sulfadimidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 2502 | 57-68-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 4 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 153.98 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 86.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 16, 1949 | FDA | LEDERLE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01EB03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Short-acting sulfonamides |
| ATC | J01EE05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:50502 | dihydropteroate synthase inhibitors |
| CHEBI has role | CHEBI:50903 | carcinogen |
| CHEBI has role | CHEBI:52214 | ligands |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Third trimester pregnancy | contraindication | 41587001 | |
| Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Porphyria | contraindication | 418470004 |
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Bacterial pneumonia | Indication |
| Cattle | Respiratory disease complex caused by Pasteurella species | Indication |
| Cattle | Colibacillosis caused by Escherichia coli | Indication |
| Cattle | Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum | Indication |
| Cattle | Diphtheria caused by Fusobacterium necrophorum | Indication |
| Cattle | Acute metritis caused by Streptococcus species | Indication |
| Cattle | Acute mastitis caused by Streptococcus species | Indication |
| Chickens | Infectious coryza caused by Avibacterium paragallinarium | Indication |
| Chickens | Coccidiosis cased by Eimeria tenella | Indication |
| Chickens | Pullorum disease caused by Salmonella Pullorum | Indication |
| Chickens | Coccidiosis cased by Eimeria necatrix | Indication |
| Chickens | Cholera caused by Pasteurella multocida | Indication |
| Swine | Colibacillosis caused by Escherichia coli | Indication |
| Swine | Bacterial pneumonia caused by Pasteurella multocida | Indication |
| Turkeys | Coccidiosis caused by Eimeria adenoeides | Indication |
| Turkeys | Coccidiosis caused by Eimeria adenoeides | Indication |
| Cattle | Bacterial pneumonia | Indication |
| Cattle | Bovine respiratory disease complex caused by Pasteurella species | Indication |
| Cattle | Colibacillosis caused by Escherichia coli | Indication |
| Cattle | Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum | Indication |
| Cattle | Diphtheria caused by Fusobacterium necrophorum | Indication |
| Cattle | Acute metritis caused by Streptococcus species | Indication |
| Cattle | Acute mastitis caused by Streptococcus species | Indication |
| Chickens | Coryza caused by Avibacterium paragallinarum | Indication |
| Chickens | Coccidiosis caused by Eimeria tenella | Indication |
| Chickens | Coccidiosis caused by Eimeria necatrix | Indication |
| Chickens | Cholera caused by Pasteurella multocida | Indication |
| Chickens | Pullorum disease caused by Salmonella Pullorum | Indication |
| Swine | Colibacillosis caused by Escherichia coli | Indication |
| Swine | Bacterial pneumonia caused by Pasteurella species | Indication |
| Turkeys | Coccidiosis caused by Eimeria meleagrimitis | Indication |
| Turkeys | Coccidiosis caused by Eimeria adenoeides | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Sulmet Drinking Water Solution, 12.5% | Huvepharma EOOD | 1 |
| Sulmet Solution Injectable | Huvepharma EOOD | 1 |
| Aureomix S 40/40 Granular | Zoetis Inc. | 2 |
| Aureo S 700 Granular, Aureo S 700 | Zoetis Inc. | 2 |
| Tylan 5 Sulfa-G, Tylan 10 Sulfa-G, Tylan 20 Sulfa-G, Tylan 40 Sulfa-G | Elanco US Inc. | 2 |
| AUREOMIX S 700-A | Zoetis Inc. | 2 |
| AUREOMIX S 700-D | Zoetis Inc. | 2 |
| Aureomix S 700-G | Zoetis Inc. | 2 |
| Aureomix S 700-E | Zoetis Inc. | 2 |
| Aureomix 700-F | Zoetis Inc. | 2 |
| Aureomix S 700-C | Zoetis Inc. | 2 |
| AUREOMIX S 700-B | Zoetis Inc. | 2 |
| AUREOMIX S 700-H | Zoetis Inc. | 2 |
| Sulfamethazine Spanbolet II | Zoetis Inc. | 1 |
| Chloronex Sulmet | Huvepharma EOOD | 2 |
| Tylan 10 Sulfa-G, Tylan 40 Sulfa-G | Zoetis Inc. | 2 |
| PoultrySulfa | Huvepharma EOOD | 3 |
| Sustain III Bolus, Sustain III Calf Bolus | Bimeda Animal Health Limited | 1 |
| Sulmet Oblets | Huvepharma EOOD | 1 |
| Sulmet Soluble Powder | Huvepharma EOOD | 1 |
| Calfspan | Zoetis Inc. | 1 |
| Pennchlor S 40/40 | Pharmgate Inc. | 2 |
| Sulfamethazine Sustained Release Bolus | Huvepharma EOOD | 1 |
| Veta-Meth | Lloyd Inc. | 1 |
| Sulka-S Bolus | Zoetis Inc. | 1 |
| Aureo S 700 and Bovatec | Zoetis Inc. | 3 |
| Pennchlor S | Pharmgate Inc. | 2 |
| SMZ-Med 454 | Bimeda Animal Health Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.24 | acidic |
| pKa2 | 2.88 | Basic |
| pKa3 | 2.27 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Lactoylglutathione lyase | Enzyme | WOMBAT-PK | |||||||
| Dihydropteroate synthase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017499 | VUID |
| N0000145884 | NUI |
| D02436 | KEGG_DRUG |
| 4017499 | VANDF |
| C0038686 | UMLSCUI |
| CHEBI:102265 | CHEBI |
| CHEMBL446 | ChEMBL_ID |
| DB01582 | DRUGBANK_ID |
| 5327 | PUBCHEM_CID |
| 12642 | IUPHAR_LIGAND_ID |
| 1981-58-4 | SECONDARY_CAS_RN |
| 10178 | RXNORM |
| NOCODE | MMSL |
| 002817 | NDDF |
| 324417001 | SNOMEDCT_US |
| 40036000 | SNOMEDCT_US |
| D013418 | MESH_DESCRIPTOR_UI |
| 1068 | INN_ID |
| 24540-76-9 | SECONDARY_CAS_RN |
| 48U51W007F | UNII |
Pharmaceutical products:
None