tolrestat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aldose reductase inhibitors | 2704 | 82964-04-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 8 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1989 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A10XA01 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES OTHER DRUGS USED IN DIABETES Aldose reductase inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| CHEBI has role | CHEBI:48550 | aldose reductase inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetic complication | indication | 74627003 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.18 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aldose reductase | Enzyme | INHIBITOR | IC50 | 8.51 | WOMBAT-PK | SCIENTIFIC LITERATURE | |||
| Alcohol dehydrogenase [NADP(+)] | Enzyme | IC50 | 6.14 | CHEMBL | |||||
| Aldo-keto reductase family 1 member B10 | Enzyme | Ki | 7.30 | CHEMBL | |||||
| Alcohol dehydrogenase [NADP(+)] | Enzyme | IC50 | 6.27 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 7.82 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 8.70 | CHEMBL | |||||
| Alcohol dehydrogenase [NADP(+)] | Enzyme | IC50 | 5.92 | CHEMBL | |||||
| Aldo-keto reductase family 1 member C21 | Enzyme | Ki | 4.66 | CHEMBL | |||||
| Aldose reductase | Enzyme | IC50 | 7.48 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02323 | KEGG_DRUG |
| C0076808 | UMLSCUI |
| CHEBI:48549 | CHEBI |
| TOL | PDB_CHEM_ID |
| CHEMBL436 | ChEMBL_ID |
| DB02383 | DRUGBANK_ID |
| C040550 | MESH_SUPPLEMENTAL_RECORD_UI |
| 53359 | PUBCHEM_CID |
| 7404 | IUPHAR_LIGAND_ID |
| 5529 | INN_ID |
| 0T93LG5NMK | UNII |
| 38386 | RXNORM |
| 003770 | NDDF |
Pharmaceutical products:
None