azatadine indications/contra

Stem definitionDrug idCAS RN
histamine-H1 receptor antagonists, tricyclic compounds 268 3964-81-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azatidine
  • azatadine
  • azatadine maleate
indulian (UD 21;71k) is dimaleate; do not confuse with AZACITIDINE
  • Molecular weight: 290.41
  • Formula: C20H22N2
  • CLOGP: 3.56
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 16.13
  • ALOGS: -3.41
  • ROTB: 0

Drug dosage:

DoseUnitRoute
2 mg O

Approvals:

DateAgencyCompanyOrphan
March 29, 1977 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R06AX09 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
CHEBI has role CHEBI:37955 H1-receptor antagonist
CHEBI has role CHEBI:50857 anti-allergic agent
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Dermatographic urticaria indication 7632005 DOID:743
Vasomotor rhinitis indication 8229003 DOID:4730
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Urticaria indication 126485001
Seasonal allergic rhinitis indication 367498001
Itching of skin indication 418363000
Allergic conjunctivitis indication 473460002 DOID:11204
Anaphylaxis Adjunct indication
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Diabetes mellitus contraindication 73211009 DOID:9351
Benign prostatic hyperplasia contraindication 266569009 DOID:2883
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.08 Basic
pKa2 3.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST DRUGBANK CHEMBL
Histamine H1 receptor GPCR Ki 8.41 CHEMBL

External reference:

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IDSource
4019620 VUID
N0000147714 NUI
C0052759 UMLSCUI
7119 IUPHAR_LIGAND_ID
D00662 KEGG_DRUG
DB00719 DRUGBANK_ID
CHEMBL946 ChEMBL_ID
19861 PUBCHEM_CID
4019620 VANDF
N0000007088 NDFRT
N0000147714 NDFRT
d00791 MMSL
18600 RXNORM
1594006 SNOMEDCT_US
372662006 SNOMEDCT_US
004805 NDDF
94Z39NID6C UNII
2327 INN_ID
CHEBI:2946 CHEBI
C006656 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL3544908 ChEMBL_ID
3978-86-7 SECONDARY_CAS_RN

Pharmaceutical products:

None