atomoxetine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
serotonin and/or norepinephrine reuptake inhibitors, fluoxetine derivatives 256 83015-26-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • LY139603
  • strattera
  • atomoxetine
  • tomoxetine
  • (-)-Tomoxetine
  • atomoxetine hydrochloride
  • tomoxetine hydrochloride
  • atomoxetine HCl
  • tomoxetine HCl
A propylamine derivative and selective ADRENERGIC UPTAKE INHIBITOR that is used in the treatment of ATTENTION DEFICIT HYPERACTIVITY DISORDER.
  • Molecular weight: 255.36
  • Formula: C17H21NO
  • CLOGP: 3.94
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -4.82
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
80 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.80 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 8.39 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 94 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.85 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 9.30 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 2002 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blepharospasm 266.99 16.91 81 11804 5915 63471222
Suicidal ideation 247.91 16.91 151 11734 62270 63414867
Taste disorder 194.81 16.91 79 11806 13583 63463554
Epilepsy 154.41 16.91 83 11802 26982 63450155
Tic 110.06 16.91 30 11855 1490 63475647
Memory impairment 108.87 16.91 115 11770 104143 63372994
Irritability 101.51 16.91 67 11818 31627 63445510
Aggression 98.70 16.91 59 11826 23439 63453698
Myocarditis 98.66 16.91 45 11840 10280 63466857
Abnormal behaviour 98.41 16.91 57 11828 21369 63455768
Prescribed overdose 94.61 16.91 66 11819 34087 63443050
Paraesthesia 88.68 16.91 127 11758 156839 63320298
Gastrooesophageal reflux disease 88.48 16.91 99 11786 95540 63381597
Agitation 84.85 16.91 78 11807 59679 63417458
Disturbance in attention 81.38 16.91 63 11822 38126 63439011
Hypoaesthesia 76.34 16.91 123 11762 168270 63308867
Product tampering 74.57 16.91 17 11868 401 63476736
Suicide attempt 74.09 16.91 73 11812 60845 63416292
Pulse abnormal 72.31 16.91 24 11861 2340 63474797
Mood swings 71.94 16.91 44 11841 18204 63458933
Depression 68.75 16.91 128 11757 196364 63280773
Crying 66.72 16.91 46 11839 23297 63453840
Adulterated product 65.43 16.91 14 11871 244 63476893
Intentional self-injury 65.03 16.91 47 11838 25640 63451497
Claustrophobia 64.07 16.91 18 11867 1000 63476137
Overdose 60.42 16.91 90 11795 114988 63362149
Liver injury 60.01 16.91 65 11820 60455 63416682
Congestive hepatopathy 59.70 16.91 22 11863 2920 63474217
Attention deficit hyperactivity disorder 58.74 16.91 22 11863 3054 63474083
Intentional overdose 57.27 16.91 70 11815 74082 63403055
Tachycardia 57.22 16.91 89 11796 118067 63359070
Somnolence 57.06 16.91 112 11773 178573 63298564
Somatic symptom disorder 50.71 16.91 19 11866 2641 63474496
Loss of consciousness 50.39 16.91 84 11801 118037 63359100
Impulsive behaviour 48.13 16.91 16 11869 1567 63475570
Brain injury 46.98 16.91 24 11861 7019 63470118
Seizure 45.83 16.91 86 11799 132548 63344589
Paranoia 45.61 16.91 28 11857 11651 63465486
Neurological symptom 45.36 16.91 22 11863 5761 63471376
Abdominal pain upper 44.98 16.91 111 11774 206333 63270804
Amenorrhoea 44.51 16.91 26 11859 9888 63467249
Raynaud's phenomenon 43.81 16.91 14 11871 1210 63475927
Hyperreflexia 41.86 16.91 21 11864 5913 63471224
Completed suicide 41.35 16.91 87 11798 145586 63331551
Vomiting 39.88 16.91 208 11677 559409 62917728
Anxiety 39.24 16.91 109 11776 217432 63259705
Mania 39.22 16.91 26 11859 12341 63464796
Anger 39.05 16.91 26 11859 12430 63464707
Trichotillomania 37.91 16.91 8 11877 130 63477007
Psychomotor hyperactivity 37.70 16.91 24 11861 10639 63466498
