sulfamethoxazole ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2514 723-46-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethoxazole
  • sulfamethalazole
  • sulfamethoxazol
  • sulfisomezole
  • sulphamethoxazole
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
  • Molecular weight: 253.28
  • Formula: C10H11N3O3S
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 98.22
  • ALOGS: -2.74
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.50 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 14 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 394.82 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 30, 1973 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sleep disorder due to general medical condition, insomnia type 1387.22 12.91 866 84122 51351 63352683
Folliculitis 1374.95 12.91 963 84025 69354 63334680
Muscle injury 1364.81 12.91 932 84056 64413 63339621
Irritable bowel syndrome 1218.58 12.91 954 84034 81458 63322576
Impaired healing 1028.99 12.91 950 84038 101592 63302442
Gastrointestinal disorder 941.61 12.91 1013 83975 130226 63273808
Blister 903.28 12.91 986 84002 128828 63275206
Stomatitis 861.41 12.91 993 83995 137732 63266302
Lower respiratory tract infection 839.90 12.91 958 84030 131349 63272685
Duodenal ulcer perforation 740.04 12.91 737 84251 86472 63317562
Ill-defined disorder 719.83 12.91 705 84283 81050 63322984
Helicobacter infection 687.51 12.91 729 84259 92056 63311978
Infection 576.97 12.91 1070 83918 228103 63175931
Therapeutic product effect decreased 547.54 12.91 950 84038 192237 63211797
Confusional state 542.39 12.91 1061 83927 235319 63168715
Sinusitis 501.37 12.91 1002 83986 225651 63178383
Pericarditis 487.29 12.91 731 84257 130848 63273186
Anti-cyclic citrullinated peptide antibody positive 486.15 12.91 684 84304 115528 63288506
Contusion 423.66 12.91 737 84251 149307 63254727
Weight increased 407.19 12.91 1003 83985 259789 63144245
Nasopharyngitis 401.32 12.91 982 84006 253275 63150759
Pyrexia 392.14 12.91 1449 83539 469029 62935005
Peripheral swelling 387.13 12.91 996 83992 264946 63139088
Hand deformity 376.50 12.91 725 84263 158732 63245302
Discomfort 374.57 12.91 744 84244 166630 63237404
Synovitis 370.22 12.91 790 84198 186128 63217906
Hypersensitivity 366.62 12.91 1037 83951 291648 63112386
Swelling 357.96 12.91 989 83999 274389 63129645
Hepatic enzyme increased 304.76 12.91 768 84220 201560 63202474
Arthropathy 304.68 12.91 843 84145 233949 63170085
Pemphigus 302.83 12.91 722 84266 183004 63221030
Glossodynia 300.29 12.91 708 84280 178168 63225866
Wound 293.61 12.91 664 84324 162599 63241435
Pruritus 280.46 12.91 1089 83899 360364 63043670
Joint swelling 278.88 12.91 1017 83971 326649 63077385
Systemic lupus erythematosus 259.03 12.91 738 84250 208180 63195854
Infusion related reaction 247.94 12.91 807 84181 244714 63159320
Fall 245.82 12.91 109 84879 392225 63011809
Product dose omission issue 216.09 12.91 29 84959 234284 63169750
Death 203.42 12.91 125 84863 374256 63029778
Toxicity to various agents 167.24 12.91 61 84927 247189 63156845
Abdominal discomfort 164.87 12.91 856 84132 320029 63084005
Contraindicated product administered 163.70 12.91 650 84338 216998 63187036
Drug intolerance 161.07 12.91 827 84161 307834 63096200
Nausea 150.76 12.91 612 84376 853859 62550175
Completed suicide 146.99 12.91 13 84975 145660 63258374
Rheumatoid arthritis 140.02 12.91 691 84297 253128 63150906
Rash 138.45 12.91 1248 83740 559623 62844411
Pain in extremity 133.75 12.91 148 84840 331338 63072696
Headache 128.23 12.91 428 84560 632813 62771221
Medication error 125.91 12.91 240 84748 52044 63351990
Cough 123.32 12.91 126 84862 292617 63111417
Injection site pain 122.16 12.91 15 84973 129785 63274249
Off label use 120.03 12.91 481 84507 673981 62730053
Dizziness 118.53 12.91 249 84739 429676 62974358
Deep vein thrombosis postoperative 111.14 12.91 104 84884 11265 63392769
Blood pressure increased 106.16 12.91 42 84946 162020 63242014
Malaise 103.20 12.91 255 84733 415699 62988335
Diarrhoea 101.94 12.91 553 84435 714813 62689221
Alopecia 99.44 12.91 782 84206 336754 63067280
Autoimmune disorder 93.16 12.91 115 84873 17062 63386972
COVID-19 91.02 12.91 20 84968 113083 63290951
Feeling abnormal 89.98 12.91 43 84945 148349 63255685
Pre-engraftment immune reaction 88.77 12.91 26 84962 212 63403822
Pneumonia 87.37 12.91 316 84672 456451 62947583
Intentional overdose 85.82 12.91 3 84985 74149 63329885
Constipation 77.57 12.91 113 84875 224830 63179204
Maternal exposure timing unspecified 75.44 12.91 68 84920 7019 63397015
Back pain 75.21 12.91 150 84838 263995 63140039
Psoriasis 74.97 12.91 13 84975 86944 63317090
Pregnancy 71.90 12.91 155 84833 36681 63367353
Drug abuse 71.72 12.91 7 84981 72511 63331523
Injection site erythema 70.48 12.91 13 84975 83161 63320873
Arthralgia 70.36 12.91 1111 83877 568599 62835435
Inappropriate schedule of product administration 69.63 12.91 26 84962 103939 63300095
Alanine aminotransferase abnormal 63.94 12.91 51 84937 4453 63399581
Injection site reaction 62.48 12.91 4 84984 58520 63345514
Injury 61.71 12.91 227 84761 73020 63331014
Therapy non-responder 60.43 12.91 231 84757 75670 63328364
Balance disorder 60.18 12.91 19 84969 84403 63319631
Urinary tract infection 59.67 12.91 170 84818 264514 63139520
Maternal exposure during pregnancy 59.36 12.91 500 84488 219562 63184472
Influenza 59.32 12.91 36 84952 108686 63295348
Hyperhidrosis 58.43 12.91 36 84952 107800 63296234
Myocardial infarction 57.47 12.91 31 84957 99862 63304172
Suicide attempt 57.39 12.91 7 84981 60911 63343123
Encephalitis viral 56.96 12.91 33 84955 1699 63402335
Wrong technique in product usage process 56.73 12.91 8 84980 62332 63341702
Oropharyngeal pain 56.32 12.91 28 84960 94459 63309575
C-reactive protein 56.26 12.91 49 84939 4833 63399201
Syncope 55.94 12.91 45 84943 117340 63286694
Dyspnoea 55.92 12.91 1216 83772 660097 62743937
Adjustment disorder with depressed mood 53.22 12.91 67 84921 10137 63393897
Deafness transitory 53.03 12.91 33 84955 1937 63402097
Red blood cell sedimentation rate 52.51 12.91 47 84941 4807 63399227
Cerebrovascular accident 51.99 12.91 41 84947 107983 63296051
Loss of consciousness 50.62 12.91 50 84938 118071 63285963
Lip dry 50.21 12.91 81 84907 15389 63388645
Stress 48.08 12.91 15 84973 67152 63336882
Hypotension 47.89 12.91 195 84793 272409 63131625
Illness 47.82 12.91 5 84983 49054 63354980
Human herpesvirus 6 infection 47.44 12.91 36 84952 2921 63401113
Vomiting 45.73 12.91 504 84484 559113 62844921
Suicidal ideation 44.58 12.91 14 84974 62407 63341627
Injection site bruising 44.33 12.91 3 84985 41907 63362127
Fear of injection 43.83 12.91 51 84937 7113 63396921
Atrial fibrillation 43.81 12.91 55 84933 116581 63287453
Injection site swelling 43.53 12.91 6 84982 47566 63356468
Fluid retention 43.32 12.91 13 84975 59673 63344361
Chest discomfort 43.27 12.91 50 84938 109919 63294115
Nasal congestion 42.99 12.91 17 84971 65643 63338391
Myalgia 42.71 12.91 82 84906 146447 63257587
