azapetine indications/contra

Stem definitionDrug idCAS RN
265 146-36-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • azapetine
  • azapetine phosphate
  • peridil
  • Ro-2-3248
  • ilidar
  • ilidar phosphate
  • Molecular weight: 235.33
  • Formula: C17H17N
  • CLOGP: 4.14
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -4.17
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.15 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C04AX30 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Peripheral vascular disease indication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenergic receptor alpha-2 GPCR IC50 5.89 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 6.69 CHEMBL

External reference:

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IDSource
D07178 KEGG_DRUG
0N2U15U85W UNII
130-83-6 SECONDARY_CAS_RN
8966 PUBCHEM_CID
30827002 SNOMEDCT_US
000701 NDDF
CHEBI:134955 CHEBI
C004448 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2103986 ChEMBL_ID
CHEMBL2110596 ChEMBL_ID

Pharmaceutical products:

None