Supine hypertension 37.18 16.91 7 11878 61 63477076
Feeling abnormal 34.66 16.91 82 11803 148310 63328827
Diarrhoea 33.97 16.91 51 11834 715315 62761822
Oppositional defiant disorder 33.29 16.91 6 11879 40 63477097
Hepatic failure 33.08 16.91 37 11848 35619 63441518
Hepatitis 33.06 16.91 39 11846 39749 63437388
Dystonia 32.07 16.91 24 11861 13795 63463342
Hepatic encephalopathy 31.68 16.91 22 11863 11260 63465877
Hyperhidrosis 31.28 16.91 65 11820 107771 63369366
Pneumonia 31.17 16.91 24 11861 456743 63020394
Bipolar I disorder 30.59 16.91 12 11873 1887 63475250
Palpitations 30.43 16.91 66 11819 112704 63364433
Electrocardiogram QT prolonged 30.41 16.91 46 11839 59484 63417653
Withdrawal syndrome 30.11 16.91 27 11858 19970 63457167
Psychotic disorder 29.74 16.91 30 11855 25682 63451455
Educational problem 29.33 16.91 8 11877 398 63476739
Encephalopathy 29.06 16.91 36 11849 38584 63438553
Drug screen positive 29.05 16.91 14 11871 3615 63473522
Renal tubular acidosis 28.35 16.91 11 11874 1681 63475456
Electrocardiogram ST segment elevation 28.00 16.91 14 11871 3913 63473224
Obsessive-compulsive disorder 27.56 16.91 14 11871 4046 63473091
Acute kidney injury 26.83 16.91 8 11877 263407 63213730
Treatment failure 26.75 16.91 3 11882 199040 63278097
Mydriasis 26.05 16.91 20 11865 11936 63465201
Thinking abnormal 25.85 16.91 19 11866 10624 63466513
Aspartate aminotransferase increased 25.69 16.91 54 11831 90223 63386914
Treatment noncompliance 25.25 16.91 33 11852 37292 63439845
Piloerection 25.11 16.91 7 11878 378 63476759
Dysmenorrhoea 24.94 16.91 13 11872 3960 63473177
Hypomania 24.27 16.91 15 11870 6315 63470822
Face oedema 24.14 16.91 24 11861 20188 63456949
Heart rate increased 24.11 16.91 54 11831 94184 63382953
Contraindicated product administered 23.30 16.91 6 11879 217642 63259495
Euphoric mood 22.42 16.91 13 11872 4874 63472263
Arthropathy 22.38 16.91 8 11877 234784 63242353
Social avoidant behaviour 22.33 16.91 11 11874 2977 63474160
Arthralgia 22.12 16.91 46 11839 569664 62907473
Infection 21.52 16.91 8 11877 229165 63247972
Joint swelling 21.35 16.91 18 11867 327648 63149489
Dermatitis atopic 20.61 16.91 16 11869 9708 63467429
Anaemia 20.53 16.91 15 11870 293415 63183722
Death 20.45 16.91 24 11861 374357 63102780
Mood altered 20.43 16.91 19 11866 14724 63462413
Emotional disorder 20.02 16.91 18 11867 13361 63463776
Hypertensive crisis 19.84 16.91 19 11866 15267 63461870
Toxicity to various agents 18.98 16.91 94 11791 247156 63229981
Bipolar disorder 18.86 16.91 14 11871 7946 63469191
Lymphocytic hypophysitis 18.69 16.91 5 11880 231 63476906
Personality change 18.19 16.91 13 11872 6960 63470177
Peripheral swelling 18.08 16.91 14 11871 265928 63211209
Merycism 17.83 16.91 5 11880 276 63476861
Abnormal dreams 17.44 16.91 15 11870 10501 63466636
Affective disorder 17.29 16.91 12 11873 6134 63471003
Generalised tonic-clonic seizure 17.11 16.91 24 11861 28992 63448145

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicidal ideation 674.51 22.10 335 14823 40053 34901720
Tic 564.24 22.10 139 15019 1919 34939854
Aggression 545.23 22.10 287 14871 38677 34903096
Prescribed overdose 477.69 22.10 178 14980 10469 34931304
Abnormal behaviour 349.07 22.10 184 14974 24785 34916988
Anger 266.50 22.10 121 15037 11763 34930010
Irritability 238.95 22.10 143 15015 24547 34917226
Crying 205.60 22.10 82 15076 5780 34935993
Intentional self-injury 199.46 22.10 104 15054 13667 34928106
Psychomotor hyperactivity 175.59 22.10 85 15073 9537 34932236
Testicular pain 174.97 22.10 60 15098 2758 34939015
Oppositional defiant disorder 155.05 22.10 38 15120 511 34941262
Agitation 148.46 22.10 152 15006 57247 34884526
Ejaculation disorder 145.64 22.10 41 15117 968 34940805
