spirapril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 2474 | 83647-97-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.43 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 11.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 8.60 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1994 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09AA11 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 2.99 | acidic |
| pKa2 | 5.23 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 9.10 | CHEMBL | CHEMBL | |||
| Angiotensin-converting enzyme | Enzyme | IC50 | 7.17 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D03765 | KEGG_DRUG |
| 94841-17-5 | SECONDARY_CAS_RN |
| 4020897 | VANDF |
| C0075007 | UMLSCUI |
| CHEMBL431 | ChEMBL_ID |
| DB01348 | DRUGBANK_ID |
| C052555 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6575 | IUPHAR_LIGAND_ID |
| C076884 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6006 | INN_ID |
| 96U2K78I3V | UNII |
| 5311447 | PUBCHEM_CID |
| 36908 | RXNORM |
| 006843 | NDDF |
| 006844 | NDDF |
| 713473008 | SNOMEDCT_US |
| C0172689 | UMLSCUI |
| CHEMBL1200831 | ChEMBL_ID |
| CHEMBL579 | ChEMBL_ID |
| 6357 | INN_ID |
| 83602-05-5 | SECONDARY_CAS_RN |
| 3033702 | PUBCHEM_CID |
| 6576 | IUPHAR_LIGAND_ID |
| QS56V5Y7EC | UNII |
Pharmaceutical products:
None