azathioprine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 3438.75 30.01 1605 10731 184456 4442200
Drug intolerance 1456.73 30.01 483 11853 21263 4605393
Rheumatoid arthritis 1352.03 30.01 473 11863 24526 4602130
Pancytopenia 1277.94 30.01 453 11883 24400 4602256
Pneumonia 1146.66 30.01 639 11697 102176 4524480
Treatment failure 1111.44 30.01 355 11981 13792 4612864
Pyrexia 1100.37 30.01 631 11705 106513 4520143
Product use in unapproved indication 1050.47 30.01 394 11942 24879 4601777
Leukopenia 995.46 30.01 364 11972 21372 4605284
Off label use 983.85 30.01 628 11708 128485 4498171
Cytomegalovirus infection 960.74 30.01 272 12064 6921 4619735
Sepsis 806.11 30.01 380 11956 42459 4584197
Blood iron abnormal 800.37 30.01 129 12207 103 4626553
Post transplant lymphoproliferative disorder 792.78 30.01 172 12164 1360 4625296
Exposure during pregnancy 789.25 30.01 346 11990 32625 4594031
Foetal exposure during pregnancy 786.44 30.01 312 12024 22857 4603799
Crohn's disease 767.44 30.01 257 12079 11562 4615094
Maternal exposure during pregnancy 707.41 30.01 266 12070 16827 4609829
Condition aggravated 679.39 30.01 374 11962 57797 4568859
Pneumocystis jirovecii pneumonia 671.10 30.01 193 12143 5185 4621471
Epstein-Barr virus infection 669.28 30.01 165 12171 2396 4624260
Drug hypersensitivity 667.61 30.01 391 11945 68009 4558647
Premature baby 634.25 30.01 214 12122 9837 4616819
Kaposi's sarcoma 618.28 30.01 137 12199 1205 4625451
Haemophagocytic lymphohistiocytosis 601.12 30.01 158 12178 3001 4623655
Abdominal pain 590.26 30.01 345 11991 59679 4566977
Squamous cell carcinoma 521.61 30.01 146 12190 3541 4623115
Infection 507.32 30.01 263 12073 35879 4590777
Arthralgia 505.64 30.01 351 11985 81643 4545013
Weight decreased 500.94 30.01 300 12036 54164 4572492
Diffuse large B-cell lymphoma 492.73 30.01 126 12210 2135 4624521
Disease recurrence 491.30 30.01 164 12172 7277 4619379
Hypersensitivity 478.11 30.01 258 12078 38163 4588493
Cushingoid 464.64 30.01 105 12231 1017 4625639
Anaemia 463.75 30.01 316 12020 71244 4555412
Colitis ulcerative 461.46 30.01 147 12189 5613 4621043
Hepatosplenic T-cell lymphoma 452.66 30.01 79 12257 149 4626507
Joint swelling 449.96 30.01 213 12123 23865 4602791
Progressive multifocal leukoencephalopathy 438.37 30.01 131 12205 4026 4622630
Bone marrow failure 436.57 30.01 173 12163 12565 4614091
Therapeutic product effect decreased 435.52 30.01 193 12143 18560 4608096
Diarrhoea 427.07 30.01 409 11927 149776 4476880
Pancreatitis 422.21 30.01 184 12152 16994 4609662
Hepatic function abnormal 415.62 30.01 173 12163 14263 4612393
Drug eruption 413.95 30.01 140 12196 6463 4620193
Renal impairment 409.62 30.01 203 12133 25135 4601521
Nausea 405.40 30.01 429 11907 176904 4449752
Basal cell carcinoma 394.45 30.01 130 12206 5534 4621122
Multiple organ dysfunction syndrome 390.88 30.01 179 12157 18577 4608079
Pain in extremity 388.00 30.01 271 12065 63468 4563188
Neutropenia 384.07 30.01 242 12094 47708 4578948
Synovitis 381.80 30.01 114 12222 3491 4623165
Kidney transplant rejection 381.28 30.01 102 12234 2074 4624582
Contraindicated product administered 365.81 30.01 120 12216 5031 4621625
Diabetes mellitus 361.30 30.01 160 12176 15341 4611315
Non-Hodgkin's lymphoma 361.15 30.01 97 12239 2003 4624653
Cytomegalovirus viraemia 352.48 30.01 86 12250 1189 4625467
Lymphopenia 351.29 30.01 118 12218 5329 4621327
Respiratory failure 350.24 30.01 194 12142 30132 4596524
Septic shock 346.13 30.01 159 12177 16607 4610049
Herpes zoster 345.00 30.01 156 12180 15707 4610949
Low birth weight baby 336.67 30.01 97 12239 2613 4624043
Transplant rejection 334.65 30.01 100 12236 3069 4623587
Rash 331.86 30.01 308 12028 108080 4518576
Lymphoproliferative disorder 329.39 30.01 81 12255 1159 4625497
Epstein-Barr virus associated lymphoproliferative disorder 321.59 30.01 72 12264 665 4625991
Osteoporosis 319.63 30.01 115 12221 6380 4620276
Hypogammaglobulinaemia 318.12 30.01 83 12253 1525 4625131
Epistaxis 313.21 30.01 156 12180 19487 4607169
Squamous cell carcinoma of skin 310.66 30.01 87 12249 2109 4624547
Stomatitis 306.92 30.01 146 12190 16493 4610163
Aspergillus infection 300.24 30.01 89 12247 2654 4624002
Vomiting 296.72 30.01 303 12033 119396 4507260
C-reactive protein increased 284.88 30.01 128 12208 12684 4613972
Pancreatitis acute 284.19 30.01 114 12222 8529 4618127
Therapeutic response decreased 282.48 30.01 132 12204 14319 4612337
Interstitial lung disease 280.65 30.01 144 12192 19141 4607515
Gastrointestinal disorder 278.22 30.01 135 12201 15926 4610730
Synovial fluid analysis 277.30 30.01 41 12295 1 4626655
Bone erosion 276.95 30.01 65 12271 753 4625903
Scleritis 273.02 30.01 58 12278 408 4626248
Dyspnoea 269.43 30.01 309 12027 138676 4487980
Therapeutic product effect incomplete 269.38 30.01 135 12201 17073 4609583
Arthritis 268.06 30.01 128 12208 14572 4612084
Renal failure 268.03 30.01 183 12153 41186 4585470
Nodular regenerative hyperplasia 266.25 30.01 53 12283 257 4626399
Urinary tract infection 261.64 30.01 182 12154 42208 4584448
