temoporfin indications/contra

Stem definitionDrug idCAS RN
benzoporphyrin derivatives 2588 122341-38-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • temoporfin
  • foscan
  • fosgel
  • foslipos
used as PHOTOCHEMOTHERAPY
  • Molecular weight: 680.76
  • Formula: C44H32N4O4
  • CLOGP: 12.13
  • LIPINSKI: 3
  • HAC: 8
  • HDO: 6
  • TPSA: 138.28
  • ALOGS: -5.23
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 2001 EMA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC L01XD05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Sensitizers used in photodynamic/radiation therapy
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
CHEBI has role CHEBI:47868 photosensitizing agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Neoplasm of head and neck indication 255055008 DOID:11934
Squamous cell carcinoma indication 402815007 DOID:1749

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.46 acidic
pKa2 9.83 acidic
pKa3 10.35 acidic
pKa4 10.72 acidic
pKa5 11.12 acidic
pKa6 11.72 acidic
pKa7 4.62 Basic
pKa8 1.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0379149 UMLSCUI
D06066 KEGG_DRUG
418647000 SNOMEDCT_US
009630 NDDF
115243 RXNORM
407735007 SNOMEDCT_US
CHEMBL383675 ChEMBL_ID
C072269 MESH_SUPPLEMENTAL_RECORD_UI
60751 PUBCHEM_CID
FU21S769PF UNII
7127 INN_ID
DB11630 DRUGBANK_ID
CHEBI:9437 CHEBI

Pharmaceutical products:

None