taltirelin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
thyrotropin releasing hormone analogues 2560 103300-74-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • taltirelin hydrate
  • ceredist
  • taltirelin tetrahydrate
  • TA-0910
  • TA 0910
  • taltirelin
  • Molecular weight: 405.42
  • Formula: C17H23N7O5
  • CLOGP: -1.40
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 4
  • TPSA: 170.59
  • ALOGS: -2.17
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018697 Nootropic Agents
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:66980 intelligence enhancer
CHEBI has role CHEBI:35470 central nervous system agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spinocerebellar disease indication 91502009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.29 acidic
pKa2 13.15 acidic
pKa3 13.8 acidic
pKa4 7.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thyrotropin-releasing hormone receptor GPCR AGONIST Ki 6.50 IUPHAR SCIENTIFIC LITERATURE

External reference:

IDSource
D01925 KEGG_DRUG
201677-75-0 SECONDARY_CAS_RN
C2960839 UMLSCUI
CHEBI:135653 CHEBI
CHEMBL2107016 ChEMBL_ID
C065049 MESH_SUPPLEMENTAL_RECORD_UI
114750 PUBCHEM_CID
2143 IUPHAR_LIGAND_ID
7503 INN_ID
DOZ62MV6A5 UNII

Pharmaceutical products:

None