Urticaria 260.98 30.01 177 12159 39396 4587260
Immunosuppression 257.61 30.01 74 12262 1970 4624686
B-cell lymphoma 257.44 30.01 71 12265 1623 4625033
Premature delivery 255.40 30.01 87 12249 4097 4622559
Lymphadenopathy 254.10 30.01 111 12225 10281 4616375
Thrombocytopenia 249.15 30.01 185 12151 47488 4579168
Colitis 240.10 30.01 107 12229 10392 4616264
Transaminases increased 239.40 30.01 104 12232 9502 4617154
Lung transplant rejection 238.71 30.01 47 12289 213 4626443
Muscle spasms 234.58 30.01 159 12177 35331 4591325
Candida infection 231.91 30.01 86 12250 5195 4621461
Tenosynovitis stenosans 231.08 30.01 43 12293 134 4626522
Hepatic enzyme increased 229.41 30.01 123 12213 17868 4608788
Musculoskeletal pain 218.79 30.01 116 12220 16472 4610184
Demyelination 214.20 30.01 62 12274 1696 4624960
Pulmonary tuberculosis 214.03 30.01 65 12271 2107 4624549
Lower respiratory tract infection 206.71 30.01 95 12241 9908 4616748
Bronchopulmonary aspergillosis 205.46 30.01 68 12268 2926 4623730
Premature labour 205.27 30.01 64 12272 2268 4624388
Rheumatoid nodule 204.60 30.01 51 12285 773 4625883
Elbow deformity 204.13 30.01 35 12301 56 4626600
Haemoglobin decreased 203.08 30.01 149 12187 37508 4589148
Therapy non-responder 203.03 30.01 109 12227 15868 4610788
Product use issue 201.65 30.01 127 12209 24909 4601747
Renal cell carcinoma 201.09 30.01 64 12272 2428 4624228
Fatigue 200.63 30.01 273 12063 145293 4481363
Systemic lupus erythematosus 197.72 30.01 77 12259 5319 4621337
Antinuclear antibody positive 197.62 30.01 57 12279 1539 4625117
Malaise 197.55 30.01 214 12122 89943 4536713
Musculoskeletal stiffness 196.53 30.01 113 12223 18789 4607867
Acute kidney injury 195.63 30.01 190 12146 70241 4556415
Drug reaction with eosinophilia and systemic symptoms 195.41 30.01 96 12240 11617 4615039
Hepatitis 194.61 30.01 97 12239 12108 4614548
Acute myeloid leukaemia 194.41 30.01 82 12254 6963 4619693
Disseminated tuberculosis 194.28 30.01 53 12283 1161 4625495
Red blood cell sedimentation rate increased 194.02 30.01 67 12269 3286 4623370
SLE arthritis 193.03 30.01 35 12301 90 4626566
Bronchiectasis 191.94 30.01 56 12280 1576 4625080
Neoplasm malignant 191.87 30.01 93 12243 10928 4615728
Ulcer 191.04 30.01 66 12270 3241 4623415
Nodule 191.00 30.01 66 12270 3243 4623413
Abortion spontaneous 189.27 30.01 100 12236 14092 4612564
Myelodysplastic syndrome 187.61 30.01 80 12256 6978 4619678
JC virus infection 182.50 30.01 42 12294 443 4626213
Pleuritic pain 182.22 30.01 50 12286 1120 4625536
C-reactive protein abnormal 180.58 30.01 49 12287 1051 4625605
Drug interaction 179.06 30.01 174 12162 64334 4562322
Foetal growth restriction 178.96 30.01 59 12277 2507 4624149
Vasculitis 177.88 30.01 67 12269 4224 4622432
Pemphigus 174.69 30.01 47 12289 975 4625681
Blood creatinine increased 174.04 30.01 119 12217 26781 4599875
Hodgkin's disease 173.83 30.01 51 12285 1464 4625192
Hypertension 173.79 30.01 154 12182 50644 4576012
Strongyloidiasis 173.79 30.01 43 12293 631 4626025
Staphylococcal infection 173.52 30.01 86 12250 10602 4616054
Crepitations 170.45 30.01 48 12288 1186 4625470
Varicella zoster virus infection 169.13 30.01 42 12294 626 4626030
Hepatotoxicity 168.89 30.01 78 12258 8221 4618435
Cytomegalovirus colitis 168.83 30.01 43 12293 714 4625942
Lymphoma 167.37 30.01 66 12270 4712 4621944
Cushing's syndrome 167.33 30.01 50 12286 1531 4625125
Lung disorder 167.30 30.01 88 12248 12283 4614373
Proteinuria 165.80 30.01 72 12264 6564 4620092
Joint effusion 164.95 30.01 52 12284 1911 4624745
Pain 163.67 30.01 197 12139 92673 4533983
Lupus nephritis 162.84 30.01 38 12298 428 4626228
Mucormycosis 162.62 30.01 47 12289 1278 4625378
Alopecia 162.47 30.01 116 12220 27964 4598692
Hepatosplenomegaly 162.38 30.01 46 12290 1162 4625494
Liver function test abnormal 161.21 30.01 91 12245 14601 4612055
Disseminated intravascular coagulation 160.75 30.01 73 12263 7400 4619256
Skin lesion 160.19 30.01 73 12263 7460 4619196
Herpes simplex 160.17 30.01 51 12285 1937 4624719
Impaired gastric emptying 159.82 30.01 48 12288 1496 4625160
Acute febrile neutrophilic dermatosis 158.07 30.01 42 12294 829 4625827
Intentional product use issue 157.60 30.01 71 12265 7064 4619592
Tenderness 157.27 30.01 56 12280 3007 4623649
Headache 157.13 30.01 222 12114 122151 4504505
Epstein-Barr virus test positive 156.95 30.01 34 12302 265 4626391
Flank pain 156.53 30.01 54 12282 2639 4624017
Bursitis 156.04 30.01 54 12282 2664 4623992
Meningitis cryptococcal 155.96 30.01 39 12297 599 4626057
Granulomatosis with polyangiitis 154.59 30.01 35 12301 341 4626315
Peritonitis 153.38 30.01 65 12271 5580 4621076
Synovial cyst 152.49 30.01 44 12292 1189 4625467
Hepatic failure 151.21 30.01 84 12252 13065 4613591
T-cell lymphoma 148.80 30.01 35 12301 409 4626247
Erythema 147.09 30.01 129 12207 41811 4584845
Cholestasis 144.39 30.01 69 12267 7851 4618805
Impaired work ability 142.99 30.01 52 12284 2968 4623688
Nocardiosis 142.22 30.01 39 12297 871 4625785
Hepatitis cholestatic 142.17 30.01 50 12286 2588 4624068
