asulacrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
acridine derivatives 252 80841-47-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • asulacrine
  • amsalog
derivative of amsacrine; structure given in first source
  • Molecular weight: 464.54
  • Formula: C24H24N4O4S
  • CLOGP: 4.37
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 109.42
  • ALOGS: -5.06
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 34 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK9,CSF1R,DDR1,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,MAP3K1,MAP3K11,MAP3K21,MAP4K1,MAP4K3,MAPK10,MAPK7,MARK4,MET,PDK1,PDK2,PDK4,PIK3CA,PIK3CD,PIK3CG,PRKCD,PRKDC,SIK2,SIK3,STK33,TTK,ULK1 40
kinase-selectivity-class AAK1,ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK9,CHEK1,CSF1R,DDR1,DYRK1A,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,JAK1,LRRK2,MAP2K3,MAP2K6,MAP3K10,MAP3K11,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK7,MAPK8,MARK4,MINK1,NTRK1,PDK4,PIK3CD,PIM3,PRKCD,SIK2,SIK3,STK33,SYK,TEK,TNK1,TTK,ULK1,ULK2 48
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.86 acidic
pKa2 11.92 acidic
pKa3 7.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme WOMBAT-PK

External reference:

IDSource
C0130561 UMLSCUI
CHEBI:135753 CHEBI
CHEMBL48880 ChEMBL_ID
C042315 MESH_SUPPLEMENTAL_RECORD_UI
S8P50T62B6 UNII
107924 PUBCHEM_CID

Pharmaceutical products:

None