Cataract 42.19 12.91 12 84976 57041 63346993
Flushing 42.17 12.91 24 84964 75063 63328971
Palpitations 41.50 12.91 54 84934 112716 63291318
Tongue disorder 40.80 12.91 60 84928 10520 63393514
Muscle spasms 40.79 12.91 93 84895 156057 63247977
Visual impairment 40.70 12.91 32 84956 84414 63319620
Neck pain 40.62 12.91 21 84967 69297 63334737
Breast cancer 40.06 12.91 8 84980 48375 63355659
Rhinorrhoea 39.73 12.91 19 84969 65558 63338476
Condition aggravated 39.19 12.91 347 84641 401870 63002164
Bronchitis 39.01 12.91 67 84921 124868 63279166
Injection site pruritus 38.33 12.91 7 84981 45109 63358925
Weight decreased 38.11 12.91 216 84772 276582 63127452
C-reactive protein abnormal 38.09 12.91 142 84846 45954 63358080
Enthesopathy 37.86 12.91 52 84936 8562 63395472
Blood pressure fluctuation 37.64 12.91 8 84980 46309 63357725
Hot flush 37.39 12.91 11 84977 51148 63352886
Dysphonia 37.14 12.91 9 84979 47605 63356429
Incorrect dose administered 36.91 12.91 17 84971 59951 63344083
Drug interaction 36.51 12.91 170 84818 228961 63175073
Therapeutic product effect incomplete 36.43 12.91 70 84918 124986 63279048
Multiple sclerosis relapse 36.21 12.91 10 84978 48468 63355566
Cardiac failure congestive 35.32 12.91 43 84945 92390 63311644
Sleep disorder 35.30 12.91 208 84780 81358 63322676
Cardiac disorder 35.22 12.91 12 84976 50804 63353230
Oxygen saturation decreased 35.15 12.91 40 84948 88545 63315489
Haematochezia 34.83 12.91 14 84974 53530 63350504
Heart rate increased 34.80 12.91 45 84943 94193 63309841
Depressed mood 34.65 12.91 6 84982 40185 63363849
Abdominal distension 34.49 12.91 39 84949 86576 63317458
Asthenia 34.33 12.91 338 84650 383266 63020768
Osteoporosis 34.15 12.91 17 84971 57321 63346713
Unevaluable event 34.15 12.91 13 84975 51373 63352661
Tenosynovitis 34.03 12.91 64 84924 13731 63390303
Influenza like illness 33.90 12.91 24 84964 66800 63337234
Overdose 33.88 12.91 64 84924 115014 63289020
Throat irritation 33.86 12.91 5 84983 37642 63366392
Gait disturbance 33.43 12.91 129 84859 183049 63220985
Disease progression 32.96 12.91 72 84916 122686 63281348
Depression 32.36 12.91 144 84844 196348 63207686
Femur fracture 32.36 12.91 8 84980 41748 63362286
No adverse event 31.95 12.91 8 84980 41397 63362637
Cytomegalovirus infection 31.92 12.91 80 84908 20872 63383162
Full blood count abnormal 31.52 12.91 3 84985 31714 63372320
Blood parathyroid hormone decreased 31.41 12.91 51 84937 9740 63394294
Bradycardia 31.36 12.91 31 84957 73196 63330838
Lower limb fracture 31.31 12.91 87 84901 24134 63379900
X-ray abnormal 31.28 12.91 46 84942 8064 63395970
Adverse event 31.00 12.91 175 84813 67384 63336650
Dry skin 30.79 12.91 19 84969 56868 63347166
Kidney transplant rejection 30.57 12.91 33 84955 4238 63399796
Hypertension 29.87 12.91 235 84753 279068 63124966
Cognitive disorder 29.72 12.91 19 84969 55796 63348238
Dislocation of vertebra 29.10 12.91 46 84942 8589 63395445
Sedation 29.00 12.91 8 84980 38801 63365233
Functional gastrointestinal disorder 28.91 12.91 32 84956 4227 63399807
Herpes zoster 28.81 12.91 41 84947 82421 63321613
Granuloma 28.74 12.91 37 84951 5724 63398310
Cardio-respiratory arrest 28.54 12.91 23 84965 59936 63344098
Device expulsion 28.44 12.91 6 84982 34916 63369118
Vision blurred 28.05 12.91 50 84938 91874 63312160
Road traffic accident 27.93 12.91 110 84878 36522 63367512
Hypokalaemia 27.77 12.91 61 84927 103743 63300291
Dysgeusia 27.59 12.91 14 84974 46696 63357338
Chronic obstructive pulmonary disease 27.47 12.91 26 84962 62660 63341374
Abdominal pain 27.32 12.91 256 84732 293200 63110834
Pain in jaw 27.29 12.91 12 84976 43484 63360550
Nephrolithiasis 27.27 12.91 11 84977 41973 63362061
Panniculitis 27.07 12.91 52 84936 11333 63392701
Foetal exposure during pregnancy 27.06 12.91 5 84983 31957 63372077
Blood glucose increased 26.99 12.91 44 84944 83712 63320322
Limb discomfort 26.60 12.91 4 84984 29712 63374322
Skin necrosis 26.42 12.91 58 84930 13892 63390142
Hypothyroidism 26.37 12.91 12 84976 42620 63361414
Intentional product misuse 25.84 12.91 26 84962 60891 63343143
Surgery 25.74 12.91 8 84980 35904 63368130
Drug ineffective for unapproved indication 25.49 12.91 7 84981 34056 63369978
Vertigo 24.91 12.91 26 84962 59861 63344173
Neuropathy peripheral 24.85 12.91 74 84914 113593 63290441
Product prescribing error 24.81 12.91 3 84985 26286 63377748
Anxiety 24.69 12.91 180 84808 217361 63186673
Paraesthesia 24.67 12.91 117 84871 156849 63247185
Meningoencephalitis herpetic 24.41 12.91 17 84971 1207 63402827
Abnormal loss of weight 24.06 12.91 34 84954 5748 63398286
Intestinal obstruction 23.79 12.91 6 84982 30893 63373141
Erythema 23.70 12.91 138 84850 175613 63228421
Epistaxis 23.62 12.91 38 84950 72687 63331347
Facet joint syndrome 23.59 12.91 51 84937 12087 63391947
Hospitalisation 23.59 12.91 49 84939 85032 63319002
Tremor 23.56 12.91 94 84894 132145 63271889
Rheumatoid nodule 23.55 12.91 63 84925 17092 63386942
Breast cancer stage II 23.40 12.91 42 84946 8694 63395340
Arrhythmia 23.18 12.91 11 84977 38129 63365905
Tachycardia 23.00 12.91 81 84907 118075 63285959
Anaphylactic reaction 22.95 12.91 33 84955 66067 63337967
Drug dependence 22.61 12.91 3 84985 24480 63379554
Malignant neoplasm progression 22.18 12.91 48 84940 82073 63321961
Dysphagia 22.13 12.91 54 84934 88531 63315503
Anaphylactic shock 21.57 12.91 3 84985 23630 63380404
Serotonin syndrome 21.26 12.91 6 84982 28676 63375358
Swollen tongue 21.21 12.91 10 84978 34790 63369244
Renal impairment 21.19 12.91 55 84933 88300 63315734
Wound infection 21.18 12.91 70 84918 21340 63382694
Complications of transplanted kidney 21.02 12.91 21 84967 2465 63401569
Oral pain 20.94 12.91 6 84982 28388 63375646
Product quality issue 20.81 12.91 11 84977 35854 63368180
Blood calcium decreased 20.63 12.91 5 84983 26446 63377588
Tinnitus 20.57 12.91 11 84977 35617 63368417
Sinus disorder 20.45 12.91 4 84984 24549 63379485
Osteonecrosis of jaw 20.05 12.91 11 84977 35112 63368922
Musculoskeletal disorder 19.98 12.91 67 84921 20577 63383457
Gastrointestinal haemorrhage 19.87 12.91 50 84938 81126 63322908
Heart rate decreased 19.84 12.91 19 84969 45541 63358493
Depressed level of consciousness 19.64 12.91 33 84955 62045 63341989
Flatulence 19.61 12.91 11 84977 34691 63369343
Anaemia 19.48 12.91 276 84712 293154 63110880
Angina pectoris 19.34 12.91 8 84980 30070 63373964
HIV infection 19.28 12.91 10 84978 413 63403621
Disturbance in attention 19.00 12.91 14 84974 38175 63365859
Cardiac arrest 18.99 12.91 62 84926 92483 63311551
Dry eye 18.94 12.91 16 84972 40745 63363289
Tooth disorder 18.91 12.91 7 84981 28150 63375884
Cardiac failure 18.79 12.91 59 84929 89083 63314951
Somnolence 18.78 12.91 151 84837 178534 63225500
Seasonal allergy 18.34 12.91 3 84985 20947 63383087
Dyspnoea exertional 18.22 12.91 33 84955 60269 63343765
Granuloma skin 18.20 12.91 37 84951 8400 63395634
Chills 18.11 12.91 84 84904 113294 63290740
Febrile bone marrow aplasia 18.09 12.91 34 84954 7291 63396743
