sulfaethidole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2504 94-19-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfaethidole
  • sulfaethylthiadiazole
  • sulfaethidol
  • sulfaethidiole
  • ethazole
minor descriptor (66-86); on-line & INDEX MEDICUS search SULFATHIAZOLES (66-86); RN given refers to parent cpd
  • Molecular weight: 284.35
  • Formula: C10H12N4O2S2
  • CLOGP: 1.10
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 97.97
  • ALOGS: -2.96
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.651 Moderate 0.68
caco2-efflux Caco-2 efflux ratio (BA/AB) 9.954 Moderate 0.68
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.272 10^-6 cm/s Moderate 0.68
dh-clint Dog hepatocyte intrinsic clearance 2.415 uL/min/10^6 cells Moderate 0.68
dppb Dog plasma protein binding (% unbound) 11.530 % Moderate 0.68
fcs-ppb Fetal calf serum protein binding (% unbound) 14.260 % Moderate 0.68
herg hERG pIC50 4.025 pIC50 Moderate 0.68
hh-clint Human hepatocyte intrinsic clearance 1.358 uL/min/10^6 cells Moderate 0.68
hlm-clint Human liver microsomal intrinsic clearance 3.334 uL/min/mg protein Moderate 0.68
hppb Human plasma protein binding (% unbound) 4.500 % Moderate 0.68
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,KIT,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 54
kinase-selectivity-class ACVR2A,AURKA,AXL,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MAP2K3,MAP2K6,MAP3K7,MAP4K1,MAPK12,MAPK7,MARK4,PDK4,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 25
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.710 Moderate 0.68
mh-clint Mouse hepatocyte intrinsic clearance 4.966 Moderate 0.68
mppb Mouse plasma protein binding (% unbound) 19.060 Moderate 0.68
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.449 Moderate 0.68
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 8.250 % Moderate 0.68
rh-clint Rat hepatocyte intrinsic clearance 3.327 uL/min/10^6 cells Moderate 0.68
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.520 % Moderate 0.68
rppb Rat plasma protein binding (% unbound) 2.910 % Moderate 0.68
solubility-dd Solubility at pH 7.4 in DMSO 990.832 uM Moderate 0.68

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.27 acidic
pKa2 2.85 Basic
pKa3 2.2 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
RAC-alpha serine/threonine-protein kinase Kinase Kd 5.11 CHEMBL

External reference:

IDSource
D02449 KEGG_DRUG
C0075508 UMLSCUI
CHEBI:107668 CHEBI
CHEMBL1355299 ChEMBL_ID
C100299 MESH_SUPPLEMENTAL_RECORD_UI
7181 PUBCHEM_CID
749 INN_ID
R77Q4O5ZMD UNII
37324 RXNORM
002826 NDDF
4480008 SNOMEDCT_US

Pharmaceutical products:

None