azasetron indications/contra

Stem definitionDrug idCAS RN
serotonin receptor antagonists (5-HT3) 267 123040-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azasetron hydrochloride
  • azasetron
  • nazasetron
  • azasetron HCl
a selective 5-HT3 receptor antagonist; structure given in first source
  • Molecular weight: 349.82
  • Formula: C17H20ClN3O3
  • CLOGP: 1.54
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 61.88
  • ALOGS: -2.96
  • ROTB: 2

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000932 Antiemetics
MeSH PA D001337 Autonomic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.43 acidic
pKa2 8.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 3A Ion channel ANTAGONIST Ki 9.27 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
2285 IUPHAR_LIGAND_ID
D01613 KEGG_DRUG
2BSS7XL60S UNII
123040-16-4 SECONDARY_CAS_RN
7005 INN_ID
007693 NDDF
2264 PUBCHEM_CID
CHEMBL1598608 ChEMBL_ID
C070671 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31246 CHEBI

Pharmaceutical products:

None