site pruritus 32.51 11.34 13 125917 42270 79576188
Burning sensation 32.33 11.34 27 125903 58605 79559853
Epistaxis 32.33 11.34 293 125637 111222 79507236
Jugular vein distension 32.07 11.34 23 125907 1447 79617011
Aortic dilatation 32.05 11.34 25 125905 1787 79616671
Perineal cyst 31.90 11.34 13 125917 256 79618202
Feeling abnormal 31.90 11.34 136 125794 159063 79459395
Platelet distribution width increased 31.82 11.34 11 125919 134 79618324
Influenza like illness 31.64 11.34 40 125890 71667 79546791
Type V hyperlipidaemia 31.58 11.34 20 125910 1023 79617435
Rash pruritic 31.56 11.34 40 125890 71589 79546869
Congestive cardiomyopathy 31.25 11.34 62 125868 11718 79606740
Transfusion 31.17 11.34 89 125841 21241 79597217
Ill-defined disorder 30.92 11.34 35 125895 65840 79552618
Activated partial thromboplastin time prolonged 30.90 11.34 69 125861 14159 79604299
Cardioversion 30.88 11.34 26 125904 2072 79616386
Neutrophil count decreased 30.59 11.34 64 125866 93895 79524563
Cardiovascular insufficiency 30.27 11.34 30 125900 2951 79615507
Congenital coronary artery malformation 30.18 11.34 10 125920 106 79618352
Blood pressure fluctuation 30.10 11.34 37 125893 67108 79551350
Hiatus hernia 30.01 11.34 93 125837 23219 79595239
Respiratory arrest 29.93 11.34 28 125902 57522 79560936
Sleep disorder 29.92 11.34 56 125874 85621 79532837
Pulmonary oedema 29.85 11.34 240 125690 88014 79530444
Incorrect route of product administration 29.85 11.34 9 125921 34920 79583538
Rales 29.76 11.34 84 125846 19917 79598541
Delayed graft function 29.67 11.34 32 125898 3475 79614983
Neoplasm progression 29.50 11.34 23 125907 51659 79566799
Hepatic cytolysis 29.39 11.34 4 125926 27147 79591311
Drug resistance 29.30 11.34 15 125915 42198 79576260
Dry eye 28.98 11.34 11 125919 36920 79581538
Pregnancy 28.97 11.34 4 125926 26847 79591611
Mental status changes 28.87 11.34 38 125892 66921 79551537
Ventricular extrasystoles 28.58 11.34 82 125848 19622 79598836
Stasis dermatitis 28.58 11.34 21 125909 1372 79617086
Eructation 28.44 11.34 57 125873 10852 79607606
Bundle branch block right 28.39 11.34 58 125872 11193 79607265
Adverse drug reaction 28.30 11.34 38 125892 66354 79552104
Adverse event 28.25 11.34 32 125898 60182 79558276
Aortic valve sclerosis 28.16 11.34 23 125907 1757 79616701
Red blood cell sedimentation rate increased 28.11 11.34 19 125911 45923 79572535
Pain in extremity 28.02 11.34 406 125524 364132 79254326
Periarthritis calcarea 28.00 11.34 9 125921 86 79618372
Wound infection pseudomonas 27.89 11.34 22 125908 1599 79616859
Gastritis 27.53 11.34 149 125781 47844 79570614
Hip arthroplasty 27.48 11.34 11 125919 35745 79582713
Upper respiratory tract infection 27.31 11.34 65 125865 91103 79527355
Fungal infection 27.28 11.34 16 125914 41732 79576726
Blood pressure decreased 27.15 11.34 258 125672 99208 79519250
Cardiovascular disorder 27.11 11.34 76 125854 17949 79600509
Serotonin syndrome 27.04 11.34 19 125911 45008 79573450
Left ventricular enlargement 26.92 11.34 16 125914 730 79617728
Cholestatic liver injury 26.85 11.34 36 125894 4905 79613553
Sudden cardiac death 26.78 11.34 37 125893 5188 79613270
Tooth erosion 26.70 11.34 13 125917 395 79618063
Neurotoxicity 26.69 11.34 9 125921 32509 79585949
