sulfaphenazole indications/contra

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2523 526-08-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfaphenazole
  • sulfabid
  • sulfaphenazol
  • sulfaphenazon
  • sulfaphenylpyrazole
  • sulphaphenazole
  • sulfafenazol
A sulfonilamide anti-infective agent.
  • Molecular weight: 314.36
  • Formula: C15H14N4O2S
  • CLOGP: 2.07
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 90.01
  • ALOGS: -3.05
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 g O

Approvals:

DateAgencyCompanyOrphan
April 2, 1974 FDA PURDUE FREDERICK

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01ED08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
ATC S01AB05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Sulfonamides
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.61 acidic
pKa2 1.87 Basic
pKa3 0.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 6.70 DRUG MATRIX
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
D01954 KEGG_DRUG
0J8L4V3F81 UNII
912 INN_ID
N0000166866 NDFRT
51569009 SNOMEDCT_US
002828 NDDF
CHEMBL1109 ChEMBL_ID
5335 PUBCHEM_CID
DB06729 DRUGBANK_ID
D013426 MESH_DESCRIPTOR_UI
CHEBI:77780 CHEBI

Pharmaceutical products:

None