asulacrine indications/contra

Stem definitionDrug idCAS RN
acridine derivatives 252 80841-47-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • asulacrine
  • amsalog
derivative of amsacrine; structure given in first source
  • Molecular weight: 464.54
  • Formula: C24H24N4O4S
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 109.42
  • ALOGS: -5.06
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.86 acidic
pKa2 11.92 acidic
pKa3 7.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme WOMBAT-PK

External reference:

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IDSource
CHEMBL48880 ChEMBL_ID
107924 PUBCHEM_CID
S8P50T62B6 UNII
C042315 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135753 CHEBI

Pharmaceutical products:

None