talbutal Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 2556 115-44-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • profundol
  • 5-Allyl-5-sec-butylbarbituric acid
  • lotusate
  • 5-Allyl-5-(1-methylpropyl) barbituric acid
  • talbutal
  • Molecular weight: 224.26
  • Formula: C11H16N2O3
  • CLOGP: 1.63
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -1.96
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
None FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC N05CA07 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Barbiturates, plain

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.79 acidic
pKa2 9.48 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL

External reference:

IDSource
4018243 VUID
N0000146574 NUI
C0301407 UMLSCUI
D06887 KEGG_DRUG
4YIR8202AX UNII
6 INN_ID
001425 NDDF
89810 RXNORM
76190009 SNOMEDCT_US
4018243 VANDF
8275 PUBCHEM_CID
CHEBI:134923 CHEBI
C446080 MESH_SUPPLEMENTAL_RECORD_UI
DB00306 DRUGBANK_ID
CHEMBL1200802 ChEMBL_ID

Pharmaceutical products:

None