Suicide attempt 132.10 22.10 120 15038 38996 34902777
Homicidal ideation 131.81 22.10 48 15110 2634 34939139
Mood swings 129.85 22.10 65 15093 7836 34933937
Urinary hesitation 126.09 22.10 47 15111 2755 34939018
Anxiety 116.69 22.10 177 14981 99251 34842522
Disturbance in attention 114.91 22.10 93 15065 25852 34915921
Impulsive behaviour 114.89 22.10 41 15117 2121 34939652
Heart rate increased 107.76 22.10 116 15042 46227 34895546
Psychotic disorder 106.91 22.10 87 15071 24365 34917408
Depressed mood 104.58 22.10 78 15080 19239 34922534
Mood altered 100.12 22.10 57 15101 8895 34932878
Death 100.02 22.10 25 15133 398024 34543749
Acute kidney injury 99.57 22.10 9 15149 304979 34636794
Hallucination, auditory 97.33 22.10 62 15096 11855 34929918
Pneumonia 96.63 22.10 20 15138 362607 34579166
Depression 93.50 22.10 158 15000 96940 34844833
Insomnia 93.41 22.10 164 14994 103743 34838030
Somnolence 93.01 22.10 170 14988 110946 34830827
Attention deficit hyperactivity disorder 90.41 22.10 36 15122 2523 34939250
Decreased eye contact 89.44 22.10 24 15134 471 34941302
Product substitution issue 86.14 22.10 54 15104 10041 34931732
Bruxism 85.06 22.10 31 15127 1704 34940069
Drug screen positive 84.72 22.10 39 15119 3904 34937869
Mania 83.99 22.10 52 15106 9459 34932314
Seizure 80.96 22.10 155 15003 104702 34837071
Alanine aminotransferase increased 73.15 22.10 128 15030 80687 34861086
Palpitations 72.45 22.10 88 15070 39898 34901875
Self-injurious ideation 71.23 22.10 27 15131 1657 34940116
Tachycardia 69.99 22.10 129 15029 84643 34857130
Feeling abnormal 67.69 22.10 108 15050 63127 34878646
Mydriasis 67.55 22.10 41 15117 7196 34934577
Suicidal behaviour 66.94 22.10 25 15133 1472 34940301
Aspartate aminotransferase increased 66.11 22.10 111 15047 67672 34874101
Penile discharge 64.25 22.10 13 15145 66 34941707
Educational problem 64.03 22.10 19 15139 543 34941230
Dystonia 63.66 22.10 46 15112 10799 34930974
Sepsis 59.84 22.10 3 15155 166558 34775215
Dysuria 59.64 22.10 66 15092 27086 34914687
Diarrhoea 58.63 22.10 50 15108 389862 34551911
Generalised tonic-clonic seizure 58.17 22.10 58 15100 21116 34920657
Anaemia 57.79 22.10 15 15143 233320 34708453
Dyskinesia 57.21 22.10 59 15099 22354 34919419
Blood alkaline phosphatase increased 57.10 22.10 69 15089 31106 34910667
Choreoathetosis 55.86 22.10 20 15138 1044 34940729
Electrocardiogram QT prolonged 55.31 22.10 78 15080 40874 34900899
Nervousness 53.28 22.10 44 15114 12562 34929211
Manic symptom 53.15 22.10 12 15146 110 34941663
Emotional disorder 52.37 22.10 32 15126 5684 34936089
Retching 52.29 22.10 34 15124 6727 34935046
Headache 48.96 22.10 194 14964 200441 34741332
Trismus 48.40 22.10 23 15135 2472 34939301
Affect lability 42.65 22.10 24 15134 3659 34938114
Febrile neutropenia 42.07 22.10 5 15153 136844 34804929
Gilbert's syndrome 41.71 22.10 8 15150 29 34941744
Coordination abnormal 41.65 22.10 31 15127 7613 34934160
Social avoidant behaviour 40.76 22.10 22 15136 3092 34938681
Screaming 39.31 22.10 17 15141 1467 34940306
Growth retardation 38.82 22.10 18 15140 1830 34939943
Panic attack 37.95 22.10 32 15126 9400 34932373
Sexual dysfunction 37.59 22.10 27 15131 6276 34935497
Thrombocytopenia 36.86 22.10 11 15147 156236 34785537
Hepatic enzyme increased 36.74 22.10 63 15095 39017 34902756
Loss of consciousness 36.54 22.10 98 15060 82569 34859204
Blood bilirubin increased 36.35 22.10 62 15096 38234 34903539
Obsessive-compulsive disorder 35.88 22.10 25 15133 5539 34936234
Disease progression 35.68 22.10 3 15155 108074 34833699
Trichotillomania 35.56 22.10 8 15150 72 34941701
General physical health deterioration 34.19 22.10 7 15151 128262 34813511
Thinking abnormal 33.68 22.10 25 15133 6112 34935661