Burning sensation 18.08 12.91 28 84960 54379 63349655
Migraine 18.07 12.91 74 84914 103272 63300762
Drug hypersensitivity 18.07 12.91 544 84444 310143 63093891
Hypoglycaemia 18.03 12.91 33 84955 60032 63344002
Urticaria 18.00 12.91 317 84671 165485 63238549
Device dislocation 17.94 12.91 6 84982 25699 63378335
Localised infection 17.92 12.91 9 84979 30201 63373833
Productive cough 17.86 12.91 36 84952 63172 63340862
Diabetic ketoacidosis 17.81 12.91 3 84985 20502 63383532
Liver disorder 17.77 12.91 128 84860 53559 63350475
Acquired immunodeficiency syndrome 17.64 12.91 6 84982 83 63403951
Cystitis 17.61 12.91 29 84959 54962 63349072
Electrocardiogram QT prolonged 17.61 12.91 33 84955 59497 63344537
Immunodeficiency 17.51 12.91 3 84985 20251 63383783
Intervertebral disc protrusion 17.50 12.91 5 84983 23704 63380330
Anti-cyclic citrullinated peptide antibody 17.48 12.91 32 84956 6726 63397308
Drug ineffective 17.31 12.91 1186 83802 1043579 62360455
Withdrawal syndrome 17.21 12.91 3 84985 19994 63384040
Hip fracture 17.16 12.91 9 84979 29465 63374569
Haemorrhage 17.04 12.91 35 84953 60987 63343047
Sleep apnoea syndrome 16.81 12.91 9 84979 29124 63374910
Blood pressure decreased 16.74 12.91 39 84949 64983 63339051
Rheumatoid lung 16.57 12.91 23 84965 3825 63400209
Mouth ulceration 16.53 12.91 12 84976 32972 63371062
Drug withdrawal syndrome 16.29 12.91 8 84980 27186 63376848
Grip strength decreased 16.25 12.91 66 84922 22221 63381813
Rheumatic fever 16.17 12.91 106 84882 43005 63361029
Product administration error 16.03 12.91 5 84983 22392 63381642
Obstructive airways disorder 15.97 12.91 4 84984 20695 63383339
Tendonitis 15.85 12.91 60 84928 19555 63384479
Orthostatic hypotension 15.84 12.91 15 84973 36145 63367889
Metastases to liver 15.67 12.91 6 84982 23633 63380401
Peripheral venous disease 15.67 12.91 51 84937 15426 63388608
Bone pain 15.54 12.91 31 84957 54610 63349424
Diverticulitis 15.54 12.91 18 84970 39539 63364495
Joint stiffness 15.45 12.91 20 84968 41849 63362185
Swollen joint count increased 14.99 12.91 91 84897 35963 63368071
Chemotherapeutic drug level increased 14.94 12.91 6 84982 135 63403899
Hallucination 14.83 12.91 32 84956 54785 63349249
Upper respiratory tract infection 14.81 12.91 58 84930 81989 63322045
Ischaemic stroke 14.80 12.91 3 84985 17954 63386080
Pulmonary arterial hypertension 14.53 12.91 6 84982 22571 63381463
Limb injury 14.51 12.91 8 84980 25469 63378565
Metastases to bone 14.50 12.91 5 84983 21014 63383020
Stevens-Johnson syndrome 14.47 12.91 69 84919 24881 63379153
Speech disorder 14.39 12.91 20 84968 40609 63363425
Exposure during pregnancy 14.32 12.91 136 84852 155411 63248623
Pneumonia aspiration 14.24 12.91 87 84901 34453 63369581
Joint range of motion decreased 14.22 12.91 83 84905 32345 63371689
Foot deformity 14.13 12.91 10 84978 27843 63376191
Aphasia 14.09 12.91 14 84974 32986 63371048
Haematemesis 14.06 12.91 12 84976 30400 63373634
Melaena 14.01 12.91 12 84976 30353 63373681
Upper limb fracture 14.00 12.91 4 84984 18964 63385070
Seizure 13.97 12.91 112 84876 132522 63271512
Swollen joint count 13.86 12.91 12 84976 1174 63402860
Angioedema 13.83 12.91 27 84961 47938 63356096
Therapeutic response unexpected 13.77 12.91 4 84984 18755 63385279
Trimethylaminuria 13.76 12.91 6 84982 167 63403867
Drug eruption 13.61 12.91 75 84913 28619 63375415
Infusion site pain 13.53 12.91 3 84985 16866 63387168
Eczema 13.45 12.91 14 84974 32277 63371757
Pulmonary hypertension 13.42 12.91 18 84970 37105 63366929
Nervousness 13.39 12.91 13 84975 30966 63373068
Psychotic disorder 13.35 12.91 9 84979 25703 63378331
Acute myocardial infarction 13.30 12.91 14 84974 32110 63371924
Dysarthria 13.24 12.91 23 84965 42688 63361346
Bacterial sepsis 13.22 12.91 21 84967 3937 63400097
Respiratory tract infection 13.17 12.91 22 84966 41461 63362573
Feeling hot 13.13 12.91 30 84958 50324 63353710
Blood pressure diastolic decreased 13.12 12.91 7 84981 22699 63381335
Eye disorder 13.10 12.91 7 84981 22678 63381356
Gait inability 13.03 12.91 118 84870 52841 63351193
Renal tubular disorder 13.03 12.91 17 84971 2665 63401369
Hypersomnia 12.98 12.91 4 84984 18051 63385983
Cytomegalovirus test positive 12.94 12.91 18 84970 3000 63401034
Fracture 12.93 12.91 5 84983 19579 63384455
Hypocalcaemia 12.93 12.91 14 84974 31699 63372335

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pyrexia 153.89 11.55 724 36044 332289 34587874
Drug ineffective 136.18 11.55 169 36599 456582 34463581
Cytomegalovirus infection 107.50 11.55 135 36633 26000 34894163
Off label use 96.35 11.55 185 36583 419339 34500824
Lymphocyte count decreased 91.67 11.55 116 36652 22506 34897657
Immune reconstitution inflammatory syndrome 91.54 11.55 75 36693 8684 34911479
Neutropenia 91.26 11.55 366 36402 156412 34763751
Death 90.96 11.55 176 36592 397873 34522290
Hyperkalaemia 88.39 11.55 213 36555 69176 34850987
Aspartate aminotransferase increased 87.34 11.55 209 36559 67574 34852589
Blood creatinine increased 86.08 11.55 257 36511 94719 34825444
Alanine aminotransferase increased 84.23 11.55 230 36538 80585 34839578
Clear cell renal cell carcinoma 84.09 11.55 35 36733 1112 34919051
Pancytopenia 81.10 11.55 252 36516 94905 34825258
Lymphoproliferative disorder 75.84 11.55 43 36725 2716 34917447
Stevens-Johnson syndrome 74.60 11.55 95 36673 18544 34901619
Transplant rejection 73.30 11.55 71 36697 10240 34909923
Product dose omission issue 62.27 11.55 24 36744 119687 34800476
Kidney transplant rejection 59.74 11.55 55 36713 7442 34912721
Acute kidney injury 54.99 11.55 525 36243 304463 34615700
Tenosynovitis 53.87 11.55 42 36726 4528 34915635
Granuloma skin 52.35 11.55 26 36742 1253 34918910
Tongue disorder 52.22 11.55 44 36724 5295 34914868
Blood urea increased 51.98 11.55 105 36663 30259 34889904
Enthesopathy 51.37 11.55 41 36727 4572 34915591
Red blood cell sedimentation rate 51.16 11.55 25 36743 1163 34919000
Hepatic cytolysis 50.46 11.55 69 36699 14427 34905736
Alanine aminotransferase abnormal 48.68 11.55 40 36728 4648 34915515
Pneumocystis jirovecii pneumonia 47.46 11.55 79 36689 19631 34900532
Panniculitis 46.67 11.55 28 36740 1966 34918197
Renal tubular necrosis 46.28 11.55 69 36699 15611 34904552
Inappropriate schedule of product administration 45.23 11.55 6 36762 62290 34857873
Blood parathyroid hormone decreased 43.22 11.55 24 36744 1456 34918707
Cytomegalovirus viraemia 41.61 11.55 45 36723 7385 34912778
Pre-engraftment immune reaction 40.37 11.55 11 36757 88 34920075
Hospitalisation 40.09 11.55 6 36762 56896 34863267
Agranulocytosis 39.14 11.55 81 36687 23740 34896423
Blood lactate dehydrogenase increased 38.75 11.55 79 36689 22911 34897252
Fall 38.54 11.55 99 36669 202786 34717377
Leukopenia 37.47 11.55 148 36620 62708 34857455
Tendonitis 37.22 11.55 47 36721 9093 34911070
Rash 35.95 11.55 375 36393 222377 34697786
Cholestasis 35.64 11.55 84 36684 26864 34893299
Toxicity to various agents 35.62 11.55 101 36667 200261 34719902
Thrombocytopenia 35.34 11.55 283 36485 155964 34764199
