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astromicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoglycosides, antibiotics obtained from various Micromonospora | 250 | 55779-06-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.23 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.37 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,BRAF,CAMK2D,CDK4,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAPK10,NTRK1,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 | 17 | |||
| kinase-selectivity-class | CHUK,EIF2AK3,IRAK4,MAP2K6,PDK1 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:25212 | metabolite |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.43 | acidic |
| pKa2 | 8.99 | Basic |
| pKa3 | 8.39 | Basic |
| pKa4 | 7.52 | Basic |
| pKa5 | 6.39 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D01881 | KEGG_DRUG |
| 72275-67-3 | SECONDARY_CAS_RN |
| C0060685 | UMLSCUI |
| CHEBI:37923 | CHEBI |
| CHEMBL3084803 | ChEMBL_ID |
| CHEMBL3989466 | ChEMBL_ID |
| 5284517 | PUBCHEM_CID |
| C023384 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4904 | INN_ID |
| 7JHD84H15J | UNII |
Pharmaceutical products:
None