Physical assault 33.25 22.10 14 15144 1131 34940642
Paranoia 33.03 22.10 33 15125 12035 34929738
Personality change 32.93 22.10 23 15135 5116 34936657
Pallor 32.14 22.10 47 15111 25433 34916340
Enuresis 31.85 22.10 17 15141 2336 34939437
Fight in school 31.37 22.10 5 15153 3 34941770
Renal failure 31.14 22.10 9 15149 130548 34811225
Apathy 30.98 22.10 25 15133 6907 34934866
Hyperkinesia 30.38 22.10 15 15143 1753 34940020
Negativism 30.27 22.10 10 15148 409 34941364
Tearfulness 29.86 22.10 17 15141 2650 34939123
Hyperhidrosis 29.76 22.10 86 15072 75606 34866167
Scrotal pain 29.43 22.10 12 15146 894 34940879
Repetitive speech 29.37 22.10 7 15151 83 34941690
Erectile dysfunction 28.88 22.10 40 15118 20597 34921176
Cardiac failure 28.87 22.10 3 15155 91245 34850528
Abdominal pain upper 28.85 22.10 82 15076 71408 34870365
Urinary retention 28.37 22.10 54 15104 36234 34905539
Sleep disorder 28.37 22.10 50 15108 31638 34910135
Restlessness 27.89 22.10 44 15114 25438 34916335
Decreased appetite 27.83 22.10 144 15014 166248 34775525
Syncope 27.75 22.10 95 15063 91356 34850417
Speech disorder 27.62 22.10 44 15114 25642 34916131
Spontaneous ejaculation 27.61 22.10 5 15153 12 34941761
Pyromania 26.98 22.10 6 15152 51 34941722
Pyrexia 26.93 22.10 66 15092 332947 34608826
Respiratory failure 26.79 22.10 7 15151 108565 34833208
Hostility 26.75 22.10 11 15147 837 34940936
Chest pain 26.48 22.10 117 15041 126645 34815128
Dyspnoea 25.77 22.10 81 15077 376701 34565072
Hyponatraemia 25.45 22.10 3 15155 82688 34859085
Raynaud's phenomenon 25.22 22.10 8 15150 287 34941486
Tourette's disorder 25.11 22.10 6 15152 72 34941701
Asthenia 24.54 22.10 43 15115 245208 34696565
Abdominal discomfort 24.50 22.10 69 15089 59766 34882007
Pain 24.22 22.10 32 15126 204643 34737130
Hallucination, visual 24.17 22.10 34 15124 17757 34924016
Dysphoria 23.98 22.10 14 15144 2288 34939485
Oedema peripheral 23.93 22.10 11 15147 119801 34821972
Drooling 23.71 22.10 16 15142 3366 34938407
Pulmonary embolism 23.69 22.10 5 15153 89741 34852032
Semen analysis abnormal 23.46 22.10 5 15153 34 34941739
Drug abuse 23.31 22.10 7 15151 99089 34842684
Amphetamines positive 23.14 22.10 7 15151 214 34941559
Sedation 22.61 22.10 36 15122 20970 34920803

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicidal ideation 747.13 16.17 385 22266 75955 79645782
Tic 685.04 16.17 161 22490 2825 79718912
Aggression 568.49 16.17 281 22370 50677 79671060
Prescribed overdose 483.06 16.17 229 22422 37654 79684083
Abnormal behaviour 403.50 16.17 200 22451 36221 79685516
Irritability 313.60 16.17 176 22475 40968 79680769
Anger 302.07 16.17 130 22521 17032 79704705
Psychomotor hyperactivity 246.16 16.17 112 22539 16737 79705000
Intentional self-injury 207.92 16.17 124 22527 32295 79689442
Crying 204.35 16.17 109 22542 22934 79698803
Agitation 200.54 16.17 190 22461 99525 79622212
Mood swings 190.38 16.17 99 22552 19781 79701956
Disturbance in attention 186.11 16.17 137 22514 50664 79671073
Oppositional defiant disorder 186.04 16.17 40 22611 457 79721280
Blepharospasm 171.41 16.17 64 22587 5787 79715950
Suicide attempt 162.86 16.17 156 22495 82776 79638961
Ejaculation disorder 149.88 16.17 34 22617 505 79721232
Homicidal ideation 143.63 16.17 49 22602 3408 79718329
Impulsive behaviour 135.89 16.17 45 22606 2855 79718882
Depression 132.65 16.17 228 22423 216562 79505175
Somnolence 127.84 16.17 237 22414 238744 79482993
Testicular pain 125.30 16.17 39 22612 2026 79719711
Anxiety 124.93 16.17 240 22411 248272 79473465
Mania 122.69 16.17 72 22579 18188 79703549
Seizure 119.98 16.17 202 22449 188632 79533105
Psychotic disorder 109.15 16.17 92 22559 41310 79680427
Educational problem 109.12 16.17 25 22626 389 79721348