Splenomegaly 140.85 30.01 56 12280 4084 4622572
Viral infection 139.91 30.01 68 12268 8030 4618626
Portal hypertension 139.59 30.01 42 12294 1317 4625339
Pleural effusion 139.30 30.01 100 12236 24298 4602358
Night sweats 138.36 30.01 62 12274 6089 4620567
Atelectasis 138.21 30.01 55 12281 4020 4622636
Conjunctivitis 137.30 30.01 56 12280 4364 4622292
Mycobacterial infection 136.80 30.01 35 12301 592 4626064
Intestinal perforation 136.39 30.01 54 12282 3894 4622762
Red blood cell sedimentation rate abnormal 135.87 30.01 35 12301 609 4626047
Tuberculosis 135.86 30.01 56 12280 4483 4622173
Diarrhoea haemorrhagic 135.01 30.01 48 12288 2565 4624091
Anaphylactic reaction 134.56 30.01 87 12249 17823 4608833
Pulmonary fibrosis 133.86 30.01 59 12277 5571 4621085
Histoplasmosis disseminated 133.25 30.01 33 12303 486 4626170
Atrial septal defect 132.10 30.01 51 12285 3438 4623218
Photophobia 131.82 30.01 52 12284 3714 4622942
Clostridium difficile infection 131.74 30.01 57 12279 5147 4621509
Epstein-Barr virus associated lymphoma 130.49 30.01 27 12309 164 4626492
Lung infiltration 130.24 30.01 55 12281 4679 4621977
Drug ineffective for unapproved indication 128.88 30.01 58 12278 5753 4620903
Human herpesvirus 8 infection 128.79 30.01 26 12310 137 4626519
Mycobacterium avium complex infection 126.41 30.01 35 12301 811 4625845
Myalgia 125.21 30.01 118 12218 41930 4584726
White blood cell count decreased 124.60 30.01 106 12230 32959 4593697
Chest pain 120.81 30.01 126 12210 50574 4576082
Abscess 120.68 30.01 52 12284 4648 4622008
Oesophageal atresia 120.25 30.01 28 12308 312 4626344
Chills 120.17 30.01 98 12238 28741 4597915
Disease progression 120.03 30.01 114 12222 40897 4585759
Klebsiella infection 120.02 30.01 40 12296 1757 4624899
Caesarean section 119.83 30.01 53 12283 5045 4621611
Pneumonia cytomegaloviral 118.24 30.01 33 12303 788 4625868
Obliterative bronchiolitis 117.87 30.01 31 12305 587 4626069
Hepatitis B 117.31 30.01 44 12292 2739 4623917
Immunosuppressant drug level increased 116.52 30.01 35 12301 1091 4625565
Heart transplant rejection 116.15 30.01 28 12308 366 4626290
Haemodialysis 115.49 30.01 51 12285 4836 4621820
Pseudomonas infection 114.97 30.01 43 12293 2656 4624000
Myopathy 114.87 30.01 47 12289 3691 4622965
Cough 114.65 30.01 128 12208 55459 4571197
Transplant dysfunction 114.38 30.01 33 12303 891 4625765
Therapeutic product effect variable 114.28 30.01 27 12309 322 4626334
Feeling jittery 113.76 30.01 44 12292 2980 4623676
Ascites 113.61 30.01 68 12268 12157 4614499
Skin ulcer 113.48 30.01 57 12279 7221 4619435
Thrombosis 113.28 30.01 79 12257 18325 4608331
Large intestinal stenosis 112.34 30.01 31 12305 709 4625947
Muscle fatigue 112.05 30.01 31 12305 716 4625940
Staphylococcal sepsis 111.53 30.01 41 12295 2412 4624244
Fungal infection 111.46 30.01 58 12278 7911 4618745
Anal fistula 111.32 30.01 35 12301 1274 4625382
Chronic allograft nephropathy 111.02 30.01 27 12309 367 4626289
Fibromyalgia 110.72 30.01 46 12290 3755 4622901
Brain abscess 110.08 30.01 32 12304 888 4625768
Asthenia 109.92 30.01 156 12180 86007 4540649
Aspartate aminotransferase increased 108.67 30.01 87 12249 24851 4601805
Liver transplant rejection 108.44 30.01 32 12304 937 4625719
Bacteraemia 107.58 30.01 46 12290 4034 4622622
Drug resistance 107.49 30.01 57 12279 8079 4618577
Pruritus 107.06 30.01 141 12195 72431 4554225
Alanine aminotransferase increased 106.97 30.01 91 12245 28282 4598374
Behcet's syndrome 104.62 30.01 25 12311 314 4626342
Acquired gene mutation 104.47 30.01 26 12310 391 4626265
Platelet count decreased 103.74 30.01 98 12238 34904 4591752
Epicondylitis 103.68 30.01 26 12310 404 4626252
Aplasia pure red cell 102.82 30.01 36 12300 1838 4624818
Histoplasmosis 102.79 30.01 29 12307 721 4625935
Extrapulmonary tuberculosis 102.58 30.01 21 12315 120 4626536
Live birth 102.55 30.01 34 12302 1469 4625187
Cellulitis 101.05 30.01 71 12265 16661 4609995
Jaundice 99.64 30.01 63 12273 12411 4614245
Eye pain 98.95 30.01 53 12283 7664 4618992
Herpes simplex hepatitis 98.80 30.01 19 12317 74 4626582
Polyomavirus-associated nephropathy 98.35 30.01 28 12308 720 4625936
Wheezing 98.27 30.01 60 12276 11114 4615542
Varicella 98.01 30.01 29 12307 857 4625799
General physical health deterioration 97.79 30.01 87 12249 28691 4597965
Dry eye 97.44 30.01 47 12289 5454 4621202
Peripheral swelling 97.33 30.01 84 12252 26608 4600048
Papilloma viral infection 96.83 30.01 25 12311 439 4626217
Neutropenic sepsis 96.80 30.01 41 12295 3512 4623144
Opportunistic infection 96.66 30.01 29 12307 900 4625756
Mycobacterium abscessus infection 96.01 30.01 21 12315 172 4626484
Frequent bowel movements 95.81 30.01 41 12295 3602 4623054
Infusion related reaction 94.99 30.01 71 12265 18331 4608325
Iron deficiency anaemia 94.82 30.01 40 12296 3392 4623264
Acute respiratory distress syndrome 94.65 30.01 51 12285 7462 4619194
Skin cancer 94.52 30.01 40 12296 3419 4623237
Complications of transplanted kidney 93.76 30.01 29 12307 999 4625657
Secondary immunodeficiency 93.69 30.01 22 12314 255 4626401