Anal inflammation 35.03 11.55 20 36748 1280 34918883
Blood bilirubin increased 34.98 11.55 104 36664 38192 34881971
Haemodialysis 34.98 11.55 49 36719 10477 34909686
Platelet count decreased 34.63 11.55 230 36538 119487 34800676
Cellulitis enterococcal 34.45 11.55 10 36758 103 34920060
Aplasia pure red cell 34.10 11.55 37 36731 6095 34914068
Rash maculo-papular 33.70 11.55 85 36683 28366 34891797
Haemoglobin decreased 32.53 11.55 228 36540 120544 34799619
Hepatitis 32.15 11.55 75 36693 23829 34896334
Plasma cell myeloma 31.83 11.55 107 36661 41930 34878233
White blood cell count decreased 31.71 11.55 190 36578 95255 34824908
SARS-CoV-2 test negative 31.05 11.55 17 36751 1003 34919160
Incision site pain 31.03 11.55 21 36747 1817 34918346
Liver transplant rejection 30.61 11.55 22 36746 2097 34918066
Rheumatoid nodule 30.30 11.55 25 36743 2922 34917241
Foetal exposure during pregnancy 29.32 11.55 3 36765 38098 34882065
Sphincter of Oddi dysfunction 28.42 11.55 9 36759 127 34920036
Encephalitis viral 28.32 11.55 17 36751 1195 34918968
C-reactive protein abnormal 28.13 11.55 40 36728 8670 34911493
C-reactive protein increased 28.01 11.55 122 36646 53976 34866187
Toxic skin eruption 27.90 11.55 46 36722 11339 34908824
Osteoporotic fracture 27.26 11.55 16 36752 1079 34919084
HIV infection 26.76 11.55 17 36751 1322 34918841
Red blood cells urine positive 26.63 11.55 19 36749 1790 34918373
Blood antidiuretic hormone increased 26.50 11.55 7 36761 49 34920114
Intentional product use issue 26.44 11.55 15 36753 59801 34860362
Rash pruritic 26.37 11.55 75 36693 26866 34893297
Product use issue 26.34 11.55 17 36751 63199 34856964
Weight increased 25.91 11.55 36 36732 92997 34827166
Intentional overdose 25.79 11.55 7 36761 43667 34876496
Dialysis 25.75 11.55 44 36724 11164 34908999
Intentional product misuse 25.67 11.55 8 36760 45603 34874560
Acquired immunodeficiency syndrome 25.65 11.55 12 36756 506 34919657
Neutrophil count decreased 25.51 11.55 114 36654 50990 34869173
Delayed graft function 25.29 11.55 20 36748 2201 34917962
Kaposi's sarcoma 24.91 11.55 14 36754 869 34919294
Asthma 24.88 11.55 7 36761 42649 34877514
Hypercalcaemia 24.71 11.55 52 36716 15416 34904747
Cerebrovascular accident 24.44 11.55 32 36736 84779 34835384
Proctalgia 24.21 11.55 30 36738 5693 34914470
Lymphocele 24.10 11.55 16 36752 1341 34918822
Skin necrosis 23.68 11.55 30 36738 5823 34914340
Graft versus host disease 23.64 11.55 41 36727 10528 34909635
Pneumonia cytomegaloviral 23.55 11.55 22 36746 3032 34917131
Aspergillus infection 22.93 11.55 44 36724 12210 34907953
Hepatomegaly 22.82 11.55 40 36728 10356 34909807
Body temperature increased 22.81 11.55 54 36714 17314 34902849
Gamma-glutamyltransferase increased 22.65 11.55 75 36693 29156 34891007
Dizziness 22.60 11.55 136 36632 218385 34701778
Renal failure 22.54 11.55 223 36545 130334 34789829
Blood alkaline phosphatase increased 22.41 11.55 78 36690 31097 34889066
Fatigue 22.38 11.55 266 36502 370387 34549776
Dyspnoea 22.14 11.55 272 36496 376510 34543653
Human herpesvirus 6 infection 22.12 11.55 18 36750 2063 34918100
Hepatitis cholestatic 22.07 11.55 34 36734 7913 34912250
Febrile neutropenia 21.84 11.55 230 36538 136619 34783544
SARS-CoV-2 antibody test positive 21.55 11.55 10 36758 414 34919749
Syncope 21.14 11.55 40 36728 91411 34828752
Parvovirus infection 20.92 11.55 10 36758 443 34919720
Chronic lymphocytic leukaemia 20.89 11.55 24 36744 4208 34915955
Culture urine positive 20.85 11.55 14 36754 1196 34918967
Dermatitis exfoliative 20.72 11.55 30 36738 6609 34913554
Drug reaction with eosinophilia and systemic symptoms 20.69 11.55 79 36689 32933 34887230
Serum sickness 20.63 11.55 17 36751 1983 34918180
Injection site pain 19.96 11.55 8 36760 38997 34881166
Clonal haematopoiesis 19.40 11.55 6 36762 78 34920085
Drug hypersensitivity 19.35 11.55 148 36620 80381 34839782
Biopsy liver abnormal 19.35 11.55 7 36761 151 34920012
Bone marrow failure 19.16 11.55 71 36697 29182 34890981
Cytomegalovirus test positive 19.12 11.55 22 36746 3864 34916299
Tubulointerstitial nephritis 19.10 11.55 57 36711 20967 34899196
Cystitis haemorrhagic 18.22 11.55 26 36742 5653 34914510
Arthralgia 18.00 11.55 105 36663 169936 34750227
Hepatosplenomegaly 17.87 11.55 22 36746 4147 34916016
Chills 17.86 11.55 146 36622 80897 34839266
Rash morbilliform 17.82 11.55 19 36749 3068 34917095
Complications of transplanted kidney 17.66 11.55 23 36745 4586 34915577
Renal tubular disorder 17.53 11.55 23 36745 4620 34915543
Wrong technique in product usage process 17.43 11.55 8 36760 35978 34884185
Drug eruption 17.19 11.55 53 36715 19845 34900318
Proteus infection 17.17 11.55 12 36756 1094 34919069
Somnolence 16.91 11.55 60 36708 111056 34809107
Protein urine present 16.87 11.55 24 36744 5204 34914959
Lung infiltration 16.81 11.55 40 36728 12865 34907298
Synovitis 16.63 11.55 42 36726 14024 34906139
Blood immunoglobulin G decreased 16.20 11.55 13 36755 1460 34918703
Culture stool positive 16.16 11.55 7 36761 246 34919917
COVID-19 16.15 11.55 36 36732 77514 34842649
Thrombotic microangiopathy 16.13 11.55 35 36733 10595 34909568
Enterovirus infection 16.02 11.55 11 36757 975 34919188
Blood pressure increased 15.93 11.55 44 36724 88058 34832105
Suicide attempt 15.64 11.55 11 36757 39105 34881058
Myocardial infarction 15.51 11.55 70 36698 121015 34799148
Blood culture positive 15.50 11.55 22 36746 4761 34915402
Cytomegalovirus chorioretinitis 15.48 11.55 19 36749 3570 34916593
Oesophageal candidiasis 15.41 11.55 21 36747 4375 34915788
Lymphadenopathy 15.35 11.55 65 36703 28398 34891765
Granuloma 15.32 11.55 18 36750 3233 34916930
Blood potassium increased 15.25 11.55 45 36723 16450 34903713
Erythema infectiosum 15.19 11.55 6 36762 166 34919997
Leukaemia recurrent 15.16 11.55 13 36755 1602 34918561
Orbital haemorrhage 14.91 11.55 4 36764 30 34920133
Mental status changes 14.73 11.55 79 36689 38004 34882159
HIV wasting syndrome 14.72 11.55 5 36763 89 34920074
Haemorrhoids 14.67 11.55 41 36727 14534 34905629
Therapeutic product effect incomplete 14.63 11.55 19 36749 50522 34869641
Renal cell carcinoma 14.59 11.55 22 36746 5026 34915137
Bronchopulmonary aspergillosis 14.53 11.55 41 36727 14618 34905545
Blood albumin decreased 14.48 11.55 39 36729 13533 34906630
Phlebitis 14.35 11.55 19 36749 3851 34916312
Feeling abnormal 14.31 11.55 28 36740 63207 34856956
Skin exfoliation 14.29 11.55 62 36706 27370 34892793
Vena cava injury 14.18 11.55 7 36761 333 34919830
Psoriasis 14.14 11.55 12 36756 38800 34881363
Hepatic steatosis 14.12 11.55 47 36721 18315 34901848
Rheumatoid lung 14.11 11.55 10 36758 932 34919231
Lymphocytic infiltration 14.09 11.55 9 36759 706 34919457
Acute graft versus host disease in skin 14.09 11.55 22 36746 5179 34914984
Light chain analysis decreased 14.07 11.55 4 36764 38 34920125
Pneumonia pneumococcal 13.81 11.55 14 36754 2132 34918031
Wound evisceration 13.77 11.55 5 36763 109 34920054
Mycobacterium avium complex infection 13.70 11.55 15 36753 2496 34917667