Infection 26.40 11.34 249 125681 241463 79376995
Left ventricular hypertrophy 26.27 11.34 56 125874 11135 79607323
Mucosal haemorrhage 26.21 11.34 26 125904 2560 79615898
Drug withdrawal syndrome 26.16 11.34 11 125919 34707 79583751
Pericardial effusion 26.16 11.34 143 125787 46094 79572364
Gastroenteritis clostridial 26.13 11.34 17 125913 911 79617547
Joint range of motion decreased 25.97 11.34 10 125920 33272 79585186
Skin haemorrhage 25.90 11.34 58 125872 11923 79606535
Oral pain 25.75 11.34 9 125921 31789 79586669
Subdural haematoma 25.61 11.34 108 125822 31326 79587132
Ear pain 25.44 11.34 10 125920 32859 79585599
Coronavirus test positive 25.40 11.34 18 125912 1111 79617347
Urogenital haemorrhage 25.34 11.34 17 125913 960 79617498
Hepatitis E antibody positive 25.26 11.34 11 125919 257 79618201
Spinal pain 25.25 11.34 67 125863 15325 79603133
Vascular compression 25.23 11.34 14 125916 560 79617898
Arteriosclerotic gangrene 25.22 11.34 8 125922 73 79618385
Emotional distress 25.17 11.34 16 125914 39953 79578505
Illness 24.94 11.34 22 125908 46489 79571969
Palisaded neutrophilic granulomatous dermatitis 24.92 11.34 5 125925 3 79618455
Liver injury 24.54 11.34 32 125898 56582 79561876
Crush syndrome 24.49 11.34 10 125920 198 79618260
C-reactive protein increased 24.31 11.34 311 125619 128716 79489742
Ear infection 24.25 11.34 12 125918 34420 79584038
Throat tightness 24.20 11.34 7 125923 27900 79590558
Hepatitis E virus test positive 24.18 11.34 11 125919 286 79618172
Psychotic disorder 24.17 11.34 18 125912 41384 79577074
Rectal prolapse 24.15 11.34 23 125907 2155 79616303
Pulmonary vein occlusion 24.03 11.34 9 125921 140 79618318
Eye injury 23.93 11.34 25 125905 2618 79615840
Carotid arteriosclerosis 23.83 11.34 25 125905 2631 79615827
Oral herpes 23.60 11.34 7 125923 27447 79591011
Disease recurrence 23.49 11.34 21 125909 44088 79574370
Suicide attempt 23.38 11.34 61 125869 82871 79535587
Gout 23.34 11.34 89 125841 24660 79593798
Anal haemorrhage 23.24 11.34 31 125899 4203 79614255
Post-traumatic amnestic disorder 23.21 11.34 7 125923 53 79618405
Poor quality sleep 23.11 11.34 4 125926 22718 79595740
Seroma 23.08 11.34 23 125907 2277 79616181
Road traffic accident 23.00 11.34 21 125909 43643 79574815
Left ventricular dysfunction 22.88 11.34 75 125855 19286 79599172
Rhonchi 22.85 11.34 30 125900 4006 79614452
Adrenal cyst 22.83 11.34 9 125921 162 79618296
Arteriosclerosis 22.81 11.34 72 125858 18155 79600303
Skin ulcer 22.72 11.34 155 125775 53995 79564463
Rash erythematous 22.71 11.34 35 125895 57734 79560724
Irritability 22.62 11.34 19 125911 41125 79577333
Haemothorax 22.57 11.34 35 125895 5443 79613015
Throat irritation 22.40 11.34 19 125911 40927 79577531
Atrioventricular block first degree 22.16 11.34 56 125874 12435 79606023
Vision blurred 22.12 11.34 89 125841 105809 79512649
Stenosis 22.09 11.34 23 125907 2399 79616059
Pneumothorax traumatic 22.05 11.34 10 125920 258 79618200
Grip strength decreased 21.92 11.34 4 125926 21865 79596593
Hyperthyroidism 21.88 11.34 81 125849 22128 79596330
Normocytic anaemia 21.87 11.34 30 125900 4177 79614281
Haemophagocytic lymphohistiocytosis 21.87 11.34 4 125926 21833 79596625
Hepatic calcification 21.82 11.34 11 125919 361 79618097
