All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

sulfanilamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anti-infectives, sulfonamides	2521	63-74-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: sulfanilamide 4-Aminobenzene-1-sulfonamide 4-Aminobenzenesulfonamide sulfamidyl sulfamine sulfana sulfanalone sulfanidyl sulfonamide sulfonylamide sulphanilamide sulphonamide	Sulfanilamide has been a useful ingredient of vaginal formulations for about four decades. It blocks certain metabolic processes essential for the growth of susceptible bacteria. Molecular weight: 172.20 Formula: C6H8N2O2S CLOGP: -0.57 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 86.18 ALOGS: -1.22 ROTB: 1 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
June 5, 1965	FDA	MEDA PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	108.84	83.17	30	46	310657	63178289

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	96.76	81.46	21	11	298895	79445461

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D06BA05	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides
ATC	J01EB06	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
CHEBI has role	CHEBI:23018	EC 4.2.1.1 inhibitor
CHEBI has role	CHEBI:33282	bactericides
CHEBI has role	CHEBI:88188	allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Vulvovaginitis	indication	53277000	DOID:2273
Candidal vulvovaginitis	indication	72605008	DOID:2272
Kidney disease	contraindication	90708001	DOID:557
Anemia due to enzyme deficiency	contraindication	111577008
Deficiency of glucose-6-phosphate dehydrogenase	contraindication	124134002	DOID:2862
Disease of blood AND/OR blood-forming organ	contraindication	191124002	DOID:74
Disease of liver	contraindication	235856003	DOID:409
Porphyria	contraindication	418470004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.33	acidic
pKa2	2.14	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN		Ki	6.52		CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	5.52		CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN		Ki	6.62		CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN		Ki	7.43		CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN		Ki	4.49		CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN		Ki	5.44		CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN		Ki	7.15		CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN		Ki	6.01		CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN		Ki	6.03		CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN		Ki	5.27		CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN		Ki	7.49		CHEMBL
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		Ki	6.62		CHEMBL
Protein argonaute-2	Unclassified	Q9UKV8	AGO2_HUMAN		Kd	4.77		CHEMBL
Dihydropteroate synthase	Enzyme		DHPS_ECOLI	INHIBITOR				CHEMBL	CHEMBL
Carbonic anhydrase	Enzyme		CYNT_HELPY		Ki	6.37		CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		Ki	7.49		CHEMBL
Carbonic anhydrase 4	Enzyme		CAH4_BOVIN		Ki	5.52		CHEMBL
Carbonic anhydrase	Enzyme		CAH_METTE		Ki	6.60		CHEMBL
Carbonic anhydrase	Enzyme		Q50565_METTH		Ki	4.24		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	5.02		CHEMBL
Carbonic anhydrase	Enzyme		CAN_YEAST		Ki	4.73		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	6.62		CHEMBL
Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase	Enzyme		P96878_MYCTU		Ki	5.20		CHEMBL
Carbonic anhydrase	Enzyme		Q6FTL6_CANGA		Ki	5.10		CHEMBL
Alpha carbonic anhydrase	Enzyme		B5SU02_9CNID		Ki	6.44		CHEMBL
Carbonic anhydrase	Enzyme		C0IX24_9CNID		Ki	6.52		CHEMBL
Carbonic anhydrase 2	Enzyme		Q3I4V7_CRYNV		Ki	6.11		CHEMBL
Astrosclerin-3	Enzyme		A6YCJ1_9METZ		Ki	5.11		CHEMBL
Beta-carbonic anhydrase 1	Enzyme		MTCA1_MYCTU		Ki	5.03		CHEMBL
Delta carbonic anhydrase	Unclassified		Q5U9J1_THAWE		Ki	6.74		CHEMBL
Carbonic anhydrase 2	Enzyme		MTCA2_MYCTU		Ki	4.53		CHEMBL
Carbonic anhydrase 2	Enzyme		CAH2_BOVIN		Ki	6.07		CHEMBL
Carbonic anhydrase	Enzyme		Q5TU56_ANOGA		Ki	6.06		CHEMBL
Carbonic anhydrase, alpha family	Unclassified		Q31FD6_HYDCU		Ki	6.20		CHEMBL
Carbonate dehydratase	Enzyme		B2V8E3_SULSY		Ki	6.19		CHEMBL

External reference:

ID	Source
4018615	VUID
N0000146928	NUI
D08543	KEGG_DRUG
4018615	VANDF
C0038702	UMLSCUI
CHEBI:45373	CHEBI
SAN	PDB_CHEM_ID
CHEMBL21	ChEMBL_ID
DB00259	DRUGBANK_ID
D000077145	MESH_DESCRIPTOR_UI
5333	PUBCHEM_CID
426	INN_ID
12631	IUPHAR_LIGAND_ID
21240MF57M	UNII
10184	RXNORM
2053	MMSL
5527	MMSL
002833	NDDF
386569003	SNOMEDCT_US
387406002	SNOMEDCT_US
56436005	SNOMEDCT_US
763875007	SNOMEDCT_US

Pharmaceutical products:

None