Liver transplant 13.58 11.55 15 36753 2519 34917644
Contusion 13.55 11.55 11 36757 36353 34883810
Hepatitis A antibody positive 13.38 11.55 4 36764 46 34920117
Ulcer 13.30 11.55 29 36739 8806 34911357
Cytomegalovirus test 13.30 11.55 4 36764 47 34920116
Traumatic liver injury 13.03 11.55 6 36762 244 34919919
Optic neuropathy 12.98 11.55 13 36755 1952 34918211
Stent removal 12.97 11.55 3 36765 11 34920152
Product prescribing error 12.93 11.55 4 36764 22923 34897240
Therapeutic product effect prolonged 12.78 11.55 6 36762 255 34919908
Cystic lymphangioma 12.76 11.55 3 36765 12 34920151
Product use in unapproved indication 12.72 11.55 72 36696 117427 34802736
Blood bilirubin unconjugated increased 12.71 11.55 8 36760 612 34919551
Respiratory failure 12.69 11.55 172 36596 108400 34811763
Hepatitis B antibody positive 12.66 11.55 4 36764 56 34920107
Epstein-Barr virus infection 12.60 11.55 26 36742 7602 34912561
Idiopathic pneumonia syndrome 12.59 11.55 6 36762 264 34919899
Prostate cancer 12.43 11.55 14 36754 39635 34880528
Anaemia 12.36 11.55 327 36441 233008 34687155
Enterococcal infection 12.29 11.55 29 36739 9277 34910886
Granulomatous rosacea 12.25 11.55 5 36763 151 34920012
Autoimmune haemolytic anaemia 12.16 11.55 19 36749 4477 34915686
Hepatitis C virus test 12.05 11.55 4 36764 66 34920097
Blood chloride increased 12.02 11.55 15 36753 2866 34917297
Haematocrit decreased 11.90 11.55 66 36702 32150 34888013
Refusal of treatment by patient 11.88 11.55 20 36748 5012 34915151
Nasopharyngitis 11.87 11.55 36 36732 69932 34850231
Accident 11.84 11.55 20 36748 5027 34915136
Hepatic enzyme increased 11.83 11.55 76 36692 39004 34881159
Epidermal necrosis 11.76 11.55 7 36761 484 34919679
Rectal prolapse 11.75 11.55 7 36761 485 34919678
Immunosuppressant drug level increased 11.64 11.55 22 36746 6033 34914130
Haemoglobinaemia 11.64 11.55 5 36763 172 34919991

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle injury 1147.05 11.58 722 96233 47839 79599594
Folliculitis 1122.74 11.58 748 96207 54632 79592801
Sleep disorder due to general medical condition, insomnia type 1092.90 11.58 673 96282 42883 79604550
Irritable bowel syndrome 1013.90 11.58 735 96220 61506 79585927
Impaired healing 798.75 11.58 738 96217 86917 79560516
Duodenal ulcer perforation 746.20 11.58 629 96326 65582 79581851
Helicobacter infection 702.05 11.58 621 96334 69083 79578350
Gastrointestinal disorder 687.45 11.58 794 96161 121411 79526022
Blister 678.34 11.58 780 96175 118696 79528737
Stomatitis 585.29 11.58 803 96152 145954 79501479
Lower respiratory tract infection 570.33 11.58 743 96212 128477 79518956
Ill-defined disorder 535.71 11.58 521 96434 65354 79582079
Anti-cyclic citrullinated peptide antibody positive 530.31 11.58 577 96378 82566 79564867
Pericarditis 505.12 11.58 628 96327 103608 79543825
Pemphigus 503.59 11.58 613 96342 98969 79548464
Hand deformity 487.46 11.58 616 96339 103303 79544130
Glossodynia 466.48 11.58 601 96354 102736 79544697
Synovitis 452.69 11.58 722 96233 150012 79497421
Discomfort 435.28 11.58 643 96312 124974 79522459
Systemic lupus erythematosus 432.61 11.58 629 96326 120520 79526913
Therapeutic product effect decreased 431.77 11.58 740 96215 163123 79484310
Infection 426.97 11.58 921 96034 240791 79406642
Sinusitis 407.80 11.58 798 96157 194703 79452730
Arthropathy 380.38 11.58 732 96223 176379 79471054
Wound 354.88 11.58 561 96394 115618 79531815
Swelling 340.17 11.58 788 96167 215923 79431510
Hepatic enzyme increased 337.46 11.58 709 96246 181901 79465532
Hypersensitivity 332.86 11.58 879 96076 261360 79386073
Pyrexia 324.86 11.58 1654 95301 677055 78970378
Contraindicated product administered 287.89 11.58 609 96346 156929 79490504
Confusional state 277.98 11.58 934 96021 317063 79330370
Contusion 274.01 11.58 577 96378 148199 79499234
Death 274.00 11.58 176 96779 566338 79081095
Infusion related reaction 266.28 11.58 746 96209 229491 79417942
Nasopharyngitis 247.32 11.58 774 96181 253107 79394326
Completed suicide 242.38 11.58 14 96941 245753 79401680
Peripheral swelling 240.92 11.58 798 96157 268819 79378614
Fall 233.63 11.58 153 96802 487476 79159957
Abdominal discomfort 231.99 11.58 751 96204 249976 79397457
Weight increased 224.20 11.58 794 96161 276592 79370841
Joint swelling 219.53 11.58 810 96145 287836 79359597
Drug intolerance 213.41 11.58 756 96199 263363 79384070
Product dose omission issue 204.49 11.58 29 96926 247508 79399925
Alopecia 201.47 11.58 679 96276 230676 79416757
Toxicity to various agents 196.82 11.58 136 96819 421404 79226029
Rheumatoid arthritis 186.06 11.58 617 96338 207853 79439580
Rash 172.68 11.58 1248 95707 577110 79070323
Pruritus 171.69 11.58 938 96017 393710 79253723
Drug abuse 167.60 11.58 7 96948 162684 79484749
Off label use 150.98 11.58 581 96374 906634 78740799
Pre-engraftment immune reaction 129.60 11.58 37 96918 304 79647129
Deep vein thrombosis postoperative 118.62 11.58 101 96854 10651 79636782
Maternal exposure during pregnancy 117.19 11.58 399 96556 136139 79511294
Alanine aminotransferase abnormal 113.93 11.58 91 96864 8776 79638657
Injection site pain 112.51 11.58 13 96942 129825 79517608
Dizziness 108.08 11.58 307 96648 526134 79121299
Red blood cell sedimentation rate 105.05 11.58 72 96883 5493 79641940
Autoimmune disorder 101.81 11.58 113 96842 16499 79630934
Pregnancy 100.94 11.58 143 96812 26708 79620725
Blood pressure increased 98.76 11.58 68 96887 211292 79436141
Enthesopathy 96.50 11.58 93 96862 11515 79635918
Tongue disorder 96.05 11.58 101 96854 13874 79633559
Intentional overdose 95.95 11.58 9 96946 105951 79541482
Tenosynovitis 95.66 11.58 106 96849 15448 79631985
Therapy non-responder 90.21 11.58 282 96673 92023 79555410
Inappropriate schedule of product administration 88.92 11.58 26 96929 133602 79513831
Encephalitis viral 88.85 11.58 49 96906 2530 79644903
Cough 87.50 11.58 198 96757 366591 79280842
Pain in extremity 86.79 11.58 197 96758 364341 79283092
Maternal exposure timing unspecified 84.31 11.58 64 96891 5728 79641705
C-reactive protein abnormal 81.37 11.58 181 96774 48186 79599247
COVID-19 80.16 11.58 46 96909 157628 79489805
Feeling abnormal 77.35 11.58 49 96906 159150 79488283
Wrong technique in product usage process 73.41 11.58 4 96951 73871 79573562
Nausea 72.85 11.58 779 96176 956417 78691016
Syncope 71.02 11.58 68 96887 179381 79468052
Blood parathyroid hormone decreased 70.38 11.58 75 96880 10461 79636972
Cytomegalovirus infection 68.85 11.58 157 96798 42487 79604946
Constipation 68.12 11.58 152 96803 282898 79364535
Panniculitis 67.10 11.58 79 96876 12292 79635141
Human herpesvirus 6 infection 66.63 11.58 54 96901 5316 79642117
Psoriasis 66.25 11.58 14 96941 89573 79557860
Malaise 65.32 11.58 340 96615 489529 79157904
Kidney transplant rejection 65.04 11.58 71 96884 10175 79637258
Fear of injection 64.25 11.58 61 96894 7413 79640020
Hypotension 62.48 11.58 299 96656 440018 79207415
Diarrhoea 62.03 11.58 729 96226 879760 78767673
