sulfathiazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2527 72-14-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfathiazole
  • norsulfasol
  • norsulfazol
  • norsulfazole
  • sulfanilamidothiazole
  • sulfathiazol
  • sulphathiazole
  • thiozamide
  • thiazamide
A sulfathiazole compound that is used as a short-acting anti-infective agent. It is no longer commonly used systemically due to its toxicity, but may still be applied topically in combination with other drugs for the treatment of vaginal and skin infections, and is still used in veterinary medicine.
  • Molecular weight: 255.31
  • Formula: C9H9N3O2S2
  • CLOGP: 0.73
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 85.08
  • ALOGS: -2.44
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 12, 1945 FDA ORTHO MCNEIL PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Swollen joint count increased 93.30 58.22 48 4681 36006 63448287
Rheumatic fever 90.71 58.22 50 4679 43061 63441232
Rheumatoid factor positive 88.82 58.22 63 4666 84343 63399950
Anti-cyclic citrullinated peptide antibody positive 87.48 58.22 71 4658 116141 63368152
Duodenal ulcer perforation 86.97 58.22 63 4666 87146 63397147
Muscle injury 83.50 58.22 55 4674 65290 63419003
Folliculitis 79.83 58.22 55 4674 70262 63414031
Helicobacter infection 79.06 58.22 61 4668 92724 63391569
Irritable bowel syndrome 74.21 58.22 56 4673 82356 63401937
Wound 74.03 58.22 75 4654 163188 63321105
Discomfort 70.66 58.22 74 4655 167300 63316993
Hand deformity 68.20 58.22 71 4658 159386 63324907
Ill-defined disorder 68 58.22 53 4676 81702 63402591
Pemphigus 66.68 58.22 75 4654 183651 63300642
Glossodynia 66.59 58.22 74 4655 178802 63305491
Blood cholesterol increased 65.60 58.22 55 4674 93977 63390316
Impaired healing 63.45 58.22 56 4673 102486 63381807
Blister 63.17 58.22 62 4667 129752 63354541
Pericarditis 62.46 58.22 62 4667 131517 63352776
Hepatic enzyme increased 59.20 58.22 74 4655 202254 63282039
Synovitis 58.94 58.22 71 4658 186847 63297446
Systemic lupus erythematosus 58.89 58.22 75 4654 208843 63275450

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Duodenal ulcer perforation 54.28 50.28 30 2305 66181 79675872

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D06BA02 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
ATC J01EB07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Short-acting sulfonamides
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50502 dihydropteroate synthase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Vulvovaginitis indication 53277000 DOID:2273
Gardnerella Vaginalis Bacterial Vaginosis indication
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Breastfeeding (mother) contraindication 413712001
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.16 acidic
pKa2 2.48 Basic
pKa3 1.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Endothelin-1 receptor GPCR IC50 4.16 WOMBAT-PK
Dihydropteroate synthase Enzyme INHIBITOR IC50 5.60 CHEMBL CHEMBL
Endothelin-1 receptor GPCR IC50 4.16 CHEMBL
Transcriptional activator protein LasR Unclassified IC50 5.05 CHEMBL

External reference:

IDSource
4018558 VUID
N0000178992 NUI
D01047 KEGG_DRUG
4018558 VANDF
C0038722 UMLSCUI
CHEBI:9337 CHEBI
YTZ PDB_CHEM_ID
CHEMBL437 ChEMBL_ID
DB06147 DRUGBANK_ID
D000077589 MESH_DESCRIPTOR_UI
5340 PUBCHEM_CID
12699 IUPHAR_LIGAND_ID
428 INN_ID
Y7FKS2XWQH UNII
10193 RXNORM
5529 MMSL
002815 NDDF
16867004 SNOMEDCT_US
387093005 SNOMEDCT_US

Pharmaceutical products:

None