thioproperazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2635	316-81-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

thioproperazine
sulfenazin
thioperazine
tioproperazin
thioproperazine dimesylate
thioproperazine mesylate
thioproperazine mesyiate
thioproperazine mesilate

Molecular weight: 446.63
Formula: C22H30N4O2S2
CLOGP: 2.31
LIPINSKI: 0
HAC: 6
HDO: 0
TPSA: 47.10
ALOGS: -3.89
ROTB: 5

Drug dosage:

Dose	Unit	Route
75	mg	O
20	mg	P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AB08	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with piperazine structure
CHEBI has role	CHEBI:37930	phenothiazine antipsychotic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.74	Basic
pKa2	4.74	Basic
pKa3	3.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	9.35		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	8.92		PDSP

External reference:

ID	Source
D01447	KEGG_DRUG
C0039936	UMLSCUI
CHEBI:59120	CHEBI
CHEMBL609109	ChEMBL_ID
DB01622	DRUGBANK_ID
C084825	MESH_SUPPLEMENTAL_RECORD_UI
911	INN_ID
2347-80-0	SECONDARY_CAS_RN
YJ050AQ56X	UNII
9429	PUBCHEM_CID
10498	RXNORM
003494	NDDF
003495	NDDF
CHEMBL1481539	ChEMBL_ID
CHEMBL1406487	ChEMBL_ID

Pharmaceutical products:

None