Pelvic fracture 93.32 30.01 33 12303 1735 4624921
Normal newborn 93.06 30.01 33 12303 1749 4624907
Actinic keratosis 92.38 30.01 29 12307 1050 4625606
Fungal endocarditis 92.25 30.01 18 12318 77 4626579
Malignant melanoma 91.53 30.01 41 12295 4020 4622636
Nephropathy toxic 90.66 30.01 41 12295 4111 4622545
Rectal haemorrhage 90.54 30.01 59 12277 12237 4614419
Ocular hyperaemia 90.42 30.01 47 12289 6393 4620263
Premature rupture of membranes 90.02 30.01 28 12308 983 4625673
Bone marrow toxicity 89.89 30.01 27 12309 841 4625815
Graft loss 88.60 30.01 23 12313 413 4626243
Hepatic cirrhosis 88.45 30.01 44 12292 5458 4621198
Central nervous system lymphoma 87.18 30.01 23 12313 441 4626215
Cytomegalovirus enteritis 87.18 30.01 18 12318 108 4626548
Hepatic fibrosis 87.15 30.01 29 12307 1267 4625389
Liver disorder 87.14 30.01 59 12277 13039 4613617
Visual impairment 87.13 30.01 69 12267 19391 4607265
Necrosis 86.84 30.01 33 12303 2129 4624527
Teratogenicity 86.20 30.01 18 12318 115 4626541
Pneumocystis jirovecii infection 85.95 30.01 24 12312 574 4626082
Hydrops foetalis 85.55 30.01 20 12316 227 4626429
Plasmablastic lymphoma 85.54 30.01 18 12318 120 4626536
Adverse drug reaction 85.43 30.01 61 12275 14678 4611978
Enterococcal infection 85.19 30.01 31 12305 1771 4624885
Pre-eclampsia 84.47 30.01 30 12306 1597 4625059
Pneumatosis intestinalis 84.23 30.01 27 12309 1047 4625609
Cryptococcosis 84.02 30.01 23 12313 510 4626146
Osteonecrosis 82.57 30.01 56 12280 12408 4614248
Haematochezia 81.24 30.01 53 12283 11011 4615645
Toxicity to various agents 81.05 30.01 123 12213 71917 4554739
Chronic kidney disease 80.63 30.01 52 12284 10593 4616063
External auditory canal atresia 80.11 30.01 16 12320 79 4626577
Hypoxia 79.97 30.01 56 12280 13065 4613591
Upper respiratory tract infection 79.76 30.01 57 12279 13730 4612926
Skin infection 79.64 30.01 33 12303 2675 4623981
Graft versus host disease 79.40 30.01 35 12301 3303 4623353
Transplant failure 79.32 30.01 25 12311 917 4625739
Neck pain 79.15 30.01 53 12283 11499 4615157
Groin pain 78.99 30.01 31 12305 2182 4624474
Metastases to liver 78.70 30.01 41 12295 5601 4621055
Acute hepatic failure 78.57 30.01 41 12295 5621 4621035
Lung abscess 78.49 30.01 24 12312 795 4625861
Posterior reversible encephalopathy syndrome 78.39 30.01 38 12298 4457 4622199
Listeriosis 78.25 30.01 21 12315 431 4626225
Ileal stenosis 78.21 30.01 23 12313 665 4625991
Erythema nodosum 78.16 30.01 26 12310 1135 4625521
Uveitis 78.10 30.01 34 12302 3114 4623542
Inflammation 77.82 30.01 50 12286 10121 4616535
Cytomegalovirus chorioretinitis 77.59 30.01 23 12313 684 4625972
Respiratory tract infection 77.21 30.01 44 12292 7176 4619480
Ankylosing spondylitis 77.21 30.01 28 12308 1584 4625072
Squamous cell carcinoma of the tongue 77.11 30.01 17 12319 145 4626511
Angiocentric lymphoma 77.02 30.01 18 12318 204 4626452
Autoimmune hepatitis 77.01 30.01 32 12304 2612 4624044
Cleft lip and palate 75.69 30.01 21 12315 490 4626166
Visceral leishmaniasis 75.48 30.01 18 12318 224 4626432
Drug-induced liver injury 75.20 30.01 46 12290 8545 4618111
Pyelonephritis 75.11 30.01 33 12303 3089 4623567
Herpes virus infection 75.00 30.01 27 12309 1495 4625161
Escherichia sepsis 74.73 30.01 26 12310 1302 4625354
Liver injury 74.66 30.01 38 12298 4947 4621709
Blood cholesterol increased 74.63 30.01 46 12290 8660 4617996
Foot deformity 74.12 30.01 31 12305 2572 4624084
Pulmonary embolism 73.89 30.01 81 12255 34345 4592311
Joint stiffness 73.47 30.01 40 12296 5971 4620685
Non-cirrhotic portal hypertension 73.23 30.01 15 12321 86 4626570
Impaired healing 73.19 30.01 45 12291 8434 4618222
Eye irritation 73.05 30.01 38 12298 5176 4621480
Microtia 73.04 30.01 17 12319 189 4626467
Immunosuppressant drug level decreased 72.90 30.01 20 12316 447 4626209
Cataract 72.76 30.01 47 12289 9599 4617057
Skin papilloma 72.71 30.01 24 12312 1022 4625634
Inflammatory bowel disease 72.69 30.01 25 12311 1209 4625447
Mouth ulceration 72.61 30.01 40 12296 6110 4620546
Post procedural complication 72.20 30.01 39 12297 5732 4620924
Oral candidiasis 71.53 30.01 33 12303 3464 4623192
Metastases to lymph nodes 71.42 30.01 28 12308 1965 4624691
Bacterial infection 71.30 30.01 36 12300 4607 4622049
Enteritis 70.94 30.01 29 12307 2271 4624385
Carpal tunnel syndrome 70.85 30.01 31 12305 2873 4623783
Gastrointestinal lymphoma 70.85 30.01 12 12324 17 4626639
Maternal drugs affecting foetus 70.59 30.01 34 12302 3931 4622725
Cytomegalovirus test positive 70.12 30.01 23 12313 960 4625696
Epstein Barr virus positive mucocutaneous ulcer 69.92 30.01 15 12321 111 4626545
Lupus myocarditis 69.86 30.01 11 12325 6 4626650
Large intestine perforation 69.81 30.01 30 12306 2662 4623994
Gait disturbance 69.75 30.01 81 12255 36559 4590097
Parvovirus B19 infection 69.75 30.01 16 12320 166 4626490
Cytopenia 69.44 30.01 29 12307 2397 4624259
Oesophageal candidiasis 68.97 30.01 25 12311 1412 4625244
Hypotension 68.71 30.01 110 12226 67290 4559366
Burkholderia cepacia complex sepsis 68.64 30.01 11 12325 8 4626648
