All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

thiamylal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	2626	77-27-0

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: thiamylal sodium thiamylal thioseconal thioquinalbarbitone

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919) Molecular weight: 254.35 Formula: C12H18N2O2S CLOGP: 3.03 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 58.20 ALOGS: -3.70 ROTB: 5 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
Vd (Volume of distribution)	1.40 L/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TTK	37
kinase-selectivity-class	AXL,BRAF,CDK9,GRK2,MAPK7,PDK1,STK33,TEK	8
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA	PARKEDALE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000777	Anesthetics
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018682	GABA Agents
MeSH PA	D018686	Anesthetics, Intravenous
MeSH PA	D018757	GABA Modulators
CHEBI has role	CHEBI:35717	sedative

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
General anesthesia	indication	50697003

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Anesthesia with ultrashort action	Indication
Cattle	Anesthesia with ultrashort action	Indication
Dogs	Anesthesia with ultrashort action	Indication
Horses	Anesthesia with ultrashort action	Indication
Swine	Anesthesia with ultrashort action	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Surital	Zoetis Inc.	1
Bio-Tal	Cronus Pharma Specialities India Private Limited	1
Anestatal	Cronus Pharma Specialities India Private Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.32	acidic
pKa2	11.33	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018651	VUID
N0000179646	NUI
D00713	KEGG_DRUG
337-47-3	SECONDARY_CAS_RN
4018651	VANDF
4019942	VANDF
C0039855	UMLSCUI
CHEBI:9536	CHEBI
CHEMBL440	ChEMBL_ID
CHEMBL1201065	ChEMBL_ID
DB01154	DRUGBANK_ID
D013840	MESH_DESCRIPTOR_UI
3032285	PUBCHEM_CID
7305	IUPHAR_LIGAND_ID
01T23W89FR	UNII
10464	RXNORM
001399	NDDF
004579	NDDF
40342009	SNOMEDCT_US
764663005	SNOMEDCT_US
764664004	SNOMEDCT_US
01T23W89FR	INXIGHT DRUGS

Pharmaceutical products:

None