tiquizium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quaternary ammonium compounds	2678	71731-58-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tiquizium
tiquizium bromide
thiaton
HSR-902

antispasmodic; RN refers to bromide (trans)-isomer

Molecular weight: 330.53
Formula: C19H24NS2
CLOGP: 0.53
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA:
ALOGS: -5.04
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:48876	muscarinic antagonists
CHEBI has role	CHEBI:49201	anti-ulcer drugs
CHEBI has role	CHEBI:53784	antispasmodics

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Abdominal pain	indication	21522001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Muscarinic acetylcholine receptor	GPCR		F1PT23_CANFA		Ki	8.70		SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor	GPCR		F1PWR7_CANFA		Ki	8.94		SCIENTIFIC LITERATURE
Muscarinic acetylcholine receptor	GPCR		F1PGZ2_CANFA		Ki	9.11		SCIENTIFIC LITERATURE

External reference:

ID	Source
D01875	KEGG_DRUG
CHEBI:32232	CHEBI
CHEMBL1872078	ChEMBL_ID
CHEMBL4301292	ChEMBL_ID
CHEMBL4297146	ChEMBL_ID
C030950	MESH_SUPPLEMENTAL_RECORD_UI
72160	PUBCHEM_CID
340Q44041A	UNII
C0145974	UMLSCUI
5190	INN_ID
149755-23-7	SECONDARY_CAS_RN

Pharmaceutical products:

None