sulfamethizole Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2512 144-82-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethizole
  • sulfamethiazole
  • sulfamethizol
  • sulfamethylthiadiazole
  • sulphamethizole
  • sulfurine
A sulfathiazole antibacterial agent.
  • Molecular weight: 270.33
  • Formula: C9H10N4O2S2
  • CLOGP: 0.42
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 97.97
  • ALOGS: -2.65
  • ROTB: 2

Drug dosage:

DoseUnitRoute
4 g O

Approvals:

DateAgencyCompanyOrphan
Oct. 28, 1953 FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC B05CA04 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
IRRIGATING SOLUTIONS
Antiinfectives
ATC D06BA04 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Sulfonamides
ATC J01EB02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Short-acting sulfonamides
ATC S01AB01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Sulfonamides
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:35441 antiinfective agent
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Haemophilus Influenzae Acute Otitis Media indication
Pneumocystis Carinii Pneumonia Prevention indication
Morganella Morganii Urinary Tract Infection indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Haemophilus Influenzae Chronic Bronchitis indication
Renal tubular acidosis contraindication 1776003 DOID:14219
Respiratory acidosis contraindication 12326000
Hyperkalemia contraindication 14140009
Metabolic acidosis, normal anion gap, acidifying salts contraindication 18104000
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Uremia contraindication 44730006 DOID:4676
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Decreased respiratory function contraindication 80954004
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of blood AND/OR blood-forming organ contraindication 191124002 DOID:74
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Pregnancy, function contraindication 289908002
Primary adrenocortical insufficiency contraindication 373662000
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001
Recurrent Calcium Renal Calculi contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.34 acidic
pKa2 2.81 Basic
pKa3 2.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR WOMBAT-PK CHEMBL

External reference:

IDSource
4018493 VUID
N0000146815 NUI
C0038687 UMLSCUI
D00870 KEGG_DRUG
25W8454H16 UNII
529 INN_ID
70254000 SNOMEDCT_US
387389006 SNOMEDCT_US
4018493 VANDF
10179 RXNORM
5525 MMSL
d01090 MMSL
002822 NDDF
CHEBI:9331 CHEBI
CHEMBL1191 ChEMBL_ID
DB00576 DRUGBANK_ID
5328 PUBCHEM_CID
D013419 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None