Labelled drug-drug interaction issue 21.81 11.34 18 125912 1395 79617063
Activated partial thromboplastin time shortened 21.79 11.34 15 125915 884 79617574
Bursitis 21.69 11.34 15 125915 35829 79582629
Renal artery stenosis 21.47 11.34 27 125903 3455 79615003
Amnesia 21.33 11.34 42 125888 63015 79555443
International normalised ratio abnormal 21.23 11.34 35 125895 5733 79612725
Lymphadenopathy 21.18 11.34 32 125898 53215 79565243
Hepatic cyst 21.14 11.34 36 125894 6053 79612405
Cardiovascular somatic symptom disorder 21.10 11.34 6 125924 36 79618422
Cachexia 21.05 11.34 51 125879 11032 79607426
Haemarthrosis 21.03 11.34 35 125895 5777 79612681
Administration site discomfort 20.93 11.34 8 125922 132 79618326
Testicular swelling 20.88 11.34 17 125913 1293 79617165
Hot flush 20.86 11.34 34 125896 54843 79563615
Heat stroke 20.84 11.34 19 125911 1684 79616774
Cytomegalovirus infection 20.74 11.34 22 125908 42622 79575836
Fracture blisters 20.73 11.34 7 125923 79 79618379
Drug reaction with eosinophilia and systemic symptoms 20.71 11.34 44 125886 64200 79554258
Spontaneous haemorrhage 20.67 11.34 14 125916 803 79617655
Articular calcification 20.64 11.34 9 125921 211 79618247
Pulmonary mass 20.63 11.34 10 125920 29024 79589434
Anaphylactic shock 20.57 11.34 16 125914 35980 79582478
Contusion 20.48 11.34 144 125786 148632 79469826
Accidental exposure to product 20.47 11.34 12 125918 31310 79587148
Appendicitis 20.42 11.34 4 125926 20790 79597668
Polyserositis 20.41 11.34 13 125917 672 79617786
Mitral valve thickening 20.39 11.34 11 125919 416 79618042
Neuroleptic malignant syndrome 20.34 11.34 9 125921 27550 79590908
Traumatic haemothorax 20.30 11.34 12 125918 542 79617916
Body temperature decreased 20.06 11.34 13 125917 32132 79586326
Gangrene 20.06 11.34 44 125886 8920 79609538
Bone marrow failure 20.06 11.34 31 125899 51076 79567382
Sinus rhythm 20.05 11.34 14 125916 844 79617614
Actinic keratosis 20.03 11.34 35 125895 6007 79612451
Scrotal oedema 20.02 11.34 18 125912 1567 79616891
Small intestinal obstruction 19.98 11.34 9 125921 27263 79591195
Coronary artery disease 19.98 11.34 174 125756 65300 79553158
Skin pressure mark 19.98 11.34 7 125923 89 79618369
Femoral artery dissection 19.95 11.34 6 125924 45 79618413
Glomerular filtration rate increased 19.90 11.34 16 125914 1195 79617263
Tooth infection 19.86 11.34 3 125927 18829 79599629
Immunodeficiency 19.74 11.34 5 125925 21763 79596695
Thrombin time prolonged 19.73 11.34 10 125920 332 79618126
Left ventricular false tendon 19.61 11.34 6 125924 48 79618410
Heart rate decreased 19.61 11.34 52 125878 70264 79548194
Withdrawal syndrome 19.46 11.34 9 125921 26845 79591613
Presyncope 19.35 11.34 121 125809 40933 79577525
Dystonia 19.24 11.34 5 125925 21394 79597064
Immature granulocyte count increased 19.12 11.34 12 125918 604 79617854
Colitis 19.11 11.34 56 125874 73251 79545207
Neuroglycopenia 19.10 11.34 11 125919 473 79617985
Diabetic foot 19.03 11.34 26 125904 3606 79614852
Fluid intake reduced 19.03 11.34 35 125895 6253 79612205
Herpes zoster 18.96 11.34 79 125851 93004 79525454
Helplessness 18.93 11.34 10 125920 362 79618096
Hypertensive heart disease 18.93 11.34 28 125902 4178 79614280
Costal cartilage fracture 18.91 11.34 9 125921 260 79618198
