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tibolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anabolic steroids | 2655 | 5630-53-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used in prevention of postmenopausal osteoporosis
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 2.50 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1988 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03CX01 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ESTROGENS Other estrogens |
| MeSH PA | D000726 | Androgen Antagonists |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D020847 | Estrogen Receptor Modulators |
| MeSH PA | D045930 | Anabolic Agents |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:50646 | bone density conservation agent |
| CHEBI has role | CHEBI:51060 | hormone agonist |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Postmenopausal osteoporosis | indication | 102447009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Transporter | Ki | 7.32 | DRUG MATRIX | |||||
| Estrogen receptor | Nuclear hormone receptor | Ki | 6.91 | DRUG MATRIX | |||||
| Androgen receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
| Progesterone receptor | Nuclear hormone receptor | WOMBAT-PK | |||||||
| Cytochrome P450 2C19 | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
| Steryl-sulfatase | Enzyme | WOMBAT-PK | |||||||
| Androgen receptor | Transcription factor | Ki | 7.12 | DRUG MATRIX | |||||
| Progesterone receptor | Transcription factor | Ki | 7.54 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4025274 | VUID |
| N0000179266 | NUI |
| D01639 | KEGG_DRUG |
| 4025274 | VANDF |
| C0076660 | UMLSCUI |
| CHEBI:32223 | CHEBI |
| CHEMBL2103774 | ChEMBL_ID |
| DB09070 | DRUGBANK_ID |
| C027385 | MESH_SUPPLEMENTAL_RECORD_UI |
| 444008 | PUBCHEM_CID |
| 9711 | IUPHAR_LIGAND_ID |
| 2777 | INN_ID |
| FF9X0205V2 | UNII |
| 38260 | RXNORM |
| 004056 | NDDF |
| 325567003 | SNOMEDCT_US |
| 395903002 | SNOMEDCT_US |
| FF9X0205V2 | INXIGHT DRUGS |
Pharmaceutical products:
None