Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
thiamylal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2626 | 77-27-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 1.40 L/kg | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | PARKEDALE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D006993 | Hypnotics and Sedatives |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018682 | GABA Agents |
| MeSH PA | D018686 | Anesthetics, Intravenous |
| MeSH PA | D018757 | GABA Modulators |
| CHEBI has role | CHEBI:35717 | sedative |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| General anesthesia | indication | 50697003 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Anesthesia with ultrashort action | Indication |
| Cattle | Anesthesia with ultrashort action | Indication |
| Dogs | Anesthesia with ultrashort action | Indication |
| Horses | Anesthesia with ultrashort action | Indication |
| Swine | Anesthesia with ultrashort action | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Surital | Zoetis Inc. | 1 |
| Bio-Tal | Cronus Pharma Specialities India Private Limited | 1 |
| Anestatal | Cronus Pharma Specialities India Private Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.32 | acidic |
| pKa2 | 11.33 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ion channel | POSITIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018651 | VUID |
| N0000179646 | NUI |
| D00713 | KEGG_DRUG |
| 337-47-3 | SECONDARY_CAS_RN |
| 4018651 | VANDF |
| 4019942 | VANDF |
| C0039855 | UMLSCUI |
| CHEBI:9536 | CHEBI |
| CHEMBL440 | ChEMBL_ID |
| CHEMBL1201065 | ChEMBL_ID |
| DB01154 | DRUGBANK_ID |
| D013840 | MESH_DESCRIPTOR_UI |
| 3032285 | PUBCHEM_CID |
| 7305 | IUPHAR_LIGAND_ID |
| 01T23W89FR | UNII |
| 10464 | RXNORM |
| 001399 | NDDF |
| 004579 | NDDF |
| 40342009 | SNOMEDCT_US |
| 764663005 | SNOMEDCT_US |
| 764664004 | SNOMEDCT_US |
| 01T23W89FR | INXIGHT DRUGS |
Pharmaceutical products:
None