Respiratory depression 18.91 11.34 10 125920 27620 79590838
Poor venous access 18.89 11.34 3 125927 18146 79600312
Tendonitis 18.86 11.34 7 125923 23823 79594635
Chronic coronary syndrome 18.75 11.34 7 125923 108 79618350
Hepatorenal syndrome 18.71 11.34 28 125902 4221 79614237
Eye pain 18.71 11.34 19 125911 37559 79580899
Red blood cell sedimentation rate abnormal 18.66 11.34 5 125925 20958 79597500
Injection site rash 18.62 11.34 3 125927 17951 79600507
Blood 25-hydroxycholecalciferol decreased 18.51 11.34 10 125920 379 79618079
Diverticulum intestinal haemorrhagic 18.48 11.34 27 125903 3984 79614474
Mouth ulceration 18.46 11.34 20 125910 38374 79580084
Gait inability 18.45 11.34 41 125889 58876 79559582
Acne 18.37 11.34 10 125920 27180 79591278
Blood glucose abnormal 18.36 11.34 47 125883 10519 79607939
Muscle spasms 18.23 11.34 182 125748 174548 79443910
Biopsy skin abnormal 18.21 11.34 8 125922 191 79618267
Systolic dysfunction 18.15 11.34 26 125904 3769 79614689
Swelling face 18.13 11.34 55 125875 71157 79547301
Iron deficiency 18.11 11.34 47 125883 10607 79607851
Ketoacidosis 18.09 11.34 39 125891 7815 79610643
Aggression 18.06 11.34 33 125897 50925 79567533
Paraesthesia oral 18.00 11.34 5 125925 20466 79597992
Encephalopathy 17.92 11.34 51 125879 67346 79551112
Pneumocystis jirovecii pneumonia 17.89 11.34 15 125915 32493 79585965
Crying 17.85 11.34 7 125923 23036 79595422
Asthenia 17.83 11.34 983 124947 510706 79107752
Akinesia 17.80 11.34 24 125906 3288 79615170
Portal hypertensive gastropathy 17.74 11.34 16 125914 1398 79617060
Drug dependence 17.71 11.34 23 125907 40746 79577712
Weight increased 17.68 11.34 568 125362 276818 79341640
Diastolic dysfunction 17.67 11.34 47 125883 10764 79607694
Inflammation 17.62 11.34 82 125848 93671 79524787
Thirst decreased 17.61 11.34 9 125921 304 79618154
Benign prostatic hyperplasia 17.50 11.34 49 125881 11563 79606895
Musculoskeletal disorder 17.49 11.34 6 125924 21442 79597016
Catheterisation cardiac 17.48 11.34 32 125898 5696 79612762
Subgaleal haematoma 17.46 11.34 7 125923 132 79618326
Jaundice 17.45 11.34 144 125786 53205 79565253
Basal ganglia haemorrhage 17.31 11.34 17 125913 1654 79616804
Lung disorder 17.27 11.34 67 125863 80490 79537968
Thoracic haemorrhage 17.24 11.34 8 125922 218 79618240
Myelosuppression 17.24 11.34 23 125907 40273 79578185
Chest wall haematoma 17.17 11.34 10 125920 439 79618019
Hip fracture 17.16 11.34 14 125916 30747 79587711
Agitation 17.14 11.34 90 125840 99625 79518833
Haemorrhagic erosive gastritis 17.13 11.34 12 125918 727 79617731
Craniocerebral injury 17.10 11.34 30 125900 5166 79613292
Uveitis 17.04 11.34 3 125927 16827 79601631
Impaired work ability 16.95 11.34 5 125925 19676 79598782
Skin infection 16.92 11.34 4 125926 18241 79600217
Overdose 16.76 11.34 198 125732 184008 79434450
Pulpitis dental 16.76 11.34 15 125915 1298 79617160
Eye disorder 16.73 11.34 8 125922 23404 79595054
Palpitations 16.71 11.34 287 125643 126323 79492135
Non-compaction cardiomyopathy 16.45 11.34 5 125925 39 79618419
Injection site haemorrhage 16.42 11.34 12 125918 27858 79590600
Photophobia 16.30 11.34 6 125924 20522 79597936
Pleurothotonus 16.30 11.34 20 125910 2496 79615962
