terizidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2602	25683-71-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: terizidone terivalidin terizidon	minor descriptor (1975-1984); on-line & Index Medicus search OXAZOLES (1975-1984); RN given refers to parent cpd without isomeric designation Molecular weight: 302.29 Formula: C14H14N4O4 CLOGP: 0.56 LIPINSKI: 0 HAC: 8 HDO: 2 TPSA: 101.38 ALOGS: -3.08 ROTB: 4

Molecule

Description

Molfile Inchi Smiles

Synonyms:

terizidone
terivalidin
terizidon

minor descriptor (1975-1984); on-line & Index Medicus search OXAZOLES (1975-1984); RN given refers to parent cpd without isomeric designation

Molecular weight: 302.29
Formula: C14H14N4O4
CLOGP: 0.56
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 101.38
ALOGS: -3.08
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myelosuppression	67.18	48.81	19	542	23684	63464777
Polyneuropathy	61.50	48.81	16	545	14573	63473888
Myopathy	55.61	48.81	14	547	11177	63477284
Neuropathy peripheral	53.65	48.81	24	537	113643	63374818
Drug resistance	49.97	48.81	15	546	22918	63465543

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myelosuppression	71.98	54.16	21	450	19244	34937216
Drug resistance	57.65	54.16	19	452	25908	34930552
Electrocardiogram QT prolonged	56.43	54.16	21	450	40931	34915529

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Myelosuppression	134.57	50.49	40	1000	40256	79703092
Polyneuropathy	112.04	50.49	31	1009	24120	79719228
Drug resistance	75.09	50.49	26	1014	42187	79701161
Anaemia	68.87	50.49	52	988	444963	79298385
Electrocardiogram QT prolonged	59.05	50.49	27	1013	90359	79652989
Neuropathy peripheral	53.13	50.49	29	1011	141276	79602072
Psychotic disorder	52.96	50.49	20	1020	41382	79701966
Bicytopenia	51.53	50.49	12	1028	4658	79738690

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FDA Adverse Event Reporting System (Pediatric)

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Pharmacologic Action:

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Source	Code	Description
ATC	J04AK03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Other drugs for treatment of tuberculosis

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Drug Use | Suggest Off label Use Form| |View source of the data|

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🐶 Veterinary Drug Use

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🐶 Veterinary products

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Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.06	acidic
pKa2	7.66	acidic
pKa3	3.32	Basic
pKa4	2.72	Basic

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Orange Book patent data (new drug applications)

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Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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External reference:

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ID	Source
005992	NDDF
1199LEX5N8	UNII
1707	INN_ID
57047	RXNORM
65720	PUBCHEM_CID
C0145184	UMLSCUI
C100142	MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135278	CHEBI
CHEMBL2107553	ChEMBL_ID
D07247	KEGG_DRUG

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Pharmaceutical products:

None