thiamylal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2626 77-27-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamylal sodium
  • thiamylal
  • thioseconal
  • thioquinalbarbitone
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
  • Molecular weight: 254.35
  • Formula: C12H18N2O2S
  • CLOGP: 3.03
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.20
  • ALOGS: -3.70
  • ROTB: 5

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 1.40 L/kg Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
None FDA PARKEDALE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35717 hypnotics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Anesthesia with ultrashort action Indication
Cattle Anesthesia with ultrashort action Indication
Dogs Anesthesia with ultrashort action Indication
Horses Anesthesia with ultrashort action Indication
Swine Anesthesia with ultrashort action Indication

🐶 Veterinary products

ProductApplicantIngredients
Surital Zoetis Inc. 1
Bio-Tal Cronus Pharma Specialities India Private Limited 1
Anestatal Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.32 acidic
pKa2 11.33 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018651 VUID
N0000179646 NUI
D00713 KEGG_DRUG
337-47-3 SECONDARY_CAS_RN
4018651 VANDF
4019942 VANDF
C0039855 UMLSCUI
CHEBI:9536 CHEBI
CHEMBL440 ChEMBL_ID
CHEMBL1201065 ChEMBL_ID
DB01154 DRUGBANK_ID
D013840 MESH_DESCRIPTOR_UI
3032285 PUBCHEM_CID
7305 IUPHAR_LIGAND_ID
01T23W89FR UNII
10464 RXNORM
001399 NDDF
004579 NDDF
40342009 SNOMEDCT_US
764663005 SNOMEDCT_US
764664004 SNOMEDCT_US

Pharmaceutical products:

None