Inappropriate schedule of product administration 16.19 11.34 134 125796 133494 79484964
Mental impairment 16.10 11.34 5 125925 19031 79599427
Upper respiratory tract irritation 16.08 11.34 8 125922 255 79618203
Intestinal haemorrhage 16.07 11.34 33 125897 6393 79612065
Foot deformity 16.05 11.34 9 125921 24065 79594393
Suspected transmission of an infectious agent via product 16.04 11.34 14 125916 1172 79617286
Urinary incontinence 15.93 11.34 115 125815 40794 79577664
Nocturnal dyspnoea 15.84 11.34 16 125914 1610 79616848
Hyperventilation 15.71 11.34 37 125893 7862 79610596
Cyanosis 15.69 11.34 80 125850 25102 79593356
Myoglobin blood increased 15.68 11.34 22 125908 3129 79615329
Oliguria 15.67 11.34 59 125871 16250 79602208
Inferior vena cava syndrome 15.59 11.34 6 125924 101 79618357
Mood swings 15.47 11.34 6 125924 19874 79598584
Disability 15.39 11.34 4 125926 17116 79601342
Gastric disorder 15.37 11.34 22 125908 37411 79581047
Multiple drug therapy 15.35 11.34 25 125905 4053 79614405
Adrenomegaly 15.32 11.34 9 125921 402 79618056
Diabetic nephropathy 15.30 11.34 21 125909 2926 79615532
Hepatic cirrhosis 15.29 11.34 101 125829 34805 79583653
Nervous system disorder 15.26 11.34 12 125918 26844 79591614
Accidental overdose 15.26 11.34 111 125819 39470 79578988
Paraparesis 15.26 11.34 24 125906 3779 79614679
Tenosynovitis 15.26 11.34 3 125927 15551 79602907
Subarachnoid haematoma 15.21 11.34 8 125922 287 79618171
Ventricular assist device insertion 15.18 11.34 5 125925 52 79618406
Dysphonia 15.15 11.34 43 125887 56829 79561629
No adverse event 15.14 11.34 22 125908 37170 79581288
Blood cholesterol decreased 15.05 11.34 16 125914 1709 79616749
Insulin autoimmune syndrome 14.90 11.34 9 125921 423 79618035
Paranoia 14.90 11.34 6 125924 19426 79599032
Alanine aminotransferase decreased 14.90 11.34 15 125915 1504 79616954
Nephrogenic anaemia 14.80 11.34 24 125906 3878 79614580
Tuberculosis 14.76 11.34 3 125927 15195 79603263
Eye pruritus 14.74 11.34 7 125923 20563 79597895
Cerebral ischaemia 14.73 11.34 45 125885 11150 79607308
Colitis ulcerative 14.69 11.34 20 125910 34722 79583736
Frequent bowel movements 14.63 11.34 15 125915 29524 79588934
Cardiomegaly 14.57 11.34 81 125849 26271 79592187
Micturition frequency decreased 14.53 11.34 12 125918 931 79617527
Cerebral haemorrhage 14.46 11.34 147 125783 57526 79560932
Personality change 14.44 11.34 42 125888 10128 79608330
Apnoea 14.43 11.34 46 125884 11658 79606800
Nocturia 14.41 11.34 51 125879 13630 79604828
Acute respiratory distress syndrome 14.35 11.34 30 125900 44037 79574421
Neuralgia 14.33 11.34 19 125911 33365 79585093
Mucosal inflammation 14.26 11.34 66 125864 75514 79542944
Viral infection 14.25 11.34 29 125901 42987 79575471
Rectal haemorrhage 14.18 11.34 67 125863 76233 79542225
Neck pain 14.15 11.34 66 125864 75351 79543107
Painful respiration 14.14 11.34 22 125908 3431 79615027
Pneumonitis 14.11 11.34 49 125881 60811 79557647
Skin turgor decreased 14.09 11.34 11 125919 787 79617671
Normochromic normocytic anaemia 14.09 11.34 35 125895 7692 79610766
Cough 14.04 11.34 711 125219 366078 79252380
Dry gangrene 14.03 11.34 12 125918 977 79617481
Vitamin B6 deficiency 14.02 11.34 8 125922 338 79618120
Dysdiadochokinesis 14.00 11.34 8 125922 339 79618119