Urinary hesitation 108.16 16.17 42 22609 4224 79717513
Attention deficit hyperactivity disorder 107.27 16.17 39 22612 3270 79718467
Acute kidney injury 105.83 16.17 12 22639 519392 79202345
Heart rate increased 104.47 16.17 149 22502 120575 79601162
Tachycardia 100.94 16.17 181 22470 177587 79544150
Hallucination, auditory 99.58 16.17 66 22585 20627 79701110
Product substitution issue 96.01 16.17 64 22587 20192 79701545
Taste disorder 94.90 16.17 58 22593 15765 79705972
Dystonia 92.82 16.17 64 22587 21335 79700402
Pneumonia 92.63 16.17 36 22615 660210 79061527
Decreased eye contact 90.82 16.17 25 22626 840 79720897
Trichotillomania 86.64 16.17 18 22633 172 79721565
Aspartate aminotransferase increased 84.94 16.17 146 22505 138495 79583242
Feeling abnormal 82.67 16.17 156 22495 159043 79562694
Epilepsy 82.31 16.17 78 22573 40782 79680955
Insomnia 79.96 16.17 199 22452 244971 79476766
Mood altered 78.87 16.17 54 22597 17793 79703944
Alanine aminotransferase increased 77.92 16.17 154 22497 162416 79559321
Depressed mood 74.63 16.17 80 22571 48400 79673337
Generalised tonic-clonic seizure 73.91 16.17 76 22575 43834 79677903
Bruxism 72.46 16.17 31 22620 3995 79717742
Loss of consciousness 70.93 16.17 151 22500 167792 79553945
Diarrhoea 70.77 16.17 88 22563 880401 78841336
Mydriasis 70.07 16.17 50 22601 17593 79704144
Dyskinesia 69.12 16.17 74 22577 44699 79677038
Death 68.41 16.17 38 22613 566476 79155261
Paranoia 67.97 16.17 51 22600 19381 79702356
Product tampering 67.12 16.17 17 22634 411 79721326
Obsessive-compulsive disorder 66.90 16.17 33 22618 5894 79715843
Anaemia 66.18 16.17 22 22629 444993 79276744
Electrocardiogram QT prolonged 65.90 16.17 103 22548 90283 79631454
Palpitations 65.62 16.17 124 22527 126486 79595251
Self-injurious ideation 65.43 16.17 28 22623 3610 79718127
Drug screen positive 63.25 16.17 32 22619 6031 79715706
Suicidal behaviour 58.43 16.17 25 22626 3222 79718515
Hyperhidrosis 58.04 16.17 131 22520 151361 79570376
Adulterated product 57.79 16.17 14 22637 280 79721457
Emotional disorder 57.66 16.17 41 22610 14346 79707391
Manic symptom 57.08 16.17 12 22639 122 79721615
Choreoathetosis 56.52 16.17 20 22631 1550 79720187
Penile discharge 55.00 16.17 10 22641 43 79721694
Social avoidant behaviour 54.92 16.17 27 22624 4787 79716950
Retching 54.85 16.17 43 22608 17424 79704313
Sepsis 52.89 16.17 7 22644 269421 79452316
Claustrophobia 52.75 16.17 18 22633 1252 79720485
Intentional overdose 51.49 16.17 101 22550 105859 79615878
Somatic symptom disorder 50.55 16.17 21 22630 2516 79719221
Blood alkaline phosphatase increased 49.84 16.17 75 22576 63589 79658148
Nervousness 49.42 16.17 54 22597 33361 79688376
Growth retardation 48.80 16.17 19 22632 1924 79719813
Pulse abnormal 47.84 16.17 22 22629 3362 79718375
Febrile neutropenia 47.82 16.17 5 22646 230994 79490743
Completed suicide 47.81 16.17 166 22485 245601 79476136
Bipolar I disorder 47.11 16.17 19 22632 2110 79719627
Memory impairment 46.61 16.17 100 22551 111634 79610103
Personality change 45.47 16.17 31 22620 10139 79711598
Thinking abnormal 44.82 16.17 34 22617 13127 79708610
Thrombocytopenia 43.27 16.17 11 22640 265248 79456489
Affect lability 42.63 16.17 31 22620 11228 79710509
Arthralgia 41.91 16.17 61 22590 571742 79149995
Overdose 41.69 16.17 131 22520 184075 79537662
Myocarditis 40.95 16.17 40 22611 21693 79700044
Disease progression 40.84 16.17 3 22648 184359 79537378
Coordination abnormal 40.61 16.17 36 22615 17276 79704461
Amenorrhoea 40.59 16.17 26 22625 7666 79714071
Brain injury 39.77 16.17 30 22621 11487 79710250
Infection 39.47 16.17 10 22641 241702 79480035
Gilbert's syndrome 38.71 16.17 7 22644 29 79721708
Nightmare 38.60 16.17 42 22609 25819 79695918