Cerebrovascular accident 61.27 11.58 59 96896 155233 79492200
C-reactive protein 59.53 11.58 49 96906 4930 79642503
Headache 59.42 11.58 509 96446 653263 78994170
Tendonitis 59.20 11.58 105 96850 23725 79623708
Intentional product misuse 58.91 11.58 21 96934 95144 79552289
Myocardial infarction 58.62 11.58 83 96872 184046 79463387
Rheumatoid nodule 58.47 11.58 88 96867 17350 79630083
Clear cell renal cell carcinoma 57.50 11.58 37 96918 2539 79644894
Drug interaction 57.12 11.58 285 96670 414898 79232535
Immune reconstitution inflammatory syndrome 56.95 11.58 77 96878 13764 79633669
Granuloma skin 55.52 11.58 62 96893 9112 79638321
Back pain 55.48 11.58 187 96768 303993 79343440
Oropharyngeal pain 55.43 11.58 32 96923 109321 79538112
Suicide attempt 55.41 11.58 16 96939 82916 79564517
Lip dry 54.85 11.58 80 96875 15338 79632095
Skin necrosis 53.29 11.58 86 96869 18001 79629432
Transplant rejection 51.35 11.58 88 96867 19349 79628084
Blood creatinine increased 50.94 11.58 343 96612 154714 79492719
Nasal congestion 50.73 11.58 15 96940 76537 79570896
Pneumonia 50.62 11.58 536 96419 659710 78987723
Influenza 50.24 11.58 50 96905 129556 79517877
Drug hypersensitivity 50.18 11.58 570 96385 298346 79349087
Balance disorder 50.00 11.58 29 96926 98828 79548605
Injection site erythema 48.84 11.58 17 96938 78180 79569253
Lymphoproliferative disorder 48.59 11.58 46 96909 5569 79641864
Rhinorrhoea 48.45 11.58 16 96939 76058 79571375
Loss of consciousness 48.38 11.58 81 96874 167862 79479571
Stevens-Johnson syndrome 47.21 11.58 129 96826 39037 79608396
Stress 46.89 11.58 19 96936 79593 79567840
Granuloma 46.69 11.58 54 96901 8243 79639190
Injury 46.33 11.58 202 96753 77294 79570139
Aspartate aminotransferase increased 45.72 11.58 307 96648 138334 79509099
Alanine aminotransferase increased 45.50 11.58 346 96609 162224 79485209
Cardio-respiratory arrest 45.44 11.58 39 96916 108471 79538962
Adjustment disorder with depressed mood 44.34 11.58 55 96900 9031 79638402
Haematochezia 43.92 11.58 26 96929 87619 79559814
Atrial fibrillation 42.28 11.58 113 96842 197773 79449660
Hyperkalaemia 41.81 11.58 260 96695 114138 79533295
Cardiac failure congestive 41.64 11.58 68 96887 142334 79505099
Overdose 40.26 11.58 104 96851 184102 79463331
Hyperhidrosis 40.09 11.58 77 96878 151415 79496018
Product prescribing error 40.05 11.58 4 96951 44809 79602624
X-ray abnormal 39.92 11.58 42 96913 5771 79641662
Medication error 39.58 11.58 177 96778 68465 79578968
Illness 39.43 11.58 5 96950 46506 79600927
Palpitations 39.37 11.58 58 96897 126552 79520881
Chronic obstructive pulmonary disease 39.18 11.58 28 96927 85391 79562042
Suicidal ideation 39.17 11.58 22 96933 76318 79571115
Arthralgia 38.78 11.58 939 96016 570864 79076569
Sedation 38.59 11.58 8 96947 51887 79595546
Injection site bruising 38.43 11.58 3 96952 40999 79606434
Neck pain 38.32 11.58 22 96933 75395 79572038
Injection site reaction 37.66 11.58 10 96945 54775 79592658
Chest discomfort 37.55 11.58 69 96886 137975 79509458
Fluid retention 37.46 11.58 19 96936 69790 79577643
Depressed mood 37.04 11.58 7 96948 48473 79598960
Rheumatic fever 36.44 11.58 96 96859 28429 79619004
Serotonin syndrome 35.49 11.58 6 96949 45021 79602412
Somnolence 35.19 11.58 160 96795 238821 79408612
Weight decreased 35.18 11.58 270 96685 354928 79292505
Cardiac failure 34.94 11.58 86 96869 154756 79492677
Psoriatic arthropathy 34.85 11.58 187 96768 77812 79569621
Lower limb fracture 34.77 11.58 83 96872 23132 79624301
Deafness transitory 34.54 11.58 19 96936 976 79646457
Bradycardia 34.07 11.58 71 96884 135486 79511947
Incorrect dose administered 34.01 11.58 26 96929 76604 79570829
Urticaria 33.72 11.58 359 96596 184842 79462591
Injection site swelling 33.57 11.58 8 96947 47124 79600309
Rheumatoid lung 33.39 11.58 33 96922 4212 79643221
Haematemesis 33.27 11.58 11 96944 52253 79595180
Multiple sclerosis relapse 32.94 11.58 8 96947 46525 79600908
Cardiac arrest 32.59 11.58 104 96851 171992 79475441
Urinary tract infection 32.47 11.58 198 96757 274314 79373119
Swollen joint count increased 32.23 11.58 80 96875 22847 79624586
Blood pressure fluctuation 32.14 11.58 21 96934 67124 79580309
Cardiogenic shock 32.14 11.58 6 96949 41908 79605525
Cataract 31.73 11.58 18 96937 62102 79585331
Ulcer 31.53 11.58 94 96861 29878 79617555
Gait disturbance 31.10 11.58 138 96817 207368 79440065
Hot flush 30.88 11.58 14 96941 54863 79592570
Condition aggravated 30.66 11.58 427 96528 500697 79146736
Breast cancer 30.23 11.58 3 96952 33778 79613655
Therapeutic product effect incomplete 30.16 11.58 81 96874 141564 79505869
Visual impairment 29.83 11.58 41 96914 92090 79555343
Gastrointestinal haemorrhage 29.59 11.58 87 96868 147632 79499801
Drug eruption 28.96 11.58 118 96837 43817 79603616
Heart rate increased 28.87 11.58 65 96890 120659 79526774
Facet joint syndrome 28.33 11.58 50 96905 11252 79636181
Anal inflammation 28.18 11.58 19 96936 1411 79646022
Incision site pain 28.02 11.58 25 96930 2805 79644628
Dyspnoea exertional 27.94 11.58 39 96916 87034 79560399
Flushing 27.87 11.58 40 96915 88228 79559205
Renal tubular necrosis 27.75 11.58 80 96875 24959 79622474
Hospitalisation 27.54 11.58 45 96910 94191 79553242
Cytomegalovirus viraemia 27.46 11.58 53 96902 12768 79634665
Drug ineffective for unapproved indication 27.41 11.58 14 96941 51224 79596209
Influenza like illness 27.40 11.58 28 96927 71679 79575754
Adverse event 27.33 11.58 145 96810 60069 79587364
Acute myocardial infarction 27.32 11.58 32 96923 77004 79570429
Pain in jaw 27.20 11.58 11 96944 46140 79601293
Unevaluable event 27.13 11.58 17 96938 55568 79591865
Drug ineffective 27.12 11.58 1058 95897 1079855 78567578
Vomiting 27.11 11.58 610 96345 665218 78982215
Cardiac disorder 27.09 11.58 24 96931 65733 79581700
Hypothyroidism 27.02 11.58 15 96940 52377 79595056
Dysphonia 26.93 11.58 18 96937 56854 79590579
Meningoencephalitis herpetic 26.81 11.58 21 96934 1968 79645465
Limb discomfort 26.74 11.58 4 96951 32846 79614587
Liver disorder 26.71 11.58 165 96790 72252 79575181
Full blood count abnormal 26.69 11.58 8 96947 40466 79606967
Depressed level of consciousness 26.56 11.58 48 96907 96604 79550829
Intentional self-injury 26.27 11.58 4 96951 32415 79615018
Osteonecrosis of jaw 25.97 11.58 10 96945 43216 79604217
Psychotic disorder 25.85 11.58 9 96946 41393 79606040
Bronchitis 25.40 11.58 78 96877 130566 79516867
Drug dependence 25.22 11.58 9 96946 40760 79606673
Haemodialysis 25.13 11.58 63 96892 18105 79629328
Injection site pruritus 25.05 11.58 10 96945 42273 79605160
Road traffic accident 24.72 11.58 112 96843 43552 79603881
Blood urea increased 24.59 11.58 121 96834 48669 79598764
Osteoporosis 24.47 11.58 18 96937 54094 79593339
Oxygen saturation decreased 24.42 11.58 78 96877 128969 79518464
Epistaxis 24.32 11.58 63 96892 111452 79535981
Sleep disorder 24.32 11.58 183 96772 85494 79561939
Heart rate decreased 24.09 11.58 30 96925 70286 79577147
Complications of transplanted kidney 24.06 11.58 34 96921 6332 79641101
