thiamylal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2626 | 77-27-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.40 L/kg | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PARKEDALE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D018686 | Anesthetics, Intravenous |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018757 | GABA Modulators |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| CHEBI has role | CHEBI:35717 | hypnotics |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| General anesthesia | indication | 50697003 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Anesthesia with ultrashort action | Indication |
| Cattle | Anesthesia with ultrashort action | Indication |
| Dogs | Anesthesia with ultrashort action | Indication |
| Horses | Anesthesia with ultrashort action | Indication |
| Swine | Anesthesia with ultrashort action | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Surital | Zoetis Inc. | 1 |
| Bio-Tal | Cronus Pharma Specialities India Private Limited | 1 |
| Anestatal | Cronus Pharma Specialities India Private Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.32 | acidic |
| pKa2 | 11.33 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ion channel | POSITIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018651 | VUID |
| N0000179646 | NUI |
| D00713 | KEGG_DRUG |
| 337-47-3 | SECONDARY_CAS_RN |
| 4018651 | VANDF |
| 4019942 | VANDF |
| C0039855 | UMLSCUI |
| CHEBI:9536 | CHEBI |
| CHEMBL440 | ChEMBL_ID |
| CHEMBL1201065 | ChEMBL_ID |
| DB01154 | DRUGBANK_ID |
| D013840 | MESH_DESCRIPTOR_UI |
| 3032285 | PUBCHEM_CID |
| 7305 | IUPHAR_LIGAND_ID |
| 01T23W89FR | UNII |
| 10464 | RXNORM |
| 001399 | NDDF |
| 004579 | NDDF |
| 40342009 | SNOMEDCT_US |
| 764663005 | SNOMEDCT_US |
| 764664004 | SNOMEDCT_US |
Pharmaceutical products:
None