Ischaemic stroke 14.00 11.34 95 125835 33036 79585422
Middle insomnia 13.99 11.34 4 125926 16065 79602393
Respiratory tract congestion 13.98 11.34 7 125923 19947 79598511
Neoplasm malignant 13.76 11.34 18 125912 31792 79586666
Tinnitus 13.76 11.34 31 125899 44302 79574156
Skin exfoliation 13.71 11.34 43 125887 55057 79563401
Benign gastrointestinal neoplasm 13.67 11.34 6 125924 143 79618315
Antidiuretic hormone abnormality 13.52 11.34 5 125925 75 79618383
Bladder cancer 13.46 11.34 7 125923 19519 79598939
Psychomotor retardation 13.44 11.34 30 125900 6154 79612304
Sinus arrest 13.36 11.34 22 125908 3600 79614858
Dyskinesia 13.34 11.34 32 125898 44741 79573717
Diabetic neuropathy 13.33 11.34 30 125900 6186 79612272
Spinal cord injury cauda equina 13.33 11.34 6 125924 152 79618306
Macroangiopathy 13.26 11.34 6 125924 154 79618304
Prostate cancer 13.23 11.34 20 125910 33248 79585210
Hypertensive emergency 13.20 11.34 19 125911 2766 79615692
Sciatica 13.18 11.34 20 125910 33202 79585256
Blood pressure diastolic decreased 13.18 11.34 17 125913 30199 79588259
Blood pressure systolic decreased 13.17 11.34 43 125887 11033 79607425
Sinus node dysfunction 13.12 11.34 34 125896 7667 79610791
Eczema 13.12 11.34 28 125902 40790 79577668
Joint effusion 13.11 11.34 6 125924 18008 79600450
Supraventricular extrasystoles 13.11 11.34 32 125898 6955 79611503
Tongue disorder 13.08 11.34 3 125927 13972 79604486
Prerenal failure 13.02 11.34 22 125908 3676 79614782
Deep vein thrombosis 13.01 11.34 125 125805 120794 79497664
Peripheral artery stenosis 12.96 11.34 13 125917 1298 79617160
Plasma cell myeloma 12.95 11.34 42 125888 53217 79565241
Product quality issue 12.93 11.34 21 125909 33919 79584539
Product substitution issue 12.90 11.34 8 125922 20248 79598210
Immune reconstitution inflammatory syndrome 12.90 11.34 3 125927 13838 79604620
Spinal osteoarthritis 12.90 11.34 57 125873 16870 79601588
Sprue-like enteropathy 12.90 11.34 13 125917 1305 79617153
Papillary renal cell carcinoma 12.89 11.34 7 125923 268 79618190
Disseminated intravascular coagulation 12.89 11.34 23 125907 35819 79582639
Flushing 12.86 11.34 84 125846 88184 79530274
Subclavian artery occlusion 12.78 11.34 6 125924 168 79618290
Breast cancer 12.77 11.34 21 125909 33760 79584698
Blood test abnormal 12.73 11.34 6 125924 17704 79600754
Genitourinary tract infection 12.66 11.34 7 125923 278 79618180
Urinary retention 12.64 11.34 141 125789 56489 79561969
Acute left ventricular failure 12.63 11.34 15 125915 1809 79616649
Graft versus host disease 12.61 11.34 4 125926 15022 79603436
Wrong product administered 12.59 11.34 37 125893 8975 79609483
Toothache 12.57 11.34 8 125922 19962 79598496
Erythema 12.53 11.34 263 125667 223027 79395431
Right ventricular dysfunction 12.52 11.34 18 125912 2617 79615841
Language disorder 12.50 11.34 20 125910 3194 79615264
Sinus congestion 12.48 11.34 8 125922 19888 79598570
Hyperparathyroidism 12.46 11.34 20 125910 3204 79615254
Mass 12.44 11.34 6 125924 17466 79600992
Tooth abscess 12.44 11.34 5 125925 16205 79602253
Cardiac murmur functional 12.37 11.34 4 125926 39 79618419
Autoimmune colitis 12.33 11.34 14 125916 1609 79616849
Injection site warmth 12.32 11.34 4 125926 14803 79603655