Escherichia infection 68.50 30.01 29 12307 2480 4624176
Blood alkaline phosphatase increased 68.45 30.01 50 12286 12457 4614199
Anal ulcer 68.16 30.01 17 12319 258 4626398
Adverse reaction 67.73 30.01 29 12307 2550 4624106
Abdominal pain upper 67.47 30.01 78 12258 35037 4591619
Coloboma 67.38 30.01 14 12322 87 4626569
Pain in jaw 66.98 30.01 43 12293 8689 4617967
Urosepsis 66.87 30.01 32 12304 3647 4623009
Death 66.72 30.01 207 12129 197956 4428700
Herpes zoster meningoencephalitis 65.81 30.01 14 12322 99 4626557
Lymphadenitis 65.61 30.01 21 12315 810 4625846
Meningitis listeria 65.41 30.01 16 12320 223 4626433
Gastroenteritis 65.23 30.01 36 12300 5519 4621137
Exostosis 65.12 30.01 26 12310 1915 4624741
Swelling face 65.09 30.01 52 12284 14788 4611868
Myositis 65.08 30.01 30 12306 3143 4623513
Cutaneous T-cell lymphoma 64.35 30.01 20 12316 700 4625956
Pre-existing condition improved 64.31 30.01 21 12315 864 4625792
Localised infection 64.30 30.01 34 12302 4787 4621869
Encephalitis 64.18 30.01 28 12308 2577 4624079
Skin mass 64.05 30.01 25 12311 1734 4624922
Productive cough 64.03 30.01 43 12293 9370 4617286
Legionella infection 63.89 30.01 16 12320 247 4626409
Clostridium difficile colitis 63.80 30.01 32 12304 4038 4622618
Hair follicle tumour benign 63.63 30.01 12 12324 41 4626615
Respiratory disorder 63.38 30.01 40 12296 7848 4618808
Decreased appetite 62.98 30.01 96 12240 56301 4570355
Respiratory distress 62.10 30.01 45 12291 11071 4615585
Small intestinal obstruction 62.08 30.01 32 12304 4276 4622380
Hypoalbuminaemia 61.99 30.01 29 12307 3141 4623515
Appendicitis 61.69 30.01 27 12309 2504 4624152
Liver function test increased 61.68 30.01 34 12302 5200 4621456
Foetal death 61.48 30.01 27 12309 2525 4624131
Influenza 61.31 30.01 58 12278 20665 4605991
Hepatitis toxic 61.08 30.01 22 12314 1220 4625436
Infectious mononucleosis 60.81 30.01 19 12317 677 4625979
Abdominal tenderness 60.68 30.01 24 12312 1724 4624932
Small for dates baby 60.61 30.01 25 12311 2002 4624654
Subcutaneous abscess 60.55 30.01 24 12312 1734 4624922
Pneumothorax 60.54 30.01 34 12302 5391 4621265
Deep vein thrombosis 59.99 30.01 63 12273 25431 4601225
Pulmonary mass 59.39 30.01 29 12307 3454 4623202
Abdominal pain lower 59.02 30.01 31 12305 4305 4622351
Sinusitis 58.64 30.01 59 12277 22653 4604003
Antiphospholipid syndrome 58.05 30.01 17 12319 484 4626172
Rash pustular 57.74 30.01 27 12309 2922 4623734
Complications of transplanted lung 57.56 30.01 12 12324 76 4626580
Therapy partial responder 57.43 30.01 19 12317 815 4625841
Influenza like illness 57.41 30.01 54 12282 19099 4607557
Hepatitis viral 57.18 30.01 15 12321 281 4626375
Hepatitis E 57.01 30.01 17 12319 516 4626140
Foetal distress syndrome 56.60 30.01 19 12317 853 4625803
Takayasu's arteritis 56.48 30.01 13 12323 137 4626519
Infection reactivation 56.35 30.01 15 12321 298 4626358
Neuroendocrine carcinoma of the skin 56.35 30.01 15 12321 298 4626358
Rectal cancer metastatic 56.31 30.01 13 12323 139 4626517
Abdominal discomfort 56.07 30.01 64 12272 28344 4598312
Anogenital warts 55.97 30.01 15 12321 306 4626350
Serum ferritin increased 55.96 30.01 23 12313 1825 4624831
Anal abscess 55.95 30.01 22 12314 1556 4625100
Gestational hypertension 55.95 30.01 16 12320 418 4626238
Aplastic anaemia 55.93 30.01 23 12313 1828 4624828
Bowen's disease 55.71 30.01 17 12319 559 4626097
White blood cell count increased 55.53 30.01 48 12288 15219 4611437
Thrombotic microangiopathy 55.35 30.01 27 12309 3209 4623447
Varices oesophageal 55.06 30.01 20 12316 1136 4625520
Meningoencephalitis viral 54.96 30.01 11 12325 55 4626601
Back pain 54.89 30.01 85 12251 50514 4576142
Patent ductus arteriosus 54.69 30.01 22 12314 1652 4625004
Muscular weakness 54.42 30.01 61 12275 26489 4600167
Fistula 54.01 30.01 26 12310 3001 4623655
Autoimmune haemolytic anaemia 53.93 30.01 22 12314 1713 4624943
Eye disorder 53.89 30.01 31 12305 5143 4621513
Granuloma 53.68 30.01 20 12316 1221 4625435
Dry mouth 53.43 30.01 44 12292 13057 4613599
Swelling 53.20 30.01 58 12278 24424 4602232
Intestinal obstruction 53.01 30.01 37 12299 8580 4618076
Functional gastrointestinal disorder 52.97 30.01 18 12318 839 4625817
Oesophageal squamous cell carcinoma 52.44 30.01 12 12324 123 4626533
Neurological symptom 52.09 30.01 22 12314 1870 4624786
Coombs positive haemolytic anaemia 52.07 30.01 13 12323 198 4626458
Oedema peripheral 51.94 30.01 75 12261 41897 4584759
Sepsis neonatal 51.81 30.01 14 12322 295 4626361
Haematuria 51.72 30.01 43 12293 12927 4613729
Colectomy 51.54 30.01 19 12317 1126 4625530
Hepatocellular injury 51.14 30.01 35 12301 7865 4618791
Cervical dysplasia 51.10 30.01 17 12319 742 4625914
Listeria sepsis 50.95 30.01 12 12324 141 4626515
Agranulocytosis 50.31 30.01 34 12302 7483 4619173
Burkitt's lymphoma 50.30 30.01 13 12323 229 4626427
Hypertelorism of orbit 50.30 30.01 13 12323 229 4626427
Depression 50.12 30.01 79 12257 47654 4579002
Blood lactate dehydrogenase increased 49.96 30.01 34 12302 7569 4619087
