testolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2606 | 968-93-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.03 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 13.88 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 3, 1969 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175080 | Aromatase Inhibitors |
| FDA EPC | N0000175563 | Aromatase Inhibitor |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Carcinoma of female breast | indication | 447782002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aromatase | Enzyme | INHIBITOR | Ki | 4.46 | IUPHAR | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017729 | VUID |
| N0000146097 | NUI |
| D00153 | KEGG_DRUG |
| 4017729 | VANDF |
| C0039600 | UMLSCUI |
| CHEBI:9460 | CHEBI |
| CHEMBL1571 | ChEMBL_ID |
| DB00894 | DRUGBANK_ID |
| D013738 | MESH_DESCRIPTOR_UI |
| 13769 | PUBCHEM_CID |
| 7303 | IUPHAR_LIGAND_ID |
| 1839 | INN_ID |
| 6J9BLA949Q | UNII |
| 10378 | RXNORM |
| 2376 | MMSL |
| 5551 | MMSL |
| d01347 | MMSL |
| 002665 | NDDF |
| 404877009 | SNOMEDCT_US |
| 63999004 | SNOMEDCT_US |
Pharmaceutical products:
None