thymopentin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2645 69558-55-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thymopentin
  • thymopoietin pentapeptide
  • thymopoietin 32-36
Synthetic pentapeptide corresponding to the amino acids 32-36 of thymopoietin and exhibiting the full biological activity of the natural hormone. It is an immunomodulator which has been studied for possible use in the treatment of rheumatoid arthritis, AIDS, and other primary immunodeficiencies.
  • Molecular weight: 679.78
  • Formula: C30H49N9O9
  • CLOGP: -3.77
  • LIPINSKI: 3
  • HAC: 18
  • HDO: 12
  • TPSA: 325.17
  • ALOGS: -3.96
  • ROTB: 22

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK3,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK1,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 37
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L03AX09 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Other immunostimulants
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D007155 Immunologic Factors

Related Drugs by ATC class:

L03AX Other immunostimulants 15 drugs
cridanimodelapegademaseglatiramer acetatehistamineleniolisiblentinanmavorixaformifamurtidemotixafortidepegademasepidotimodplerixafor show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.26 acidic
pKa2 3.94 acidic
pKa3 10.6 acidic
pKa4 12.76 acidic
pKa5 13.37 acidic
pKa6 10.81 Basic
pKa7 10.0 Basic
pKa8 7.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167482 NUI
D06117 KEGG_DRUG
C0080225 UMLSCUI
CHEMBL156025 ChEMBL_ID
D016305 MESH_DESCRIPTOR_UI
DB11996 DRUGBANK_ID
5146 INN_ID
O3Y80ZF13F UNII
451417 PUBCHEM_CID
40230 RXNORM
006776 NDDF
CHEBI:135870 CHEBI

Pharmaceutical products:

None