Leukocytosis 49.84 30.01 34 12302 7600 4619056
Hepatitis C 49.70 30.01 29 12307 4941 4621715
Pulmonary alveolar haemorrhage 49.63 30.01 22 12314 2103 4624553
Tuberculosis of central nervous system 49.56 30.01 11 12325 97 4626559
Clear cell renal cell carcinoma 49.53 30.01 13 12323 244 4626412
Lymphocyte count decreased 49.34 30.01 31 12305 6032 4620624
Joint dislocation 49.34 30.01 22 12314 2132 4624524
Transitional cell carcinoma 49.31 30.01 15 12321 488 4626168
Upper limb fracture 49.27 30.01 26 12310 3644 4623012
Enterococcal sepsis 49.13 30.01 14 12322 361 4626295
Camptodactyly congenital 49.12 30.01 9 12327 25 4626631
Gastrointestinal haemorrhage 49.12 30.01 62 12274 30473 4596183
Anaplastic large cell lymphoma T- and null-cell types 49.07 30.01 11 12325 102 4626554
Central nervous system lesion 48.85 30.01 25 12311 3290 4623366
Respiratory gas exchange disorder 48.78 30.01 11 12325 105 4626551
Diffuse alveolar damage 48.73 30.01 15 12321 508 4626148
Rash erythematous 48.61 30.01 38 12298 10471 4616185
Lipase increased 48.45 30.01 25 12311 3347 4623309
Proctitis 48.03 30.01 16 12320 701 4625955
Mycobacterium chelonae infection 47.58 30.01 13 12323 286 4626370
Lupus-like syndrome 47.45 30.01 24 12312 3081 4623575
Intestinal resection 47.45 30.01 18 12318 1155 4625501
Red blood cell count decreased 47.26 30.01 34 12302 8269 4618387
Lung consolidation 47.11 30.01 18 12318 1178 4625478
Hydrocephalus 47.09 30.01 21 12315 2036 4624620
Neuromyelitis optica spectrum disorder 47.07 30.01 13 12323 298 4626358
Respiratory tract infection fungal 47.06 30.01 12 12324 200 4626456
Pneumonia bacterial 46.98 30.01 22 12314 2388 4624268
Lung neoplasm 46.91 30.01 20 12316 1740 4624916
Intestinal fistula 46.82 30.01 14 12322 429 4626227
Polyhydramnios 46.76 30.01 14 12322 431 4626225
Atypical haemolytic uraemic syndrome 46.72 30.01 11 12325 129 4626527
Tubulointerstitial nephritis 46.60 30.01 30 12306 6089 4620567
Tachycardia 46.58 30.01 61 12275 31084 4595572
Cow pox 46.57 30.01 7 12329 1 4626655
Skin necrosis 46.25 30.01 21 12315 2124 4624532
Gestational diabetes 46.21 30.01 19 12317 1509 4625147
Hepatic steatosis 46.11 30.01 30 12306 6198 4620458
Abscess rupture 45.92 30.01 10 12326 80 4626576
Anterograde amnesia 45.88 30.01 12 12324 222 4626434
Dehydration 45.80 30.01 71 12265 42219 4584437
Loss of personal independence in daily activities 45.70 30.01 33 12303 8072 4618584
Metastatic malignant melanoma 45.66 30.01 16 12320 818 4625838
Anaemia macrocytic 45.59 30.01 16 12320 822 4625834
Systemic inflammatory response syndrome 45.51 30.01 20 12316 1873 4624783
Rheumatoid factor negative 45.48 30.01 9 12327 42 4626614
Pneumoperitoneum 45.48 30.01 15 12321 637 4626019
Nervous system disorder 45.23 30.01 30 12306 6401 4620255
Aphasia 45.21 30.01 34 12302 8846 4617810
Immune-mediated myositis 45.18 30.01 14 12322 485 4626171
Bacterial sepsis 45.15 30.01 18 12318 1320 4625336
Eczema 45.02 30.01 29 12307 5892 4620764
Hemiparesis 45.01 30.01 30 12306 6454 4620202
Osteoarthritis 45.01 30.01 35 12301 9569 4617087
Breast cancer 44.63 30.01 36 12300 10375 4616281
Aphthous ulcer 44.61 30.01 21 12315 2306 4624350
Glaucoma 44.46 30.01 24 12312 3520 4623136
Dermatitis 44.20 30.01 26 12310 4495 4622161
Pneumonitis 44.11 30.01 34 12302 9176 4617480
Corynebacterium infection 44.09 30.01 11 12325 167 4626489
Coagulopathy 43.88 30.01 29 12307 6151 4620505
Arthropathy 43.77 30.01 36 12300 10662 4615994
BK virus infection 43.71 30.01 16 12320 929 4625727
Colon cancer 43.68 30.01 25 12311 4108 4622548
Cytomegalovirus syndrome 43.44 30.01 9 12327 55 4626601
Toxoplasmosis 43.30 30.01 13 12323 404 4626252
Therapeutic response unexpected 43.23 30.01 30 12306 6892 4619764
Dermatomyositis 43.21 30.01 15 12321 746 4625910
Hydronephrosis 43.19 30.01 22 12314 2867 4623789
Oesophageal varices haemorrhage 43.08 30.01 16 12320 968 4625688
Drug level below therapeutic 42.98 30.01 17 12319 1221 4625435
Abdominal abscess 42.83 30.01 18 12318 1511 4625145
Small intestinal stenosis 42.77 30.01 12 12324 292 4626364
Pulmonary nocardiosis 42.77 30.01 9 12327 60 4626596
Disseminated cryptococcosis 42.77 30.01 11 12325 190 4626466
Epstein-Barr viraemia 42.65 30.01 12 12324 295 4626361
Pneumonia cryptococcal 42.42 30.01 12 12324 301 4626355
American trypanosomiasis 42.14 30.01 9 12327 65 4626591
Lymphocytic infiltration 42.05 30.01 13 12323 447 4626209
Immune reconstitution inflammatory syndrome 42.04 30.01 22 12314 3032 4623624
Endocarditis 41.93 30.01 19 12317 1912 4624744
Autoimmune disorder 41.87 30.01 17 12319 1307 4625349
Febrile neutropenia 41.64 30.01 53 12283 26259 4600397
Mass 41.63 30.01 22 12314 3093 4623563
Congenital cystic lung 41.44 30.01 9 12327 71 4626585
Cardiac valve vegetation 41.30 30.01 11 12325 219 4626437
Hand deformity 41.29 30.01 17 12319 1355 4625301
Femoral artery aneurysm 41.23 30.01 8 12328 33 4626623
Thrombocytopenia neonatal 41.18 30.01 10 12326 135 4626521
Tonsil cancer 40.83 30.01 11 12325 229 4626427
Dysplasia 40.80 30.01 12 12324 347 4626309
Chronic myeloid leukaemia 40.78 30.01 17 12319 1398 4625258