Hyperreflexia 38.54 16.17 26 22625 8359 79713378
Abdominal pain upper 38.28 16.17 145 22506 223674 79498063
Trismus 37.88 16.17 22 22629 5445 79716292
Physical assault 37.81 16.17 15 22636 1596 79720141
Neurological symptom 37.45 16.17 26 22625 8757 79712980
Peripheral swelling 37.21 16.17 15 22636 269602 79452135
Scrotal pain 35.96 16.17 11 22640 539 79721198
Pancytopenia 35.86 16.17 3 22648 165742 79555995
Decreased appetite 35.36 16.17 191 22460 342227 79379510
Dysuria 34.29 16.17 56 22595 50895 79670842
Speech disorder 34.17 16.17 58 22593 54387 79667350
Pain in extremity 34.08 16.17 32 22619 364506 79357231
Joint swelling 33.86 16.17 20 22631 288626 79433111
General physical health deterioration 33.83 16.17 18 22633 275220 79446517
Enuresis 33.82 16.17 17 22634 3159 79718578
Pyrexia 33.70 16.17 91 22560 678618 79043119
Hyperkinesia 33.22 16.17 16 22635 2713 79719024
Raynaud's phenomenon 32.77 16.17 12 22639 1026 79720711
Tourette's disorder 32.63 16.17 7 22644 79 79721658
Paraesthesia 32.46 16.17 117 22534 176206 79545531
School refusal 31.78 16.17 6 22645 33 79721704
Vomiting 31.65 16.17 308 22343 665520 79056217
Restlessness 31.15 16.17 51 22600 46441 79675296
Bipolar disorder 30.96 16.17 22 22629 7685 79714052
Chest pain 30.86 16.17 160 22491 282144 79439593
Treatment noncompliance 30.61 16.17 54 22597 52214 79669523
Liver injury 29.99 16.17 56 22595 56558 79665179
Spontaneous ejaculation 29.72 16.17 5 22646 12 79721725
Renal failure 29.71 16.17 10 22641 200958 79520779
Dyspnoea 29.70 16.17 134 22517 856891 78864846
Arthropathy 29.54 16.17 7 22644 177104 79544633
Neuropathy peripheral 29.39 16.17 3 22648 141302 79580435
Petit mal epilepsy 29.33 16.17 19 22632 5708 79716029
Panic attack 28.84 16.17 35 22616 24181 79697556
Distractibility 28.77 16.17 10 22641 735 79721002
Feeling jittery 28.72 16.17 26 22625 12815 79708922
Drooling 28.72 16.17 19 22632 5915 79715822
Euphoric mood 28.63 16.17 21 22630 7705 79714032
Fall 28.45 16.17 60 22591 487569 79234168
Blood bilirubin increased 28.44 16.17 60 22591 66172 79655565
Gastrooesophageal reflux disease 28.19 16.17 79 22572 104167 79617570
Congestive hepatopathy 28.11 16.17 17 22634 4530 79717207
Rheumatoid arthritis 28.11 16.17 12 22639 208458 79513279
Treatment failure 27.93 16.17 7 22644 170479 79551258
Hyponatraemia 27.81 16.17 8 22643 177840 79543897
Hypoaesthesia 27.26 16.17 112 22539 179240 79542497
Pyromania 27.05 16.17 5 22646 24 79721713
Infusion related reaction 26.93 16.17 16 22635 230221 79491516
Sinus tachycardia 26.80 16.17 42 22609 36866 79684871
Renal impairment 26.79 16.17 6 22645 157777 79563960
Hostility 26.48 16.17 13 22638 2297 79719440
Tearfulness 26.02 16.17 18 22633 6027 79715710
Drug hypersensitivity 25.92 16.17 28 22623 298888 79422849
Headache 25.66 16.17 291 22360 653481 79068256
Sleep disorder 25.23 16.17 67 22584 85610 79636127
Urinary retention 25.13 16.17 52 22599 56578 79665159
Screaming 25.08 16.17 15 22636 3918 79717819
Cardiac failure congestive 25.02 16.17 5 22646 142397 79579340
Hypotension 24.99 16.17 55 22596 440262 79281475
Staring 24.82 16.17 13 22638 2632 79719105
Viral infection 24.62 16.17 44 22607 42972 79678765
Hypomania 24.61 16.17 19 22632 7525 79714212
Erectile dysfunction 23.98 16.17 25 22626 14639 79707098
Medication error 23.68 16.17 57 22594 68585 79653152
Negativism 23.68 16.17 9 22642 854 79720883
Sedation 23.43 16.17 48 22603 51847 79669890
Synovitis 23.17 16.17 7 22644 150727 79571010
Apathy 22.81 16.17 23 22628 12954 79708783
Dysphoria 22.53 16.17 15 22636 4719 79717018
Drug abuse 22.52 16.17 9 22642 162682 79559055
Gastrointestinal haemorrhage 22.45 16.17 7 22644 147712 79574025
Penile pain 22.29 16.17 9 22642 1002 79720735
