sulfalene Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2517 152-47-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulphamethopyrazine
  • sulfamethopyrazine
  • sulfamethoxypyrazine
  • sulfametopyrazine
  • sulfapyrazinemethoxine
  • sulfapyrazinemethoxyine
  • sulfapyrazinemethoxyne
  • sulfalene
Long-acting plasma-bound sulfonamide used for respiratory and urinary tract infections and also for malaria.
  • Molecular weight: 280.30
  • Formula: C11H12N4O3S
  • CLOGP: 1.05
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 107.20
  • ALOGS: -2.84
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
ATC P01BF04 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.4 acidic
pKa2 2.39 Basic
pKa3 1.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
N0000166861 NUI
C0038683 UMLSCUI
D01216 KEGG_DRUG
324407006 SNOMEDCT_US
10175 RXNORM
004041 NDDF
395890008 SNOMEDCT_US
CHEBI:32162 CHEBI
DB00664 DRUGBANK_ID
T6BL4ZC15G UNII
1209 INN_ID
9047 PUBCHEM_CID
CHEMBL1525826 ChEMBL_ID
D013415 MESH_DESCRIPTOR_UI
10174 IUPHAR_LIGAND_ID

Pharmaceutical products:

None