Nephrotic syndrome 40.76 30.01 21 12315 2802 4623854
Immunodeficiency 40.64 30.01 18 12318 1717 4624939
Large intestinal ulcer 40.44 30.01 15 12321 904 4625752
Weight increased 40.42 30.01 62 12274 36519 4590137
Lupus vasculitis 40.31 30.01 8 12328 38 4626618
Growth retardation 40.22 30.01 15 12321 918 4625738
Right aortic arch 40.19 30.01 9 12327 83 4626573
Peripheral T-cell lymphoma unspecified stage IV 40.16 30.01 7 12329 13 4626643
Psoriatic arthropathy 39.97 30.01 28 12308 6530 4620126
Abdominal distension 39.74 30.01 43 12293 17946 4608710
Cytomegalovirus hepatitis 39.65 30.01 10 12326 159 4626497
Human ehrlichiosis 39.65 30.01 8 12328 42 4626614
Pulmonary vasculitis 39.62 30.01 9 12327 89 4626567
Odynophagia 39.61 30.01 18 12318 1824 4624832
Hepatic cancer 39.47 30.01 20 12316 2577 4624079
Optic neuritis 39.46 30.01 20 12316 2579 4624077
Sciatica 39.35 30.01 21 12315 3010 4623646
Nonalcoholic fatty liver disease 39.35 30.01 9 12327 92 4626564
Central nervous system vasculitis 39.31 30.01 12 12324 395 4626261
Viral test positive 39.20 30.01 10 12326 167 4626489
Eosinophilic myocarditis 39.12 30.01 11 12325 270 4626386
Pericardial effusion 39.01 30.01 30 12306 8068 4618588
Renal tubular necrosis 39.00 30.01 23 12313 3995 4622661
Transient hypogammaglobulinaemia of infancy 38.99 30.01 6 12330 2 4626654
Thiopurine methyltransferase decreased 38.99 30.01 6 12330 2 4626654
Arthritis bacterial 38.61 30.01 17 12319 1599 4625057
Dyspepsia 38.34 30.01 40 12296 16014 4610642
Molluscum contagiosum 38.34 30.01 10 12326 183 4626473
Pyometra 38.32 30.01 7 12329 19 4626637
Food intolerance 38.29 30.01 13 12323 604 4626052
Haemoptysis 38.27 30.01 31 12305 8983 4617673
Hepatomegaly 38.00 30.01 22 12314 3693 4622963
Bursitis infective 37.84 30.01 10 12326 193 4626463
Glucose tolerance impaired 37.73 30.01 15 12321 1092 4625564
Polycythaemia neonatorum 37.65 30.01 6 12330 4 4626652
Abscess intestinal 37.65 30.01 13 12323 636 4626020
Cholangitis sclerosing 37.64 30.01 12 12324 457 4626199
Nephrectomy 37.63 30.01 11 12325 311 4626345
Ataxia 37.61 30.01 25 12311 5352 4621304
Hepatic necrosis 37.58 30.01 18 12318 2054 4624602
Faecal calprotectin increased 37.43 30.01 11 12325 317 4626339
Neonatal respiratory distress syndrome 37.39 30.01 17 12319 1724 4624932
Encephalitis viral 37.19 30.01 12 12324 475 4626181
Thyroid cancer 37.07 30.01 16 12320 1434 4625222
Cardiac failure 37.06 30.01 51 12285 27237 4599419
Status epilepticus 36.97 30.01 24 12312 4939 4621717
Normochromic normocytic anaemia 36.90 30.01 16 12320 1450 4625206
Otitis media 36.89 30.01 15 12321 1158 4625498
Cytomegalovirus duodenitis 36.87 30.01 7 12329 25 4626631
Dysphagia 36.62 30.01 49 12287 25482 4601174
Fungal skin infection 36.51 30.01 14 12322 925 4625731
Neutrophilic dermatosis 36.49 30.01 9 12327 130 4626526
Haemolysis 36.45 30.01 19 12317 2596 4624060
Laryngeal stenosis 36.37 30.01 9 12327 132 4626524
Lung adenocarcinoma 36.17 30.01 16 12320 1521 4625135
Craniofacial deformity 36.10 30.01 8 12328 70 4626586
B-cell unclassifiable lymphoma high grade 36.08 30.01 6 12330 7 4626649
Meningitis 36.06 30.01 18 12318 2247 4624409
Metastases to lung 36.05 30.01 21 12315 3566 4623090
Acute respiratory failure 36.03 30.01 26 12310 6350 4620306
Lethargy 35.98 30.01 40 12296 17201 4609455
Jaw fracture 35.71 30.01 13 12323 743 4625913
Chronic hepatitis 35.67 30.01 11 12325 375 4626281
Haemodynamic instability 35.63 30.01 19 12317 2720 4623936
Pulmonary function test decreased 35.32 30.01 14 12322 1011 4625645
Fibrosis 35.15 30.01 14 12322 1024 4625632
HELLP syndrome 35.08 30.01 10 12326 258 4626398
Meningitis aseptic 35.00 30.01 15 12321 1321 4625335
Papule 35.00 30.01 16 12320 1643 4625013
Lymphocele 34.96 30.01 11 12325 401 4626255
Renal transplant 34.91 30.01 13 12323 792 4625864
Acinetobacter infection 34.68 30.01 11 12325 412 4626244
Clinodactyly 34.61 30.01 8 12328 86 4626570
Congenital arterial malformation 34.61 30.01 8 12328 86 4626570
Confusional state 34.59 30.01 68 12268 48766 4577890
Pneumomediastinum 34.58 30.01 12 12324 596 4626060
Migraine 34.26 30.01 35 12301 13674 4612982
Renal mass 33.98 30.01 11 12325 440 4626216
Myasthenic syndrome 33.84 30.01 9 12327 178 4626478
Overlap syndrome 33.80 30.01 9 12327 179 4626477
Diverticulitis 33.68 30.01 26 12310 7031 4619625
Abortion induced 33.47 30.01 21 12315 4076 4622580
Neutropenic colitis 33.46 30.01 12 12324 657 4625999
Oedema 33.25 30.01 40 12296 18711 4607945
Osteopenia 33.24 30.01 18 12318 2656 4624000
Seizure 33.24 30.01 68 12268 50169 4576487
Meningitis viral 33.15 30.01 11 12325 476 4626180
Meningoencephalitis herpetic 33.15 30.01 11 12325 476 4626180
Abdominal mass 33.08 30.01 12 12324 679 4625977
Hepatitis B reactivation 33.04 30.01 13 12323 921 4625735
Cystic eyeball, congenital 33.02 30.01 5 12331 1 4626655
Microsporidia infection 32.74 30.01 8 12328 111 4626545
Death neonatal 32.63 30.01 11 12325 500 4626156
Intestinal diaphragm disease 32.60 30.01 8 12328 113 4626543
Necrotising retinitis 32.60 30.01 9 12327 206 4626450