Gastric hypomotility 22.26 16.17 6 22645 186 79721551
Infectious mononucleosis 21.95 16.17 11 22640 2031 79719706
Vision blurred 21.84 16.17 73 22578 105825 79615912
Cyanosis 21.63 16.17 31 22620 25151 79696586
Supine hypertension 21.56 16.17 7 22644 417 79721320
Dysphemia 21.47 16.17 13 22638 3471 79718266
Pulmonary embolism 21.41 16.17 11 22640 171643 79550094
Haemoglobin decreased 21.33 16.17 19 22632 222100 79499637
Blood creatinine increased 20.78 16.17 9 22642 155048 79566689
Electrocardiogram ST segment elevation 20.77 16.17 18 22633 8379 79713358
Hallucination 20.32 16.17 62 22589 85683 79636054
Arthritis 20.25 16.17 4 22647 114876 79606861
Rash 20.24 16.17 90 22561 578268 79143469
Withdrawal syndrome 20.11 16.17 31 22620 26823 79694914
Contraindicated product administered 19.79 16.17 10 22641 157528 79564209
Wolff-Parkinson-White syndrome 19.55 16.17 6 22645 297 79721440
Fight in school 19.42 16.17 3 22648 3 79721734
Male genital atrophy 19.42 16.17 3 22648 3 79721734
Prostatic pain 18.82 16.17 4 22647 43 79721694
Sinus arrhythmia 18.75 16.17 10 22641 2100 79719637
Urinary tract infection 18.43 16.17 31 22620 274481 79447256
Priapism 18.42 16.17 13 22638 4492 79717245
Electroencephalogram abnormal 18.42 16.17 14 22637 5420 79716317
Hypokalaemia 18.31 16.17 9 22642 144031 79577706
Chromaturia 18.28 16.17 29 22622 25717 79696020
Streptococcal infection 18.05 16.17 17 22634 8813 79712924
Sexual dysfunction 17.92 16.17 16 22635 7747 79713990
Urethral discharge 17.89 16.17 3 22648 7 79721730
Syncope 17.74 16.17 99 22552 179350 79542387
Pallor 17.72 16.17 42 22609 50020 79671717
Thalassaemia 17.66 16.17 4 22647 59 79721678
Iron metabolism disorder 17.66 16.17 4 22647 59 79721678
Eye movement disorder 17.49 16.17 16 22635 7995 79713742
Growth hormone-producing pituitary tumour 17.29 16.17 4 22647 65 79721672
Peripheral coldness 17.28 16.17 22 22629 15948 79705789
Back pain 17.24 16.17 38 22613 304142 79417595
Semen analysis abnormal 17.10 16.17 3 22648 10 79721727
Hypertensive crisis 17.01 16.17 25 22626 20745 79700992
Dizziness 17.01 16.17 226 22425 526215 79195522
Laryngeal pain 16.96 16.17 14 22637 6100 79715637
Tremor 16.93 16.17 94 22557 169989 79551748
Postictal state 16.92 16.17 9 22642 1880 79719857
Respiratory failure 16.75 16.17 16 22635 180895 79540842
Dehydration 16.68 16.17 28 22623 248159 79473578
Piloerection 16.58 16.17 6 22645 496 79721241
Flat affect 16.26 16.17 9 22642 2032 79719705

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BA09 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Centrally acting sympathomimetics
FDA MoA N0000000102 Norepinephrine Uptake Inhibitors
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
FDA EPC N0000175695 Norepinephrine Reuptake Inhibitor
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Attention deficit hyperactivity disorder indication 406506008
Delay when starting to pass urine contraindication 5972002
Priapism contraindication 6273006 DOID:9286
Suicidal thoughts contraindication 6471006
Sinus tachycardia contraindication 11092001
Bipolar disorder contraindication 13746004 DOID:3312
Hyperbilirubinemia contraindication 14783006 DOID:2741
Myocardial infarction contraindication 22298006 DOID:5844
Feeling agitated contraindication 24199005
Orthostatic hypotension contraindication 28651003
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Feeling irritable contraindication 55929007
Aggressive behavior contraindication 61372001
Cerebrovascular disease contraindication 62914000 DOID:6713
Psychotic disorder contraindication 69322001
Cardiomyopathy contraindication 85898001 DOID:0050700
Structural disorder of heart contraindication 128599005
