todralazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihypertensives, hydrazinephthalazine derivatives 2691 14679-73-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • todralazine
  • carboethoxyphthalazinohydrazine
  • todralazine hydrochloride
  • todralazine HCl
An antihypertensive agent with both central and peripheral action; it has some central nervous system depressant effects.
  • Molecular weight: 232.24
  • Formula: C11H12N4O2
  • CLOGP: 1.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 76.14
  • ALOGS: -3.49
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.7 acidic
pKa2 6.02 Basic
pKa3 3.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01951 KEGG_DRUG
C0040354 UMLSCUI
CHEBI:94706 CHEBI
CHEMBL1079787 ChEMBL_ID
D014032 MESH_DESCRIPTOR_UI
5501 PUBCHEM_CID
3122 INN_ID
WEN3K83YKD UNII
CHEMBL1318529 ChEMBL_ID

Pharmaceutical products:

None