Spiramycin II 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2472 24916-51-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Spiramycin II
  • acetylspiramycin
  • Foromacidin B
  • Foromacidine B
  • Spiramycin 2
  • Molecular weight: 885.10
  • Formula: C45H76N2O15
  • CLOGP: 2.87
  • LIPINSKI: 2
  • HAC: 17
  • HDO: 3
  • TPSA: 201.45
  • ALOGS: -4.01
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.404 High 0.86
caco2-efflux Caco-2 efflux ratio (BA/AB) 22.336 High 0.86
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.851 10^-6 cm/s High 0.86
dh-clint Dog hepatocyte intrinsic clearance 14.028 uL/min/10^6 cells High 0.86
dppb Dog plasma protein binding (% unbound) 54.590 % High 0.86
fcs-ppb Fetal calf serum protein binding (% unbound) 42.120 % High 0.86
herg hERG pIC50 4.395 pIC50 High 0.86
hh-clint Human hepatocyte intrinsic clearance 8.453 uL/min/10^6 cells High 0.86
hlm-clint Human liver microsomal intrinsic clearance 71.945 uL/min/mg protein High 0.86
hppb Human plasma protein binding (% unbound) 54.930 % High 0.86
kinase-safety-class ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK 18
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 7.780 High 0.86
mh-clint Mouse hepatocyte intrinsic clearance 11.298 High 0.86
mppb Mouse plasma protein binding (% unbound) 55.670 High 0.86
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 11.722 High 0.86
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 58.490 % High 0.86
rh-clint Rat hepatocyte intrinsic clearance 15.311 uL/min/10^6 cells High 0.86
rh-fuinc Rat hepatocyte fraction unbound in incubation 75.420 % High 0.86
rppb Rat plasma protein binding (% unbound) 50 % High 0.86
solubility-dd Solubility at pH 7.4 in DMSO 816.582 uM High 0.86

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:76969 bacterial metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.8 acidic
pKa2 8.03 Basic
pKa3 7.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02420 KEGG_DRUG
C0050540 UMLSCUI
CHEMBL6195749 ChEMBL_ID
C033163 MESH_SUPPLEMENTAL_RECORD_UI
05298J5WMU UNII
49787020 PUBCHEM_CID
698261002 SNOMEDCT_US
CHEBI:31168 CHEBI

Pharmaceutical products:

None