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Disease of liver contraindication 235856003 DOID:409
Raynaud's phenomenon contraindication 266261006
Retention of urine contraindication 267064002
Pheochromocytoma contraindication 302835009
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009
Myocardial infarction in recovery phase contraindication 418044006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 8.69 CHEMBL CHEMBL
Sodium-dependent serotonin transporter Transporter Kd 8.05 CHEMBL
Sodium-dependent dopamine transporter Transporter Kd 5.97 CHEMBL
Cytochrome P450 2D6 Enzyme Ki 4.77 WOMBAT-PK
G protein-activated inward rectifier potassium channel 2 Ion channel IC50 4.28 WOMBAT-PK
Kir3.1/Kir3.2 Ion channel IC50 4.48 WOMBAT-PK
Kir3.1/Kir3.4 Ion channel IC50 4.85 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.68 CHEMBL
Krueppel-like factor 10 Nuclear other IC50 4 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 7.37 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.85 CHEMBL
Transporter Transporter Ki 9.15 CHEMBL
Transporter Transporter Ki 8.40 CHEMBL

External reference:

IDSource
D02574 KEGG_DRUG
82248-59-7 SECONDARY_CAS_RN
353103 RXNORM
C0076823 UMLSCUI
CHEBI:331697 CHEBI
CHEMBL641 ChEMBL_ID
CHEMBL1702 ChEMBL_ID
DB00289 DRUGBANK_ID
D000069445 MESH_DESCRIPTOR_UI
54841 PUBCHEM_CID
7118 IUPHAR_LIGAND_ID
5354 INN_ID
ASW034S0B8 UNII
17042 MMSL
192105 MMSL
45567 MMSL
d04827 MMSL
407037005 SNOMEDCT_US
407038000 SNOMEDCT_US
412577007 SNOMEDCT_US
4021364 VANDF
4024296 VANDF
009862 NDDF
009863 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3227 CAPSULE 10 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3228 CAPSULE 25 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3229 CAPSULE 40 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3238 CAPSULE 18 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3239 CAPSULE 60 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3250 CAPSULE 80 mg ORAL NDA 38 sections
Strattera HUMAN PRESCRIPTION DRUG LABEL 1 0002-3251 CAPSULE 100 mg ORAL NDA 38 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3542 CAPSULE 10 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3542 CAPSULE 10 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3542 CAPSULE 10 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3543 CAPSULE 18 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3543 CAPSULE 18 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3543 CAPSULE 18 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3544 CAPSULE 25 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3544 CAPSULE 25 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3544 CAPSULE 25 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3545 CAPSULE 40 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3545 CAPSULE 40 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3545 CAPSULE 40 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3546 CAPSULE 60 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3546 CAPSULE 60 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3546 CAPSULE 60 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3547 CAPSULE 80 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3547 CAPSULE 80 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3547 CAPSULE 80 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3548 CAPSULE 100 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3548 CAPSULE 100 mg ORAL ANDA 33 sections
Atomoxetine HUMAN PRESCRIPTION DRUG LABEL 1 0093-3548 CAPSULE 100 mg ORAL ANDA 33 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2260 CAPSULE 10 mg ORAL ANDA 32 sections
Atomoxetine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-2261 CAPSULE 18 mg ORAL ANDA 32 sections