Bladder tamponade 12.32 11.34 9 125921 583 79617875
Pseudomonas infection 12.32 11.34 9 125921 20894 79597564
Iron deficiency anaemia 12.31 11.34 76 125854 25596 79592862
Anticoagulation drug level increased 12.28 11.34 10 125920 761 79617697
Dyspepsia 12.27 11.34 111 125819 108576 79509882
Foot amputation 12.24 11.34 11 125919 957 79617501
Bone density decreased 12.23 11.34 3 125927 13344 79605114
Sneezing 12.23 11.34 8 125922 19675 79598783
Cerebral infarction 12.22 11.34 118 125812 45558 79572900
Respiratory distress 12.20 11.34 49 125881 58290 79560168
Nodule 12.18 11.34 11 125919 22983 79595475
Ocular hyperaemia 12.16 11.34 16 125914 28190 79590268
Potentiating drug interaction 12.12 11.34 36 125894 8783 79609675
Immobile 12.10 11.34 31 125899 6942 79611516
Hemiparesis 12.10 11.34 93 125837 33640 79584818
Femoral neck fracture 12.09 11.34 39 125891 9945 79608513
Cold sweat 12.07 11.34 60 125870 18639 79599819
Urogenital infection bacterial 12.02 11.34 5 125925 104 79618354
Pulmonary fibrosis 12.01 11.34 33 125897 44079 79574379
Somatosensory evoked potentials abnormal 11.98 11.34 6 125924 194 79618264
Cerebral arteriosclerosis 11.96 11.34 10 125920 789 79617669
Transplant rejection 11.94 11.34 8 125922 19429 79599029
Cerebral ventricular rupture 11.92 11.34 8 125922 452 79618006
Vascular encephalopathy 11.91 11.34 9 125921 614 79617844
Blood glucose fluctuation 11.90 11.34 30 125900 6652 79611806
Intervertebral disc degeneration 11.90 11.34 5 125925 15780 79602678
Catheter management 11.86 11.34 21 125909 3642 79614816
Skin fissures 11.86 11.34 3 125927 13070 79605388
Rash macular 11.85 11.34 17 125913 28882 79589576
Varices oesophageal 11.84 11.34 28 125902 5963 79612495
Epstein-Barr virus infection 11.81 11.34 4 125926 14412 79604046
Parotitis 11.80 11.34 17 125913 2477 79615981
Drug level decreased 11.79 11.34 4 125926 14398 79604060
Emotional disorder 11.77 11.34 4 125926 14383 79604075
Impaired quality of life 11.77 11.34 4 125926 14382 79604076
Corynebacterium test positive 11.76 11.34 5 125925 110 79618348
Drug tolerance decreased 11.73 11.34 3 125927 12975 79605483
Abnormal behaviour 11.69 11.34 25 125905 36396 79582062
Metamyelocyte count increased 11.69 11.34 9 125921 631 79617827
Intervertebral disc space narrowing 11.58 11.34 14 125916 1721 79616737
Cardiopulmonary failure 11.56 11.34 30 125900 6771 79611687
Bone pain 11.54 11.34 47 125883 55695 79562763
Paraplegia 11.53 11.34 25 125905 5028 79613430
Swollen tongue 11.48 11.34 32 125898 42538 79575920
Mycobacterium fortuitum infection 11.44 11.34 6 125924 214 79618244
Atheroembolism 11.44 11.34 7 125923 337 79618121
Ventricular remodelling 11.36 11.34 5 125925 120 79618338

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C03CA04 CARDIOVASCULAR SYSTEM
DIURETICS
HIGH-CEILING DIURETICS
Sulfonamides, plain
FDA PE N0000175366 Increased Diuresis at Loop of Henle
FDA EPC N0000175590 Loop Diuretic
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
MeSH PA D049994 Sodium Potassium Chloride Symporter Inhibitors
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:77608 loop diuretics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Decompensated cardiac failure indication 195111005
Edema indication 267038008
