sulfadimethoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2501 122-11-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfadimethoxine
  • neostreptal
  • suldixine
  • sulfabon
  • sulfadimethoxin
  • sulfadimethoxydiazin
  • sulfadimetoxin
  • sulfadimetoxine
  • sulfadimoxine
A sulfanilamide that is used as an anti-infective agent.
  • Molecular weight: 310.33
  • Formula: C12H14N4O4S
  • CLOGP: 1.98
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 116.43
  • ALOGS: -3.05
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 59.10 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01ED01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Long-acting sulfonamides
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Respiratory genitourinary tract infections caused by Streptococci Indication
Cats Respiratory genitourinary tract infections caused by Staphylococci Indication
Cats Respiratory genitourinary tract infections caused by Escherichia Indication
Cats Respiratory genitourinary tract infections caused by Salmonella Indication
Cats Respiratory genitourinary tract infections caused by Klebsiella Indication
Cats Respiratory genitourinary tract infections caused by Proteus Indication
Cats Respiratory genitourinary tract infections caused by Shigella Indication
Cats Enteric infections caused by Streptococci Indication
Cats Enteric infections caused by Staphylococci Indication
Cats Enteric infections caused by Escherichia Indication
Cats Enteric infections caused by Salmonella Indication
Cats Enteric infections caused by Klebsiella Indication
Cats Enteric infections caused by Proteus Indication
Cats Enteric infections caused by Shigella Indication
Cats Soft tissue infections infections caused by Streptococci Indication
Cats Soft tissue infections infections caused by Staphylococci Indication
Cats Soft tissue infections infections caused by Escherichia Indication
Cats Soft tissue infections infections caused by Salmonella Indication
Cats Soft tissue infections infections caused by Klebsiella Indication
Cats Soft tissue infections infections caused by Proteus Indication
Cats Soft tissue infections infections caused by Shigella Indication
Cats Bacterial enteritis associated with coccidiosis Indication
Cats Bacterial enteritis associated with Salmonellosis Indication
Cattle Shipping fever complex Indication
Cattle Bacterial pneumonia associated with Pasteurella spp Indication
Cattle Diphtheria Indication
Cattle Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum Indication
Chickens Coccidiosis Indication
Chickens Cholera Indication
Chickens Coryza Indication
Dogs Respiratory genitourinary tract infections caused by Streptococci Indication
Dogs Respiratory genitourinary tract infections caused by Staphylococci Indication
Dogs Respiratory genitourinary tract infections caused by Escherichia Indication
Dogs Respiratory genitourinary tract infections caused by Salmonella Indication
Dogs Respiratory genitourinary tract infections caused by Klebsiella Indication
Dogs Respiratory genitourinary tract infections caused by Proteus Indication
Dogs Respiratory genitourinary tract infections caused by Shigella Indication
Dogs Enteric infections caused by Streptococci Indication
Dogs Enteric infections caused by Staphylococci Indication
Dogs Enteric infections caused by Escherichia Indication
Dogs Enteric infections caused by Salmonella Indication
Dogs Enteric infections caused by Klebsiella Indication
Dogs Enteric infections caused by Proteus Indication
Dogs Enteric infections caused by Shigella Indication
Dogs Soft tissue infections infections caused by Streptococci Indication
Dogs Soft tissue infections infections caused by Staphylococci Indication
Dogs Soft tissue infections infections caused by Escherichia Indication
Dogs Soft tissue infections infections caused by Salmonella Indication
Dogs Soft tissue infections infections caused by Klebsiella Indication
Dogs Soft tissue infections infections caused by Proteus Indication
Dogs Soft tissue infections infections caused by Shigella Indication
Dogs Bacterial enteritis associated with coccidiosis Indication
Dogs Bacterial enteritis associated with Salmonellosis Indication
Horses Respiratory disease caused by Streptococcus equi (strangles) Indication
Turkeys Coccidiosis Indication
Turkeys Cholera Indication

🐶 Veterinary products

ProductApplicantIngredients
Bactrovet Tablets 250 mg Intervet Inc. 1
Albon Tablets Zoetis Inc. 1
AGRIBON Concentrated Solution 12.5%, ALBON Concentrated Solution 12.5% Zoetis Inc. 1
Albon, Agribon Boluses - 2.5, Agribon Boluses - 5.0, Agribon Boluses - 15.0 Zoetis Inc. 1
Bactrovet Oral Suspension 12.5% Intervet Inc. 1
Rofenaid 40 Zoetis Inc. 2
Agribon Injection 40%, Albon Zoetis Inc. 1
Albon Oral Suspension 5% Zoetis Inc. 1
Albon Zoetis Inc. 1
Albon S.R. (Sustained Release) Zoetis Inc. 1
Medacide-SDM Injection 10% Cronus Pharma Specialities India Private Limited 1
Primor Tablets Zoetis Inc. 2
Romet-30 Pharmaq AS 2
DI-METHOX Huvepharma EOOD 1
DI-METHOX Huvepharma EOOD 1
Di-Methox Injection 40%, Sulfadimethoxine Injection 40% Huvepharma EOOD 1
Sulfadimethoxine Concentrated Solution 12.5% Cronus Pharma Specialities India Private Limited 1
Sulfadimethoxine Injection 40% Huvepharma EOOD 1
Sulfadimethoxine 12.5% Oral Solution Huvepharma EOOD 1
Sulfasol Soluble Powder Med-Pharmex Inc. 1
Sulforal Med-Pharmex Inc. 1
Sulfadimethoxine Soluble Powder Phibro Animal Health Corp. 1
Sulfamed-G Bimeda Animal Health Limited 1
Sulfadimethoxine Soluble Powder First Priority Inc. 1
SulfaMed Bimeda Animal Health Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.93 acidic
pKa2 1.99 Basic
pKa3 0.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 6 GPCR Ki 6.21 DRUG MATRIX

External reference:

IDSource
N0000166864 NUI
D01142 KEGG_DRUG
C0038676 UMLSCUI
CHEBI:32161 CHEBI
CHEMBL62193 ChEMBL_ID
DB06150 DRUGBANK_ID
D013412 MESH_DESCRIPTOR_UI
5323 PUBCHEM_CID
12638 IUPHAR_LIGAND_ID
840 INN_ID
30CPC5LDEX UNII
10172 RXNORM
002825 NDDF
387279005 SNOMEDCT_US
51013009 SNOMEDCT_US

Pharmaceutical products:

None