Anaphylactic shock 23.94 11.58 7 96948 35989 79611444
Diabetic ketoacidosis 23.89 11.58 6 96949 34116 79613317
Dysphagia 23.69 11.58 73 96882 122063 79525370
Hypertension 23.58 11.58 273 96682 330719 79316714
Drug tolerance decreased 23.45 11.58 50 96905 12928 79634505
Asthenia 23.38 11.58 460 96495 511229 79136204
Muscle spasms 23.38 11.58 121 96834 174609 79472824
Labelled drug-drug interaction medication error 23.37 11.58 3 96952 27647 79619786
Dry skin 23.31 11.58 29 96926 67966 79579467
Tachycardia 23.28 11.58 124 96831 177644 79469789
Liver transplant rejection 23.26 11.58 24 96931 3224 79644209
Malignant neoplasm progression 23.16 11.58 86 96869 135904 79511529
Melaena 23.01 11.58 24 96931 60866 79586567
Aggression 22.98 11.58 17 96938 50941 79596492
Peripheral venous disease 22.88 11.58 56 96899 15853 79631580
Ischaemic stroke 22.86 11.58 6 96949 33125 79614308
Abdominal distension 22.86 11.58 72 96883 119578 79527855
Hypercalcaemia 22.83 11.58 100 96855 38330 79609103
Cognitive disorder 22.76 11.58 31 96924 69895 79577538
Depression 22.29 11.58 163 96792 216627 79430806
SARS-CoV-2 test negative 21.85 11.58 16 96939 1355 79646078
Pancytopenia 21.75 11.58 302 96653 165443 79481990
Cytomegalovirus test positive 21.36 11.58 31 96924 5916 79641517
Wound infection 21.34 11.58 71 96884 23920 79623513
Drug tolerance 21.26 11.58 38 96917 8637 79638796
Pain 21.17 11.58 1052 95903 702750 78944683
Poisoning 20.75 11.58 3 96952 25269 79622164
Throat irritation 20.72 11.58 12 96943 40934 79606499
Surgery 20.67 11.58 7 96948 32759 79614674
Acne 20.62 11.58 4 96951 27186 79620247
Pneumocystis jirovecii pneumonia 20.40 11.58 86 96869 32422 79615011
Rash pruritic 20.33 11.58 153 96802 71476 79575957
Anti-cyclic citrullinated peptide antibody 20.29 11.58 30 96925 5822 79641611
Withdrawal syndrome 20.26 11.58 4 96951 26850 79620583
Arrhythmia 20.11 11.58 27 96928 61245 79586188
Anaphylactic reaction 20.09 11.58 45 96910 83698 79563735
Femur fracture 20.03 11.58 11 96944 38641 79608792
Febrile bone marrow aplasia 19.98 11.58 47 96908 12973 79634460
Speech disorder 19.97 11.58 22 96933 54423 79593010
Agitation 19.76 11.58 59 96896 99656 79547777
Electrocardiogram QT prolonged 19.76 11.58 51 96904 90335 79557098
Cerebral infarction 19.63 11.58 16 96939 45660 79601773
Tooth disorder 19.59 11.58 4 96951 26229 79621204
Vision blurred 19.35 11.58 65 96890 105833 79541600
Disturbance in attention 19.22 11.58 20 96935 50781 79596652
Serum sickness 19.20 11.58 23 96932 3643 79643790
Productive cough 19.19 11.58 50 96905 88281 79559152
Basal cell carcinoma 19.06 11.58 93 96862 37282 79610151
Neuroleptic malignant syndrome 19.00 11.58 5 96950 27554 79619879
Blood antidiuretic hormone increased 18.76 11.58 6 96949 75 79647358
No adverse event 18.68 11.58 11 96944 37181 79610252
Abdominal pain 18.45 11.58 348 96607 389221 79258212
Tremor 18.40 11.58 126 96829 169957 79477476
Hypomagnesaemia 18.28 11.58 18 96937 46893 79600540
Respiratory arrest 18.24 11.58 26 96929 57524 79589909
Swollen tongue 18.19 11.58 15 96940 42555 79604878
Oral pain 18.06 11.58 8 96947 31790 79615643
Anxiety 17.68 11.58 205 96750 248307 79399126
Lupus vulgaris 17.54 11.58 21 96934 3325 79644108
Dislocation of vertebra 17.40 11.58 33 96922 7847 79639586
Heart rate irregular 17.37 11.58 9 96946 32670 79614763
Tinnitus 17.29 11.58 17 96938 44316 79603117
Liver transplant 17.28 11.58 24 96931 4399 79643034
Haematoma 17.13 11.58 23 96932 52172 79595261
Product quality issue 17.10 11.58 10 96945 33930 79613503
Sphincter of Oddi dysfunction 17.08 11.58 9 96946 424 79647009
Paraesthesia 16.98 11.58 135 96820 176188 79471245
Hypokalaemia 16.96 11.58 104 96851 143936 79503497
Musculoskeletal disorder 16.92 11.58 61 96894 21387 79626046
Acquired immunodeficiency syndrome 16.89 11.58 8 96947 299 79647134
Blood pressure decreased 16.87 11.58 63 96892 99403 79548030
Hypoglycaemia 16.81 11.58 65 96890 101529 79545904
Delayed graft function 16.75 11.58 21 96934 3486 79643947
Inflammation 16.71 11.58 181 96774 93572 79553861
Breast cancer stage II 16.70 11.58 33 96922 8087 79639346
Cytomegalovirus test 16.64 11.58 5 96950 50 79647383
Biopsy liver abnormal 16.53 11.58 9 96946 453 79646980
Transient ischaemic attack 16.51 11.58 24 96931 52671 79594762
Prostate cancer 16.48 11.58 10 96945 33258 79614175
Transfusion 16.47 11.58 3 96952 21327 79626106
Pulmonary arterial hypertension 16.33 11.58 7 96948 28359 79619074
Blood bilirubin unconjugated increased 16.30 11.58 12 96943 1025 79646408
Agranulocytosis 16.23 11.58 102 96853 44928 79602505
Myalgia 16.14 11.58 146 96809 185495 79461938
Treatment failure 16.07 11.58 294 96661 170192 79477241
Cephalhaematoma 16.06 11.58 4 96951 18 79647415
Coronary artery disease 15.86 11.58 35 96920 65439 79581994
Blood culture positive 15.84 11.58 33 96922 8396 79639037
Angina pectoris 15.78 11.58 24 96931 51708 79595725
Lung neoplasm malignant 15.77 11.58 7 96948 27785 79619648
Device dislocation 15.62 11.58 6 96949 25964 79621469
Cystitis 15.58 11.58 25 96930 52707 79594726
Device expulsion 15.51 11.58 6 96949 25855 79621578
Perinephric collection 15.50 11.58 8 96947 361 79647072
Lethargy 15.47 11.58 49 96906 81243 79566190
Hypocalcaemia 15.39 11.58 23 96932 49901 79597532
Renal tubular disorder 15.37 11.58 28 96927 6458 79640975
Iron deficiency anaemia 15.32 11.58 6 96949 25666 79621767
Circulatory collapse 15.21 11.58 14 96941 37654 79609779
Dysgeusia 15.17 11.58 29 96926 57148 79590285
Drug withdrawal syndrome 15.12 11.58 12 96943 34706 79612727
Nephrolithiasis 15.06 11.58 26 96929 53265 79594168
HIV wasting syndrome 15.05 11.58 5 96950 71 79647362
Fracture 14.94 11.58 4 96951 21797 79625636
Dysarthria 14.90 11.58 38 96917 67584 79579849
Flatulence 14.87 11.58 18 96937 42706 79604727
Musculoskeletal discomfort 14.87 11.58 3 96952 19832 79627601
Obstructive airways disorder 14.84 11.58 10 96945 31449 79615984
Urinary retention 14.79 11.58 29 96926 56601 79590832
Bursitis 14.71 11.58 84 96871 35760 79611673
Liver function test increased 14.67 11.58 16 96939 39757 79607676
Swollen joint count 14.62 11.58 12 96943 1203 79646230
Rhabdomyolysis 14.60 11.58 70 96885 103061 79544372
Dystonia 14.53 11.58 4 96951 21395 79626038
Limb injury 14.45 11.58 9 96946 29519 79617914
Orbital haemorrhage 14.45 11.58 4 96951 29 79647404
Liver injury 14.45 11.58 118 96837 56496 79590937
Drug reaction with eosinophilia and systemic symptoms 14.35 11.58 130 96825 64114 79583319
Vertigo 14.33 11.58 40 96915 69042 79578391
Culture urine positive 14.33 11.58 22 96933 4413 79643020
Blood lactate dehydrogenase increased 14.29 11.58 89 96866 39081 79608352
Unresponsive to stimuli 14.20 11.58 29 96926 55759 79591674
Renal impairment 14.19 11.58 123 96832 157660 79489773
Chronic lymphocytic leukaemia 14.15 11.58 23 96932 4843 79642590
Dialysis 14.14 11.58 52 96903 18410 79629023
Lung disorder 14.11 11.58 155 96800 80402 79567031
Intestinal obstruction 14.07 11.58 19 96936 43001 79604432
Night sweats 14.07 11.58 110 96845 51985 79595448