Pulmonary Edema due to Chronic Heart Failure indication
Peripheral Edema due to Chronic Heart Failure indication
Renal Disease with Edema indication
Edema due to Hepatic Cirrhosis indication
Metabolic alkalosis contraindication 1388004
Anuria contraindication 2472002 DOID:2983
Cirrhosis of liver contraindication 19943007 DOID:5082
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypokalemia contraindication 43339004
Gout contraindication 90560007 DOID:13189
Hearing disorder contraindication 128540005
Hypertriglyceridemia contraindication 302870006
Ascites contraindication 389026000
Azotemia contraindication 445009001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.25 acidic
pKa2 6.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 12 member 1 Transporter INHIBITOR IC50 6.40 WOMBAT-PK CHEMBL

External reference:

IDSource
4020851 VUID
N0000148359 NUI
D00382 KEGG_DRUG
4020851 VANDF
C0076840 UMLSCUI
CHEBI:9637 CHEBI
CHEMBL1148 ChEMBL_ID
DB00214 DRUGBANK_ID
D000077786 MESH_DESCRIPTOR_UI
41781 PUBCHEM_CID
7312 IUPHAR_LIGAND_ID
3938 INN_ID
W31X2H97FB UNII
38413 RXNORM
43738 MMSL
5604 MMSL
d03189 MMSL
004414 NDDF
108476002 SNOMEDCT_US
318034005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0054-0077 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0770 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0517-0771 INJECTION, SOLUTION 10 mg INTRAVENOUS ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-5575 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7997 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0615-7997 TABLET 20 mg ORAL ANDA 23 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 0904-7283 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 23155-871 TABLET 5 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-872 TABLET 10 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-873 TABLET 20 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 23155-874 TABLET 100 mg ORAL ANDA 25 sections
Torsemide Human Prescription Drug Label 1 31722-529 TABLET 5 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-530 TABLET 10 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-531 TABLET 20 mg ORAL ANDA 24 sections
Torsemide Human Prescription Drug Label 1 31722-532 TABLET 100 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-816 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-816 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-817 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-817 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-818 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-818 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-819 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 42291-819 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 43353-315 TABLET 20 mg ORAL ANDA 24 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50090-6495 TABLET 100 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50090-6499 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-915 TABLET 5 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-916 TABLET 10 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-917 TABLET 20 mg ORAL ANDA 22 sections
Torsemide HUMAN PRESCRIPTION DRUG LABEL 1 50111-918 TABLET 100 mg ORAL ANDA 22 sections