Gastrointestinal stoma complication 32.59 30.01 11 12325 502 4626154
Female genital tract fistula 32.57 30.01 11 12325 503 4626153
Pregnancy 32.54 30.01 28 12308 8816 4617840
Cellulitis orbital 32.52 30.01 9 12327 208 4626448
No adverse event 32.50 30.01 43 12293 22120 4604536
Sjogren's syndrome 32.35 30.01 14 12322 1263 4625393
Gastritis 32.34 30.01 27 12309 8159 4618497
Phaeohyphomycosis 32.27 30.01 9 12327 214 4626442
Trichostasis spinulosa 32.25 30.01 5 12331 2 4626654
Burkitt's lymphoma stage III 32.25 30.01 5 12331 2 4626654
Skin neoplasm excision 32.23 30.01 9 12327 215 4626441
Renal transplant failure 31.88 30.01 10 12326 361 4626295
Hodgkin's disease nodular sclerosis 31.82 30.01 7 12329 59 4626597
Petechiae 31.74 30.01 20 12316 3911 4622745
Peripheral artery aneurysm 31.62 30.01 8 12328 129 4626527
Germ cell cancer 31.61 30.01 7 12329 61 4626595
Mycobacterium kansasii infection 31.51 30.01 7 12329 62 4626594
Vasculitis necrotising 31.38 30.01 10 12326 380 4626276
Ill-defined disorder 31.33 30.01 23 12313 5767 4620889
Myasthenia gravis crisis 31.28 30.01 8 12328 135 4626521
Laryngeal mass 31.27 30.01 6 12330 23 4626633
Cerebral haemorrhage 31.22 30.01 33 12303 13408 4613248
Peripheral ischaemia 31.15 30.01 15 12321 1732 4624924
Scedosporium infection 31.12 30.01 9 12327 245 4626411
Blood bilirubin increased 31.07 30.01 32 12304 12620 4614036
Peritonitis bacterial 30.98 30.01 15 12321 1753 4624903
Multi-organ disorder 30.74 30.01 11 12325 598 4626058
Enterocutaneous fistula 30.73 30.01 10 12326 407 4626249
Blood albumin decreased 30.72 30.01 19 12317 3595 4623061
Spirometry abnormal 30.66 30.01 7 12329 71 4626585
Leiomyosarcoma 30.64 30.01 8 12328 147 4626509
Stenotrophomonas infection 30.61 30.01 10 12326 412 4626244
Diffuse large B-cell lymphoma stage III 30.50 30.01 6 12330 27 4626629
Immunoglobulin G4 related disease 30.48 30.01 7 12329 73 4626583
Herpes simplex test positive 30.44 30.01 8 12328 151 4626505
Shock 30.34 30.01 27 12309 8889 4617767
Spermatozoa progressive motility decreased 30.31 30.01 7 12329 75 4626581
Congenital central nervous system anomaly 30.29 30.01 10 12326 426 4626230
Mucosal inflammation 30.25 30.01 30 12306 11313 4615343
Human polyomavirus infection 30.19 30.01 8 12328 156 4626500
Porokeratosis 30.14 30.01 7 12329 77 4626579
Skin plaque 30.13 30.01 16 12320 2271 4624385
Proctalgia 30.12 30.01 14 12322 1494 4625162
Acute monocytic leukaemia 30.06 30.01 7 12329 78 4626578

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
FDA Chemical/Ingredient N0000175459 Nucleoside Analog
FDA EPC N0000175712 Purine Antimetabolite
FDA Chemical/Ingredient N0000008065 Purines
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Crohn's disease off-label use 34000006
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Ulcerative colitis off-label use 64766004 DOID:8577
Pemphigus off-label use 65172003 DOID:9182
Autoimmune hepatitis off-label use 408335007
Prevention of Liver Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Lung Transplant Rejection off-label use
Systemic Dermatomyositis off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Protozoal Infection contraindication
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thiopurine S-methyltransferase Enzyme WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Unclassified WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
DNA DNA OTHER DRUG LABEL SCIENTIFIC LITERATURE
RNA RNA OTHER DRUG LABEL SCIENTIFIC LITERATURE

External reference:

IDSource
D001379 MESH_DESCRIPTOR_UI
4018766 VUID
N0000147069 NUI
C0004482 UMLSCUI
D00238 KEGG_DRUG
111165009 SNOMEDCT_US
4018766 VANDF
1256 RXNORM
6041 MMSL
d00024 MMSL
372574004 SNOMEDCT_US
4234 MMSL
003419 NDDF
AM94R510MS UNII
55774-33-9 SECONDARY_CAS_RN
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
CHEMBL1200400 ChEMBL_ID
1291 INN_ID
7120 IUPHAR_LIGAND_ID
2265 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7568 TABLET 50 mg ORAL ANDA 11 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51079-620 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 13 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 14 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 13 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 14 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-492 TABLET 25 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-493 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-494 TABLET 75 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-495 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-120 TABLET 100 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68462-502 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1139 TABLET 25 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1140 TABLET 75 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1141 TABLET 100 1 ORAL ANDA 1 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 71610-124 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 71610-306 TABLET 50 mg ORAL ANDA 14 sections