Culture stool positive 14.06 11.58 9 96946 612 79646821
Bronchopulmonary aspergillosis 14.00 11.58 59 96896 22235 79625198
Cystitis haemorrhagic 13.96 11.58 33 96922 9139 79638294
Disease progression 13.93 11.58 150 96805 184212 79463221
Neoplasm progression 13.90 11.58 26 96929 51656 79595777
Skin ulcer 13.89 11.58 113 96842 54037 79593396
Product administration error 13.88 11.58 11 96944 31835 79615598
Lacrimation increased 13.84 11.58 5 96950 22472 79624961
Red blood cells urine positive 13.81 11.58 23 96932 4940 79642493
Eye pruritus 13.68 11.58 4 96951 20566 79626867
Trimethylaminuria 13.59 11.58 6 96949 190 79647243
Gait inability 13.56 11.58 120 96835 58797 79588636
Dermatitis exfoliative 13.38 11.58 36 96919 10793 79636640
Tumour flare 13.32 11.58 11 96944 1112 79646321
Herpes zoster 13.28 11.58 63 96892 93020 79554413
Blood creatine phosphokinase increased 13.17 11.58 39 96916 66051 79581382
Poor venous access 13.08 11.58 3 96952 18146 79629287
Therapeutic response unexpected 13.04 11.58 4 96951 19942 79627491
Granulomatous rosacea 13.04 11.58 6 96949 210 79647223
Vena cava injury 12.99 11.58 7 96948 345 79647088
Graft versus host disease 12.95 11.58 44 96911 14982 79632451
Chemotherapeutic drug level increased 12.90 11.58 7 96948 350 79647083
Burning sensation 12.88 11.58 33 96922 58599 79588834
Restlessness 12.85 11.58 23 96932 46469 79600964
Purpura senile 12.80 11.58 8 96947 522 79646911
Altered state of consciousness 12.73 11.58 21 96934 43801 79603632
Tarsal tunnel syndrome 12.71 11.58 8 96947 528 79646905
Cellulitis enterococcal 12.58 11.58 4 96951 49 79647384
Blood pressure diastolic decreased 12.48 11.58 11 96944 30205 79617228
Diverticulitis 12.45 11.58 23 96932 45913 79601520
Complications of transplant surgery 12.44 11.58 9 96946 748 79646685
Pulmonary fibrosis 12.39 11.58 94 96861 44018 79603415
Anaemia 12.33 11.58 430 96525 444585 79202848
Rash maculo-papular 12.28 11.58 113 96842 55965 79591468
Hallucination 12.25 11.58 58 96897 85687 79561746
Wound evisceration 12.14 11.58 5 96950 133 79647300
Sleep apnoea syndrome 12.04 11.58 16 96939 36462 79610971
Acute respiratory failure 11.96 11.58 35 96920 59506 79587927
Hernia 11.94 11.58 3 96952 17056 79630377
Localised infection 11.88 11.58 17 96938 37558 79609875
Intervertebral disc protrusion 11.84 11.58 7 96948 23614 79623819
Aplasia pure red cell 11.78 11.58 28 96927 7782 79639651
Lymphocyte count decreased 11.76 11.58 98 96857 47191 79600242
Nervousness 11.72 11.58 14 96941 33401 79614032
Lactic acidosis 11.65 11.58 45 96910 70314 79577119

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Intermediate-acting sulfonamides
ATC J01EE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA CS M0020790 Sulfonamides
FDA EPC N0000175504 Sulfonamide Antimicrobial
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50183 P450 inhibitors
CHEBI has role CHEBI:50502 dihydropteroate synthase inhibitors
CHEBI has role CHEBI:53000 epitope role
CHEBI has role CHEBI:74234 sepiapterin reductase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Haemophilus Influenzae Acute Otitis Media indication 19021002
Nocardiosis indication 29227009 DOID:2312
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Toxoplasmosis indication 187192000 DOID:9965
Chlamydial conjunctivitis indication 231861005 DOID:13800
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Acute exacerbation of chronic bronchitis indication 425748003
Haemophilus Influenzae Chronic Bronchitis indication
Aerobic Gram-Positive Cocci Infection indication
Pneumocystis Carinii Pneumonia Prevention indication
Aerobic Gram-Negative Bacillary Infection indication
Morganella Morganii Urinary Tract Infection indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Typhoid fever off-label use 4834000 DOID:13258
Infection of skin AND/OR subcutaneous tissue off-label use 19824006
Pertussis off-label use 27836007
Granuloma inguinale off-label use 28867007 DOID:9113
Listeria meningitis off-label use 31568009 DOID:11572
Sinusitis off-label use 36971009
Whipple's disease off-label use 41545003 DOID:8476
Bacterial pneumonia off-label use 53084003 DOID:874
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Cholera off-label use 63650001 DOID:1498
Brucellosis off-label use 75702008 DOID:11077
Paratyphoid fever off-label use 85904008 DOID:3055
Chlamydial infection off-label use 105629000
Infection of bone off-label use 111253001
Meningococcus carrier off-label use 170486006
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Chancroid off-label use 266143009 DOID:13778
Diverticulitis of gastrointestinal tract off-label use 271366000
Bacterial endocarditis off-label use 301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Diabetic Foot Infection off-label use
Toxoplasmosis Prevention off-label use
Postexposure Plague Prophylaxis off-label use
Chronic Bacterial Prostatitis off-label use
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Third trimester pregnancy contraindication 41587001
Uremia contraindication 44730006 DOID:4676
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Folic acid deficiency contraindication 190633005
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.79 acidic
pKa2 2.08 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR IC50 5.33 CHEMBL CHEMBL
Bifunctional protein FolC Enzyme WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 7 CHEMBL
Pol polyprotein Enzyme Ki 8 CHEMBL
Endothelin-1 receptor GPCR IC50 5.40 CHEMBL

External reference:

IDSource
4017734 VUID
N0000146102 NUI
D00447 KEGG_DRUG
4017734 VANDF
C0038689 UMLSCUI
CHEBI:9332 CHEBI
08D PDB_CHEM_ID
CHEMBL443 ChEMBL_ID
DB01015 DRUGBANK_ID
D013420 MESH_DESCRIPTOR_UI
5329 PUBCHEM_CID
10933 IUPHAR_LIGAND_ID
1386 INN_ID
JE42381TNV UNII
10180 RXNORM
2035 MMSL
5526 MMSL
d00119 MMSL
002827 NDDF
363528007 SNOMEDCT_US
70047000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-0853 SUSPENSION 200 mg ORAL NDA 28 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 200 mg ORAL NDA 29 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 200 mg ORAL NDA 29 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-4793 SUSPENSION 200 mg ORAL ANDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0440-2406 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-8121 TABLET 800 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 31 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0904-2725 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-053 TABLET 800 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-092 TABLET 800 mg ORAL ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-525 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-926 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-940 TABLET 800 mg ORAL ANDA 27 sections
Sulfamethoxazole and Trimethoprim DS HUMAN PRESCRIPTION DRUG LABEL 2 12634-177 TABLET 800 mg ORAL ANDA 21 sections
SULFAMETHOXAZOLE and TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 12634-779 SUSPENSION 200 mg ORAL ANDA 21 sections